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公开(公告)号：NO20000542D0
公开(公告)日：2000-02-02
申请号：NO20000542
申请日：2000-02-02
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY ALAN , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: C07D491/048 , A61K31/40 , A61K31/41 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/495 , A61K31/506 , A61K31/535 , A61K31/55 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/08 , A61P13/12 , A61P21/00 , A61P21/04 , A61P25/06 , A61P35/00 , A61P43/00 , C07D207/16 , C07D207/26 , C07D207/27 , C07D403/04 , C07D405/00 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D491/056 , A61K
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公开(公告)号：ZA9501743B
公开(公告)日：1996-03-15
申请号：ZA9501743
申请日：1995-03-02
Applicant: ABBOTT LAB
Inventor： ROSENBERG SAUL H , SULLIVAN GERARD M , BOYD STEVEN A , ZYDOWSKY THOMAS M , TASKER ANDREW S , GELDERN THOMAS W VON
IPC: A61K20060101 , C07C20060101 , C07D20060101 , C07C , A61K , C07D
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33.发明专利
公开(公告)号：AU647174B2
公开(公告)日：1994-03-17
申请号：AU8374491
申请日：1991-09-09
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , DE BISWANATH , ZYDOWSKY THOMAS M , KERKMAN DANIEL J , DEBERNARDIS JOHN F , ROSENBERG SAUL H , SHIOSAKI KAZUMI , BASHA FATIMA Z , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY A , HOLLEMAN WILLIAM H
IPC: A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/53 , A61P1/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P27/02 , A61P43/00 , C07D213/64 , C07D213/70 , C07D213/71 , C07D213/72 , C07D213/74 , C07D213/80 , C07D239/26 , C07D239/34 , C07D239/42 , C07D257/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , A61K31/43 , A61K31/535 , A61K31/41
Abstract: Novel pyrimidine, pyridine, pyridazine, pyrazine and triazine compounds are provided of the formula (I). The compounds of the invention are useful for treating hypertension, edema, renal failure, congestive heart failure, psoriasis and glaucoma, and in the prevention and treatment of atherosclerosis or to treat gastrointestinal disorders associated with enhanced contractility and/or motility of intestinal smooth muscle or to treat contractile disorders of the uterus.
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34.发明专利
公开(公告)号：AU781355B2
公开(公告)日：2005-05-19
申请号：AU2984101
申请日：2001-03-23
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J JR , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: A61K31/40 , C07D207/16 , C07D401/04 , C07D405/04 , C07D405/14 , C07F9/572 , C07F9/59
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公开(公告)号：HRP20010776A2
公开(公告)日：2002-12-31
申请号：HRP20010776
申请日：2001-10-23
Applicant: ABBOTT LAB
Inventor： LINK JAMES , LIU GANG , PEI ZHONGHUA , GELDERN THOMAS W VON , WINN MARTIN , XIN ZHILI , WANG SHELDON , BOYD STEVEN A , ZHU GUI-DONG , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , STAEGER MICHAEL A , JAE HWAN-SOO , LYNCH JOHN K
IPC: C07D243/08 , A61K20060101 , A61K31/10 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/451 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P29/00 , A61P37/06 , C07C20060101 , C07C323/60 , C07C323/62 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/273 , C07D209/08 , C07D209/12 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/81 , C07D215/24 , C07D217/02 , C07D217/04 , C07D217/06 , C07D233/61 , C07D239/42 , C07D241/04 , C07D241/24 , C07D257/04 , C07D279/12 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/22 , C07D295/26 , C07D307/24 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/66 , C07D319/18 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D471/20 , C07D487/04 , C07D491/113 , C07D521/00
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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Patent Agency Ranking36.发明专利
公开(公告)号：NZ502395A
公开(公告)日：2002-08-28
申请号：NZ50239598
申请日：1998-07-27
Applicant: ABBOTT LAB
Inventor： KING STEVEN A , WITTENBERGER STEVEN J , WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG
IPC: C07D491/048 , A61K31/40 , A61K31/41 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/495 , A61K31/506 , A61K31/535 , A61K31/55 , A61P1/00 , A61P1/04 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/08 , A61P13/12 , A61P21/00 , A61P21/04 , A61P25/06 , A61P35/00 , A61P43/00 , C07D207/16 , C07D207/26 , C07D207/27 , C07D403/04 , C07D405/00 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D491/056
Abstract: [2S,3R,4S]-2-(2,2-Dimethylpentyl)-4-(7-methoxy-1,3-benzodioxol-5-yl)-1 -(N,N-di-(n-butyl)-aminocarbonylmethyl)-pyrrolidine-3-carboxylic acid and [2S,3R,4S]-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-[(N-butyl-N- (4-dimethylaminobutyl)-amino)carbonylmethyl]-pyrrolidine-3-carboxylic acid, a pharmaceutically acceptable salt thereof and the pharmaceutical composition thereof are useful for antagonizing the endothelin activity.
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公开(公告)号：NO996244L
公开(公告)日：2000-01-12
申请号：NO996244
申请日：1999-12-16
Applicant: ABBOTT LAB
Inventor： TASKER ANDREW S , WINN MARTIN , BOYD STEVEN A , JAE HWAN-SOO , GELDERN THOMAS W VON , SORENSEN BRYAN K , HENRY KENNETH J
IPC: C07D207/16 , C07D405/04 , A61K31/40
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公开(公告)号：NO996244A
公开(公告)日：2000-01-12
申请号：NO996244
申请日：1999-12-16
Applicant: ABBOTT LAB
Inventor： TASKER ANDREW S , WINN MARTIN , BOYD STEVEN A , JAE HWAN-SOO , GELDERN THOMAS W VON , SORENSEN BRYAN K , HENRY KENNETH J
IPC: C07D207/16 , C07D405/04 , A61K31/40
CPC classification number: C07D405/04 , C07D207/16
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公开(公告)号：NO996244D0
公开(公告)日：1999-12-16
申请号：NO996244
申请日：1999-12-16
Applicant: ABBOTT LAB
Inventor： TASKER ANDREW S , WINN MARTIN , BOYD STEVEN A , JAE HWAN-SOO , GELDERN THOMAS W VON , SORENSEN BRYAN K , HENRY KENNETH J
IPC: C07D207/16 , C07D405/04 , C07D
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公开(公告)号：ZA986908B
公开(公告)日：1999-04-26
申请号：ZA986908
申请日：1998-07-31
Applicant: ABBOTT LAB
Inventor： WINN MARTIN , BOYD STEVEN A , HUTCHINS CHARLES W , JAE HWAN-SOO , TASKER ANDREW S , GELDERN THOMAS W VON , KESTER JEFFREY A , SORENSEN BRYAN K , SZCZEPANKIEWICZ BRUCE G , HENRY KENNETH J , LIU GANG , WITTENBERGER STEVEN J , KING STEVEN A
IPC: A61K20060101 , C07D20060101 , C07F20060101 , C07D , A61K , C07F
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