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公开(公告)号：NO332843B1
公开(公告)日：2013-01-21
申请号：NO20055314
申请日：2005-11-10
Applicant: PTC THERAPEUTICS INC
Inventor： KARP GARY MITCHELL , HWANG SEONGWOO , CHEN GUANGMING , ALMSTEAD NEIL GREGORY , MOON YOUNG-CHOON
IPC: C07D271/06 , A61K31/4245 , C07D271/12 , C07D413/04 , C07D413/06 , C07D413/10
Abstract: Provided herein is a compound of formulaor a pharmaceutically acceptable salt thereof for use in a method for treating a lysosomal storage disorder associated with a premature stop codon in a patient.
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公开(公告)号：MX2011010482A
公开(公告)日：2012-01-30
申请号：MX2011010482
申请日：2010-04-05
Applicant: PTC THERAPEUTICS INC
Inventor： NJOROGE F GEORGE , LENNOX WILLIAM JOSEPH , TAKASUGI JAMES , REN HONGYU , KARP GARY MITCHELL , LI CHUNSHI , ZHANG XIAOYAN , ZHU JIN , LIU RONGGANG , MACCOSS MALCOLM , NOMEIR AMIN , CHEN GUANGMING , HUANG SONG XIAO , KAKARLA RAMESH , LIU YALEI , MORRILL CHRISTIE , PAGET STEVEN D , SMITH SEAN W , TURPOFF ANTHONY A , ZHANG NANJING
IPC: C07D401/04 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/506 , A61P31/12 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: La presente invención está dirigida a compuestos y formas y composiciones farmacéuticas de los mismos, útiles para el tratamiento de una infección viral, o para afectar la actividad viral modulando la replicación viral.
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公开(公告)号：AU2004229487B9
公开(公告)日：2010-06-10
申请号：AU2004229487
申请日：2004-04-09
Applicant: PTC THERAPEUTICS INC
Inventor： CHEN GUANGMING , KARP GARY MITCHELL , MOON YOUNG-CHOON , HWANG SEONGWOO , ALMSTEAD NEIL GREGORY
IPC: C07D271/06 , A61K31/4245 , C07D271/12 , C07D413/04 , C07D413/10
Abstract: Provided herein is a compound of formulaor a pharmaceutically acceptable salt thereof for use in a method for treating a lysosomal storage disorder associated with a premature stop codon in a patient.
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公开(公告)号：NO20070194A
公开(公告)日：2007-04-16
申请号：NO20070194
申请日：2007-01-11
Applicant: PTC THERAPEUTICS INC
Inventor： CAMPBELL JEFFREY ALLEN , KARP GARY MITCHELL , CHEN GUANGMING , HWANG PETER SEONGWOO , TAKASUGI JAMES , REN HONGYU , WILDE RICHARD GERALD , TURPOFF ANTHONY , AREFOLOV ALEXANDER
IPC: A61K31/404 , A61P31/14
CPC classification number: A61K31/404 , A61K31/405 , A61K31/4439 , Y02A50/465
Abstract: In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
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公开(公告)号：BRPI0409319A
公开(公告)日：2006-04-25
申请号：BRPI0409319
申请日：2004-04-09
Applicant: PTC THERAPEUTICS INC
Inventor： KARP GARY MITCHELL , HWANG SEONGWOO , CHEN GUANGMING , ALMSTEAD NEIL GREGORY
IPC: A61K31/4245 , C07D271/06 , C07D271/12 , C07D413/04 , C07D413/10
Abstract: Provided herein is a compound of formulaor a pharmaceutically acceptable salt thereof for use in a method for treating a lysosomal storage disorder associated with a premature stop codon in a patient.
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Patent Agency Ranking
公开(公告)号：CA2521992A1
公开(公告)日：2004-10-28
申请号：CA2521992
申请日：2004-04-09
Applicant: PTC THERAPEUTICS INC
Inventor： MOON YOUNG-CHOON , HWANG SEONGWOO , KARP GARY MITCHELL , ALMSTEAD NEIL GREGORY , CHEN GUANGMING
IPC: A61K31/4245 , C07D271/06 , C07D271/12 , C07D413/04 , C07D413/10
Abstract: Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
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公开(公告)号：HRP20240935T1
公开(公告)日：2024-11-22
申请号：HRP20240935
申请日：2019-06-25
Applicant: PTC THERAPEUTICS INC
Inventor： SYDORENKO NADIYA , ALAM MD RAUFUL , ARNOLD MICHAEL A , BABU SURESH , BHATTACHARYYA ANURADHA , CHEN GUANGMING , GERASYUTO ALEKSEY I , KARP GARY MITCHELL , KASSICK ANDREW J , MAZZOTTI ANTHONY R , MOON YOUNG-CHOON , NARASIMHAN JANA , PATEL JIGAR , TURPOFF ANTHONY , WOLL MATTHEW G , YAN WUMING , ZHANG NANJING
IPC: C07D487/04 , A61K31/4985 , A61K31/5025 , A61P25/00 , A61P25/14 , A61P25/28 , C07D491/04 , C07D495/04 , C07D519/00
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公开(公告)号：CO2024000890A2
公开(公告)日：2024-04-29
申请号：CO2024000890
申请日：2024-01-30
Applicant: PTC THERAPEUTICS INC
Inventor： KARP GARY MITCHELL , BABU SURESH , ALAM RAUFUL , BHATTACHARYYA ANURADHA , CHEN GUANGMING , EASTWOOD MATTHEW S , HOSSEYNI SEYEDMORTEZA , JIANG YAO , MOON YOUNG-CHOON , NARASIMHAN JANA , REN HONGYU , SYDORENKO NADIYA , WOLL MATTHEW G , ZHANG NANJING
IPC: C07D487/04 , A61K31/5025 , A61P25/14 , A61P25/28
Abstract: La presente descripción se refiere a compuestos, formas y composiciones farmacéuticas de los mismos y métodos de uso de dichos compuestos, formas o composiciones de los mismos para tratar o mejorar la enfermedad de Huntington. En particular, la presente descripción se refiere a compuestos de heteroarilo bicíclicos sustituidos, formas y composiciones farmacéuticas de los mismos y métodos de uso de dichos compuestos, formas o composiciones de los mismos para tratar o mejorar la enfermedad de Huntington.
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公开(公告)号：AU2021254418A1
公开(公告)日：2022-11-03
申请号：AU2021254418
申请日：2021-04-08
Applicant: PTC THERAPEUTICS INC
Inventor： SYDORENKO NADIYA , ALAM RAUFUL , BABU SURESH , BHATTACHARYYA ANURADHA , CHEN GUANGMING , CHIERCHIA MATTEO , KARP GARY MITCHELL , LUONG TOM TUAN , MAZZOTTI ANTHONY R , MOON YOUNG-CHOON , MSZAR NICHOLAS WALTER , NARASIMHAN JANA , PATEL JIGAR S , REN HONGYU , WANG GANG , WOLL MATTHEW G , ZHANG NANJING , ZHANG XIAOYAN
IPC: C07D401/14 , A61K31/53 , A61P25/28 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D513/04
Abstract: The present description relates to compounds of Formula (I), forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
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50.发明专利
公开(公告)号：DK3889142T3
公开(公告)日：2022-09-12
申请号：DK21169137
申请日：2004-04-09
Applicant: PTC THERAPEUTICS INC
Inventor： KARP GARY MITCHELL , HWANG SEONGWOO , CHEN GUANGMING , ALMSTEAD NEIL G , MOON YOUNG-CHOON
IPC: A61K31/4245 , C07D271/06 , A61P35/00 , C07D271/12 , C07D413/04 , C07D413/10
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