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公开(公告)号：BRPI0009299A
公开(公告)日：2001-12-18
申请号：BRPI0009299
申请日：2000-03-17
Applicant: BASF AG
Inventor： ROSENBERG JOERG , BERNDL GUNTHER , LIEPOLD BERND , BREITENBACH JOERG
IPC: A61K9/16 , A61K47/10 , A61K9/20 , A61K47/14 , A61K47/34 , A61P31/10 , A61P35/00 , A61P37/06 , A61P43/00
Abstract: "formas de administração farmacêutica mecanicamente estável para administração oral, e, processo para produzir formas de administração farmacêutica mecanicamente estável". a invenção diz respeito à formas de formas de administração farmacêutica mecanicamente estáveis para a administração peroral, que além de um ou mais ingredientes ativos e pelo menos um auxiliar formador de matriz termoplasticamente moldável, contêm mais do que 10 e até 40 % em peso de uma substância ativa de superfície que tenha um hlb entre 2 e 18 e seja líquida a 20 c ou tenha um ponto de gotejamento entre 20 e 50 c.
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公开(公告)号：BR0009299A
公开(公告)日：2001-12-18
申请号：BR0009299
申请日：2000-03-17
Applicant: BASF AG
Inventor： ROSENBERG JUERG , BERNDL GUNTHER , LIEPOLD BERND , BREITENBACH JUERG
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公开(公告)号：DE10017102A1
公开(公告)日：2001-10-11
申请号：DE10017102
申请日：2000-04-06
Applicant: BASF AG
Inventor： KESSEL KNUT , SCHERR GUENTER , BOGENSTAETTER THOMAS , BERNDL GUNTHER , BREITENBACH JOERG
IPC: A61K9/20 , A61K31/198 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/38 , A61P3/02 , A61P21/00 , C08K5/29 , C08L101/00 , A61K31/197 , A61K9/18
Abstract: Preparation of a solid dosage form containing creatine (I) involves: (a) forming a mixture containing at least one water-soluble or water-swellable thermoplastic binder (II), (I) and 1-20 moles of water per mole of (I); (b) heating the mixture to or above the softening point of (II); and (c) shaping the plasticized mixture into the dosage form and cooling. Independent claims are included for the following: (i) the dosage forms obtained by the above process; and (ii) dosage forms containing (I) at 3.3 mmol or more per g of the dosage form, in finely dispersed or molecular dispersion form in a matrix of (II).
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公开(公告)号：DE19943501A1
公开(公告)日：2001-03-15
申请号：DE19943501
申请日：1999-09-10
Applicant: BASF AG
Inventor： ERNST ANDREAS , KESLER THOMAS , BERNDL GUNTHER
IPC: A01N25/10 , A01N25/12 , A23K40/10 , A23K40/20 , A23L33/15 , A23L33/155 , A23P1/02 , A61J3/00 , A61K9/16 , A61K9/19 , A61K47/32 , B01J2/20 , B29B9/06 , C08J3/205 , A23K1/00 , A23L1/29
Abstract: Production of granules comprising biologically active substances (I) dispersed in a thermoplastic polymer matrix having pH-dependent solubility in aqueous media comprises mixing (I) with the molten matrix material and extruding the melt into a coolant medium in which the granules are not soluble or dispersible An Independent claim is also included for granules produced by the process.
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公开(公告)号：NO20005769D0
公开(公告)日：2000-11-14
申请号：NO20005769
申请日：2000-11-14
Applicant: BASF AG
Inventor： HEGER ROBERT , AUWETER HELMUT , PFLUEGER PETER , BREITENBACH JOERG , BINDER RUDOLF , ZEIDLER JUERGEN , BERNDL GUNTHER
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Patent Agency Ranking
公开(公告)号：NO20005769A
公开(公告)日：2000-11-14
申请号：NO20005769
申请日：2000-11-14
Applicant: BASF AG
Inventor： HEGER ROBERT , AUWETER HELMUT , PFLUEGER PETER , BREITENBACH JOERG , BINDER RUDOLF , ZEIDLER JUERGEN , BERNDL GUNTHER
CPC classification number: A61K9/5123 , A61K9/0095 , A61K9/1617 , A61K9/1658 , A61K9/5169 , A61K38/13
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公开(公告)号：DE19843903A1
公开(公告)日：2000-03-30
申请号：DE19843903
申请日：1998-09-24
Applicant: BASF AG
Inventor： KOTHRADE STEPHAN , BERNDL GUNTHER , SANNER AXEL , SIMON DIRK
Abstract: A solid dosage form contains a copolymer of an N-vinyl-lactam and methyl methacrylate, having a limited water uptake, as polymeric binder. A solid dosage form comprises least one polymeric binder, at least one active agent (A) and optionally conventional additives, where the binder is a copolymer of at least one N-vinyl-lactam of formula (I) (10-60 wt. %) with methyl methacrylate (40-90 wt. %), having a water uptake on swelling of less than 50 wt. % (based on the weight of the binder). n = 1-3. An Independent claim is included for the preparation of the dosage form, by mixing the components (directly or after preliminary melting) and shaping the obtained plastic mixture into the required dosage form.
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公开(公告)号：CA2332270A1
公开(公告)日：1999-11-25
申请号：CA2332270
申请日：1999-05-04
Applicant: BASF AG
Inventor： BERNDL GUNTHER , ZEIDLER JURGEN , BINDER RUDOLF , BREITENBACH JORG , PFLUGER PETER , AUWETER HELMUT , HEGER ROBERT
Abstract: The invention relates to solid or liquid cyclosporin preparations for oral administration in which the cyclosporin is presented in the form of solid Xamorphous particles embedded in a coating matrix in a colloidally dispersed manner.
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公开(公告)号：DE19821951A1
公开(公告)日：1999-11-18
申请号：DE19821951
申请日：1998-05-15
Applicant: BASF AG
Inventor： HEGER ROBERT , AUWETER HELMUT , PFLUEGER PETER , BREITENBACH JOERG , BINDER RUDOLF , ZEIDLER JUERGEN , BERNDL GUNTHER
Abstract: Orally administered solid or liquid cyclosporin compositions comprise cyclosporin in the form of solid, X-ray amorphous particles colloidally dispersed in a matrix. Orally administered solid or liquid cyclosporin compositions are claimed, which comprise cyclosporin in the form of solid, X-ray amorphous particles colloidally dispersed in a matrix. An Independent claim is also included for preparation of the compositions.
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