公开(公告)号：FR2842407A1

公开(公告)日：2004-01-23

申请号：FR0209099

申请日：2002-07-18

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC ,  CLADE SOPHIE

IPC: A61B1/00 ,  G01N21/64 ,  A61B1/04 ,  A61B5/00 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.

公开(公告)号：AU2002364332A1

公开(公告)日：2003-07-30

申请号：AU2002364332

申请日：2002-12-20

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  BOURG-HECKLY GENEVIEVE ,  VILETTE SANDRINE ,  LACOMBE FRANCOIS ,  LOISEAU ALEXANDRE ,  ABRAT BENJAMIN

IPC: A61B1/00 ,  A61B5/00 ,  G01N21/64 ,  A61B1/04 ,  G02B23/26

Abstract: An equipment includes an excitation source ( 1 ), elements for injecting ( 2 ) an excitation signal produced by the source in an ordered bundle ( 3 ) of flexible optical fibers, elements for analyzing ( 21, 22 ) an emitted autofluorescence signal. The equipment also includes at the output of the optical fiber bundle ( 3 ) an optical head ( 4 ) designed to be placed in contact with the biological tissue ( 6 ), the optical head being equipped with optical elements adapted to cause the excitation signal output from the bundle ( 3 ) to converge into a subsurface analyzing zone ( 5 ), the same optical fiber(s) used for excitation of the bundle ( 3 ) being used for detecting the signal emitted by the subsurface analyzing zone, elements (D) placed upstream of the injection elements ( 2 ) being further provided to separate the wavelength of the excitation signal and the wavelength of the autofluorescence signal.

公开(公告)号：ES2410538T3

公开(公告)日：2013-07-02

申请号：ES07731377

申请日：2007-04-27

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  MATHIEU GILLES ,  VIELLEROBE BERTRAND ,  DOUSSOUX FRANCOIS ,  BOULAROT NICOLAS ,  LAVILLONNIERE NICOLAS

IPC: A61B1/00 ,  G02B21/00 ,  G02B23/24

Abstract: Cabezal óptico miniaturizado previsto para equipar el extremo distal de un haz de fibras ópticas flexibles barridopor un haz láser, estando dicho cabezal óptico destinado a entrar en contacto con una muestra y excitar dichamuestra de manera confocal; comprendiendo este cabezal óptico un bloque óptico de corrección de aberracionesesféricas y un bloque óptico de enfoque; caracterizado porque el bloque de enfoque comprende: - al menos una primera lente convergente (4; 18, 19) asociada con una lente esférica o semiesférica (5; 10)dispuesta en el extremo distal del cabezal óptico, y - medios de corrección del cromatismo axial y lateral que se proporcionan con una sola lente divergente (3b) quetiene una curvatura centrada sobre la pupila del haz de fibras ópticas; estando esta lente divergente asociada conuna segunda lente convergente (3a) en forma de un doblete (3; 17) comprendiendo el bloque de corrección de las aberraciones esféricas una tercera lente convergente (2); estando los espesores de la primera (4) y tercera (2) lentes convergentes dispuestos para corregir la aberraciónesférica acumulada sobre las dioptrías convergentes, estando también el espesor de la tercera lente convergente (2) dispuesto para obtener imágenes de la pupila sobrela segunda lente convergente (3).

公开(公告)号：AU2010296946A1

公开(公告)日：2012-05-03

申请号：AU2010296946

申请日：2010-09-17

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BOULAROT NICOLAS ,  GENET MAGALIE ,  SCHWARZ FRANCE

IPC: A61B1/04

Abstract: A method to inspect a solid organ in a subject includes introducing a needle in a predetermined area of the solid organ, inserting an optical probe through a lumen of the needle, and imaging the predetermined area using the optical probe. An optical probe to inspect a solid organ in a subject, the optical probe being intended to be positioned in the solid organ through a needle, the optical probe includes an optical fiber bundle, a ferule to protect the distal tip of the optical fiber bundle, the ferule comprising a shank and a head, and a sheath wrapping the fiber bundle and the shank, wherein the head of the ferule has a length adapted for the optical probe to image the solid organ while keeping the sheath inside the needle.

公开(公告)号：FR2864438B1

公开(公告)日：2006-11-17

申请号：FR0315627

申请日：2003-12-31

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： MATHIEU GILLES ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

IPC: A61B1/07 ,  A61B1/00 ,  A61B1/005 ,  A61B1/04 ,  A61B1/05 ,  A61B5/00 ,  G02B6/06 ,  G02B6/26 ,  G02B6/35 ,  G02B7/02 ,  G02B21/00 ,  G02B26/08 ,  G02B26/10 ,  H01J3/14

Abstract: The head has a laser source to produce a light beam (13), and a ball lens (12), with a large numerical aperture, disposed at the end of the head to converge the beam at an excitation point (19). The point is located in an observed sub-surface field (14) of a sample (15). A scanning unit (10) displaces the source in rotation such that the point scans the field. An independent claim is also included for a confocal imaging system.

公开(公告)号：DE60205408D1

公开(公告)日：2005-09-08

申请号：DE60205408

申请日：2002-12-20

Applicant: MAUNA KEA TECHNOLOGIES PARIS

Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

IPC: G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00 ,  G02B23/24

Abstract: Equipment includes an image guide ( 1 ) consisting of flexible optical fibers with: on the proximal end side: a source ( 2 ), angular scanning elements ( 3 ), injection elements ( 4 ) in one of the fibers, elements for splitting ( 5 ) the illuminating beam and the backscattered signal, elements for spatial filtering ( 6 ), elements for detecting ( 7 ) the signal, electronic elements ( 8 ) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head ( 9 ) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M 1 ) and a galvanometric field mirror (M 2 ) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M 1 , M 2 ) firstly in the field mirror (M 2 ) and the injection elements ( 4 ) in the image guide in a second step.

公开(公告)号：FR2842407B1

公开(公告)日：2005-05-06

申请号：FR0209099

申请日：2002-07-18

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC ,  CLADE SOPHIE

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  A61B5/00 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.

公开(公告)号：FR2834340B1

公开(公告)日：2004-07-16

申请号：FR0116981

申请日：2001-12-28

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  BOURG HECKLY GENEVIEVE ,  VILETTE SANDRINE ,  LACOMBE FRANCOIS ,  LOISEAU ALEXANDRE ,  ABRAT BENJAMIN

IPC: A61B1/00 ,  A61B5/00 ,  G01N21/64 ,  G01N33/483 ,  A61B1/07

Abstract: An equipment includes an excitation source ( 1 ), elements for injecting ( 2 ) an excitation signal produced by the source in an ordered bundle ( 3 ) of flexible optical fibers, elements for analyzing ( 21, 22 ) an emitted autofluorescence signal. The equipment also includes at the output of the optical fiber bundle ( 3 ) an optical head ( 4 ) designed to be placed in contact with the biological tissue ( 6 ), the optical head being equipped with optical elements adapted to cause the excitation signal output from the bundle ( 3 ) to converge into a subsurface analyzing zone ( 5 ), the same optical fiber(s) used for excitation of the bundle ( 3 ) being used for detecting the signal emitted by the subsurface analyzing zone, elements (D) placed upstream of the injection elements ( 2 ) being further provided to separate the wavelength of the excitation signal and the wavelength of the autofluorescence signal.

公开(公告)号：FR2834349B1

公开(公告)日：2004-04-09

申请号：FR0116980

申请日：2001-12-28

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

IPC: G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00 ,  G02B23/24 ,  G02B26/10 ,  G06F19/00

Abstract: Equipment includes an image guide ( 1 ) consisting of flexible optical fibers with: on the proximal end side: a source ( 2 ), angular scanning elements ( 3 ), injection elements ( 4 ) in one of the fibers, elements for splitting ( 5 ) the illuminating beam and the backscattered signal, elements for spatial filtering ( 6 ), elements for detecting ( 7 ) the signal, electronic elements ( 8 ) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head ( 9 ) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M 1 ) and a galvanometric field mirror (M 2 ) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M 1 , M 2 ) firstly in the field mirror (M 2 ) and the injection elements ( 4 ) in the image guide in a second step.

公开(公告)号：CA2471721A1

公开(公告)日：2003-07-10

申请号：CA2471721

申请日：2002-12-20

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BOURRIAUX STEPHANE ,  LACOMBE FRANCOIS ,  BERIER FREDERIC ,  MARTI SANDRA ,  VIELLEROBE BERTRAND ,  GENET MAGALIE ,  LE GOUALHER GEORGES ,  PERCHANT AYMERIC

IPC: G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00 ,  G02B23/24

Abstract: Il comporte un guide d~image (1) constitué de fibres optiques souples avec : du côté de l~extrémité proximale : une source (2), des moyens de balayage angulaire (3), des moyens d~injection (4) dans l~une des fibres, des moyens de séparation (5) du faisceau d~illumination et du signal rétroémis, des moyens de filtrage spatial (6), des moyens de détection (7) dudit signal, des moyens électroniques (8) de commande, d~analyse et de traitement numérique du signal détecté et de visualisation ; et du côté de l~extrémité distale : une tête optique (9) adaptée à focaliser le faisceau d~illumination sortant de la fibre illuminée. Selon l~invention, les moyens (3) comprennent un miroir ligne résonnant (M1) et un miroir trame (M2) galvanométrique avec une fréquence variable et deux systèmes optiques d~afocaux adaptés à conjuguer les deux miroirs (M1, M2) dams un premier temps puis le miroir trame (M2) et le moyen d~injection (4) dans le guide d~image dans un deuxième temps.