公开(公告)号：NO20084007L

公开(公告)日：2008-10-07

申请号：NO20084007

申请日：2008-09-19

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  BLANCO MIGUEL GARCIA-GUZMAN ,  NAKATANI AKIKO ,  DRUTU IOANA ,  BERGERON DANIELE M ,  TERMIN ANDREAS P ,  RAFFAI GABRIEL ,  SILINA ALINA ,  HURLEY DENNIS J

IPC: C07D471/10 ,  C07D519/00

Abstract: The present invention relates to modulators of muscarinic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：ZA200604721B

公开(公告)日：2008-03-26

申请号：ZA200604721

申请日：2006-06-08

Applicant: VERTEX PHARMA

Inventor： GROOTENHUIS PETER D J ,  MAKINGS LEWIS R ,  MIGUEL GARCIA-GUZMAN BLANCO ,  MARTIN LONDO PHILIP

IPC: A61K20090101 ,  A61K31/4745 ,  A61P20090101 ,  C07D20090101 ,  C07D471/02 ,  C07D471/04

Abstract: The modulator compounds described herein modulate muscarinic receptors and are useful for treating muscarinic receptor mediated diseases.

公开(公告)号：NO20071272A

公开(公告)日：2007-04-17

申请号：NO20071272

申请日：2007-03-08

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  BLANCO MIGUEL GARCIA-GUZMAN ,  HURLEY DENNIS JAMES ,  RAFFAI GABRIEL ,  DRUTU IOANA

IPC: A61K31/438 ,  A61K31/435 ,  A61P25/00 ,  C07D221/20 ,  C07D405/04 ,  C07D471/10 ,  C07D491/10

CPC classification number: C07D401/06 ,  A61K31/435 ,  A61K31/438 ,  A61K31/4747 ,  A61K31/55 ,  C07D221/20 ,  C07D223/32 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D451/02 ,  C07D451/04 ,  C07D471/10 ,  C07D491/10

公开(公告)号：MXPA06013842A

公开(公告)日：2007-03-01

申请号：MXPA06013842

申请日：2005-05-31

Applicant: VERTEX PHARMA

Inventor： BLANCO MIGUEL GARCIA-GUZMAN ,  NAKATANI AKIKO ,  MAKINGS LEWIS R ,  HURLEY DENNIS J ,  BERGERON DANIELE M

IPC: A61K31/454 ,  A61K31/496 ,  A61K31/506 ,  A61P1/04 ,  A61P9/00 ,  A61P11/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/06 ,  A61P29/02 ,  A61P43/00 ,  C07D213/74 ,  C07D213/82 ,  C07D213/85 ,  C07D237/24 ,  C07D239/42 ,  C07D241/20 ,  C07D241/24 ,  C07D401/04 ,  C07D451/04

Abstract: La presente invencion se relaciona a moduladores de receptores muscarinicos. La presente invencion tambien proporciona composiciones que comprenden tales moduladores, y metodos con los mismos para tratar las enfermedades mediadas del receptor muscarinico.

公开(公告)号：AU2005309365A1

公开(公告)日：2006-06-01

申请号：AU2005309365

申请日：2005-11-29

Applicant: VERTEX PHARMA

Inventor： DAVIES ROBERT J ,  RAFFAI GABRIEL ,  NAKATANI AKIKO ,  MAKINGS LEWIS R ,  DRUTU IOANA ,  BANDARAGE UPUL K ,  CHARIFSON PAUL S ,  BLANCO MIGUEL GARCIA-GUZMAN ,  HURLEY DENNIS J ,  BERGERON DANIELE M

IPC: A61K31/4747 ,  A61K31/435 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61P1/00 ,  A61P3/04 ,  A61P9/00 ,  A61P17/02 ,  A61P25/00 ,  A61P27/02 ,  A61P43/00 ,  C07D471/00

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：CA2548009A1

公开(公告)日：2005-06-23

申请号：CA2548009

申请日：2004-12-07

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  LONDO PHILIP MARTIN ,  GROOTENHUIS PETER D J ,  GARCIA-GUZMAN BLANCO MIGUEL

IPC: C07D471/04 ,  A61K31/4745 ,  A61P25/00 ,  C07D471/02

Abstract: A compound of formula (I) wherein: Ring A is aryl or heteroaryl; one of V, W , Y or Z is nitrogen and the other of V, W, Y and Z are -C(R5)-; modulate muscarinic receptors and are useful for treating muscarinic receptor mediate d diseases.

公开(公告)号：NZ553202A

公开(公告)日：2010-12-24

申请号：NZ55320205

申请日：2005-08-19

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  GARCIA-GUZMAN BLANCO MIGUEL ,  HURLEY DENNIS J ,  DRUTU IOANA ,  RAFFAI GABRIEL ,  BERGERON DANIELE M ,  NAKATANI AKIKO ,  TERMIN ANDREAS P ,  SILINA ALINA

IPC: A61K31/435 ,  A61K31/438 ,  A61P25/00 ,  A61P43/00 ,  C07D471/00

Abstract: Disclosed is a compound of formula (I) or a pharmaceutically acceptable salt therof wherein the substituent G is a adamantyl, or a bicyclic or a tricyclic group of formula (III) and the remaining substituents are as defined in the specification. Also disclosed is the use of the compounds for treating muscarinic receptor mediated diseases such as CNS derived pathologies, Attention Deficit Hyperactivity Disorder (ADHD), obesity, Alzheimer's disease and dementia.

公开(公告)号：AU2007221220A1

公开(公告)日：2007-09-07

申请号：AU2007221220

申请日：2007-02-22

Applicant: VERTEX PHARMA

Inventor： SILINA ALINA ,  NAKATANI AKIKO ,  BLANCO MIGUEL GARCIA-GUZMAN ,  DRUTU IOANA ,  MAKINGS LEWIS R ,  TERMIN ANDREAS P ,  BERGERON DANIELE M ,  RAFFAI GABRIEL ,  HURLEY DENNIS J

IPC: C07D471/10 ,  A61K31/438 ,  A61K31/46 ,  A61K31/4747 ,  A61P25/00 ,  C07D519/00

Abstract: The present invention relates to modulators of muscarinic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：NO20073369L

公开(公告)日：2007-08-29

申请号：NO20073369

申请日：2007-06-29

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  DAVIES ROBERT J ,  MAKINGS LEWIS R ,  BLANCO MIGUEL GARCIA-GUZMAN ,  HURLEY DENNIS JAMES ,  NAKATANI AKIKO ,  RAFFAI GABRIEL ,  DRUTU IOANA ,  BANDARAGE UPUL K ,  BERGERON DANIELE M

IPC: A61K31/4353 ,  A61P25/00 ,  C07D471/10

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：ZA200602449B

公开(公告)日：2007-05-30

申请号：ZA200602449

申请日：2006-03-24

Applicant: VERTEX PHARMA

Inventor： MIGUEL GARCIA-GUZMAN BLANCO ,  GROOTENHUIS PETER D J ,  AKIKO NAKATANI ,  DANIEL DISEPIO ,  DANIELE BERGERON ,  JAMES HURLEY DENNIS ,  MAKINGS LEWIS R ,  GABRIEL RAFFAI

IPC: A61K20090101 ,  A61K31/495 ,  A61K31/496 ,  A61P20090101 ,  C07D20090101 ,  C07D295/02 ,  C07D295/033 ,  C07D295/073 ,  C07D295/096 ,  C07D295/135 ,  C07D295/155 ,  C07D309/14 ,  C07D451/02 ,  C07D451/04 ,  C07D493/08

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.