公开(公告)号：HUE031048T2

公开(公告)日：2017-06-28

申请号：HUE10726760

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  GERMANN URSULA A ,  JONES STEVEN ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: A61P31/16

公开(公告)号：PL2442809T3

公开(公告)日：2017-02-28

申请号：PL10726760

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  GERMANN URSULA A ,  JONES STEVEN ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: A61K31/506 ,  A61P31/16

公开(公告)号：ME02558B

公开(公告)日：2017-02-20

申请号：MEP27216

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H ,  KENNEDY JOSEPH M ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BYRN RANDAL ,  ZHOU YI ,  LIN CHAO ,  JIANG MIN ,  GERMANN URSULA A ,  JONES STEVEN ,  SALITURO FRANCESCO G ,  KWONG ANN DAK-YEE

IPC: A61K31/506 ,  A61P31/16

公开(公告)号：AP3867A

公开(公告)日：2016-10-31

申请号：AP2014007402

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DAVIES IOANA ,  DENG HONGBO ,  GAO HUAI ,  GU WENXIN ,  FARMER LUC J ,  DUFFY JOHN P ,  KENNEDY JOSEPH M ,  REDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG

IPC: C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61P31/16

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A compound is represented by Structural Formula ( I ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：AU2012290127B2

公开(公告)日：2016-10-27

申请号：AU2012290127

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BANDARAGE UPUL K ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DAVIES IOANA ,  DENG HONGBO ,  DUFFY JOHN P ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  LEDEBOER MARK W ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  WANG TIANSHENG

IPC: C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61P31/16

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：GEP201606531B

公开(公告)日：2016-08-25

申请号：GEAP2012013400

申请日：2012-08-01

Applicant: VERTEX PHARMA

Inventor： BANDARAGE UPUL K ,  DENG HONGBO ,  LEDEBOER MARK W ,  DUFFY JOHN P ,  CHARIFSON PAUL S ,  CLARK MICHAEL P ,  BETHIEL RANDY S ,  BOYD MICHAEL J ,  DAVIES IOANA ,  FARMER LUC J ,  GAO HUAI ,  GU WENXIN ,  KENNEDY JOSEPH M ,  LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  WANG TIANSHENG ,  PEROLA EMANUELE

IPC: C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61P31/16

Abstract: Compound of formula (2), pharmaceutically acceptable salt thereof, and pharmaceutical composition on a basis thereof. Method for preparation of said compound to treat influenza virus. Table: 6

公开(公告)号：ZA201409246B

公开(公告)日：2016-05-25

申请号：ZA201409246

申请日：2014-12-15

Applicant: VERTEX PHARMA

Inventor： WANG TIANSHENG ,  PEROLA EMANUELE ,  MALTAIS FRANCOIS ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  KENNEDY JOSEPH M ,  GU WENXIN ,  GAO HUAI ,  FARMER LUC J ,  DUFFY JOHN P ,  DENG HONGBO ,  DAVIES IOANA ,  BOYD MICHAEL J ,  BETHIEL RANDY S ,  BANDARAGE UPUL K ,  CLARK MICHAEL P ,  CHARIFSON PAUL S

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A compound is represented by Structural Formula ( I ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：PE20160127A1

公开(公告)日：2016-02-24

申请号：PE2015002683

申请日：2010-06-17

Applicant: VERTEX PHARMA

Inventor： BANDARAGE UPUL K ,  ZHOU YI ,  BYRN RANDAL ,  CHARIFSON PAUL ,  CLARK MICHAEL P ,  COURT JOHN J ,  DENG HONGBO ,  DRUTU IOANA ,  DUFFY JOHN P ,  FARMER LUC ,  GAO HUAI ,  GERMANN URSULA A ,  GU WENXIN ,  JACOBS DYLAN H ,  JIANG MIN ,  JONES STEVEN ,  KENNEDY JOSEPH M ,  KWONG ANN DAK-YEE ,  LEDEBOER MARK W ,  LEDFORD BRIAN ,  LIN CHAO ,  MALTAIS FRANCOIS ,  PEROLA EMANUELE ,  SALITURO FRANCESCO G ,  WANG TIANSHENG ,  WANNAMAKER M WOODS ,  BETHIEL RANDY S

IPC: A61K31/506 ,  A61P31/16

Abstract: Referida a un compuesto derivado de pirrolopiridina de formula IA, donde Z1, Z2, Z3, R1, R2, R3 y R4 tienen la definicion dada en la memoria descriptiva. Dichos compuestos son utiles en la inhibicion de la replicacion de los virus de influenza. Tambien esta referida a una composicion farmaceutica

公开(公告)号：HK1208022A1

公开(公告)日：2016-02-19

申请号：HK15108582

申请日：2015-09-02

Applicant: VERTEX PHARMA

Inventor： GAO HUAI ,  CHARIFSON PAUL S ,  COTTRELL KEVIN MICHAEL ,  DENG HONGBO ,  DUFFY JOHN P ,  GIROUX SIMON ,  GREEN JEREMY ,  JACKSON KATRINA LEE ,  MAXWELL JOHN PATRICK ,  MORRIS MARK A ,  PIERCE ALBERT CHARLES ,  WAAL NATHAN D ,  LAUFFER DAVID J ,  KENNEDY JOSEPH M ,  LEDEBOER MARK WILLEM ,  LI PAN ,  XU JINWANG

IPC: C07D20060101

Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：HK1204322A1

公开(公告)日：2015-11-13

申请号：HK15104769

申请日：2012-10-12

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL P ,  CLARK MICHAEL P MP ,  BANDARAGE UPUL K UK ,  BETHIEL RANDY S RS ,  COURT JOHN J JJ ,  DENG HONGBO ,  DRUTU IOANA I ,  DUFFY JOHN P JP ,  FARMER LUC L ,  GAO HUAI ,  GU WENXIN ,  JACOBS DYLAN H DH ,  KENNEDY JOSEPH M JM ,  LEDEBOER MARK W MW ,  LEDFORD BRIAN B ,  MALTAIS FRANCOIS F ,  PEROLA EMANUELE E ,  WANG TIANSHENG ,  WANNAMAKER M WOODS MW ,  GERMANN URSULA A UA ,  JONES STEVEN S ,  JIANG MIN ,  LIN CHAO ,  ZHOU YI ,  BYRN RANDAL R ,  SALITURO FRANCESCO G FG ,  KWONG ANN DAK-YEE

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.