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公开(公告)号：AU2021248641A1
公开(公告)日：2022-10-27
申请号：AU2021248641
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： CLARK MICHAEL PHILIP , GIROUX SIMON , COLLIER PHILIP NOEL , TANG QING , WAAL NATHAN D , KESAVAN SARATHY , JONES PETER , BRODNEY MICHAEL AARON , GU WENXIN , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE , COTTRELL KEVIN MICHAEL
IPC: C07D491/04 , A61K31/407 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00
Abstract: Pyrano[4,3-b]indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD)
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公开(公告)号：AU2021247282A1
公开(公告)日：2022-10-27
申请号：AU2021247282
申请日：2021-04-02
Applicant: VERTEX PHARMA
Inventor： GIROUX SIMON , BOYD MICHAEL JOHN , FIMOGNARI JR ROBERT FRANCIS , ZAKY MARIAM , GREY JR RONALD LEE , XU JINWANG , KESAVAN SARATHY , NUHANT PHILIPPE MARCEL , GARCIA BARRANTES PEDRO MANUEL , JONES PETER , BRODNEY MICHAEL AARON , BOUCHER DIANE MARIE , FANNING LEV T D , HALL AMY B , HURLEY DENNIS JAMES , JOHNSON JR , MAXWELL JOHN PATRICK , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN A , DAMAGNEZ VERONIQUE , COTTRELL KEVIN MICHAEL
IPC: C07D487/04 , A61K31/407 , A61K31/4162 , A61K31/437 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00 , C07D471/14
Abstract: Pyrrolo[2,3-f]indazole and 2,4,5,10-tetrazatricyclo[7.3.0.03,7]dodeca-l,3(7),5,8,ll-pentaene derivatives as alpha-l-antitrypsin modulators for treating alpha-l-antitrypsin deficiency (AATD)
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公开(公告)号：CO2021016594A2
公开(公告)日：2022-04-29
申请号：CO2021016594
申请日：2021-12-07
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , BRODNEY MICHAEL AARON , GAGNON KEVIN JAMES , HOOD SARAH CAROL , LOOKER ADAM , MAXWELL JOHN PATRICK , MEDEK ALES , RODAY SETU , ROEPER STEFANIE , SAWANT RUPA , SHI YI , TANG QING , BANDARAGE UPUL KEERTHI , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , GIROUX SIMON , GREY JR RONALD LEE , HALL AMY BETH , HURLEY DENNIS JAMES , JOHNSON JR MAC ARTHUR , JONES PETER , KESAVAN SARATHY , NUHANT PHILIPPE MARCEL , SWETT REBECCA JANE , TAPLEY TIMOTHY LEWIS , XU JINWANG , COTTRELL KEVIN MICHAEL , SHRESTHA MUNA , BOUCHER DIANE , CLARK MICHAEL PHILIP , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GUIDO SAMANTHA , LAI MEI-HSIU , LIU SIYING , MAXWELL BRAD , OVERHOFF KIRK ALAN , RONKIN STEVEN M , SPOSATO MARISA , STAVROPOULOS KATHY , THOMSON STEPHEN , ZAKY MARIAM
IPC: C07D231/56 , A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: La descripción proporciona compuestos útiles para tratar la deficiencia de alfa-1 antitripsina (AATD), de acuerdo con la fórmula (I), tautómeros de estos, sales farmacéuticamente aceptables de los compuestos, sales farmacéuticamente aceptables de los tautómeros, derivados deuterados de los compuestos, derivados deuterados de los tautómeros y derivados deuterados de las sales, formas sólidas de esos compuestos y procesos para preparar esos compuestos.
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公开(公告)号：CR20210608A
公开(公告)日：2022-02-11
申请号：CR20210608
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BLIGH CAVAN MCKEON , GUIDO SAMANTHA , HOOD SARAH CAROL , THOMSON STEPHEN , BOYD MICHAEL JOHN , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , KESAVAN SARATHY , MAXWELL JOHN PATRICK , OVERHOFF KIRK ALAN , STAVROPOULOS KATHY , XU JINWANG , CLARK MICHAEL PHILIP , GAGNON KEVIN JAMES , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , LOOKER ADAM , MEDEK ALES , FLEMING GABRIELLE SIMONE , HURLEY DENNIS JAMES , RONKIN STEVEN M , SHRESTHA MUNA , JONES PETER , BOUCHER DIANE , BRODNEY MICHAEL AARON , GARCIA BARRANTES PEDRO MANUEL , NUHANT PHILIPPE MARCEL , HALL AMY BETH , RODAY SETU , SAWANT RUPA , SPOSATO MARISA , BANDARAGE UPUL KEERTHI , JOHNSON JR MAC ARTHUR , LAI MEI-HSIU , MAXWELL BRAD , SWETT REBECCA JANE , ZAKY MARIAM , COTTRELL KEVIN MICHAEL , GREY JR RONALD LEE , LIU SIYING , ROEPER STEFANIE , TANG QING , TAPLEY TIMOTHY LEWIS , SHI YI
IPC: A61K31/429 , A61K31/4162 , A61P1/16 , A61P11/00 , C07D231/56 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: La descripción proporciona compuestos útiles para tratar la deficiencia de alfa-1 antitripsina (AATD), de acuerdo con la fórmula (I), tautómeros de estos, sales farmacéuticamente aceptables de los compuestos, sales farmacéuticamente aceptables de los tautómeros, derivados deuterados de los compuestos, derivados deuterados de los tautómeros y derivados deuterados de las sales, formas sólidas de esos compuestos y procesos para preparar esos compuestos
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公开(公告)号：HUE054031T2
公开(公告)日：2021-08-30
申请号：HUE18186230
申请日：2013-04-23
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
IPC: C07D401/14 , A61K41/00 , A61P35/00 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04
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Patent Agency Ranking
公开(公告)号：CA3140039A1
公开(公告)日：2020-12-10
申请号：CA3140039
申请日：2020-05-14
Applicant: VERTEX PHARMA
Inventor： BANDARAGE UPUL KEERTHI , BLIGH CAVAN MCKEON , BOUCHER DIANE , BOYD MICHAEL JOHN , BRODNEY MICHAEL AARON , CLARK MICHAEL PHILIP , DAMAGNEZ VERONIQUE , FANNING LEV TYLER DEWEY , FIMOGNARI ROBERT FRANCIS , FLEMING GABRIELLE SIMONE , GAGNON KEVIN JAMES , GARCIA BARRANTES PEDRO MANUEL , GIACOMETTI ROBERT DANIEL , GIROUX SIMON , GREY JR RONALD LEE , GUIDO SAMANTHA , HALL AMY BETH , HOOD SARAH CAROL , HURLEY DENNIS JAMES , JOHNSON JR , JONES PETER , KESAVAN SARATHY , LAI MEI-HSIU , LIU SIYING , LOOKER ADAM , MAXWELL BRAD , MAXWELL JOHN PATRICK , MEDEK ALES , NUHANT PHILIPPE MARCEL , OVERHOFF KIRK ALAN , RODAY SETU , ROEPER STEFANIE , RONKIN STEVEN M , SAWANT RUPA , SHI YI , SHRESTHA MUNA , SPOSATO MARISA , STAVROPOULOS KATHY , SWETT REBECCA JANE , TANG QING , TAPLEY TIMOTHY LEWIS , THOMSON STEPHEN , XU JINWANG , ZAKY MARIAM , COTTRELL KEVIN MICHAEL
IPC: A61K31/4162 , A61K31/429 , A61P1/16 , A61P11/00 , C07D231/56 , C07D487/04 , C07D498/18 , C07D513/04
Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
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公开(公告)号：AU2017239481B2
公开(公告)日：2019-05-16
申请号：AU2017239481
申请日：2017-10-03
Applicant: VERTEX PHARMA
Inventor： GAO HUAI , CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , LAUFFER DAVID J , KENNEDY JOSEPH M , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
IPC: C07D401/14 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048
Abstract: Abstract N' -QR The present invention relates to compounds of following formula (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, such as cancer.
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公开(公告)号：SI2841428T1
公开(公告)日：2018-12-31
申请号：SI201331260
申请日：2013-04-23
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
IPC: C07D401/00 , C07D239/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D413/00 , C07D417/00 , C07D471/00 , C07D491/00
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公开(公告)号：AU2017239481A1
公开(公告)日：2017-10-26
申请号：AU2017239481
申请日：2017-10-03
Applicant: VERTEX PHARMA
Inventor： GAO HUAI , CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , LAUFFER DAVID J , KENNEDY JOSEPH M , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
IPC: C07D401/14 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048
Abstract: Abstract N' -Q R1 The present invention relates to compounds of following formula (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, such as cancer.
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公开(公告)号：SG10201704095UA
公开(公告)日：2017-06-29
申请号：SG10201704095U
申请日：2013-04-23
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , GAO HUAI , DENG HONGBO , DUFFY JOHN P , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , LAUFFER DAVID J , KENNEDY JOSEPH M , LEDEBOER MARK WILLEM , LI PAN , XU JINWANG
Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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