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公开(公告)号：ZA9820B
公开(公告)日：1998-07-02
申请号：ZA9820
申请日：1998-01-02
Applicant: ABBOTT LAB
Inventor： DAVIDSEN STEVEN K , SHEPPARD GEORGE S , HOLMS JAMES H , FLORJANCIC ALAN S , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , XU LIANHONG , GUO YAN , SUMMERS JAMES B
IPC: A61K31/395 , A61K31/40 , A61K31/404 , A61K31/4188 , A61K31/427 , A61K31/4427 , A61K31/4523 , A61K31/553 , A61K38/00 , A61K38/55 , A61P1/02 , A61P7/00 , A61P11/06 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D225/06 , C07D245/02 , C07D245/06 , C07D267/00 , C07D273/01 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D487/08 , C07K5/078 , C07D , A61K
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公开(公告)号：CA2767091A1
公开(公告)日：2011-01-20
申请号：CA2767091
申请日：2010-07-14
Applicant: ABBOTT LAB
Inventor： PENNING THOMAS D , GANDHI VIRAJ B , ZHU GUIDONG , TONG YUNSONG , WOODS KEITH W , LAI CHUNQIU , GONG JANE , FLORJANCIC ALAN S
IPC: C07D487/04 , A61P35/00
Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
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公开(公告)号：DOP2008000060A
公开(公告)日：2009-01-15
申请号：DO2008000060
申请日：2008-11-27
Applicant: ABBOTT LAB
Inventor： DART MICHAEL J , CARROLL WILLIAM A , FLORJANCIC ALAN S , FROST JENNIFER M , GALLAGHER MEGAN E , LI TONGMEI , NELSON DEREK W , PATEL MEENA V , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , RYTHER KEITH B , ROSEMARIE KARIN , TEODZYJ
Abstract: Compuestos de la fórmula (1), o sales farmacéuticas, prodrogas, sales de prodrogas, o combinaciones de los mismos, donde R1, R2, R3, R4, y Li se definen en la memoria descriptiva, composiciones que comprenden dichos compuestos, y métodos para tratar condiciones y trastornos usando dichos compuestos y composiciones. La presente invención también se refiere a compuestos de fórmula (II), o sales farmacéuticas, prodrogas, sales de prodrogas, o combinaciones de los mismos, donde Ria, R23 y (R) tienen los valores definidos en la memoria descriptiva, composiciones que comprenden dichos compuestos, y métodos para tratar condiciones y trastornos usando dichos compuestos y composiciones.
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公开(公告)号：NO20085385A
公开(公告)日：2008-12-29
申请号：NO20085385
申请日：2008-12-29
Applicant: ABBOTT LAB
Inventor： RYTHER KEITH B , KOLASA TEODOZYJ , PATEL MEENA V , DART MICHAEL J , CARROLL WILLIAM A , FLORJANCIC ALAN S , FROST JENNIFER M , GALLAGHER MEGAN E , LI TONGMEI , NELSON DEREK W , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , TIETJE KARIN ROSEMARIE
IPC: C07D277/28
CPC classification number: C07D277/82 , C07D277/46 , C07D277/48 , C07D277/60 , C07D417/06 , C07D417/12 , C07D477/14 , C07D513/04
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公开(公告)号：MX2008015217A
公开(公告)日：2008-12-12
申请号：MX2008015217
申请日：2007-05-30
Applicant: ABBOTT LAB
Inventor： PEREZ-MEDRANO ARTURO , DART MICHAEL J , GALLAGHER MEGAN E , RYTHER KEITH B , CARROLL WILLIAM A , FLORJANCIC ALAN S , NELSON DEREK W , KOLASA TEODOZYJ , PATEL MEENA V , LI TONGMEI , FROST JENNIFER M , PEDDI SRIDHAR , TIETJE KARIN ROSEMARIE
IPC: C07D277/46 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , A61P29/00 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: La presente invención se refiere a compuesto de la fórmula (I), o sales farmacéuticas, profármacos, sales de profármacos, o combinaciones de los mismo, en donde R1, R2, R3, R4, y L1 se definen en la memoria descriptiva, composiciones que comprenden dichos compuestos, y métodos para tratar condiciones y trastornos usando dichos compuestos y composiciones. La presente invención también se refiere a compuestos de fórmula (II), o sales farmacéuticas, profármacos, sales de profármacos, o combinaciones de los mismos, en donde R1a, R2a y (Rx)n son como se definen en la memoria descriptiva, composiciones que comprenden dichos compuestos, y métodos para tratar condiciones y trastornos usando dichos compuestos y composiciones.
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Patent Agency Ranking
公开(公告)号：CA2647597A1
公开(公告)日：2007-12-06
申请号：CA2647597
申请日：2007-05-30
Applicant: ABBOTT LAB
Inventor： CARROLL WILLIAM A , FLORJANCIC ALAN S , PATEL MEENA V , FROST JENNIFER M , DART MICHAEL J , TIETJE KARIN ROSEMARIE , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , RYTHER KEITH B , NELSON DEREK W , KOLASA TEODOZYJ , LI TONGMEI , GALLAGHER MEGAN E
IPC: C07D277/46 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , A61P29/00 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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公开(公告)号：CA2294171C
公开(公告)日：2005-10-18
申请号：CA2294171
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： WADA CAROL K , DAVIDSEN STEVEN K , GIESLER JAMIE , XU LIANHONG , DELLARIA JOSEPH F JR , GONG JIANCHUN , FLORJANCIC ALAN S , GUO YAN , CURTIN MICHAEL L , MICHAELIDES MICHAEL R , HOLMS JAMES H , HEYMAN H ROBIN , STEINMAN DOUGLAS
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00 , C07D249/12 , A61K31/16 , A61K31/35 , A61K31/357 , C07D209/40 , A61K31/40 , A61K31/4164 , A61K31/42 , A61K31/44 , A61K31/445
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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38.发明专利
公开(公告)号：BG64307B1
公开(公告)日：2004-09-30
申请号：BG10399599
申请日：1999-12-13
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00
Abstract: The compounds with the formula are inhibitors of matrix metallproteinases. The invention also relates to pharmaceutical compositions and methods for the inhibition of matrix metallproteinases in mammals. 18 claims
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公开(公告)号：SI1001930T1
公开(公告)日：2003-08-31
申请号：SI9830356
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG
IPC: C07C259/00
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公开(公告)号：DK1001930T3
公开(公告)日：2003-03-24
申请号：DK98936014
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , GIESLER JAMIE , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , STEINMAN DOUGLAS H , WADA CAROL K , FLORJANCIC ALAN S , MICHAELIDES MICHAEL R , XU LIANHONG , GONG JIANCHUN
IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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