Patent search ap:("VERTEX PHARMA") AND inv:"SHAW DAVID MATTHEW" Page 1

1.

发明专利
SUBSTITUIRANI TETRAHIDROFURANI KOT MODULATORJI NATRIJEVIH KANALČKOV 未知

公开(公告)号：SI4069691T1

公开(公告)日：2025-02-28

申请号：SI202030535

申请日：2020-12-04

Applicant: VERTEX PHARMA

Inventor： DURRANT STEVEN JOHN , AHMAD NADIA , BECK ELIZABETH MARY , CARVALHO MEIRELES LIDIO , CHUDYK EWA IWONA , ETXEBARRIA JARDI GORKA , GALAN BHAIRAVI , HADIDA RUAH SARA S , HURLEY DENNIS JAMES , KNEGTEL RONALD MARCELLUS , NEUBERT TIMOTHY DONALD , PINDER JOANNE LOUISE , PONTILLO JOSEPH , PULLIN ROBERT , SCHMIDT YVONNE , SHAW DAVID MATTHEW , SKERRATT SARAH , STAMOS DEAN , THOMSON STEPHEN ANDREW , VIRANI ANISA NIZARALI , WRAY CHRISTOPHER

IPC: C07D405/12 , A61K31/443 , A61P29/00 , C07D405/14

2.

发明专利
SUPSTITUIRANI TETRAHIDROFURANI KAO MODULATORI NATRIJEVIH KANALA 未知

公开(公告)号：HRP20241695T1

公开(公告)日：2025-02-14

申请号：HRP20241695

申请日：2020-12-04

Applicant: VERTEX PHARMA

Inventor： DURRANT STEVEN JOHN , AHMAD NADIA , BECK ELIZABETH MARY , CARVALHO MEIRELES LIDIO , CHUDYK EWA IWONA , ETXEBARRIA JARDI GORKA , GALAN BHAIRAVI , HADIDA RUAH SARA S , HURLEY DENNIS JAMES , KNEGTEL RONALD MARCELLUS , NEUBERT TIMOTHY DONALD , PINDER JOANNE LOUISE , PONTILLO JOSEPH , PULLIN ROBERT , SCHMIDT YVONNE , SHAW DAVID MATTHEW , SKERRATT SARAH , STAMOS DEAN , THOMSON STEPHEN ANDREW , VIRANI ANISA NIZARALI , WRAY CHRISTOPHER

IPC: C07D405/12 , A61K31/443 , A61P29/00 , C07D405/14

3.

发明专利
2-amino-6-fluoro-N-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as ATR kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof 未知

公开(公告)号：AU2019200723B2

公开(公告)日：2021-08-26

申请号：AU2019200723

申请日：2019-02-04

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN , DAVIS CHRISTOPHER JOHN , FRAYSSE DAMIEN , ETXEBARRIA I JARDI GORKA , PEGG SIMON , PIERARD FRANCOISE , PINDER JOANNE , STUDLEY JOHN , ZWICKER CARL , SANGHVI TAPAN , WALDO MICHAEL , MEDEK ALES , SHAW DAVID MATTHEW , PANESAR MANINDER , ZHANG YUEGANG , ALEM NAZIHA

IPC: C07D487/04 , A61K31/519 , A61P35/00 , C07B59/00

Abstract: N&RXFN N 2 N F 91 Y'5 V N/ N -X X N H \.- '> \' FR1 X-0 I-A I-B The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.

4.

发明专利
ZWIĄZEK 2-AMINO-6-FLUORO-N-[5-FLUORO-PIRYDYN-3-YLO]PYRAZOLO [1,5-A]PIRYMIDINO-3-KARBOKSAMIDU PRZYDATNY JAKO INHIBITOR KINAZY ATR, JEGO WYTWARZANIE, RÓŻNE POSTACIE STAŁE I ICH RADIOZNAKOWANE POCHODNE 未知

公开(公告)号：PL3077397T3

公开(公告)日：2020-04-30

申请号：PL14815187

申请日：2014-12-05

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN , DAVIS CHRISTOPHER JOHN , FRAYSSE DAMIEN , ETXEBARRIA I JARDI GORKA , PEGG SIMON , PIERARD FRANCOISE , PINDER JOANNE , STUDLEY JOHN , ZWICKER CARL , SANGHVI TAPAN , WALDO MICHAEL , MEDEK ALES , SHAW DAVID MATTHEW , PANESAR MANINDER , ZHANG YUEGANG , ALEM NAZIHA

IPC: C07D487/04 , A61K31/519 , A61P35/00 , C07B59/00

5.

发明专利
2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, ITS PREPARATION, DIFFERENT SOLID FORMS AND RADIOLABELLED DERIVATIVES THEREOF 未知

公开(公告)号：CA2932757A1

公开(公告)日：2015-06-11

申请号：CA2932757

申请日：2014-12-05

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN , DAVIS CHRISTOPHER JOHN , FRAYSSE DAMIEN , ETXEBARRIA I JARDI GORKA , PEGG SIMON , PIERARD FRANCOISE , PINDER JOANNE , STUDLEY JOHN , ZWICKER CARL , SANGHVI TAPAN , WALDO MICHAEL , MEDEK ALES , SHAW DAVID MATTHEW , PANESAR MANINDER , ZHANG YUEGANG , ALEM NAZIHA

IPC: C07D487/04 , A61K31/519 , A61P35/00 , C07B59/00

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.

6.

发明专利
PODSTAWIONE TETRAHYDROFURANY JAKO MODULATORY KANAŁÓW SODOWYCH 未知

公开(公告)号：PL4069691T3

公开(公告)日：2025-01-27

申请号：PL20825397

申请日：2020-12-04

Applicant: VERTEX PHARMA

Inventor： DURRANT STEVEN JOHN , AHMAD NADIA , BECK ELIZABETH MARY , CARVALHO MEIRELES LIDIO , CHUDYK EWA IWONA , ETXEBARRIA JARDI GORKA , GALAN BHAIRAVI , HADIDA RUAH SARA S , HURLEY DENNIS JAMES , KNEGTEL RONALD MARCELLUS , NEUBERT TIMOTHY DONALD , PINDER JOANNE LOUISE , PONTILLO JOSEPH , PULLIN ROBERT , SCHMIDT YVONNE , SHAW DAVID MATTHEW , SKERRATT SARAH , STAMOS DEAN , THOMSON STEPHEN ANDREW , VIRANI ANISA NIZARALI , WRAY CHRISTOPHER

IPC: C07D405/12 , A61K31/443 , A61P29/00 , C07D405/14

7.

发明专利
2-amino-6-fluoro-N-(5-fluoro-piridin-3-IL)pirazolo(1,5-A)pirimidin-3- karboksamidna spojina, koristna kot inhibitor kinaze ATR, njena priprava, različne trdne oblike in njeni radioaktivno označeni derivati 未知

公开(公告)号：SI3077397T1

公开(公告)日：2020-02-28

申请号：SI201431432

申请日：2014-12-05

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN , DAVIS CHRISTOPHER JOHN , FRAYSSE DAMIEN , ETXEBARRIA I JARDI GORKA , PEGG SIMON , PIERARD FRANCOISE , PINDER JOANNE , STUDLEY JOHN , ZWICKER CARL , SANGHVI TAPAN , WALDO MICHAEL , MEDEK ALES , SHAW DAVID MATTHEW , PANESAR MANINDER , ZHANG YUEGANG , ALEM NAZIHA

IPC: C07D487/00 , A61K31/00 , A61P35/00 , C07B59/00

8.

发明专利
SPOJ 2-AMINO-6-FLUORO-N-[5-FLUORO-PIRIDIN-3-IL]PIRAZOLO[1,5-A]PIRIMIDIN-3-KARBOKSAMIDA KORISTAN KAO INHIBITOR ATR KINASE, NJEGOVA PRIPRAVA, RAZLIČITI KRUTI OBLICI TE NJEGOVI RADIOAKTIVNO OZNAČENI DERIVATI 未知

公开(公告)号：HRP20192183T1

公开(公告)日：2020-02-21

申请号：HRP20192183

申请日：2019-12-04

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN , DAVIS CHRISTOPHER JOHN , FRAYSSE DAMIEN , ETXEBARRIA I JARDI GORKA , PEGG SIMON , PIERARD FRANCOISE , PINDER JOANNE , STUDLEY JOHN , ZWICKER CARL , SANGHVI TAPAN , WALDO MICHAEL , MEDEK ALES , SHAW DAVID MATTHEW , PANESAR MANINDER , ZHANG YUEGANG , ALEM NAZIHA

IPC: C07D487/04 , A61K31/519 , A61P35/00 , C07B59/00

9.

发明专利
JEDINJENJE 2-AMINO-6-FLUORO-N-[5-FLUORO-PIRIDIN-3-IL]PIRAZOLO[1,5-A]PIRIMIDIN-3-KARBOKSAMIDA KORISNO KAO INHIBITOR ATR KINAZE, NJEGOVO DOBIJANJE, RAZLIČITI ČVRSTI OBLICI I NJEGOVI RADIOAKTIVNO OBELEŽENI DERIVATI 未知

公开(公告)号：RS59679B1

公开(公告)日：2020-01-31

申请号：RSP20191631

申请日：2014-12-05

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN , DAVIS CHRISTOPHER JOHN , FRAYSSE DAMIEN , ETXEBARRIA I JARDI GORKA , PEGG SIMON , PIERARD FRANCOISE , PINDER JOANNE , STUDLEY JOHN , ZWICKER CARL , SANGHVI TAPAN , WALDO MICHAEL , MEDEK ALES , SHAW DAVID MATTHEW , PANESAR MANINDER , ZHANG YUEGANG , ALEM NAZIHA

IPC: C07D487/04 , A61K31/519 , A61P35/00 , C07B59/00

10.

发明专利
2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, ITS PREPARATION, DIFFERENT SOLID FORMS AND RADIOLABELLED DERIVATIVES THEREOF 未知

公开(公告)号：SG11201604519PA

公开(公告)日：2016-07-28

申请号：SG11201604519P

申请日：2014-12-05

Applicant: VERTEX PHARMA

Inventor： CHARRIER JEAN-DAMIEN , DAVIS CHRISTOPHER JOHN , FRAYSSE DAMIEN , ETXEBARRIA I JARDI GORKA , PEGG SIMON , PIERARD FRANCOISE , PINDER JOANNE , STUDLEY JOHN , ZWICKER CARL , SANGHVI TAPAN , WALDO MICHAEL , MEDEK ALES , SHAW DAVID MATTHEW , PANESAR MANINDER , ZHANG YUEGANG , ALEM NAZIHA

IPC: C07D487/04 , A61K31/519 , A61P35/00 , C07B59/00

Abstract: wherein the variables are as defined herein.

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