公开(公告)号：SG10201804026WA

公开(公告)日：2018-06-28

申请号：SG10201804026W

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： NTI-ADDAE KWAME ,  WALDO MICHAEL ,  O'NEIL SIMON ,  VAN ALSTEN JOHN ,  MACIKENAS DAINIUS ,  MUDUNURI PRAVEEN ,  SHI YI ,  LEDEBOER MARK ,  JURKAUSKAS VALDAS ,  MEDEK ALES ,  JONES STEVEN ,  BYRN RANDAL ,  ASMAL MOHAMMED ,  ROBERTSON SARAH ,  TSAI WANJUNG

Abstract: INHIBITORS OF INFLUENZA VIRUSES REPLICATION Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1)·1/2 Η20, Form F of HCl salt of Compound (1)·3 Η20, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.

公开(公告)号：BRPI1013338A2

公开(公告)日：2016-03-29

申请号：BRPI1013338

申请日：2010-04-27

Applicant: VERTEX PHARMA

Inventor： LOOKER ADAM ,  TANOURY GERALD J ,  COCHRAN JOHN E ,  CHEN MINZHANG ,  JURKAUSKAS VALDAS

IPC: C07D209/52 ,  A61K31/403 ,  C07D471/08

公开(公告)号：RS52306B

公开(公告)日：2012-12-31

申请号：RSP20120160

申请日：2008-02-27

Applicant: VERTEX PHARMA

Inventor： CONNELLY PATRICK R ,  KADIYALA IRINA ,  STAVROPOLUS KATHY ,  ZHANG YUEGANG ,  JOHNSTON STEVE ,  BHISETTI GOVINDA RAO ,  JURKAUSKAS VALDAS ,  ROSE PETER

IPC: C07D403/12 ,  A61K31/497 ,  A61K38/07 ,  C07K5/10

Abstract: The invention relates to compositions and co-crystals each comprising VX-950 and a co-crystal former selected from the group consisting of 4-hydroxybenzoic acid, 4-amino salicyclic acid, phenylalanine, threonline, tartaric acid, adipic acid, succinic acetate, proline, methyl 4-hydroxybenzoate, anthranilic acid, and d-Biotin. Also within the scope of this invention are methods of making and using the same.