公开(公告)号：BR112012008082A2

公开(公告)日：2016-03-01

申请号：BR112012008082

申请日：2010-02-18

Applicant: VERTEX PHARMA

Inventor： GROSSI ALFREDO ,  YOUNG CHRISTOPHER R ,  GOOR FREDRICK F VAN ,  ZLOKARNIK GREGOR ,  DINEHART KIRK ,  OVERHOFF KIRK ,  VERWIJS MARINUS JACOBUS ,  BOTFIELD MARTYN ,  HURTER PATRICIA ,  GROOTENHUIS PETER D J ,  ROWE WILLIAM

IPC: A61K9/14 ,  A61K31/47 ,  A61P19/00 ,  A61P19/10 ,  A61P43/00

公开(公告)号：ZA201200722B

公开(公告)日：2013-05-29

申请号：ZA201200722

申请日：2012-01-30

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER R ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO ,  ZLOKARNIK GREGOR ,  VAN GOOR FREDRICK F

IPC: A61K20060101 ,  A61P20060101

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

公开(公告)号：NZ588471A

公开(公告)日：2012-02-24

申请号：NZ58847105

申请日：2005-06-08

Applicant: VERTEX PHARMA

Inventor： MURPHY MAURA ,  DINEHART KIRK ,  HURTER PATRICIA ,  CONNELLY PATRICK ,  CUI YONG

IPC: A01N43/40 ,  A61K9/14 ,  A61K9/48 ,  A61K31/454 ,  A61K45/06

Abstract: Disclosed herein are solid dispersion comprising VX-950 (telaprevir) and a polymer, particularly hydroxyproplymethylcellulose (HPMC) or hydroxypropylmethylcellulose acetate succinate (HPMCAS), wherein the solid dispersion is obtained by spray drying and a polymer is present in an amount from about 10% by weight to about 80% by weight. Said forms and formulations disclosed herein have improved bioavailability relative to crystalline VX-950 and are useful for treating HCV infection.

公开(公告)号：AU2010282986A1

公开(公告)日：2012-02-16

申请号：AU2010282986

申请日：2010-02-18

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER R ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO ,  ZLOKARNIK GREGOR ,  VAN GOOR FREDRICK F

IPC: A61K9/14 ,  A61K31/47 ,  A61P19/00 ,  A61P19/10 ,  A61P43/00

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis( 1, 1 -dimethylethyl)-5-hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

公开(公告)号：PL2037887T3

公开(公告)日：2011-03-31

申请号：PL07795477

申请日：2007-05-30

Applicant: VERTEX PHARMA

Inventor： KADIYALA IRINA NIKOLAEVNA ,  LIN WU ,  HURTER PATRICIA

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/401

公开(公告)号：AU2009282419A2

公开(公告)日：2011-03-31

申请号：AU2009282419

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO

IPC: A61K47/32

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

公开(公告)号：ZA200802676B

公开(公告)日：2009-12-30

申请号：ZA200802676

申请日：2008-03-26

Applicant: VERTEX PHARMA

Inventor： MURPHY MAURA ,  DINEHART KIRK ,  HURTER PATRICIA ,  CONNELLY PATRICK ,  CUI YONG ,  PANICUCCI RICCARDO N

IPC: A61K20100101 ,  A61K9/14 ,  A61K31/454 ,  A61K45/06

Abstract: Forms and formulations of VX-950 and uses thereof.

公开(公告)号：CA2653625A1

公开(公告)日：2007-12-13

申请号：CA2653625

申请日：2007-05-30

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA ,  KADIYALA IRINA NIKOLAEVNA ,  LIN WU

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/401

Abstract: The invention relates to a controlled release formulation for an oral cyt okine inhibitor of interleukin-1 beta converting enzyme.

公开(公告)号：NO20070130A

公开(公告)日：2007-01-25

申请号：NO20070130

申请日：2007-01-08

Applicant: VERTEX PHARMA

Inventor： MURPHY MAURA ,  DINEHART KIRK ,  HURTER PATRICIA ,  CONNELLY PATRICK ,  CUI YONG

IPC: A61K9/20 ,  A61K9/14 ,  A61K9/48 ,  A61K31/454 ,  A61K45/00 ,  A61K45/06 ,  A61P31/12

CPC classification number: A61K38/07 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1635 ,  A61K9/1652 ,  A61K31/497 ,  A61K45/06

公开(公告)号：NZ720958A

公开(公告)日：2022-02-25

申请号：NZ72095814

申请日：2014-10-31

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA ,  SWINNEY KELLY ,  NADIG DAVID ,  SMITH DAVID ,  THOMAS VANCE ,  WARMAN MARTIN

IPC: A61K31/435 ,  A61K31/44 ,  A61K31/47 ,  A61P43/00

Abstract: Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2- difluorobenzo[d][1,3] dioxol-5 -yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5- hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-lH-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.