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公开(公告)号：CA2869945A1
公开(公告)日：2007-10-18
申请号：CA2869945
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL , YANG XIAOQING
IPC: C07D405/12 , A61K31/404 , A61K31/41 , A61K31/4439 , A61K31/454 , C07D209/08 , C07D403/12 , C07D413/12 , G01N33/48
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：AU2007235260A1
公开(公告)日：2007-10-18
申请号：AU2007235260
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , MCCARTNEY JASON , ZHOU JINGLAN , GOOR FREDERICK VAN , MILLER MARK T , NUMA MEHDI MICHEL JAMEL , BEAR BRIAN , GROOTENHUIS PETER D J
IPC: C07D405/12 , A61K31/404 , A61P31/00 , C07D405/14
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：CA2856037A1
公开(公告)日：2007-08-02
申请号：CA2856037
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , MILLER MARK T , BEAR BRIAN , MCCARTNEY JASON , GROOTENHUIS PETER D J
IPC: C07C237/24 , A61K31/00 , C07C311/46 , C07D207/12 , C07D307/79 , C07D317/60 , C07D319/18 , C07D405/12 , C07D409/12 , C07D413/12 , C07D498/04
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP -Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：CA2635760A1
公开(公告)日：2007-08-02
申请号：CA2635760
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： MCCARTNEY JASON , RUAH SARA S HADIDA , MILLER MARK T , BEAR BRIAN , GROOTENHUIS PETER D J
IPC: C07D317/68 , A61K31/36 , A61P11/00
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：ZA200602755B
公开(公告)日：2007-06-27
申请号：ZA200602755
申请日：2004-09-07
Applicant: VERTEX PHARMA
Inventor： MILLER MARK T , HADIDA RUAH SARA S , SINGH ASHAVINI K , THOMAS CLEVELAND , MARKINGS LEWIS R , MATTHEW HAMILTON , GROOTENHUIS PETER D J
IPC: A61K20090101 , A61K31/426 , A61K31/427 , A61P20090101 , A61P43/00 , C07D20090101 , C07D263/48 , C07D277/46 , C07D277/82 , C07D417/02 , C07D417/04 , C07D417/06 , C07D417/12
Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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Patent Agency Ranking
公开(公告)号：NO20062040A
公开(公告)日：2006-06-06
申请号：NO20062040
申请日：2006-05-08
Applicant: VERTEX PHARMA
Inventor： MILLER MARK T , RUAH SARA S HADIDA , HAMILTON MATTHEW , GROOTENHUIS PETER D J , SINGH ASHVANI K
IPC: C07C233/11 , A61K31/00 , A61K31/335 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/495 , A61K45/06 , C07C233/08 , C07C233/22 , C07C233/60 , C07C233/65 , C07C233/73 , C07C235/34 , C07C235/46 , C07C235/48 , C07C307/00 , C07C311/15 , C07C311/16 , C07C311/17 , C07C323/60 , C07D209/42 , C07D213/82 , C07D215/54 , C07D215/56 , C07D217/26 , C07D231/14 , C07D231/56 , C07D237/28 , C07D261/20 , C07D307/68 , C07D307/85 , C07D307/87 , C07D333/32 , C07D333/70 , C07D407/12
CPC classification number: C07D307/87 , A61K31/00 , A61K31/335 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/495 , A61K45/06 , C07C233/22 , C07C233/60 , C07C233/65 , C07C233/73 , C07C235/34 , C07C235/46 , C07C235/48 , C07C311/16 , C07C311/17 , C07C323/60 , C07C2601/08 , C07D209/42 , C07D213/82 , C07D215/54 , C07D217/26 , C07D231/14 , C07D231/56 , C07D237/28 , C07D261/20 , C07D307/68 , C07D307/85 , C07D333/32 , C07D333/70 , C07D407/12
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公开(公告)号：AR047759A1
公开(公告)日：2006-02-22
申请号：ARP040103481
申请日：2004-09-24
Applicant: VERTEX PHARMA
Inventor： GARCIA-GUZMAN BLANCO MIGUEL , BERGERON DANIELE , GROOTENHUIS PETER D J , HURLEY DENNIS , NAKATANI AKIKO , MAKINGS LEWIS R , DISEPIO DANIEL , RAFFAI GABRIEL
IPC: A61K31/495 , A61K31/496 , C07D295/02 , C07D295/033 , C07D295/073 , C07D295/096 , C07D295/135 , C07D295/155 , C07D309/14 , C07D451/02 , C07D451/04 , C07D493/08 , C07D295/04 , A61P43/00 , A61P25/00
Abstract: Moduladores de receptores muscarínicos, composiciones que comprenden tales moduladores, y métodos para tratar enfermedades mediadas por receptores muscarínicos que los utilizan.
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公开(公告)号：RU2765714C2
公开(公告)日：2022-02-02
申请号：RU2016150386
申请日：2016-12-21
Applicant: VERTEX PHARMA
Inventor： HADIDA RUAH SARA , HAMILTON MATTHEW , MILLER MARK , GROOTENHUIS PETER D J , BEAR BRIAN , MCCARTHY JASON , ZHOU JINGLAN
IPC: C07D405/12 , A61K31/443 , A61P11/00
Abstract: Изобретениеотноситсяк фармацевтическойкомпозициидлялечениязаболеваний, опосредуемыхтрансмембраннымрегулятороммуковисцидоза («CFTR»), причемкомпозициясодержитфармацевтическиприемлемыйносительитерапевтическиэффективноеколичествосоединенияформулыТехническийрезультат: полученановаяфармацевтическаякомпозиция, котораяможетбытьиспользованадлялечениязаболеваний, опосредуемыхтрансмембраннымрегулятороммуковисцидоза («CFTR»). 7 табл.
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公开(公告)号：HUE053357T2
公开(公告)日：2021-06-28
申请号：HUE17204189
申请日：2009-08-13
Applicant: VERTEX PHARMA
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公开(公告)号：LT3345625T
公开(公告)日：2021-02-10
申请号：LT17204189
申请日：2009-08-13
Applicant: VERTEX PHARMA
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