公开(公告)号：EP2027253A4

公开(公告)日：2014-04-30

申请号：EP07845184

申请日：2007-06-11

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： FOQUET MATHIEU ,  PELUSO PAUL ,  TURNER STEPHEN ,  ROITMAN DANIEL BERNARDO ,  OTTO GEOFFREY

IPC: C12M3/00

CPC classification number: G02B6/10 ,  G01N21/648 ,  G01N2021/7713

公开(公告)号：EP2245444A4

公开(公告)日：2014-04-16

申请号：EP09700236

申请日：2009-01-09

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： LUONG KHAI ,  LUNDQUIST PAUL ,  DALAL RAVI ,  LYLE JOHN ,  TURNER STEPHEN

IPC: G01N21/64 ,  G01N21/00

CPC classification number: C12M1/34 ,  G01N21/6428 ,  G01N21/645 ,  G01N2021/6417 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/7786 ,  Y10T436/2525

公开(公告)号：EP2425023A4

公开(公告)日：2012-10-17

申请号：EP10772361

申请日：2010-04-26

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： KORLACH JONAS ,  TURNER STEPHEN ,  SCHADT ERIC

IPC: C12Q1/68 ,  C12N15/10

CPC classification number: C12Q1/6869 ,  C12Q1/702 ,  C12Q2565/518 ,  C12Q2547/101

公开(公告)号：EP2183388A4

公开(公告)日：2010-09-08

申请号：EP08780319

申请日：2008-07-25

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： CHRISTIANS FRED ,  TURNER STEPHEN

IPC: C12Q1/68 ,  C07H21/02

CPC classification number: C12Q1/6869

公开(公告)号：EP1971364A4

公开(公告)日：2010-06-30

申请号：EP06838800

申请日：2006-12-01

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： EID JOHN ,  MURPHY DEVON ,  OTTO GEOFFREY ,  TURNER STEPHEN

IPC: G01N33/53 ,  C12N11/02 ,  G01N33/58

CPC classification number: A61K38/446 ,  A61K38/063 ,  A61K38/443 ,  G01N33/582

公开(公告)号：EP2994544A4

公开(公告)日：2017-01-25

申请号：EP14794438

申请日：2014-05-05

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： TURNER STEPHEN ,  HANES JEREMIAH ,  BJORNSON KEITH

IPC: C12Q1/68

CPC classification number: C12Q1/6874 ,  C12Q1/6823 ,  G01N27/227 ,  C12Q2521/101 ,  C12Q2521/543 ,  C12Q2535/122 ,  C12Q2563/113 ,  C12Q2563/116 ,  C12Q2563/157 ,  C12Q2565/607

Abstract: Real time electronic sequencing methods, devices, and systems are described. Arrays of nanoscale electronic elements comprising capacitive devices with one or two electrodes, or arrays of nanoFET devices are used to provide sequence information about a template nucleic acid in a polymerase-template complex bound proximate to the nanoscale electronic elements or to the substrate proximate to the nanoscale electronic element. A sequencing reaction mixture comprising nucleotide analogs having impedance labels, capacitive labels, or conductivity labels is introduced to the array of nanoscale electronic elements comprising capacitive devices or nanoFETs under conditions of polymerase mediated nucleic acid synthesis. The time sequence of incorporation of nucleotide analogs is determined by identifying the types of labels of the nucleotide analogs that are incorporated into the growing strand using measured impedance, conductivity, or capacitance.

公开(公告)号：EP1790202A4

公开(公告)日：2013-02-20

申请号：EP05812440

申请日：2005-09-16

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： TURNER STEPHEN ,  KORLACH JONAS

IPC: C12Q1/68

CPC classification number: G01N21/6452 ,  B01L3/5085 ,  B01L2200/0668 ,  B01L2300/0654 ,  B01L2300/0896 ,  B82Y20/00 ,  B82Y30/00 ,  G02B6/13 ,  Y10T436/10

Abstract: The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.

Abstract translation: 本发明涉及光学限制，其制备方法和使用它们分析分子和/或监测化学反应的方法。 本发明中体现的装置和方法对于高通量和低成本的单分子分析特别有用。

公开(公告)号：EP1920277A4

公开(公告)日：2013-01-16

申请号：EP06813384

申请日：2006-08-10

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： LUNDQUIST PAUL ,  TURNER STEPHEN ,  ZACCARIN DENIS

IPC: G02B6/00 ,  G01J3/36 ,  G01N21/64

CPC classification number: G01N21/6452 ,  G01J3/2803 ,  G01J3/36 ,  G01N21/6428

公开(公告)号：EP2286217A4

公开(公告)日：2011-05-25

申请号：EP09755181

申请日：2009-03-30

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： EID JOHN ,  TURNER STEPHEN ,  DALAL RAVI ,  FLUSBERG BENJAMIN ,  KORLACH JONAS ,  LIN STEVEN ,  FEHR ADRIAN ,  CHRISTIANS FRED ,  EMIG ROBIN

IPC: G01N33/48 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/52

CPC classification number: B01J19/0046 ,  B01J2219/00596 ,  C12N2310/50 ,  C12N2310/51 ,  C12Q1/6869 ,  C12Q2535/122 ,  C40B40/06 ,  G01N33/54313 ,  G01N33/54366

公开(公告)号：CA2738626C

公开(公告)日：2017-08-08

申请号：CA2738626

申请日：2009-09-25

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： ZACCARIN DENIS ,  LUNDQUIST PAUL ,  ZHAO PEIQIAN ,  ZHONG FRANK ,  TURNER STEPHEN ,  HUANG YANQIAO ,  MONADGEMI PEZHMAN ,  SAXENA RAVI ,  GROT ANNETTE ,  RULISON AARON

IPC: G02B6/12 ,  G01N21/00

Abstract: Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.