公开(公告)号：KR1020100018741A

公开(公告)日：2010-02-18

申请号：KR1020080077386

申请日：2008-08-07

Applicant: 신풍제약주식회사 ,  충남대학교산학협력단

Inventor： 황성주 ,  박희준 ,  이영주 ,  김민수 ,  김정수 ,  김기원 ,  노정열 ,  남대영

IPC: A61K9/08 ,  A61K31/337 ,  A61P35/00

CPC classification number: A61K47/10 ,  A61K9/0019 ,  A61K31/337 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/34 ,  A61K2121/00

Abstract: PURPOSE: An injection composition for anti-cancer which containing docetaxel as an active ingredient is provided ensure bioavailability same as a conventional injection product and low hemolysis. CONSTITUTION: An injection composition contains docetaxel as an active ingredient, glycofurol(tetrahydrofurfuryl alcohol polyethyleneglycolether) or DMA(dimethylaceteamide) as a solubilizing agent, and solutol, acepol, or poroxamer as a surfactant. The weight ratio between solubilizing agent and surfactant is 1:0.5-6. The pH concentration of the injection composition is adjusted at pH 4-6.

Abstract translation: 目的：提供含有多西紫杉醇作为活性成分的抗癌注射用组合物，确保与常规注射产品相同的生物利用度和低溶血性。 构成：注射用组合物含有作为活性成分的多西紫杉醇，作为增溶剂的糖醇（四氢糠醇聚乙二醇醚）或DMA（二甲基乙酰胺），作为表面活性剂的溶剂型，acepol或poroxamer。 增溶剂与表面活性剂的重量比为1:0.5-6。 注射组合物的pH浓度调节至pH 4-6。

公开(公告)号：KR100863572B1

公开(公告)日：2008-10-15

申请号：KR1020070060419

申请日：2007-06-20

Applicant: 충남대학교산학협력단

Inventor： 성낙도 ,  박창식 ,  성민규 ,  조종운 ,  장석찬 ,  김찬경 ,  박형연 ,  이영주 ,  정훈성

IPC: C07D307/12 ,  A61K31/341

Abstract: A novel pheromonal odorant is provided to be easily synthesized, thereby a composition comprising the same compound improving breeding efficiency through estrus synchronization of pig stably and economically and increasing the efficiency of pig farming management by decreasing labor force. A tetrahydrofuran based compound is represented by a formula(1). A composition for inducing estrus of pig or cow comprises the tetrahydrofuran based compound as an effective ingredient.

Abstract translation: 提供了一种易于合成的新型信息增感剂，由此提供了一种包含相同化合物的组合物，通过猪的发情同步稳定和经济地提高育种效率，并通过减少劳动力提高养猪管理的效率。 四氢呋喃类化合物由式（1）表示。 用于诱导猪或牛发情的组合物包括四氢呋喃类化合物作为有效成分。

公开(公告)号：KR101156665B1

公开(公告)日：2012-06-15

申请号：KR1020110090878

申请日：2011-09-07

Applicant: 충남대학교산학협력단

Inventor： 성용주 ,  오민택 ,  김동섭 ,  이영주

IPC: D21H11/12 ,  D21C3/02 ,  D21C9/00 ,  D21C7/10

Abstract: 본 발명은 왕겨섬유 및 이를 이용한 고벌크의 왕겨섬유 제지에 관한 것으로, 상기 본 발명의 제지는 왕겨섬유를 이용함으로써 왕겨섬유의 톱니모양에 독특한 형태에 따라 제조된 제지제품의 공극이 발달하고 상대적으로 두껍고 벌크한 구조를 형성하게 되어, 기존의 벌크향상용으로 적용되고 있는 목분과 비교하여 우수한 벌크향상 효과가 있을 뿐 아니라 목분과는 다르게 이화학적 특성이 목재섬유와 유사함으로써 활용성이 높아 이를 적용하여 고벌크 제지제품을 생산함으로써 강직도 등 종이물성의 향상 및 생산공정에서의 건조속도를 증가시켜 건조에너지를 감소시키고, 생산원가, 원료의 절감 효과로 전 세계적으로 자원이 부족한 목재섬유의 대체자원으로 폐자원의 재활용 및 제지산업의 발전에 크게 기여할 것이다.

公开(公告)号：KR1020120028242A

公开(公告)日：2012-03-22

申请号：KR1020110090878

申请日：2011-09-07

Applicant: 충남대학교산학협력단

Inventor： 성용주 ,  오민택 ,  김동섭 ,  이영주

IPC: D21H11/12 ,  D21C3/02 ,  D21C9/00 ,  D21C7/10

CPC classification number: D21H11/12 ,  D21C1/06 ,  D21C3/028 ,  D21C5/00

Abstract: PURPOSE: A rice husk friber and a rice husk fiber paper using the same are provided to ensure relatively thickness of the paper due to air gap and to reduce drying energy during production process. CONSTITUTION: A rice husk paper of high bulk contains 1-50 wt% of rice husk fiber having cylindrical fiber and fiber of sawdust. The rice bran fiber is prepared by digesting rice husks or straw to separate digested liquid and residue, isolating silica from the isolated digested liquid; and obtaining fiber powder. The rice husk is treated with 150-200 g/m^3 of ozone after acetic acid treatment. The rice husk fiber has chemical composition containing 65-75% of carbon, 25-30% of oxygen, 0.1-0.5% of silicon, and 0.3-1% of calcium.

Abstract translation: 目的：提供一种稻壳捣碎机和使用其的稻壳纤维纸，以确保由于空气间隙而造成的纸张的相对厚度，并减少生产过程中的干燥能量。 构成：大块稻壳纸含有1-50重量％的具有圆柱纤维和锯屑纤维的稻壳纤维。 米糠纤维通过消化稻壳或秸秆来分离消化的液体和残留物，从分离的消化液中分离二氧化硅; 并获得纤维粉末。 在乙酸处理后，稻壳用150-200g / m 3的臭氧处理。 稻壳纤维具有含有65-75％的碳，25-30％的氧，0.1-0.5％的硅和0.3-1％的钙的化学组成。

公开(公告)号：KR100807643B1

公开(公告)日：2008-02-28

申请号：KR1020060129277

申请日：2006-12-18

Applicant: 충남대학교산학협력단

Inventor： 박창식 ,  이영주

IPC: C12N5/07

Abstract: A boar semen diluent for artificial insemination is provided to be simple for preparation, be able to be stored in a general refrigerator at a temperature of 4 deg.C, and be used for 5 days at any time, thereby being easy for artificial insemination in swine farming and in vitro fertilization in laboratories and significantly contributing to species improvement of the swine and the study of a biological engineering field. A boar semen diluent for artificial insemination comprises 30-40 grams of glucose, 10-15 grams of TES(N-tris[hydroxymethyl]methyl-2-aminoethane-sulfonic acid), 1-3 grams of Tris[hydroxymethyl]aminomethane, 0.1-2 grams of KCl, 0.1-2 grams of N-acetyl-D glucosamine, 150-250 ml of yolk, and 2-5 grams of BSA(Bovine serum albumin) per 1,000 ml of an aqueous solution.

Abstract translation: 提供用于人工授精的公猪精液稀释剂，其制备简单，能够在4℃的温度下储存在通用冰箱中，并且随时使用5天，从而容易进行人工授精 在实验室进行猪饲养和体外受精，并对猪的物种改良和生物工程领域的研究作出重大贡献。 用于人工授精的公猪精液稀释液包含30-40克葡萄糖，10-15克TES（N-三[羟甲基]甲基-2-氨基乙磺酸），1-3克三羟甲基氨基甲烷，0.1 -2克KCl，0.1-2克N-乙酰-D-葡糖胺，150-250毫升蛋黄和2-5克BSA（牛血清白蛋白）/ 1000毫升水溶液。

公开(公告)号：KR100807644B1

公开(公告)日：2008-02-28

申请号：KR1020070026707

申请日：2007-03-19

Applicant: 충남대학교산학협력단

Inventor： 박창식 ,  김명철 ,  진동일 ,  이영주

IPC: C12N5/16 ,  C12N5/00 ,  A01K67/00 ,  A01K67/02

CPC classification number: C12N5/0609 ,  A01K2227/108 ,  C12N2500/84 ,  C12N2501/11 ,  C12N2501/31 ,  C12N2517/10

Abstract: A method for producing piglet is provided to be able to increase the normal birth rate of cloned pig by co-transplantation of in vitro fertilization and somatic cell cloned fertilized eggs, significantly shorten the culturing period of the fertilized egg and improve the normal birth rate from a small number of ova. A method for producing piglet comprises the steps of: (a) culturing collected immature ova of slaughtered pig; (b) after preparing (i) a fertilized egg obtained by in vitro fertilization of the mature ova prepared by the step(a) and liquid semen, and (ii) a somatic cell transplanted fertilized egg obtained by transplanting a donor somatic cell into an enucleated prepared mature ova prepared by enucleating the mature ova of the step(a), respectively culturing (i) and (ii) for 16-36 hours; and (c) transplanting 150-250 fertilized eggs prepared by the in vitro fertilization and the somatic cell transplantation into one surrogate mother. Further, a culture ground of the immature ova contains 2-6 follicle films having 4-6 mm of size.

Abstract translation: 提供了一种生产小猪的方法，通过共同移植体外受精和体细胞克隆受精卵，能够提高克隆猪的正常出生率，大大缩短受精卵的培养期，提高正常出生率 少量的ova。 一种生产仔猪的方法包括以下步骤：（a）培养屠宰猪的未成熟卵; （b）制备（i）通过体外受精通过步骤（a）制备的成熟卵和液体精液获得的受精卵，和（ii）通过将供体体细胞移植到 通过摘除步骤（a）的成熟卵，分别培养（i）和（ii）16-36小时制备的去核制备的成熟卵; 和（c）将通过体外受精和体细胞移植制备的150-250个受精卵移植到一个代孕母亲中。 此外，未成熟卵的培养基含有2-6mm大小的2-6个卵泡膜。

公开(公告)号：KR1020080085426A

公开(公告)日：2008-09-24

申请号：KR1020070026925

申请日：2007-03-20

Applicant: 충남대학교산학협력단

Inventor： 박창식 ,  김명철 ,  진동일 ,  이영주

IPC: C12N5/07 ,  C12N5/02 ,  C12N5/00

Abstract: A method for in vitro maturation of a porcine oocyte is provided to increase in vitro maturation rate of immature porcine oocyte, and reduce intrusion of multiple sperms, increase normal fertilization rate, and enhance blastocyst formation rate in the in vitro fertilization. A method for in vitro maturation of a porcine oocyte comprises the steps of: adding theca follicle into an in vitro maturation medium, which is prepared by adding 26.19 mM NaHCO3, 3.05 mM glucose, 0.91 mM sodium pyruvate, 75 mug/ml sodium penicillin G, 50 mug/ml streptomycin sulfate and 0.1% polyvinyl alcohol(PVA) in tissue culture medium(TCM) 199, in an amount of 1-6 theca follicle with the size of 2-4 mm per 2 ml of medium, and performing in vitro culture of the porcine oocyte in the in vitro maturation medium for 36-48 hours.

Abstract translation: 提供猪卵母细胞体外成熟的方法，以增加未成熟猪卵母细胞的体外成熟率，减少多次精子的侵入，增加正常受精率，增加体外受精中的囊胚形成率。 猪卵母细胞体外成熟的方法包括以下步骤：将卵泡加入到体外成熟培养基中，其通过加入26.19mM NaHCO 3，3.05mM葡萄糖，0.91mM丙酮酸钠，75ug / ml青霉素G ，组织培养基（TCM）199中的50μg/ ml硫酸链霉素硫酸盐和0.1％聚乙烯醇（PVA），其量为每2ml培养基尺寸为2-4mm的1-6个卵泡，并进行 体外培养猪卵母细胞体外成熟培养基36-48小时。