公开(公告)号：NZ547160A

公开(公告)日：2009-11-27

申请号：NZ54716004

申请日：2004-11-12

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  ELMORE STEVEN ,  KUNZER AARON R ,  LYNCH CHRISTOPHER L ,  MCCLELLAN WILLIAM ,  PARK CHEOL-MIN ,  PETROS ANDREW ,  SONG XIAOHONG ,  WANG XILU ,  TU NOAH ,  WENDT MICHAEL D

IPC: A61K31/635 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61P35/00 ,  C07C311/51 ,  C07C323/25 ,  C07D205/04 ,  C07D207/16 ,  C07D211/44 ,  C07D211/46 ,  C07D211/60 ,  C07D211/74 ,  C07D213/70 ,  C07D213/75 ,  C07D233/06 ,  C07D233/84 ,  C07D239/06 ,  C07D263/58 ,  C07D277/36 ,  C07D277/74 ,  C07D295/13 ,  C07D295/14 ,  C07D295/155 ,  C07D295/192 ,  C07D307/64 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D409/12 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D487/04 ,  C07D487/08

Abstract: Disclosed are N-acylsulfonamide compounds of formula (I), wherein the substituents are as defined in the specification, which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases such as bladder cancer, brain cancer, breast cancer, bone marrow cancer, cervical cancer, chronic lymphocytic leukemia, colorectal cancer, esophageal cancer, hepatocellular cancer, lymphoblastic leukemia, follicular lymphoma, lymphoid malignancies of T-cell or B-cell origin, melanoma, myelogenous leukemia, myeloma, oral cancer, ovarian cancer, non-small cell lung cancer, prostate cancer, small cell lung cancer or spleen cancer.

公开(公告)号：DOP2009000246A

公开(公告)日：2009-11-15

申请号：DO2009000246

申请日：2009-10-14

Applicant: ABBOTT LAB

Inventor： ELMORE STEVEN W ,  SOUERS ANDREW J ,  BRUNCKO MILAN ,  SONG XIAOHONG ,  WANG XILU ,  HASVOLD LISA A ,  WANG LE ,  KUNZER AARON R ,  PARK CHEOL-MIN ,  WENDT MICHAEL D ,  TAO ZHI-FU ,  MADAR DAVID

IPC: C07D209/34

Abstract: Compuestos que inhiben la actividad de la proteína antiapoptóticas Mcl-1, composiciones que contienen los compuestos, y métodos para tratar enfermedades relacionadas con la sobreexpresion o falta de regulación de la proteína Mcl-1

公开(公告)号：CA2606147A1

公开(公告)日：2007-04-12

申请号：CA2606147

申请日：2006-05-12

Applicant: ABBOTT LAB

Inventor： WANG XILU ,  ELMORE STEVEN W ,  SONG XIAOHONG ,  KUNZER AARON R ,  LYNCH CHRISTOPHER L ,  PARK CHEOL MIN ,  MCCELLAN WILLIAM J ,  BRUNCKO MILAN ,  DING HONG

IPC: C07D295/14 ,  A61K31/496 ,  A61P35/00 ,  C07D487/08 ,  C07D491/08

Abstract: Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.

公开(公告)号：CA2546101A1

公开(公告)日：2005-06-02

申请号：CA2546101

申请日：2004-11-12

Applicant: ABBOTT LAB

Inventor： WANG XILU ,  SONG XIAOHONG ,  MCCLELLAN WILLIAM ,  PARK CHEOL-MIN ,  LYNCH CHRISTOPHER L ,  PETROS ANDREW ,  TU NOAH ,  WENDT MICHAEL D ,  BRUNCKO MILAN ,  DING HONG ,  KUNZER AARON R ,  ELMORE STEVEN

IPC: C07D295/14 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/635 ,  A61P35/00 ,  C07C311/51 ,  C07C323/25 ,  C07D205/04 ,  C07D207/16 ,  C07D211/44 ,  C07D211/46 ,  C07D211/60 ,  C07D211/74 ,  C07D213/70 ,  C07D213/75 ,  C07D233/06 ,  C07D233/84 ,  C07D239/06 ,  C07D263/58 ,  C07D277/36 ,  C07D277/74 ,  C07D295/13 ,  C07D295/155 ,  C07D295/192 ,  C07D307/64 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D409/12 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D487/04 ,  C07D487/08

Abstract: Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti - apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein famil y member.

公开(公告)号：AU2004290666A1

公开(公告)日：2005-06-02

申请号：AU2004290666

申请日：2004-11-12

Applicant: ABBOTT LAB

Inventor： TU NOAH ,  KUNZER AARON R ,  BRUNCKO MILAN ,  WANG XILU ,  LYNCH CHRISTOPHER L ,  DING HONG ,  MCCLELLAN WILLIAM ,  SONG XIAOHONG ,  ELMORE STEVEN ,  PETROS ANDREW ,  WENDT MICHAEL D ,  PARK CHEOL-MIN

IPC: A61K31/635 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  C07C311/51 ,  C07C323/25 ,  C07D205/04 ,  C07D207/16 ,  C07D211/44 ,  C07D211/46 ,  C07D211/60 ,  C07D211/74 ,  C07D213/70 ,  C07D213/75 ,  C07D233/06 ,  C07D233/84 ,  C07D239/06 ,  C07D263/58 ,  C07D277/36 ,  C07D277/74 ,  C07D295/13 ,  C07D295/155 ,  C07D295/192 ,  C07D307/64 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D409/12 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D487/04 ,  C07D487/08

Abstract: Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein family member.

公开(公告)号：HK1177202A1

公开(公告)日：2013-08-16

申请号：HK13104084

申请日：2013-04-03

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DAI YUJIA ,  DING HONG ,  DOHERTY GEORGE A ,  ELMORE STEVEN W ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON ,  MANTEI ROBERT A ,  MCCLELLAN WILLIAM J ,  PARK CHANG H ,  PARK CHEOL-MIN ,  PETROS ANDREW M ,  SONG XIAOHONG ,  SOUERS ANDREW J ,  SULLIVAN GERARD M ,  TAO ZHI-FU ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WENDT MICHAEL D ,  HANSEN TODD M

IPC: C07D20060101

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：ECSP12012020A

公开(公告)日：2012-08-31

申请号：ECSP12012020

申请日：2012-07-03

Applicant: ABBOTT LAB

Inventor： HASVOLD LISA A ,  SULLIVAN GERARD M ,  WANG GARY ,  WANG XILU ,  MANTEI ROBERT A ,  ELMORE STEVEN W ,  SOUERS ANDREW J ,  BRUNCKO MILAN ,  SONG XIAOHONG ,  WANG LE ,  KUNZER AARON R ,  PARK CHEOL-MIN ,  WENDT MICHAEL D ,  DAI YUJIA ,  DING HONG ,  HEXAMER LAURA ,  MCCLELLAN WILLIAM J ,  PARK CHANG H ,  PETROS ANDREW M ,  HANSEN TODD M ,  DOHERTY GEORGE A ,  TAO ZHI FU

IPC: C07D209/08 ,  C07D211/58 ,  C07D213/74 ,  C07D235/06 ,  C07D277/24 ,  C07D309/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.

公开(公告)号：SG181491A1

公开(公告)日：2012-07-30

申请号：SG2012040820

申请日：2010-06-01

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  DOHERTY GEORGE A ,  ELMORE STEVEN W ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON ,  MANTEI ROBERT A ,  MCCLELLAN WILLIAM J ,  PARK CHANG H ,  PARK CHEOL-MIN ,  PETROS ANDREW M ,  SONG XIAOHONG ,  SOUERS ANDREW J ,  SULLIVAN GERARD M ,  TAO ZHI-FU ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WENDT MICHAEL D ,  HANSEN TODD M

Abstract: Disclosed are compounds (I) which inhibit the activity of anti-apoptotic Bc1-2 or Bc1 xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti apoptotic Bc1-2 protein.

公开(公告)号：ZA201103807B

公开(公告)日：2012-02-29

申请号：ZA201103807

申请日：2011-05-24

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  ELMORE STEVEN W ,  HEXAMER LAURA ,  MANTEI ROBERT A ,  PARK CHANG HEE ,  PETROS ANDREW J ,  SOUERS ANDREW J ,  TAO ZHI-FU ,  WANG LE ,  WENDT MICHAEL D ,  DAI YUJIA ,  DOHERTY GEORGE A ,  HASVOLD LISA A ,  KUNZER AARON R ,  MCCLELLAN WILLIAM J ,  PARK CHEOL-MIN ,  SONG XIAOHONG ,  SULLIVAN GERARD M ,  WANG GARY T ,  WANG XILU

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：CA2606147C

公开(公告)日：2011-07-05

申请号：CA2606147

申请日：2006-05-12

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  ELMORE STEVEN W ,  KUNZER AARON R ,  LYNCH CHRISTOPHER L ,  MCCELLAN WILLIAM J ,  PARK CHEOL MIN ,  SONG XIAOHONG ,  WANG XILU

IPC: C07D295/14 ,  A61K31/496 ,  A61P35/00 ,  C07D487/08 ,  C07D491/08

Abstract: Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an antiapoptotic family protein member are disclosed.