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公开(公告)号：KR101258878B1
公开(公告)日：2013-04-30
申请号：KR1020090080443
申请日：2009-08-28
Applicant: 한국전자통신연구원
IPC: G01N27/327 , G01N27/414 , A61B5/00
CPC classification number: G01N21/75 , B01L3/502761 , B01L2200/0668 , B01L2300/0645 , B01L2400/043 , G01N21/253 , G01N35/0098 , G01N2035/00158 , G01N2035/00237 , H01L27/14601
Abstract: 본 발명은 바이오 센서 칩에 대한 것으로서, 이 장치는 행렬로 배열되어 있으며, 외부의 광 주사에 의해 선택적으로 감지 신호를 출력하는 복수의 바이오 센서 셀, 상기 복수의 바이오 센서 셀과 동시에 연결되어 선택된 상기 바이오 센서 셀로부터의 상기 감지 신호를 전달하는 감지선, 그리고 상기 감지선으로부터 상기 감지 신호를 받아 외부로 출력하는 출력 단자를 포함한다. 따라서, 바이오 센서 칩에서 복수의 바이오 센서 셀을 어레이 형태로 구현하면서 별도의 구동부를 포함하지 않으므로 제조 공정이 단순화된다. 즉, 외부의 광원을 통해 감지하고자 하는 셀을 선택적으로 주사함으로써 일회성으로 사용되고 버려지는 바이오 센서 칩의 단가를 줄일 수 있다.
바이오 센서, 바이오 센서 어레이, 광 주사, 광 어드레싱-
公开(公告)号：KR101111669B1
公开(公告)日：2012-02-14
申请号：KR1020080130969
申请日：2008-12-22
Applicant: 한국전자통신연구원
Abstract: 본 발명은 검출 장치에 관한 것이다. 본 발명의 검출 장치는 검출 물질과 반응하여 저항 변화를 발생하는 저항성 반응부, 상기 저항 변화에 따라 비선형적 특성을 갖는 전류 신호를 생성하는 검출 신호 생성부, 및 상기 전류 신호를 검출하는 신호 검출부를 포함하고, 상기 저항성 반응부와 상기 검출 신호 생성부는 병렬 연결된다.
검출 장치, 저항, 기준 저항, 다이오드, 비선형, 고감도-
33.发明公开비변형 고체표면을 선택적으로 광응답형 코팅막으로 개질하는 방법 및 광응답형 코팅막을 이용한 활성물질 고정화 방법 失效用于功能化选择性非改性固体表面的方法和用于在活性固体表面上固定活性材料的方法
公开(公告)号：KR1020110069348A
公开(公告)日：2011-06-23
申请号：KR1020090126051
申请日：2009-12-17
Applicant: 한국전자통신연구원
CPC classification number: G01N33/54353 , B01J2219/00612 , B01J2219/00637 , B01J2219/00725
Abstract: PURPOSE: A method of selectively reforming a non-deformation solid surface into an optical response type coating film, and an active material fixing method using the optical response type coating film are provided to selectively combining an active material in the desired part. CONSTITUTION: A method of selectively reforming a non-deformation solid surface into an optical response type coating film comprises the following steps: reforming the non-deformation solid surface without an oxidation process or a nitration process using hydrogen; forming an EGPA coating film on the non-deformation solid surface using light; removing an amine protector or amine slat from the EGPA coating film; forming a coating layer with a functional group reacting to the light on the non-deformation solid surface using the EGPA coating film; and dipping a substrate including the non-deformation solid surface into a buffered oxide etching solution for 10seconds.
Abstract translation: 目的：将非变形固体表面选择性地重整成光响应型涂膜的方法和使用该光响应型涂膜的活性物质定影方法，以选择性地组合所需部分中的活性物质。 构成：将非变形固体表面选择性地重整成光学响应型涂膜的方法包括以下步骤：在不进行氧化处理或使用氢气的硝化工艺下重整非变形固体表面; 使用光在非变形固体表面上形成EGPA涂膜; 从EGPA涂膜中除去胺保护剂或胺板条; 使用EGPA涂膜在非变形固体表面上形成具有与光反应的官能团的涂层; 并将包含非变形固体表面的衬底浸入缓冲氧化物蚀刻溶液中10秒钟。
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公开(公告)号：KR1020100067016A
公开(公告)日：2010-06-18
申请号：KR1020090035121
申请日：2009-04-22
Applicant: 한국전자통신연구원
IPC: G01N33/553 , G01N21/27 , G01N33/53 , G01N33/551
Abstract: PURPOSE: An apparatus for detecting bio-material and a method for detecting the bio-material using the same are provided to cause surface plasmon resonance phenomenon and to easily detect bio-material. CONSTITUTION: An apparatus for detecting a bio-material comprises: a light source unit(200) for providing the incident light; a reaction unit(100) in which surface plasmon resonance phenomenon is induced by incident light and which is separated from a substrate; and a detection unit(300) which detects resonance wavelength of emitted light from the metal nanoparticles by surface plasmon resonance phenomenon. A method for detecting the bio-material comprises: a step of fixing a first sensing molecule on the surface of the metal nanoparticfles having fluidity; a step of inducing surface plasmon phenomenon by irradiating the metal nanoparticles to detect a first resonance wave length of emitted light from the metal nanoparticles; a step of specifically binding target molecules to the first sensing molecule which is fixed at the metal nanoparticles; a step of inducing surface Plasmon resonance phenomenon by irradiating to the metal nanoparticles on which the target molecules are fixed to detect a second resonance wavelength of the emitted light; and a step of comparing the first and second resonance wave length to analyze the target molecules.
Abstract translation: 目的：提供用于检测生物材料的装置和使用其的生物材料的检测方法，以引起表面等离子体共振现象并容易地检测生物材料。 构成：用于检测生物材料的装置包括：用于提供入射光的光源单元（200）; 反应单元（100），其中表面等离子体共振现象由入射光诱导并与衬底分离; 以及检测单元（300），其通过表面等离子体共振现象检测来自金属纳米颗粒的发射光的共振波长。 检测生物材料的方法包括：将具有流动性的金属纳米颗粒表面上的第一感测分子固定的步骤; 通过照射金属纳米粒子来检测来自金属纳米颗粒的发射光的第一共振波长而引起表面等离子体现象的步骤; 将靶分子特异性结合到固定在金属纳米颗粒上的第一感测分子的步骤; 通过照射固定目标分子的金属纳米粒子来检测发射光的第二共振波长来诱导表面等离子体共振现象的步骤; 以及比较第一和第二谐振波长以分析目标分子的步骤。
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公开(公告)号：KR1020100065032A
公开(公告)日：2010-06-15
申请号：KR1020090027383
申请日：2009-03-31
Applicant: 한국전자통신연구원
IPC: G01N33/50 , G01N33/72 , G01N33/563
Abstract: PURPOSE: A bio sensor and a method for detecting bio molecules are provided to electrochemically detect a target molecules having small molecular weight. CONSTITUTION: A bio sensor for detecting a target molecule comprises: a sensing unit on which target molecules for detecting on the surface; and a fluid channel for supplying analysis solution containing the probe molecules to a target molecules. The probe molecules specifically bind to target molecules. The probe molecules have larger charge than the target molecules.
Abstract translation: 目的：提供生物传感器和检测生物分子的方法，以电化学检测分子量小的靶分子。 构成：用于检测靶分子的生物传感器包括：感测单元，其上用于在表面上检测的目标分子; 以及用于将含有探针分子的分析溶液供应给靶分子的流体通道。 探针分子特异性结合靶分子。 探针分子具有比靶分子更大的电荷。
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Patent Agency Ranking
公开(公告)号：KR1020100052631A
公开(公告)日：2010-05-20
申请号：KR1020080111433
申请日：2008-11-11
Applicant: 한국전자통신연구원
CPC classification number: G01N33/54353 , C12Q1/6834 , G01N33/551 , B82Y5/00
Abstract: PURPOSE: A method for fixing an active material on the substrate surface is provided to reproductively form monomolecular film of uniform silane comound in high density. CONSTITUTION: A method for fixing an active material on the substrate surface comprises: a step of cleaning the substrate; a step of modifying the surface with hydroxyl group; a step of modifying the surface using steam of organic silane compound; a step of fixing the active material on the surface end; a step of immersing the substrate in acetone; a step of immersing substrate in methanol; a step of immersing the substrate in mixture solution of sulfuric acid and hydrogen peroxide; and a step of immersing the substrate in mixture of hydrofluoric acid and ammonium fluoride.
Abstract translation: 目的：提供一种将活性材料固定在基材表面上的方法，以高密度再生形成均匀硅烷化合物的单分子膜。 构成：将活性物质固定在基材表面上的方法包括：清洗基材的步骤; 用羟基改性表面的步骤; 使用有机硅烷化合物的蒸汽改性表面的步骤; 将活性物质固定在表面端上的步骤; 将基材浸入丙酮中的步骤; 将底物浸入甲醇中的步骤; 将基板浸入硫酸和过氧化氢的混合溶液中的步骤; 以及将基板浸入氢氟酸和氟化铵的混合物中的步骤。
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公开(公告)号：KR1020100019059A
公开(公告)日：2010-02-18
申请号：KR1020080077893
申请日：2008-08-08
Applicant: 한국전자통신연구원
CPC classification number: G01N27/4145
Abstract: PURPOSE: A method for measuring isoelectric point using FET and a measurement apparatus using the same are provided to measure the isoelectric point of material by calculating current variance difference on a current measurement part even without controlling the acidity of electrolyte solution. CONSTITUTION: A method for measuring isoelectric point comprises following steps. FET is provided. The electrolyte solution of the first concentration is provided to a channel region of FET and first current value flowing in the channel region between the drain electrode and source is measured(S20). The electrolyte solution of the second concentration which is higher than the first concentration is supplied and second current value flowing in the channel region between the drain electrode and the source is measured(S30). The FET or the isoelectric point of material on the FET is decided by using the difference between the first and the second current value(S70).
Abstract translation: 目的：使用FET测量等电点的方法和使用该方法的测量装置，通过计算电流测量部分上的电流方差差来测量材料的等电点，即使不控制电解质溶液的酸度。 构成：测量等电点的方法包括以下步骤。 提供FET。 将第一浓度的电解液提供给FET的沟道区域，并测量在漏极和源极之间的沟道区域中流动的第一电流值（S20）。 提供高于第一浓度的第二浓度的电解液，并测量在漏极和源极之间的沟道区域中流动的第二电流值（S30）。 通过使用第一和第二电流值之间的差来确定FET上的FET或等离子体电位点（S70）。
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公开(公告)号：KR1020090060635A
公开(公告)日：2009-06-15
申请号：KR1020070127521
申请日：2007-12-10
Applicant: 한국전자통신연구원
Abstract: A bio sensor which detects bio material through interaction between target molecule and probe molecule is provided to minimize the sensitivity to the difference of pH concentration and salt concentration and improve detection accuracy. A bio sensor comprises: a photo diode which contains a P-type doping layer(440), N-type doping layer(450) and non-doping area; an electrode which is formed at the both ends of P-type doping layer and N-type doping layer; and a probe molecule(P) which is fixed at the upper side of non-doping area. A method for manufacturing the bio sensor comprises: a step of forming photo diode containing the P-type doping layer, N-type doping layer and non-doping area; a step of forming electrode at the both ends of the P-type doping layer and N-type doping layer; a step of fixing the probe molecule at the upper side of the non-doping area; and a step of injecting target molecule into a sample.
Abstract translation: 提供通过靶分子和探针分子之间的相互作用检测生物材料的生物传感器，以最小化对pH浓度和盐浓度的差异的敏感性，并提高检测精度。 生物传感器包括：光电二极管，其包含P型掺杂层（440），N型掺杂层（450）和非掺杂区域; 在P型掺杂层和N型掺杂层的两端形成的电极; 以及固定在非掺杂区域的上侧的探针分子（P）。 一种用于制造生物传感器的方法，包括：形成含有P型掺杂层，N型掺杂层和非掺杂区的光电二极管的步骤; 在P型掺杂层和N型掺杂层的两端形成电极的步骤; 将探针分子固定在非掺杂区域的上侧的步骤; 以及将靶分子注入样品的步骤。
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公开(公告)号：KR100758285B1
公开(公告)日：2007-09-12
申请号：KR1020060094397
申请日：2006-09-27
Applicant: 한국전자통신연구원
CPC classification number: G01N33/54366 , B01L3/502707 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0887 , G01N35/085
Abstract: A bio sensor is provided to improve sensitivity of bio materials by adsorbing them with all four surfaces of a sensing part, and simultaneously detect various kinds of bio materials through flow of fluid containing various bio materials. A bio sensor(100) comprises a supporting part(110) having a fluid pathway(115A), and a sensing part(113) crossing over the fluid pathway and having reactant capable of reacting with bio materials injected through the fluid pathway on the surface, wherein the supporting part contains a substrate(111), an etching barrier layer(114) in the rear side of the substrate, and an insulating layer(112) in the upper side of the substrate; the sensing part has a dumbbell shape with a center part(113A) having smaller width and left and right parts(113B) having larger width which transfer the detected signal from the center part to electrodes(116) formed in both left and right part.
Abstract translation: 提供生物传感器，以通过将感光部件的所有四个表面吸附来提高生物材料的灵敏度，并通过含有各种生物材料的流体的流动同时检测各种生物材料。 生物传感器（100）包括具有流体通道（115A）的支撑部分（110）和与流体通道交叉的感测部分（113），并具有能够通过表面上的流体通道注入的生物材料反应的反应物 ，其中所述支撑部分包含衬底（111），在所述衬底的后侧中的蚀刻阻挡层（114）以及在所述衬底的上侧中的绝缘层（112）; 感测部具有哑铃形状，具有宽度较小的中心部分（113A），宽度大的左右部分（113B）将检测信号从中心部分转移到左右两部分形成的电极（116）。
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公开(公告)号：KR1020070058937A
公开(公告)日：2007-06-11
申请号：KR1020060035654
申请日：2006-04-20
Applicant: 한국전자통신연구원
IPC: H01L27/115 , B82Y10/00
CPC classification number: H01L51/0512 , B82Y10/00
Abstract: An organic semiconductor device is provided to vary a distance between nano particles by using a charge storage medium as a nano particle with a uniform size distribution. An organic semiconductor layer includes a first electrode(210), an electron channel layer(230) formed on the first electrode and a second electrode(250) formed on the electron channel layer. The electron channel layer is composed of a lower organic material layer(231) formed on the first electrode, a nano particle layer(233), and an upper organic material layer(235) formed on the nano particle layer. The nano particle layer is formed on the lower organic material layer, nano particles having a predetermined size such that the nano particles are separated from each other by a predetermined interval. The electron channel layer can maintain a high conductive state and a low conductive state when a voltage is not applied from the outside.
Abstract translation: 提供有机半导体器件以通过使用具有均匀尺寸分布的电荷存储介质作为纳米颗粒来改变纳米颗粒之间的距离。 有机半导体层包括第一电极（210），形成在第一电极上的电子通道层（230）和形成在电子通道层上的第二电极（250）。 电子通道层由在第一电极上形成的下部有机材料层（231），纳米颗粒层（233）和形成在纳米颗粒层上的上部有机材料层（235）组成。 纳米颗粒层形成在下部有机材料层上，具有预定尺寸的纳米颗粒，使得纳米颗粒彼此间隔预定间隔。 当不从外部施加电压时，电子通道层可以保持高导电状态和低导电状态。
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