公开(公告)号：AU5673196A

公开(公告)日：1996-11-21

申请号：AU5673196

申请日：1996-05-02

Applicant: ABBOTT LAB

Inventor： BAKER WILLIAM R ,  ROSENBERG SAUL H ,  FUNG K L ANTHONY ,  ROCKWAY TODD W ,  FAKHOURY STEPHEN A ,  GARVEY DAVID S ,  DONNER B GREGORY ,  O'CONNOR STEPHEN J ,  PRASAD RAJNANDAN N ,  SHEN WANG ,  STOUT DAVID M ,  SULLIVAN GERARD M

IPC: C07C65/24 ,  C07C65/28 ,  C07C65/40 ,  C07C69/94 ,  C07C229/38 ,  C07C233/22 ,  C07C233/65 ,  C07C233/69 ,  C07C233/73 ,  C07C233/87 ,  C07C235/16 ,  C07C235/34 ,  C07C235/42 ,  C07C235/48 ,  C07C235/60 ,  C07C235/84 ,  C07C237/08 ,  C07C237/20 ,  C07C237/32 ,  C07C251/48 ,  C07C255/57 ,  C07C259/10 ,  C07C271/48 ,  C07C275/42 ,  C07C311/08 ,  C07C311/29 ,  C07C311/51 ,  C07C323/59 ,  C07C327/48 ,  C07C333/04 ,  C07D209/16 ,  C07D213/40 ,  C07D231/12 ,  C07D271/10 ,  C07D271/113 ,  C07D307/88 ,  C07D307/89 ,  C07D309/32 ,  C07D311/68 ,  C07D319/06 ,  C07D333/20 ,  C07C235/38 ,  C07D257/04 ,  C07C335/22 ,  C07C233/12

Abstract: The present invention provides a compound of the formula which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.

公开(公告)号：CA2218597A1

公开(公告)日：1996-10-24

申请号：CA2218597

申请日：1996-04-18

Applicant: ABBOTT LAB

Inventor： STEIN HERMAN H ,  FUND K L ANTHONY ,  AUGERI DAVID J ,  BAKER WILLIAM R ,  SULLIVAN GERARD M ,  ROSENBERG SAUL H ,  O'CONNOR STEPHEN J ,  FAKHOURY STEPHEN A ,  PRASAD RAJNANDAN N ,  STOUT DAVID M ,  SHEN WANG ,  ROCKWAY TODD W ,  MCCLELLAN WILLIAM J ,  GARVEY DAVIS S ,  ARENDSEN DAVID L

IPC: A61K31/195 ,  A61K31/215 ,  A61K31/38 ,  A61K31/381 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/433 ,  A61P3/06 ,  A61P9/00 ,  A61P9/08 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C235/40 ,  C07C235/82 ,  C07D271/06 ,  C07D271/10 ,  C07D285/10 ,  C07D333/20 ,  A61K38/04 ,  C07D215/14 ,  A61K31/16 ,  A61K31/19 ,  C07D333/24 ,  C07D263/32 ,  A61K31/33 ,  C07C323/40 ,  C07C317/44 ,  C07C311/45 ,  C07D307/54 ,  C07D213/56 ,  C07C233/57 ,  C07D317/60 ,  C07D333/60

Abstract: The present invention provides a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.

公开(公告)号：AT206390T

公开(公告)日：2001-10-15

申请号：AT96912978

申请日：1996-04-18

Applicant: ABBOTT LAB

Inventor： ARENDSEN DAVID L ,  BAKER WILLIAM R ,  FAKHOURY STEPHEN A ,  FUNG K L ANTHONY ,  GARVEY DAVID S ,  MCCLELLAN WILLIAM J ,  O'CONNOR STEPHEN J ,  PRASAD RAJNANDAN N ,  ROCKWAY TODD W ,  ROSENBERG SAUL H ,  STEIN HERMAN H ,  SHEN WANG ,  STOUT DAVID M ,  SULLIVAN GERARD M ,  AUGERI DAVID J

IPC: A61K31/195 ,  A61K31/215 ,  A61K31/38 ,  A61K31/381 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/433 ,  A61P3/06 ,  A61P9/00 ,  A61P9/08 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C235/40 ,  C07C235/82 ,  C07D271/06 ,  C07D271/10 ,  C07D285/10 ,  C07D333/20 ,  A61K31/19

Abstract: The present invention provides a compound of formula (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.

公开(公告)号：MX9708077A

公开(公告)日：1998-01-31

申请号：MX9708077

申请日：1996-04-18

Applicant: ABBOTT LAB

Inventor： ARENDESEN DAVID L ,  BAKER WILLIAM R ,  FAKHOURY STEPHEN A ,  FUNG K L ANTHONY ,  GARVEY DAVID S ,  MCCLELLAN WILLIAM J ,  O'CONNOR STEPHEN J ,  PRASAD RAJNANDAN N ,  ROCKWAY TODD W

IPC: C07D333/20 ,  A61K31/16 ,  A61K31/19 ,  A61K31/215 ,  A61K31/38 ,  C07C233/58 ,  C07C233/59 ,  C07C235/40

Abstract: La presente invencion provee un compuesto de la formula (1) o (11) o una sal farmacéuticamente aceptable del mismo, el cual es util para inhibir farnesiltransferasa de proteína y la farnesilacion de la proteína de oncogen Ras, o para inhibir la produccion de escualeno que da como resultado la inhibicion de biosíntesis de colesterol, procedimientos para la preparacion de los compuestos de la invencion, además de intermediarios utiles en estos procedimientos, una composicion farmacéutica, a métodos para utilizar dichos compuestos.