公开(公告)号：EA002853B1

公开(公告)日：2002-10-31

申请号：EA200000132

申请日：1998-07-21

Applicant: BASF AG

Inventor： ZEIDER JURGEN ,  NEUMANN JORG ,  LIEPOLD BERND ,  ROSENBERG JOERG ,  BERNDL GUNTHER ,  BREITENBACH JORG ,  VOLLGRAF CHRISTIANE

IPC: A61K9/20 ,  A61K31/192 ,  A61K47/02 ,  A61K47/32 ,  A61P29/00 ,  A61P29/02

Abstract: Настоящееизобретениеотноситсяк быстродействующемуобезболивающемупрепарату, содержащемув качествеобезболивающеговеществаибупрофенв матрицевспомогательныхвеществи имеющемупористуюструктуруи плотностьотболее 1 г/смидо 2,5 г/см. Изобретениетакжеотноситсяк способуполучениятакогопрепарата.

公开(公告)号：ES2170259T3

公开(公告)日：2002-08-01

申请号：ES96929292

申请日：1996-08-21

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JORG

IPC: A61K9/20

Abstract: Lipids are used as aids in the production of solid drug forms by melt extrusion.

公开(公告)号：ES2163008T3

公开(公告)日：2002-01-16

申请号：ES96907439

申请日：1996-03-12

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JORG

IPC: A61K9/14 ,  A61K9/20 ,  B01J2/20

Abstract: PCT No. PCT/EP96/01047 Sec. 371 Date Nov. 21, 1996 Sec. 102(e) Date Nov. 21, 1996 PCT Filed Mar. 12, 1996 PCT Pub. No. WO96/29061 PCT Pub. Date Sep. 26, 1996A process for producing active substance compositions in the form of a solid solution of the active substance in a polymer matrix, which comprises melt extrusion of the active substance in nonionic form together with a polymer and a salt.

公开(公告)号：SK282275B6

公开(公告)日：2002-01-07

申请号：SK76997

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05117 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19962 PCT Pub. Date Jul. 4, 1996A process for the production of divisible tablets by melt calendering in which two molding rolls are combined together, at least one of which has depressions with at least one bar which extends up to the surface line of the molding roll and forms a score.

公开(公告)号：AU6603301A

公开(公告)日：2001-12-11

申请号：AU6603301

申请日：2001-05-29

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  BREITENBACH JORG ,  HERR DIETER ,  LAUX VOLKER ,  HEGER ROBERT

IPC: A61K47/12 ,  A61K9/16 ,  A61K31/726 ,  A61K31/727 ,  A61K47/14 ,  A61K47/30 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K47/44 ,  A61P1/04 ,  A61P7/02 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/06 ,  A61K9/48

公开(公告)号：CA2369951A1

公开(公告)日：2000-11-02

申请号：CA2369951

申请日：2000-04-11

Applicant: BASF AG

Inventor： SCHROF WOLFGANG ,  VOELKEL RUDIGER ,  ZEIDLER JURGEN ,  BINDER RUDOLF ,  HEGER ROBERT ,  BREITENBACH JORG ,  LIEPOLD BERND ,  BERNDL GUNTHER ,  RIEGER JENS

IPC: A61K47/22 ,  A61K9/16 ,  A61K31/4184 ,  A61K31/4439 ,  A61K45/00 ,  A61K47/34 ,  A61K47/42 ,  A61P1/00 ,  A61P1/04 ,  A61P35/00

Abstract: The invention relates to a solid preparation, containing an acid-sensitive proton-pump blocker as the active substance, whereby said active substance i s present in an x-ray amorphous form and is embedded in molecularly dispersed form in an auxiliary agent matrix.

公开(公告)号：CA2368625A1

公开(公告)日：2000-10-05

申请号：CA2368625

申请日：2000-03-17

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  RUCHATZ FOLKER ,  BERNDL GUNTHER ,  SACK HEINRICH ,  SANNER AXEL

IPC: A61K47/14 ,  A61K9/20 ,  A61K47/32

Abstract: The invention relates to additives in powder form for use in solid pharmaceutical presentation forms. Said aids contain a pharmaceutically acceptable polymer and a liquid or semi-solid surface-active substance with solubilizing action.

公开(公告)号：CA2368138A1

公开(公告)日：2000-10-05

申请号：CA2368138

申请日：2000-03-17

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  LIEPOLD BERND ,  ROSENBERG JORG ,  BREITENBACH JORG

IPC: A61K47/10 ,  A61K9/16 ,  A61K9/20 ,  A61K47/14 ,  A61K47/34 ,  A61P31/10 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00

Abstract: The invention relates to mechanically stable pharmaceutical presentation for ms for peroral administration which in addition to one or more active ingredien ts and at least one thermoplastically mouldable matrix-forming auxiliary contai n more than 10 and up to 40 % by weight of a surface-active substance which ha s an HLB of between 2 and 18 and is liquid at 20 ~C or has a dropping point at between 20 and 50 ~C.

公开(公告)号：CA2353809A1

公开(公告)日：2000-06-15

申请号：CA2353809

申请日：1999-12-07

Applicant: BASF AG

Inventor： BOHN HERIBERT ,  BREITENBACH JORG ,  HEGER ROBERT ,  AUWETER HELMUT

IPC: A61K47/30 ,  A61K8/02 ,  A61K8/04 ,  A61K8/11 ,  A61K8/72 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61K9/20 ,  A61K9/51 ,  A61K9/70 ,  A61K31/426 ,  A61K47/42 ,  A61Q19/00 ,  A61K9/50

Abstract: Nanoparticulate preparations of pharmaceutical and cosmetic active substance s with a core-shell structure, whereby the active substance is present in an X - ray amorphous form, together with a polymer matrix and the shell consists of a stabilizing sheathing matrix.

公开(公告)号：ES2135790T3

公开(公告)日：1999-11-01

申请号：ES95943203

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05119 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19964 PCT Pub. Date Jul. 4, 1996The present invention relates to a process for the production of lenticular tablets by melt calendering in which molding rolls with depressions in the shape of segments of an ellipsoid are used. The process according to the invention affords tablets which are easily deflashed and in which the tablet residue to be abraded when there is a displacement between the upper and lower half of the tablet is small.