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公开(公告)号：RS57306B1
公开(公告)日：2018-08-31
申请号：RSP20180605
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , XU JINWANG
IPC: C07D403/12 , A61K31/506 , A61P35/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D493/04
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公开(公告)号：DK3057959T3
公开(公告)日：2018-06-06
申请号：DK14800181
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , XU JINWANG
IPC: C07D403/12 , A61K31/506 , A61P35/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D493/04
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公开(公告)号：AU2014337208B2
公开(公告)日：2018-05-24
申请号：AU2014337208
申请日：2014-10-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DENG HONGBO , DUFFY JOHN P , GAO HUAI , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , KENNEDY JOSEPH M , LAUFFER DAVID J , LEDEBOER MARK WILLEM , LI PAN , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , XU JINWANG
IPC: C07D403/12 , A61K31/506 , A61P35/00 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D493/04
Abstract: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：AU2018200219A1
公开(公告)日：2018-02-22
申请号：AU2018200219
申请日：2018-01-11
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , CLARK MICHAEL P , BANDARAGE UPUL K , BETHIEL RANDY S , COURT JOHN J , DENG HONGBO , DRUTU IOANA , DUFFY JOHN P , FARMER LUC , GAO HUAI , GU WENXIN , JACOBS DYLAN H , KENNEDY JOSEPH M , LEDEBOER MARK W , LEDFORD BRIAN , MALTAIS FRANCOIS , PEROLA EMANUELE , WANG TIANSHENG , WANNAMAKER M WOODS , BYRN RANDAL , ZHOU YI , LIN CHAO , JIANG MIN , JONES STEVEN , GERMANN URSULA A , SALITURO FRANCESCO G , KWONG ANN DAK YEE
IPC: A61K31/506 , A61P31/16
Abstract: 2-(3H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-amine derivatives and their use in inhibiting influenza virus replication.
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公开(公告)号：NZ716783A
公开(公告)日：2017-08-25
申请号：NZ71678312
申请日：2012-08-01
Applicant: VERTEX PHARMA
Inventor： CLARK MICHAEL P , BANDARAGE UPUL K , DENG HONGBO , DUFFY JOHN P , LEDEBOER MARK W , LEDFORD BRIAN , PEROLA EMANUELE , CHARIFSON PAUL S , DAVIES IOANA , BETHIEL RANDY S , BOYD MICHAEL J , FARMER LUC J , GAO HUAI , GU WENXIN , KENNEDY JOSEPH M , MALTAIS FRANCOIS , WANG TIANSHENG
IPC: C07D471/04 , A61K31/407 , A61K31/4162 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/506 , A61P31/16 , C07D213/61 , C07D213/74 , C07D239/30 , C07D239/42
Abstract: Disclosed are 3-((2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid and 3-((6-(1H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl)amino)-4,4-dimethylpentanoic acid derivatives and analogues as represented by Formula (IV): or a pharmaceutically acceptable salt thereof, wherein: X1 is fluoro, chloro, trifluoromethyl, cyano, or methyl; X2 is hydrogen, fluoro, or chloro; Z1 is N or CH; Z2 is N or CH, CF, or CCN; R1, R2, and R3 are each independently methyl, fluoromethyl, trifluoromethyl, ethyl, 2-fluoroethyl, or 2,2,2,-trifluoroethyl; R4 and R5 are hydrogen; Q is –C(O)OR; and R is hydrogen or alkyl; provided that the compound of Formula (IV) is not (R)-3-((5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid. Also disclosed is a pharmaceutical composition which comprises a compound of Formula (IV) or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier, adjuvant or vehicle; for treating or preventing influenza virus infection in a patient.
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Patent Agency Ranking
公开(公告)号：GEP201706698B
公开(公告)日：2017-07-10
申请号：GEAP2012013685
申请日：2012-08-01
Applicant: VERTEX PHARMA
Inventor： BANDARAGE UPUL K , DENG HONGBO , LEDEBOER MARK W , DUFFY JOHN P , CHARIFSON PAUL S , CLARK MICHAEL P , BETHIEL RANDY S , BOYD MICHAEL J , DAVIES IOANA , FARMER LUC J , GAO HUAI , GU WENXIN , KENNEDY JOSEPH M , LEDFORD BRIAN , MALTAIS FRANCOIS , WANG TIANSHENG , PEROLA EMANUELE
IPC: C07D471/04 , A61K31/444 , A61K31/506 , A61P31/16
Abstract: Compound of formula (IV), which values Z1, Z2, X1, X2, Q, R1, R2, R3, R4, R5 are provided in the claims or pharmaceutically acceptable salt thereof, pharmaceutical composition on basis thereof, and their usage for viral infection treating drug preparation. Table: 4
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公开(公告)号：NZ700928A
公开(公告)日：2017-06-30
申请号：NZ70092813
申请日：2013-04-23
Applicant: VERTEX PHARMA
Inventor： LAUFFER DAVID J , LI PAN , DENG HONGBO , KENNEDY JOSEPH M , GAO HUAI , CHARIFSON PAUL S , COTTRELL KEVIN MICHAEL , DUFFY JOHN P , GIROUX SIMON , GREEN JEREMY , JACKSON KATRINA LEE , MAXWELL JOHN PATRICK , MORRIS MARK A , PIERCE ALBERT CHARLES , WAAL NATHAN D , LEDEBOER MARK WILLEM , XU JINWANG
IPC: C07D401/14 , A61K31/506 , A61K31/5377 , A61P35/00 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04
Abstract: The present invention relates to compounds of following formula (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, such as cancer.
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公开(公告)号：HUE031048T2
公开(公告)日：2017-06-28
申请号：HUE10726760
申请日：2010-06-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , CLARK MICHAEL P , BANDARAGE UPUL K , BETHIEL RANDY S , COURT JOHN J , DENG HONGBO , DRUTU IOANA , DUFFY JOHN P , FARMER LUC , GAO HUAI , GU WENXIN , JACOBS DYLAN H , KENNEDY JOSEPH M , LEDEBOER MARK W , LEDFORD BRIAN , MALTAIS FRANCOIS , PEROLA EMANUELE , WANG TIANSHENG , WANNAMAKER M WOODS , BYRN RANDAL , ZHOU YI , LIN CHAO , JIANG MIN , GERMANN URSULA A , JONES STEVEN , SALITURO FRANCESCO G , KWONG ANN DAK-YEE
IPC: A61P31/16
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公开(公告)号：PL2442809T3
公开(公告)日：2017-02-28
申请号：PL10726760
申请日：2010-06-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , CLARK MICHAEL P , BANDARAGE UPUL K , BETHIEL RANDY S , COURT JOHN J , DENG HONGBO , DRUTU IOANA , DUFFY JOHN P , FARMER LUC , GAO HUAI , GU WENXIN , JACOBS DYLAN H , KENNEDY JOSEPH M , LEDEBOER MARK W , LEDFORD BRIAN , MALTAIS FRANCOIS , PEROLA EMANUELE , WANG TIANSHENG , WANNAMAKER M WOODS , BYRN RANDAL , ZHOU YI , LIN CHAO , JIANG MIN , GERMANN URSULA A , JONES STEVEN , SALITURO FRANCESCO G , KWONG ANN DAK-YEE
IPC: A61K31/506 , A61P31/16
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公开(公告)号：ME02558B
公开(公告)日：2017-02-20
申请号：MEP27216
申请日：2010-06-17
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL , CLARK MICHAEL P , BANDARAGE UPUL K , BETHIEL RANDY S , COURT JOHN J , DENG HONGBO , DRUTU IOANA , DUFFY JOHN P , FARMER LUC , GAO HUAI , GU WENXIN , JACOBS DYLAN H , KENNEDY JOSEPH M , LEDEBOER MARK W , LEDFORD BRIAN , MALTAIS FRANCOIS , PEROLA EMANUELE , WANG TIANSHENG , WANNAMAKER M WOODS , BYRN RANDAL , ZHOU YI , LIN CHAO , JIANG MIN , GERMANN URSULA A , JONES STEVEN , SALITURO FRANCESCO G , KWONG ANN DAK-YEE
IPC: A61K31/506 , A61P31/16
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