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    33.
    发明专利
    未知

    公开(公告)号：DE59702687D1

    公开(公告)日：2001-01-04

    申请号：DE59702687

    申请日：1997-04-24

    Applicant: BASF AG

    Inventor： BREITENBACH JOERG ,  KOLTER KARL ,  SCHMITT ANGELIKA

    IPC: A61K8/81 ,  C08J3/12 ,  A61K9/28 ,  A61K47/32 ,  A61Q1/12 ,  C08J3/03 ,  C08L31/00 ,  C08L33/08 ,  C08L33/10

    Abstract: Polymer powders redispersible in aqueous solution, their use in cosmetic, pharmaceutical or crop protection formulations and a process for preparing polymer powders redispersible in aqueous solution comprising copolymers carrying free acid or base groups and, if appropriate, auxiliaries, which comprises adjusting the pH of the dispersion prior to drying by the addition of at least one buffer system to a pH of from 2.0 to 6.5 in the case of copolymers carrying free acid groups or a pH of from pH 7.5 to 12 in the case of copolymers carrying free base groups.

    Flexible, water-soluble or water-dispersible coating agent, binder or film former for pharmaceutical formulations, comprises new or known vinyl ester-polyether graft copolymer,
    35.
    发明专利
    Flexible, water-soluble or water-dispersible coating agent, binder or film former for pharmaceutical formulations, comprises new or known vinyl ester-polyether graft copolymer, 未知

    公开(公告)号：DE19905906A1

    公开(公告)日：2000-08-17

    申请号：DE19905906

    申请日：1999-02-11

    Applicant: BASF AG

    Inventor： ANGEL MAXIMILIAN ,  GOTSCHE MICHAEL ,  KOLTER KARL

    IPC: A61K9/12 ,  A61K9/20 ,  A61K9/28 ,  A61K9/30 ,  A61K47/34 ,  C08L31/00 ,  C08L29/10 ,  C08L59/00 ,  C08L71/00

    Abstract: The use of polymers (I), obtained by graft polymerization of vinyl esters of aliphatic carboxylic acids onto polyethers (II), as coating agent, binder and/or film-former in pharmaceutical dosage forms is new. Some (I) are new compounds. The use of polymers (I), obtained by polymerization of at least one vinyl ester of a 1-24C aliphatic carboxylic acid in presence of a polyether of formula (II), is claimed as coating agent, binder and/or film-forming auxiliary in pharmaceutical dosage forms. R1 = H, R9, R9C(O)-, R9NHC(O)- or a polyol residue; R8 = H, R9, R9C(O)- or R9NHC(O)-; R2-R7 = (CH2)2, (CH2)3, (CH2)4, CH2CH(Me), CH2CH(Et) or CH2CH(OR10)CH2; R9 = 1-24C alkyl; R10 = H, R9 or R9C(O)-; A = C(O)O, C(O)-B-C(O)O or C(O)NH-B-C(O)O; B = (CH2)t or arylene (optionally substituted); n = 1-8; s = 0-500; t = 1-12; u, x = 1-5000; v, w, y, z = 0-5000. Independent claims are included for: (a) pharmaceutical dosage forms containing (I); and (b) new polymers (I'), as defined for (I) above provided that: (i) R1 and R8 are other than R9NHC(O)-, A is other than C(O)NH-B-C(O)O and s is other than 0; (ii) R1 and R8 are other than R9NHC(O)-, R2-R4 are other than CH2CH(OR10)CH2, A is other than C(O)NH-B-C(O)O, s = 0 and (I) also contain units derived from at least further monomer (III) selected from 3-8C monoethylenically unsaturated carboxylic acids (or their 1-24C alkyl or 1-24C hydroxyalkyl esters), 1-24C alkyl-vinyl ethers or N-vinyl-lactams; or (iii) (II) is a polyglycerol in which R2 = CH2CH(OR10)CH2; s, v, w = 0; u = 1-2000; and R1 and R8 are other than R9NHC(O).

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