公开(公告)号：DE19809242A1

公开(公告)日：1999-09-09

申请号：DE19809242

申请日：1998-03-05

Applicant: BASF AG

Inventor： KLEINKE ANDREAS ,  KESLER THOMAS ,  ROSENBERG JOERG ,  KRULL HARALD ,  BERNDL GUNTHER ,  MAIER WERNER ,  BREITENBACH JOERG

IPC: A61K9/16 ,  A61K31/135 ,  A61K31/192 ,  A61K9/26 ,  A61K31/215

Abstract: The invention relates to a method for producing solid, spherical forms containing at least one pharmaceutical active agent homogeneously dispersed in an auxiliary matrix. According to this method, the constituents are mixed to form a melt which is then shaped. The invention is characterised in that at least one pharmaceutical active agent is processed with at least one thermoplastically processable matrix auxiliary to form a homogeneous melt with a viscosity of less than 5000 mPas and in that this melt is shaped into drops using a rotating perforated roll. These drops are then cooled so that they solidify.

公开(公告)号：BR9610799A

公开(公告)日：1999-07-13

申请号：BR9610799

申请日：1996-09-30

Applicant: BASF AG

Inventor： ZEIDLER JURGEN ,  ROSENBERG JOERG ,  NUEMANN JORG ,  BREITENBACH JORG

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/277 ,  A61K47/24 ,  A61K47/26 ,  A61K47/30

Abstract: The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients,A) 10-90% by weight of a melt-processable, water-soluble polymer,B) 5-85% by weight of isomalt, andC) 0-5% by weight of lecithin,where the total of all the ingredients is to be equal to 100% by weight.

公开(公告)号：CZ82999A3

公开(公告)日：1999-06-16

申请号：CZ82999

申请日：1997-09-11

Applicant: BASF AG

Inventor： BREITENBACH JORG ,  KLEINKE ANDREAS ,  KOTHRADE STEPHAN ,  ROSENBERG JOERG

IPC: A61J3/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22

Abstract: A process for producing solid dose forms by mixing at least one polymeric binder, with or without at least one active ingredient and with or without conventional additives, and shaping the mixture, where at least one of the components is employed in liquid form.

公开(公告)号：BG102346A

公开(公告)日：1998-10-30

申请号：BG10234698

申请日：1998-03-24

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  ROSENBERG JOERG ,  NEUMANN JOERG ,  BREITENBACH JOERG

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/277 ,  A61K47/24 ,  A61K47/26 ,  A61K47/30

Abstract: The solid medicamentous forms are produced by the extrusionand formulation of a smelt containing no solvent, and includingone or more of the following active substances, in wt.%: from 2 to90 thermoplastically treatable water soluble polymer, from 5 to89.9 isomalt and from 0 to 5 lecythin. The sum of the content ofall the substances should be 100 wt.%.8 claims

公开(公告)号：AT171613T

公开(公告)日：1998-10-15

申请号：AT95943202

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JOERG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05117 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19962 PCT Pub. Date Jul. 4, 1996A process for the production of divisible tablets by melt calendering in which two molding rolls are combined together, at least one of which has depressions with at least one bar which extends up to the surface line of the molding roll and forms a score.

公开(公告)号：BR9607796A

公开(公告)日：1998-07-07

申请号：BR9607796

申请日：1996-03-09

Applicant: BASF AG

Inventor： SANNER AXEL ,  ROSENBERG JOERG ,  RIEGER JENS ,  BRETEINBACH JORG

IPC: A61K9/20 ,  A61K9/16 ,  A61K47/30

公开(公告)号：HUT77458A

公开(公告)日：1998-04-28

申请号：HU9800063

申请日：1995-12-22

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  GRABOWSKI SVEN ,  MAIER WERNER ,  ROSENBERG JOERG

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04

公开(公告)号：ZA968849B

公开(公告)日：1998-04-22

申请号：ZA968849

申请日：1996-10-22

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  HAERTL AXEL PAUL ,  HOFFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：ZA9608849B

公开(公告)日：1998-04-22

申请号：ZA9608849

申请日：1996-10-22

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  HAERTL AXEL PAUL ,  HOFFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K

CPC classification number: A61J3/10 ,  A61J2200/20 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/2893 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/616 ,  B30B11/14 ,  B30B11/16 ,  B30B11/18 ,  B30B11/34 ,  B30B15/308 ,  A61K31/19 ,  A61K2300/00

公开(公告)号：NO981798D0

公开(公告)日：1998-04-22

申请号：NO981798

申请日：1998-04-22

Applicant: BASF AG

Inventor： BREITENBACH J RG ,  HORTL AXEL PAUL ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61K9/16 ,  A61K9/20