公开(公告)号：AU2009313198A1

公开(公告)日：2011-06-30

申请号：AU2009313198

申请日：2009-11-10

Applicant: VERTEX PHARMA

Inventor： JEAN-DAMIEN CHARRIER ,  STEVEN DURRANT ,  DAVID KAY ,  MICHAEL O'DONNELL ,  RONALD KNEGTEL ,  SOMHAIRLE MACCORMICK ,  JOANNE PINDER ,  ANISA VIRANI ,  STEPHEN YOUNG ,  HAYLEY BINCH ,  THOMAS CLEVELAND ,  FANNING LEV T D ,  DENNIS HURLEY ,  PRAMOD JOSHI ,  URVI SHETH ,  ALINA SILINA ,  MICHAEL REAPER PHILIP

IPC: C07D401/04 ,  A61K31/4965 ,  A61P35/00 ,  C07D403/04 ,  C07D413/04

Abstract: The present disclosure relates to pyrazine compounds of formula (I) wherein L, n, R, and R are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.

公开(公告)号：ZA200702375B

公开(公告)日：2009-03-25

申请号：ZA200702375

申请日：2005-08-31

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN M ,  TERMIN ANDREAS P ,  GONZALEZ JESUS E III ,  FANNING LEV T D ,  NEUBERT TIMOTHY D ,  PAUL KRENITSKY ,  PRAMOD JOSHI ,  HURLEY DENNIS J ,  URVI SHETH ,  BOGER JOSHUA S

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：MX2008006303A

公开(公告)日：2009-02-26

申请号：MX2008006303

申请日：2006-11-13

Applicant: VERTEX PHARMA

Inventor： TERMIN ANDREAS ,  DEAN WILSON ,  FANNING LEV T D ,  PAUL KRENITSKY ,  JOSHI PRAMOD ,  URVI SHETH

IPC: C07D403/04 ,  A61K31/505 ,  A61P29/00

Abstract: La presente invención se relaciona con los compuestos de la siguiente fórmula (ver fórmula) útiles como inhibidores de canales de sodio gatillados por tensión. La invención también proporciona las composiciones farmacéuticamente aceptables que comprenden los compuestos de la invención y los métodos para utilizar las composiciones en el tratamiento de diversos trastornos.