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    MODIFIED STARCH AS A REPLACEMENT FOR GELATIN IN SOFT GEL FILMS AND CAPSULES
    71.
    发明申请
    MODIFIED STARCH AS A REPLACEMENT FOR GELATIN IN SOFT GEL FILMS AND CAPSULES 审中-公开
    改性淀粉作为软胶囊和胶囊中的凝胶的替代物

    公开(公告)号：WO0191721A3

    公开(公告)日：2002-05-30

    申请号：PCT/US0114888

    申请日：2001-05-09

    Applicant: STALEY MFG CO A E

    Inventor： GILLELAND GREGORY M ,  TURNER JUDY L ,  PATTON PENELOPE A ,  HARRISON MICHAEL D

    IPC: A61K9/48 ,  C08J5/18 ,  C08L3/00

    CPC classification number: C08J5/18 ,  A61K9/4816 ,  C08J2303/00 ,  C08L3/00 ,  Y10S514/962 ,  C08L2666/02

    Abstract: Film-forming compositions are disclosed that can comprise, on a dry solid basis, 25 to 75 percent by weight of certain starch derivatives having a DE less than about 1,25 to 75 % plasticizer, and 0.1 to 15 % hydrocolloid gum. The starch derivatives can be chemically modified starches which range in molecular weight from 100,000 to 2,000,000. These starch-based systems can completely replace gelatin in edible film-forming applications such as soft and hard gel capsules.

    Abstract translation: 公开了可以基于干固体包含25至75重量％的具有DE小于约1,25至75％增塑剂和0.1至15％水胶体胶的某些淀粉衍生物的成膜组合物。 淀粉衍生物可以是分子量为100,000至2,000,000的化学改性淀粉。 这些基于淀粉的系统可以完全替代可食用成膜应用中的明胶，例如软和硬凝胶胶囊。

    PYRUVATE PRODUCING YEAST STRAIN
    75.
    发明申请
    PYRUVATE PRODUCING YEAST STRAIN 审中-公开
    生产YEAST菌株

    公开(公告)号：WO2004099425A3

    公开(公告)日：2005-01-27

    申请号：PCT/US2004013495

    申请日：2004-05-03

    Applicant: STALEY MFG CO A E

    Inventor： VAN MARIS ANTONIUS J A ,  PRONK JACOBUS THOMAS ,  VAN DIJKEN JOHANNES PIETER

    IPC: C07C51/44 ,  C12N1/14 ,  C12N1/16 ,  C12N1/18 ,  C12N1/19 ,  C12P20060101 ,  C12P7/40 ,  C12P7/56 ,  C12R1/645

    CPC classification number: C12N1/16 ,  C07C51/44 ,  C12P7/40 ,  C12P7/56 ,  C12R1/645

    Abstract: Disclosed herein are glucose tolerant C2 carbon source-independent (GCSI) yeast strains having no detectable amount of pyruvate decarboxylase activity, wherein wild type yeast strains for the glucose tolerant C2 carbon source-independent yeast strains are Crabtree positive. Also disclosed are methods of selecting glucose tolerant C2 carbon source-dependent yeast strains, and methods of producing pyruvic acid or salts thereof using glucose tolerant C2 carbon source-independent yeast strain. Further disclosed herein are GCSI yeast strains having a genome that comprises an exogenous lactate dehydrogenase gene.

    Abstract translation: 本文公开了不具有可检测量的丙酮酸脱羧酶活性的耐葡萄糖C2碳源（GCSI）酵母菌株，其中用于葡萄糖耐量的C2碳源独立酵母菌株的野生型酵母菌株为Crabtree阳性。 还公开了选择耐受葡萄糖的C2碳源依赖性酵母菌株的方法，以及使用不含葡萄糖的C2碳源独立酵母菌株生产丙酮酸或其盐的方法。 本文进一步公开的是具有包含外源乳酸脱氢酶基因的基因组的GCSI酵母菌株。

    A PROCESS FOR THE RECOVERY OF CITRIC ACID
    76.
    发明申请
    A PROCESS FOR THE RECOVERY OF CITRIC ACID 审中-公开
    柠檬酸的回收方法

    公开(公告)号：WO2004087631A3

    公开(公告)日：2004-12-02

    申请号：PCT/IL2004000203

    申请日：2004-03-03

    Applicant: STALEY MFG CO A E ,  BANIEL AVRAHAM ,  VITNER ASHER ,  GONEN DAVID ,  HEIDEL DAVID

    Inventor： BANIEL AVRAHAM ,  VITNER ASHER ,  GONEN DAVID ,  HEIDEL DAVID

    IPC: C07C51/43 ,  C07C51/48 ,  C07C59/265

    CPC classification number: C07C51/43 ,  C07C51/48 ,  C07C59/265

    Abstract: The invention provides a process for the recovery of citric acid from an aqueous solution feed stream originating in fermentation of carbohydrates and utilizing an amine solvent extraction step for separation of impurities comprising: subjecting said aqueous solution feed stream A to a treatment for partial recovery of citric acid, wherein said treatment is other than amine solvent extraction, to form a first portion of purified citric acid B and a secondary feed stream F; subjecting at least a portion G of said secondary feed stream F to a treatment consisting of amine solvent extraction to form a second portion of purified citric acid solution and to reject substantial of impurities initially present in said portion of said secondary feed stream; subjecting said second portion of purified citric acid solution to crystallization; and recycling mother liquor from said crystallization.

    Abstract translation: 本发明提供从源自碳水化合物发酵的水溶液进料流中回收柠檬酸的方法，并利用胺溶剂提取步骤分离杂质，所述方法包括：使所述水溶液进料流A经受部分回收柠檬酸 酸，其中所述处理不是胺溶剂萃取，以形成纯化柠檬酸B的第一部分和第二进料流F; 使至少部分G的所述二级原料流F经受由胺溶剂萃取组成的处理以形成第二部分纯化的柠檬酸溶液并且除去最初存在于所述二级原料流的所述部分中的大量杂质; 使所述第二部分纯化的柠檬酸溶液结晶; 并从所述结晶回收母液。

    PROCESS FOR PRODUCING 1, 3-PROPANEDIOL
    77.
    发明申请
    PROCESS FOR PRODUCING 1, 3-PROPANEDIOL 审中-公开
    生产1,3-丙二醇的方法

    公开(公告)号：WO2004101437A2

    公开(公告)日：2004-11-25

    申请号：PCT/US2004013905

    申请日：2004-05-06

    Applicant: STALEY MFG CO A E

    Inventor： BANIEL AVRAHAM M ,  JANSEN ROBERT P ,  VITNER ASHER ,  BAIADA ANTHONY

    IPC: B01D11/04 ,  C02F1/26 ,  C07C29/86 ,  C02F

    CPC classification number: C07C29/86 ,  B01D11/0446 ,  B01D11/0488 ,  B01D11/0492 ,  C02F1/26 ,  C07C31/205

    Abstract: Disclosed herein are processes for the recovery of 1,3-propanediol from an aqueous feed stream. The present invention involves contacting an aqueous feed stream that comprises water, 1,3-propanediol, and at least one contaminant with at least one solvent extractant to form a mixture. The mixture is separated into a first phase and a second phase. The second phase comprises a majority of the water from the aqueous feed stream. The first phase comprises solvent extractant and at least some of the 1,3-propanediol that was present in the aqueous feed stream. The weight ratio in the first phase of 1,3-propanediol to any one contaminant present is greater than the weight ratio of 1,3-propanediol to the same contaminant in the aqueous feed stream prior to the aqueous feed stream being contacted with the solvent extractant. The first phase can be removed from the separated second phase in order to recover the 1,3-propanediol.

    Abstract translation: 本文公开了从含水原料流中回收1,3-丙二醇的方法。 本发明涉及将包含水，1,3-丙二醇和至少一种污染物的含水进料流与至少一种溶剂萃取剂接触以形成混合物。 将混合物分离成第一相和第二相。 第二相包含来自含水进料流的大部分水。 第一阶段包括溶剂萃取剂和存在于含水进料流中的至少一些1,3-丙二醇。 在水性进料流与溶剂接触之前，1,3-丙二醇与任何一种污染物的第一相中的重量比大于1,3-丙二醇与含水进料流中相同污染物的重量比 萃取剂。 为了回收1,3-丙二醇，可以将第一相从分离的第二相中除去。

    ENZYMATIC STARCH SACCHARIFICATION INCLUDING A MEMBRANE SEPARATION STEP
    78.
    发明申请
    ENZYMATIC STARCH SACCHARIFICATION INCLUDING A MEMBRANE SEPARATION STEP 审中-公开
    包括膜分离步骤的酶淀粉糖化

    公开(公告)号：WO9927124A9

    公开(公告)日：1999-09-10

    申请号：PCT/US9824871

    申请日：1998-11-23

    Applicant: NOVO NORDISK AS ,  STALEY MFG CO A E

    Inventor： LIAW GIAN C ,  PEDERSEN SVEN ,  HENDRIKSEN HANNE VANG ,  SVENDSEN ALLAN ,  NIELSEN BJARNE ROENFELDT ,  NIELSEN RUBY ILLUM

    IPC: C12N9/34 ,  C12P19/02 ,  C12P19/12 ,  C12P19/14 ,  C12P19/18 ,  C12P19/20 ,  C12R1/07

    CPC classification number: C12N9/2428 ,  C12P19/12 ,  C12P19/14 ,  C12P19/18 ,  C12P19/20

    Abstract: The present invention relates to a method for the production of saccharide preparations, i.e., syrups, by saccharifying a liquefied starch solution, which method comprises a saccharification step during which step one or more enzymatic saccharification stages take place, and the subsequent steps of one or more high temperature membrane separation steps, and re-circulation of the saccharification enzyme, in which method the membrane separation steps are carried out as an integral part of the saccharification step. In another specific aspect, the invention provides a method of producing a saccharide preparation, which method comprises an enzymatic saccharification step, and the subsequent steps of one or more high temperature membrane separation steps and re-circulation of the saccharification enzyme.

    Abstract translation: 本发明涉及通过糖化液化淀粉溶液生产糖制品（即糖浆）的方法，该方法包括糖化步骤，在该步骤中进行一个或多个酶促糖化阶段，以及随后的步骤 更高温的膜分离步骤和糖化酶的再循环，其中膜分离步骤作为糖化步骤的组成部分进行。 在另一具体方面，本发明提供了生产糖制品的方法，该方法包括酶糖化步骤以及一个或多个高温膜分离步骤和糖化酶再循环的后续步骤。

    AZEOTROPIC DISTILLATION OF CYCLIC ESTERS OF HYDROXY ORGANIC ACIDS
    79.
    发明公开
    AZEOTROPIC DISTILLATION OF CYCLIC ESTERS OF HYDROXY ORGANIC ACIDS 有权
    有机羟基酸的共沸蒸馏环酯

    公开(公告)号：EP1412043A4

    公开(公告)日：2004-09-29

    申请号：EP02778185

    申请日：2002-03-06

    Applicant: STALEY MFG CO A E

    Inventor： COCKREM MICHAEL CHARLES MILNER ,  KOVACS ISTVAN

    IPC: B01D3/36 ,  C07C51/42 ,  C07C51/46 ,  B01D3/10 ,  B01D3/16 ,  B01D3/38 ,  C07C51/48 ,  C07C59/06 ,  C07C59/08 ,  C07C59/10 ,  C07C69/68

    CPC classification number: C07C51/46 ,  B01D3/36 ,  C07C51/42 ,  C07C59/06 ,  C07C59/08

    Abstract: Cyclic esters of hydroxy organic acids can be produced and recovered via azeotropic distillation. In certain embodiments, cyclic esters such as glycolide and lactide can be produced from a fermentation broth or other feedstream that comprises a hydroxy organic acid, an ammonium salt of a hydroxy organic acid, or an ester of a hydroxy organic acid using azeotropic distillation. The hydroxy organic acid for the feedstream or the organic acid derived from the feedstream by decomposition is related to produce the cyclic ester. In other embodiments a crude composition of a cyclic ester of an organic ester can be purified using azeotropic distillation. The feedstream (10) and an azeotroping agent (12) are mixed in a reactor (14). A first vapor stream (20) can be purified using a first column (22), a second column (27) and a separator (38). A first column bottoms stream (24) from the first column (22) can be recycled back to reactor (14).

    PROCESS FOR OBTAINING AN ORGANIC ACID FROM AN ORGANIC ACID AMMONIUM SALT, AN ORGANIC ACID AMIDE, OR AN ALKYLAMINE ORGANIC ACID COMPLEX
    80.
    发明公开
    PROCESS FOR OBTAINING AN ORGANIC ACID FROM AN ORGANIC ACID AMMONIUM SALT, AN ORGANIC ACID AMIDE, OR AN ALKYLAMINE ORGANIC ACID COMPLEX 有权
    VERFAHREN ZUM ERHALT EINER ORGANISCHENSÄUREAUS EINEM AMMONIUMSALZ EINER ORGANISCHENSÄURE，EINEM ORGANISCHENSÄUREAMIDODER EINEM ORGANISCHENALKYLAMINSÄARDKOMPLEX

    公开(公告)号：EP1385593A4

    公开(公告)日：2004-08-11

    申请号：EP02753604

    申请日：2002-03-06

    Applicant: STALEY MFG CO A E

    Inventor： COCKREM MICHAEL CHARLES MILNER ,  KOVACS ISTVAN

    IPC: B01D3/36 ,  C07C51/02 ,  C07C51/06 ,  C07C51/46 ,  C07C231/24 ,  C07C235/06 ,  B01D3/10 ,  B01D3/16 ,  B01D3/38 ,  C07C51/48 ,  C07C59/06 ,  C07C59/08 ,  C07C59/10 ,  C07C69/68

    CPC classification number: C07C235/06 ,  B01D3/36 ,  C07C51/02 ,  C07C51/06 ,  C07C51/46 ,  C07C231/24 ,  Y10S516/07 ,  C07C59/08

    Abstract: A method for the recovery of an organic acid, such as a heat stable lactic acid, from a feedstream (1) comprising at least one of an organic acid amide, an organic acid ammonium salt or an alkylamine-organic acid complex. The feedstream is mixed with at least one azeotroping agent (2) and the mixture fed to a fractional distillation apparatus or reactor (3). The azeotroping agent is a hydrocarbon capable of forming at least one azeotrope with the organic acid that is produced by the thermal decomposition of the amide, ammonium salt, or complex in the feedstream. The mixture is heated to produce vapor stream (11) that comprises an azeotrope. The vapor stream can be condensed in condenser (12) to a liquid stream, and the organic acid is recovered in the liquid stream that is produced. When the azeotrope is a heteroazeotrope, the vapor stream can be condensed into a liquid stream, which can be separated into a first phase (18) and a second phase (17). The first phase contains the highest concentration of organic acid and the second phase comprises azetroping agent. The organic acid can be further purified and/or concentrated from the separated first phase or form the liquid stream.

    Abstract translation: 一种从包含有机酸酰胺，有机酸铵盐或烷基胺 - 有机酸络合物中的至少一种的进料流（1）回收有机酸（例如热稳定乳酸）的方法。 进料流与至少一种共沸剂（2）混合并将混合物进料到分馏装置或反应器（3）。 共沸剂是能够与通过原料流中的酰胺，铵盐或络合物的热分解产生的有机酸形成至少一种共沸物的烃。 加热混合物以产生包含共沸物的蒸气流（11）。 蒸汽流可以在冷凝器（12）中冷凝成液体流，并且将有机酸回收在所产生的液体流中。 当共沸混合物是一种异相共沸混合物时，蒸汽流可以冷凝成液体流，该液流可以分成第一相（18）和第二相（17）。 第一相含有最高浓度的有机酸，第二相含有共沸剂。 有机酸可以从分离的第一相中进一步纯化和/或浓缩或形成液体流。

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