公开(公告)号：AU7598401A

公开(公告)日：2002-02-05

申请号：AU7598401

申请日：2001-07-19

Applicant: HARVARD COLLEGE

Inventor： GRACIAS DAVID H ,  TIEN JOE ,  WHITESIDES GEORGE M

IPC: H01L21/98

Abstract: Techniques for self assembly of macro-scale objects, optionally defining electrical circuitry, are described, as well as articles formed by self assembly. Components can be joined, during self-assembly by minimization of free energy, capillary attraction, or a combination.

公开(公告)号：CA2329412A1

公开(公告)日：1999-10-28

申请号：CA2329412

申请日：1999-04-20

Applicant: MASSACHUSETTS INST TECHNOLOGY ,  HARVARD COLLEGE

Inventor： JENSEN KLAVS F ,  WHITESIDES GEORGE M ,  VAETH KATHLEEN M ,  JACKMAN REBECCA J ,  DUFFY DAVID C

IPC: B41C1/14 ,  B05D1/32 ,  G03F1/00 ,  G03F7/00 ,  G03F7/12 ,  H01L27/32 ,  H01L51/50 ,  H05B33/10

Abstract: An elastomeric mask is provided that allows deposition of a variety of materials through mask openings. The mask seals effectively against substrate surfaces, allowing simple deposition from fluid phase, gas phase, and the like or removal of material using gaseous or liquid etchants. The mask then can be simply peeled from the surface of the substrate leaving the patterned material behind. Multi-layered mask techniques are described in which openings in an upper mask allow selected openings of a lower mask to remain unshielded, while other openings of the lower mask are shielded. A first deposition step, followed by re-orientation of the upper mask to expose a different set of lower mask openings, allows selective deposition of different materials in different openings of the lower mask. Pixelated organic electroluminescent devices are provided via the described technique.

公开(公告)号：AU2015305311B2

公开(公告)日：2020-04-23

申请号：AU2015305311

申请日：2015-08-21

Applicant: HARVARD COLLEGE

Inventor： LESSING JOSHUA AARON ,  WHITESIDES GEORGE M ,  MARTINEZ RAMSES V ,  YANG DIAN ,  MOSADEGH BOBAK ,  GALLOWAY KEVIN C ,  GUDER FIRAT ,  TAYI ALOK SURYAVAMSEE

IPC: B25J9/00 ,  B25J9/14

Abstract: A soft robotic device with one or more sensors is described. The sensor may be embedded in the soft body of the soft robotic device, attached to the soft body of the soft robotic device, or otherwise linked to the soft body of the soft robotic device.

公开(公告)号：AU2017213581B2

公开(公告)日：2018-12-13

申请号：AU2017213581

申请日：2017-08-11

Applicant: HARVARD COLLEGE

Inventor： MORIN STEPHEN A ,  SHEPHERD ROBERT F ,  STOKES ADAM ,  ILIEVSKI FILIP ,  MARTINEZ RAMSES V ,  BRANCH JAMIE L ,  FISH CARINA R ,  JIN LIHUA ,  NUNES RUI M D ,  SUO ZHIGANG ,  WHITESIDES GEORGE M

IPC: B25J9/10 ,  B25J9/14

Abstract: A robotic system comprising a soft robot system comprising a flexible body having a plurality of embedded fluid channels, wherein the plurality of embedded fluid channels is defined by upper, lower and side walls, wherein at least one wall is strain limiting, wherein the soft robot further comprises a pressurizing inlet coupled to the plurality of embedded fluid channels, wherein the pressurizing inlet is configured to receive pressurized fluid to pressurize at least a portion of the plurality of embedded fluid channels to cause a movement of the soft robot; a hard robot coupled to the soft robot, configured to provide locomotion to the robotic system; and a robotic control system coupled to the soft robot and the hard robot, wherein the robotic control system comprises a fluidic system configured to provide the pressurized fluid to the fluid inlet. )(N en en ee C> -e en ---------- en -------------- 4* - ( c uD Vk u to ) en r11 e n ( en 2 cr ---------- '-4 -e u6 Q0 -Kt en o (N e en (N rr

公开(公告)号：CA2754577C

公开(公告)日：2018-07-10

申请号：CA2754577

申请日：2010-03-08

Applicant: HARVARD COLLEGE

Inventor： NIE ZHIHONG ,  NIJHUIS CHRISTIAN ,  CHEN XIN ,  MARTINEZ ANDRES W ,  NAROVLYANSKY MAX ,  WHITESIDES GEORGE M

IPC: B01L3/00

Abstract: Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic commu-nication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a ref-erence electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of as-sembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

公开(公告)号：CA2834041C

公开(公告)日：2017-05-16

申请号：CA2834041

申请日：2004-12-29

Applicant: HARVARD COLLEGE

Inventor： SIA SAMUEL K ,  LINDER VINCENT ,  PARVIZ BABAK A ,  SIEGEL ADAM ,  WHITESIDES GEORGE M

IPC: G01N33/543 ,  B01L3/00 ,  B81B1/00 ,  G01N21/05 ,  G01N21/53 ,  G01N21/59 ,  G01N33/53 ,  G01N33/58

Abstract: An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold- conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.

公开(公告)号：CA2667702C

公开(公告)日：2016-06-14

申请号：CA2667702

申请日：2007-10-18

Applicant: HARVARD COLLEGE

Inventor： WHITESIDES GEORGE M ,  PHILLIPS SCOTT T ,  MARTINEZ ANDRES W ,  BUTTE MANISH J ,  WONG AMY ,  THOMAS SAMUEL ,  SINDI HAYAT ,  VELLA SARAH JANE ,  CARRILHO EMANUEL ,  MIRICA KATHERINE A ,  LIU YANYAN

IPC: G01N33/558

Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.

公开(公告)号：AU2011212916B2

公开(公告)日：2015-07-02

申请号：AU2011212916

申请日：2011-02-03

Applicant: HARVARD COLLEGE

Inventor： WHITESIDES GEORGE M ,  MIRICA KATHERINE A ,  MARTINEZ ANDRES W ,  CHENG CHAO-MIN ,  PHILLIPS SCOTT T ,  MASCARENAS MONICA ,  LIU XINYU ,  LI XIUJUN

IPC: B01L3/00

Abstract: The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.

公开(公告)号：AU2009228014B2

公开(公告)日：2014-10-02

申请号：AU2009228014

申请日：2009-03-27

Applicant: HARVARD COLLEGE

Inventor： DICKEY MICHAEL D ,  WHITESIDES GEORGE M ,  BUTTE MANISH J ,  RECHES MEITAL

IPC: G01N35/00 ,  G01N33/48 ,  G01N33/49 ,  G01N33/493 ,  G01N33/50

Abstract: Hydrophilic threads as platforms for inexpensive, low volume, portable diagnostic systems, and methods of making and using the same are described.

公开(公告)号：AU2013209422A1

公开(公告)日：2014-09-04

申请号：AU2013209422

申请日：2013-01-22

Applicant: HARVARD COLLEGE

Inventor： MAZZEO AARON D ,  MORIN STEPHEN A ,  SHEPHERD ROBERT F ,  WHITESIDES GEORGE M ,  KALB WILLIAM B

IPC: B25J9/10 ,  B25J9/14

Abstract: The laminated robotic actuator includes a strain - limiting layer comprising a flexible, non - extensible material in the form of a sheet or thin film, a flexible inflatable layer in the form of a thin film or sheet in facing relationship with the strain - limiting layer, wherein the inflatable layer is selectively adhered to the strain - limiting layer, and wherein a portion of an un- adhered region between the strain - limiting layer and the inflatable layer defines a pressurizable channel, and at least one fluid inlet in fluid communication with the pressurizable channel. The first flexible non - extensible material has a stiffness that is greater than the stiffness of the second flexible elastomeric material and the flexible elastomer is non - extensible under actuation conditions.