公开(公告)号：CA1301648C

公开(公告)日：1992-05-26

申请号：CA615951

申请日：1990-12-06

Applicant: ABBOTT LAB

Inventor： BROWN WILLIAM E III ,  CLEMENS JOHN M ,  DEVEREAUX SHARON M ,  HOFLER JOHN G ,  KNIGGE KEVIN M ,  SAFFORD SARAH E

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76 ,  C12M1/34

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.

公开(公告)号：AU618586B2

公开(公告)日：1992-01-02

申请号：AU3156489

申请日：1989-03-21

Applicant: ABBOTT LAB

Inventor： BROWN WILLIAM E III ,  SAFFORD SARAH E ,  CLEMENS JOHN M

IPC: G01N33/52 ,  G01N33/543 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76 ,  G01N33/53

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens, antibodies, or other ligands or DNA segments. The material and device comprises a reaction site having procedural controls and an analyte binding area capable of being simultaneously contacted by the sample and reagent used in the performance of the assay. The procedural controls and analyte binding areas operate to provide readable results as to the presence or absence of analyte and simultaneously verify the assay procedure and therefore the assay result.

公开(公告)号：DE602004031152D1

公开(公告)日：2011-03-03

申请号：DE602004031152

申请日：2004-11-17

Applicant: ABBOTT LAB

Inventor： CLEMENS JOHN M ,  SHAIN ERIC B ,  JENG TZYY-WEN ,  SCHNEIDER GEORGE J

IPC: G06F19/00 ,  C12Q1/68

公开(公告)号：CA2538953C

公开(公告)日：2009-09-29

申请号：CA2538953

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： MOORE LARRY W ,  YOST DAVID A ,  MERRIAM RICHARD A ,  MITCHELL JAMES E ,  KANEWSKE WILLIAM J III ,  SMITH B JANE ,  PENNINGTON CHARLES D ,  CLARK FREDERIC L ,  WALKER DONNY RAY ,  TAYI APPARAO ,  VAUGHT JAMES A ,  CLIFT GILBERT ,  LOGOCKI PETER A ,  HENDRICK KENDALL B ,  MARTIN RICHARD R ,  WALKER EDNA S ,  CLEMENS JOHN M ,  RUMBAUGH WILLIAM

IPC: G01F23/284 ,  B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  B67D99/00 ,  C12M1/34 ,  G01F23/26 ,  G01N1/00 ,  G01N1/14 ,  G01N1/28 ,  G01N21/03 ,  G01N21/25 ,  G01N21/76 ,  G01N21/77 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G05D23/19 ,  H01J49/04 ,  H05B1/02

Abstract: An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multip le assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assay s on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample, reagents to a reaction vessel without initiation of a n assay reaction sequence, followed by physical transfer of the unit dose disposable to a process work station, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

公开(公告)号：CA2346951C

公开(公告)日：2008-12-23

申请号：CA2346951

申请日：1999-10-12

Applicant: ABBOTT LAB

Inventor： GRAY ROBERT C ,  BACH MARK C ,  PEPE CURTIS J ,  DAHLKE DANIEL G ,  BAY DANIEL ,  HERCHENBACH STEVE ,  HALAKA FOLIM ,  ZUCK GARY ,  GALITZ CHARLES M ,  PIERCE MARK ,  SAFAR SCOTT G ,  CARTER MICHAEL K ,  TOTH JULIUS ,  CLEMENS JOHN M ,  KUKLA RONALD E

IPC: G01N35/00 ,  G01N35/02 ,  B01L7/00 ,  C12M1/38 ,  C12M1/40 ,  C12N15/10 ,  C12P19/34 ,  C12Q1/68

Abstract: A method of performing a determination of an item of interest in a sample using a single structure is disclosed. A sample is provided accesssible to the single structure. A first container for processing the sample is placed in a first process path on the single structure. The sample is transferred to the first container in the first process path. A reagent is added to the first container in the first process path. Contents of the first container is mixed in the first process path. The item of interest in the sample is separated from the contents of the first container in the first process path. The separated item of interest in the sample is transferred from the first container in the first process path to a second container in a second process path on the single structure. Contents of the second container are brought to a first temperature different from a temperature of the first process path in the second process path. The item of interest in the second container is detected in the second process path.

公开(公告)号：AT220799T

公开(公告)日：2002-08-15

申请号：AT94929339

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： CLARK FREDERICK L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MCDOWELL DOUGLAS D ,  MERRIAM RICHARD A ,  MOORE LARRY W ,  OLEKSAK CARL M ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  RUMBAUGH WILLIAM D ,  SCHMIDT LINDA S ,  SCHRIER PAUL R ,  SMITH B JANE ,  SPRONK ADRIAN M ,  WALKER EDNA S ,  VAUGHT JAMES A ,  VICKSTROM RICHARD L ,  WALKER DONNY RAY ,  WATKINS WILLIAM E III ,  WINTER GARY E ,  WOHLFORD ROBERT A ,  CLIFT GILBERT ,  CLOONAN KEVIN M ,  MITCHELL JAMES E ,  STANTON ALYN K ,  YOST DAVID A ,  HILLS DAVID B

IPC: G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

Abstract: The invention relates to an automated liquid level sensing system for detecting the presence of liquid in a container, said liquid level sensing system comprising: a vertically oriented, electrically conductive probe positioned above said container; means for vertically moving said probe into and out of said container; a signal source electrically connected to said probe, said signal source energizing said probe with an electrical signal and causing said probe to transmit said electrical signal; a receiving antenna positioned below said container for receiving said transmitted electrical signal; means for analyzing said received electrical signal for indications that said probe has contacted liquid in said container; means for transferring said received electrical signal from said receiving antenna to said analyzing means; and means for indicating that liquid has been detected. Further, the invention also provides for a method for automatically detecting the presence of liquid in a container, said method comprising the steps of: vertically positioning an electrically conductive probe above said container; vertically moving said probe into and out of said container; electrically connecting a signal source to said probe, said signal source energizing said probe with an electrical signal and causing said probe to transmit said electrical signal; positioning a receiving antenna below said container for receiving said transmitted electrical signal; analyzing said received electrical signal for indications that said probe has contacted liquid in said container; transferring said received electrical signal from said receiving antenna to said analyzing means; and indicating that liquid has been detected.

公开(公告)号：AU7843194A

公开(公告)日：1995-04-10

申请号：AU7843194

申请日：1994-09-22

Applicant: ABBOTT LAB

Inventor： CLARK FREDERICK L ,  CLEMENS JOHN M ,  HANCE ROBERT B ,  HENDRICK KENDALL B ,  TAYI APPARAO ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MCDOWELL DOUGLAS D ,  MERRIAM RICHARD A ,  MOORE LARRY W ,  OLEKSAK CARL M ,  PENNINGTON CHARLES D ,  RAYMOURE WILLIAM J ,  RUMBAUGH WILLIAM D ,  SCHMIDT LINDA S ,  SCHRIER PAUL R ,  SMITH B JANE ,  SPRONK ADRIAN M ,  WALKER EDNA S

IPC: G01N33/483 ,  B01F11/00 ,  B01L3/00 ,  B29C45/00 ,  G01F23/22 ,  G01F23/26 ,  G01N1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N33/53 ,  G01N33/542 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04

Abstract: The invention relates to an automated liquid level sensing system for detecting the presence of liquid in a container, said liquid level sensing system comprising: a vertically oriented, electrically conductive probe positioned above said container; means for vertically moving said probe into and out of said container; a signal source electrically connected to said probe, said signal source energizing said probe with an electrical signal and causing said probe to transmit said electrical signal; a receiving antenna positioned below said container for receiving said transmitted electrical signal; means for analyzing said received electrical signal for indications that said probe has contacted liquid in said container; means for transferring said received electrical signal from said receiving antenna to said analyzing means; and means for indicating that liquid has been detected. Further, the invention also provides for a method for automatically detecting the presence of liquid in a container, said method comprising the steps of: vertically positioning an electrically conductive probe above said container; vertically moving said probe into and out of said container; electrically connecting a signal source to said probe, said signal source energizing said probe with an electrical signal and causing said probe to transmit said electrical signal; positioning a receiving antenna below said container for receiving said transmitted electrical signal; analyzing said received electrical signal for indications that said probe has contacted liquid in said container; transferring said received electrical signal from said receiving antenna to said analyzing means; and indicating that liquid has been detected.

公开(公告)号：AU3929093A

公开(公告)日：1993-11-08

申请号：AU3929093

申请日：1993-03-24

Applicant: ABBOTT LAB

Inventor： CLARK FREDERIC L ,  CLIFT GILBERT ,  HENDRICK KENDALL B ,  KANEWSKE WILLIAM J III ,  LAGOCKI PETER A ,  MARTIN RICHARD R ,  MITCHELL JAMES E ,  MOORE LARRY W ,  PENNINGTON CHARLES D ,  WALKER EDNA S ,  SMITH JANE B ,  TAYI APPARAO ,  VAUGHT JAMES A ,  YOST DAVID A ,  MERRIAM RICHARD A ,  WALKER DONNY RAY ,  MCDOWELL DOUGLAS D ,  RUMBAUGH WILLIAM A ,  CLEMENS JOHN M

IPC: B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  B67D99/00 ,  C12M1/34 ,  G01F23/284 ,  G01N1/00 ,  G01N1/14 ,  G01N1/28 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G05D23/19 ,  H01J49/04 ,  H05B1/02 ,  G01N33/531 ,  B67D5/00 ,  G01N33/533 ,  G01N33/535 ,  G01N35/06 ,  G05D9/00 ,  H05B6/00

公开(公告)号：AU1762992A

公开(公告)日：1993-11-08

申请号：AU1762992

申请日：1992-03-31

Applicant: ABBOTT LAB

Inventor： TASKAR SUHAS ,  CLEMENS JOHN M ,  MIMMS LARRY T ,  CHAU KURT H ,  VALLARI DAVID S

IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/543 ,  G01N33/569 ,  G01N33/576 ,  G01N33/563 ,  G01N33/537

公开(公告)号：DE3687276D1

公开(公告)日：1993-01-21

申请号：DE3687276

申请日：1986-10-03

Applicant: ABBOTT LAB

Inventor： BROWN III ,  DEVEREAUX SHARON M ,  KNIGGE KEVIN M ,  CLEMENS JOHN M ,  HOFLER JOHN G ,  SAFFORD SARAH E

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.