公开(公告)号：CA2218597A1

公开(公告)日：1996-10-24

申请号：CA2218597

申请日：1996-04-18

Applicant: ABBOTT LAB

Inventor： STEIN HERMAN H ,  FUND K L ANTHONY ,  AUGERI DAVID J ,  BAKER WILLIAM R ,  SULLIVAN GERARD M ,  ROSENBERG SAUL H ,  O'CONNOR STEPHEN J ,  FAKHOURY STEPHEN A ,  PRASAD RAJNANDAN N ,  STOUT DAVID M ,  SHEN WANG ,  ROCKWAY TODD W ,  MCCLELLAN WILLIAM J ,  GARVEY DAVIS S ,  ARENDSEN DAVID L

IPC: A61K31/195 ,  A61K31/215 ,  A61K31/38 ,  A61K31/381 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/433 ,  A61P3/06 ,  A61P9/00 ,  A61P9/08 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C235/40 ,  C07C235/82 ,  C07D271/06 ,  C07D271/10 ,  C07D285/10 ,  C07D333/20 ,  A61K38/04 ,  C07D215/14 ,  A61K31/16 ,  A61K31/19 ,  C07D333/24 ,  C07D263/32 ,  A61K31/33 ,  C07C323/40 ,  C07C317/44 ,  C07C311/45 ,  C07D307/54 ,  C07D213/56 ,  C07C233/57 ,  C07D317/60 ,  C07D333/60

Abstract: The present invention provides a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.