公开(公告)号：AU2019294478A1

公开(公告)日：2021-01-21

申请号：AU2019294478

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  ALAM MD RAUFUL ,  ARNOLD MICHAEL A ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  GERASYUTO ALEKSEY I ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING ,  ZHANG NANJING

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/5025 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. Formula (I). In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：AU2016366694B2

公开(公告)日：2020-02-06

申请号：AU2016366694

申请日：2016-12-11

Applicant: PTC THERAPEUTICS INC

Inventor： BABU SURESH ,  BHATTACHARYYA ANURADHA ,  HWANG SEONGWOO ,  JANI MINAKSHI ,  MOON YOUNG-CHOON ,  SYDORENKO NADIYA

IPC: C07D405/12 ,  A61K31/506 ,  A61P25/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：SG11201911615WA

公开(公告)日：2020-01-30

申请号：SG11201911615W

申请日：2018-06-05

Applicant: PTC THERAPEUTICS INC

Inventor： WOLL MATTHEW ,  AMEDZO LUKIANA ,  BABU SURESH ,  BARRAZA SCOTT ,  BHATTACHARYYA ANURADHA ,  KARP GARY ,  MAZZOTTI ANTHONY ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  XU ZHENRONG

IPC: C07D239/74 ,  C07D239/94 ,  C07D239/95

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：CA3104516A1

公开(公告)日：2020-01-02

申请号：CA3104516

申请日：2019-06-25

Applicant: PTC THERAPEUTICS INC

Inventor： ZHANG NANJING ,  BABU SURESH ,  BARRAZA SCOTT J ,  BHATTACHARYYA ANURADHA ,  CHEN GUANGMING ,  KARP GARY MITCHELL ,  KASSICK ANDREW J ,  MAZZOTTI ANTHONY R ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  SYDORENKO NADIYA ,  TURPOFF ANTHONY ,  WOLL MATTHEW G ,  YAN WUMING

IPC: C07D417/14 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/55 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted benzothiazole compounds of Formula (I) or (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：CA3094703A1

公开(公告)日：2019-10-03

申请号：CA3094703

申请日：2019-03-26

Applicant: PTC THERAPEUTICS INC

Inventor： SYDORENKO NADIYA ,  BABU SURESH ,  BHATTACHARYYA ANURADHA ,  MOON YOUNG-CHOON ,  NARASIMHAN JANA ,  PATEL JIGAR S

IPC: C07D401/14 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/53 ,  A61P25/14 ,  A61P25/28 ,  C07D487/04 ,  C07D487/10

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：CA3066224A1

公开(公告)日：2018-12-13

申请号：CA3066224

申请日：2018-06-05

Applicant: PTC THERAPEUTICS INC

Inventor： WOLL MATTHEW G ,  AMEDZO LUKIANA ,  BABU SURESH ,  BARRAZA SCOTT J ,  BHATTACHARYYA ANURADHA ,  KARP GARY MITCHELL ,  MAZZOTTI ANTHONY R ,  NARASIMHAN JANA ,  PATEL JIGAR ,  TURPOFF ANTHONY ,  XU ZHENRONG

IPC: C07D239/74 ,  C07D239/94 ,  C07D239/95

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：CA3007412A1

公开(公告)日：2017-06-15

申请号：CA3007412

申请日：2016-12-11

Applicant: PTC THERAPEUTICS INC

Inventor： BABU SURESH ,  BHATTACHARYYA ANURADHA ,  HWANG SEONGWOO ,  JANI MINAKSHI ,  MOON YOUNG-CHOON ,  SYDORENKO NADIYA

IPC: A61K31/506 ,  A61P25/00 ,  C07D405/12

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.