公开(公告)号：WO2015031657A1

公开(公告)日：2015-03-05

申请号：PCT/US2014/053230

申请日：2014-08-28

Applicant: ABBOTT LABORATORIES

Inventor： JOHNS, Paul ,  VURMA, Mustafa ,  ALBRECHT, Daniel ,  DEMICHELE, Stephen ,  KATZ, Gary ,  REDDY, Todime

IPC: A23L1/30 ,  A23L1/302 ,  A23C9/20 ,  A23L1/29

CPC classification number: A23L33/115 ,  A23C9/1526 ,  A23C9/1528 ,  A23L33/15 ,  A23L33/155 ,  A23L33/17 ,  A23L33/19 ,  A23L33/40 ,  A23V2002/00 ,  A23V2250/182 ,  A23V2250/192 ,  A23V2250/211 ,  A23V2250/71

Abstract: Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides ("MDG") and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000 x g for 1 hour at 20°C.

Abstract translation: 本文公开了具有至少一种蛋白质，至少一种脂肪和至少一种亲脂性化合物的营养组合物，所述组合物包含至少一种包含至少一种疏水蛋白，单酸甘油酯和甘油二酯（“MDG”）的组合物和至少一种 亲脂性化合物，其中营养组合物中总MDG的至少1％在20℃下以100,000×g离心1小时后保持在水相中。

公开(公告)号：WO2019161362A1

公开(公告)日：2019-08-22

申请号：PCT/US2019/018496

申请日：2019-02-19

Applicant: ABBOTT LABORATORIES

Inventor： DEMICHELE, Stephen ,  VURMA, Mustafa ,  TERP, Megan

IPC: A23D7/005 ,  A23L33/00 ,  A23L33/12 ,  A23D7/01

Abstract: Aqueous lipid emulsions for providing enteral nutrition are provided. The aqueous lipid emulsions include at least 33% of lipids, lipid soluble nutrients, or a combination thereof, based upon the total weight of the emulsion, and are essentially free of carbohydrate and protein. The aqueous lipid emulsions are shelf-stable for at least 7 months. The aqueous lipid emulsions are a source of supplemental enteral nutrition for any patient in need thereof, including preterm infants.

公开(公告)号：WO2015069974A1

公开(公告)日：2015-05-14

申请号：PCT/US2014/064471

申请日：2014-11-07

Applicant: ABBOTT LABORATORIES

Inventor： MARRIAGE, Barbara ,  WILLIAMS, Jennifer ,  DEMICHELE, Stephen ,  KATZ, Gary ,  VURMA, Mustafa

IPC: A23L1/30 ,  A23L1/302 ,  A61K9/48 ,  A61K31/07 ,  A61P39/06

CPC classification number: A61K9/4858 ,  A23L33/10 ,  A23L33/105 ,  A23L33/12 ,  A23L33/15 ,  A61K9/4875 ,  A61K31/01 ,  A61K31/015 ,  A61K31/07 ,  A61K31/122 ,  A61K31/202 ,  A61K31/355 ,  A61K31/59 ,  A61K2300/00

Abstract: Capsules containing nutritional supplement formulations are disclosed which include a lipophilic MDG carrier oil comprising a mixture of monoglycerides and diglycerides, but with no more than 10% triglycerides. One or more lipophilic nutrients are also included in the nutritional supplement formulation. Methods for enhancing the absorption of the lipophilic nutrient in a subject using such capsules are also disclosed.

Abstract translation: 公开了含有营养补充剂制剂的胶囊，其包括亲脂性MDG载体油，其包含单酸甘油酯和甘油二酯的混合物，但不超过10％的甘油三酸酯。 一种或多种亲脂性营养素也包括在营养补充剂制剂中。 还公开了使用这种胶囊增强受试者中亲脂性营养素吸收的方法。

公开(公告)号：WO2005025334A1

公开(公告)日：2005-03-24

申请号：PCT/US2004/025161

申请日：2004-08-04

Applicant: ABBOTT LABORATORIES ,  MUSTAD, Vikkie, A. ,  DEMICHELE, Stephen ,  ZINKER, Bradley, A. ,  HUANG, Yung-Sheng

Inventor： MUSTAD, Vikkie, A. ,  DEMICHELE, Stephen ,  ZINKER, Bradley, A. ,  HUANG, Yung-Sheng

IPC: A23L1/30

CPC classification number: A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A23V2250/1862 ,  A23V2250/1866 ,  A23V2250/1868 ,  A23V2250/187 ,  A23V2250/1872 ,  A23V2250/1874

Abstract: The present invention relates to a lipid system, and methods for using such a lipid system, containing specific relative ratios of omega-3, omega-6, and omega-9 fatty acids. The lipid system may be used independently or as a component of a nutritional product. A lipid system according to the present invention may contain omega-3 fatty acids, omega-6 fatty acids, and omega-9 fatty acids with the ratio of omega-6 fatty acids to omega-3 fatty acids preferably being between 0.25:1 and 3:1, and the ratio of omega-9 fatty acids to omega-3 fatty acids preferably being between 0.4:1 and 3:1. The present invention also relates to methods for administering a lipid system or a nutritional product containing the lipid system to an individual.

Abstract translation: 本发明涉及一种脂质体系，以及使用含有ω-3，ω-6和ω-9脂肪酸的特定相对比例的脂质体系的方法。 脂质系统可以单独使用或作为营养产品的组分使用。 根据本发明的脂质体系可以含有ω-3脂肪酸，ω-6脂肪酸和ω-9脂肪酸，ω-6脂肪酸与ω-3脂肪酸的比例优选在0.25:1和 3：1，ω-9脂肪酸与ω-3脂肪酸的比例优选为0.4：1至3：1。 本发明还涉及向个体施用含有脂质系统的脂质系统或营养产品的方法。

公开(公告)号：WO2015187795A1

公开(公告)日：2015-12-10

申请号：PCT/US2015/033928

申请日：2015-06-03

Applicant: ABBOTT LABORATORIES

Inventor： JOHNS, Paul ,  VURMA, Mustafa ,  DEMICHELE, Stephen ,  KATZ, Gary

IPC: A23L1/30 ,  A23L1/302 ,  A23L1/305 ,  A23C9/20 ,  A23L1/22

CPC classification number: A23L2/52 ,  A23C2230/15 ,  A23L27/80 ,  A23L33/105 ,  A23L33/15 ,  A23L33/19 ,  A23V2002/00 ,  A23V2250/192 ,  A23V2250/54246

Abstract: Disclosed embodiments provide methods and compositions for improving the metabolic health of consumers. Bovine beta-casein, a major component of milk from cattle, has many genetic variants. Certain genetic variants, A1 in particular, have been associated with type 1 diabetes. The disclosed methods and compositions include reduced amounts of genetic variants of beta-casein that have been associated with diabetes. In some embodiments, the compositions display improved emulsions due to the solubility and hydrophobicity of the genetic variants of beta-casein used therein.

Abstract translation: 公开的实施方案提供了用于改善消费者的代谢健康的方法和组合物。 牛β-酪蛋白是来自牛的牛奶的主要成分，具有许多遗传变体。 某些遗传变异体，特别是A1与1型糖尿病有关。 所公开的方法和组合物包括与糖尿病有关的β-酪蛋白的遗传变异体的量减少。 在一些实施方案中，由于其中使用的β-酪蛋白的遗传变体的溶解度和疏水性，组合物显示出改进的乳液。

公开(公告)号：WO2015031637A1

公开(公告)日：2015-03-05

申请号：PCT/US2014/053197

申请日：2014-08-28

Applicant: ABBOTT LABORATORIES

Inventor： JOHNS, Paul ,  VURMA, Mustafa ,  ALBRECHT, Daniel ,  DEMICHELE, Stephen ,  KATZ, Gary ,  REDDY, Todime

IPC: A23L1/30 ,  A23L1/302 ,  A23C9/20 ,  A23L1/29 ,  A61K31/593

CPC classification number: A23L33/115 ,  A23C9/1526 ,  A23C9/1528 ,  A23L33/15 ,  A23L33/155 ,  A23L33/17 ,  A23L33/19 ,  A23L33/40 ,  A23V2002/00 ,  A23V2250/182 ,  A23V2250/192 ,  A23V2250/211 ,  A23V2250/71

Abstract: Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides ("MDG") and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000 x g for 1 hour at 20 °C.

Abstract translation: 本文公开了具有至少一种蛋白质，至少一种脂肪和至少一种亲脂性化合物的营养组合物，所述组合物包含至少一种包含至少一种疏水蛋白，单酸甘油酯和甘油二酯（“MDG”）的组合物和至少一种 亲脂性化合物，其中营养组合物中总MDG的至少1％在20℃下以100,000×g离心1小时后保持在水相中。

公开(公告)号：WO2018052758A1

公开(公告)日：2018-03-22

申请号：PCT/US2017/050099

申请日：2017-09-05

Applicant: ABBOTT LABORATORIES

Inventor： GARVEY, Sean ,  DEMICHELE, Stephen ,  TYRE, Roger ,  TORGERSON, Eric ,  HERTZLER, Steven

IPC: A23L33/00

CPC classification number: A23L33/40 ,  A23L33/00 ,  A23L33/115 ,  A23L33/185 ,  A23L33/19 ,  A23L33/30 ,  A23V2002/00 ,  A23V2200/332 ,  A23V2200/3322

Abstract: A nutritional composition comprises fat, protein and carbohydrate such that the fat provides from about 60 to about 90 % of the total calories of the composition, the protein provides from about 10 to about 30 % of the total calories of the composition, and the carbohydrate provides from about 0.1 to about 15 % of the total calories of the composition, and the composition comprises from about 0.01 to about 10 wt % beta-hydroxy-beta-methylbutyrate (HMB). A method of achieving or sustaining metabolic ketosis in an individual comprises administering the nutritional composition to the individual. A method of maintaining lean body mass and muscle strength in an individual during dietary ketosis comprises administering the nutritional composition to the individual.

Abstract translation: 营养组合物包含脂肪，蛋白质和碳水化合物，使得脂肪提供组合物总热量的约60至约90％，蛋白质提供总量的约10至约30％ 所述组合物的卡路里以及所述碳水化合物提供所述组合物的总卡路里的约0.1至约15％，并且所述组合物包含约0.01至约10wt％的β-羟基-β-甲基丁酸酯（HMB）。 在个体中实现或维持代谢性酮病的方法包括向个体施用营养组合物。 在饮食酮病过程中维持个体瘦体重和肌肉力量的方法包括向个体施用营养组合物。

公开(公告)号：WO2016044167A1

公开(公告)日：2016-03-24

申请号：PCT/US2015/049990

申请日：2015-09-14

Applicant: ABBOTT LABORATORIES

Inventor： PEREIRA, Suzette ,  EDENS, Neile ,  DEMICHELE, Stephen

IPC: A23L1/30 ,  A61K31/202 ,  A61P21/00

CPC classification number: A23L33/12 ,  A23V2002/00 ,  A61K31/202 ,  A23V2200/316 ,  A23V2250/1874 ,  A23V2250/54 ,  A61K2300/00

Abstract: Methods of increasing muscle strength and mobility in a subject experiencing significant physical inactivity include administering gamma linolenic acid to the subject as part of a nutritional composition containing fat and at least one of protein and carbohydrate. Administration of the nutritional composition to the subject increases muscle strength and mobility of the subject by increasing levels of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) in muscle of the subject.

Abstract translation: 在经历显着身体不活动的受试者中增加肌肉力量和移动性的方法包括向受试者施用γ-亚麻酸，作为含有脂肪和至少一种蛋白质和碳水化合物的营养组合物的一部分。 通过增加受试者肌肉中过氧化物酶体增殖物激活的受体γ共激活因子-1α（PGC-1α）的水平，对受试者施用营养组合物增加受试者的肌肉力量和流动性。

公开(公告)号：EP3091860B1

公开(公告)日：2019-03-27

申请号：EP14762193.2

申请日：2014-08-28

Applicant: Abbott Laboratories

Inventor： JOHNS, Paul ,  VURMA, Mustafa ,  ALBRECHT, Daniel ,  DEMICHELE, Stephen ,  KATZ, Gary ,  REDDY, Todime

IPC: A23L33/15 ,  A23C9/20 ,  A23L33/00

公开(公告)号：EP1662905A1

公开(公告)日：2006-06-07

申请号：EP04780062.8

申请日：2004-08-04

Applicant: ABBOTT LABORATORIES

Inventor： MUSTAD, Vikkie, A. ,  DEMICHELE, Stephen ,  ZINKER, Bradley, A. ,  HUANG, Yung-Sheng

IPC: A23L1/30 ,  A23L1/29

CPC classification number: A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A23V2250/1862 ,  A23V2250/1866 ,  A23V2250/1868 ,  A23V2250/187 ,  A23V2250/1872 ,  A23V2250/1874

Abstract: The present invention relates to a lipid system, and methods for using such a lipid system, containing specific relative ratios of omega-3, omega-6, and omega-9 fatty acids. The lipid system may be used independently or as a component of a nutritional product. A lipid system according to the present invention may contain omega-3 fatty acids, omega-6 fatty acids, and omega-9 fatty acids with the ratio of omega-6 fatty acids to omega-3 fatty acids preferably being between 0.25:1 and 3:1, and the ratio of omega-9 fatty acids to omega-3 fatty acids preferably being between 0.4:1 and 3:1. The present invention also relates to methods for administering a lipid system or a nutritional product containing the lipid system to an individual.