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101.发明授权System and method for analyzing biological samples using Raman molecular imaging 有权使用拉曼分子成像分析生物样品的系统和方法公开(公告)号：US07990533B2
公开(公告)日：2011-08-02
申请号：US12834370
申请日：2010-07-12
Applicant: John Maier , Shona Stewart , Jeffrey Cohen
Inventor： John Maier , Shona Stewart , Jeffrey Cohen
CPC classification number: G01J3/10 , A61B5/0071 , A61B5/0075 , A61B5/417 , A61B5/7264 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G02B21/365 , G06F19/00 , G16H50/70
Abstract: A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression.
Abstract translation: 用于确定测试的肾或前列腺样品的疾病状态，代谢状态，临床结果和疾病进展中的至少一个的系统和方法。 从样品获得测试拉曼数据集，其中所述测试拉曼数据集可以包括多个拉曼光谱和多个空间上准确的波长分辨拉曼图像中的至少一个。 使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。 对于肾样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知肾样品和相关联的已知代谢状态，临床结果和/或疾病进展。 对于前列腺样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知前列腺样品和相关的已知疾病状态，代谢状态，临床结果和/或疾病进展。
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公开(公告)号：US07978317B2
公开(公告)日：2011-07-12
申请号：US12343366
申请日：2008-12-23
Applicant: Wayne D. Jung , Russell W. Jung , Walter W. Sloan , Alan R. Loudermilk
Inventor： Wayne D. Jung , Russell W. Jung , Walter W. Sloan , Alan R. Loudermilk
CPC classification number: G01N21/25 , A61C19/04 , G01J1/0271 , G01J3/02 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0278 , G01J3/0291 , G01J3/0294 , G01J3/36 , G01J3/46 , G01J3/462 , G01J3/463 , G01J3/508 , G01J3/51 , G01J3/513 , G01J3/524 , G01J2003/466 , G01N21/57
Abstract: A miniaturized spectrometer/spectrophotometer system and methods are disclosed. A probe tip including one or more light sources and a plurality of light receivers is provided. A first spectrometer system receives light from a first set of the plurality of light receivers. A second spectrometer system receives light from a second set of the plurality of light receivers. A processor, wherein the processor receives data generated by the first spectrometer system and the second spectrometer system, wherein an optical measurement of a sample under test is produced based on the data generated by the first and second spectrometer systems.
Abstract translation: 公开了一种小型化光谱仪/分光光度计系统和方法。 提供了包括一个或多个光源和多个光接收器的探针尖端。 第一光谱仪系统接收来自多个光接收器的第一组的光。 第二光谱仪系统接收来自多个光接收器的第二组的光。 一种处理器，其中所述处理器接收由所述第一光谱仪系统和所述第二光谱仪系统产生的数据，其中，基于由所述第一和第二光谱仪系统产生的数据产生待测试样品的光学测量。
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公开(公告)号：US20110117532A1
公开(公告)日：2011-05-19
申请号：US12619370
申请日：2009-11-16
Applicant: Don Relyea , Michelle Felt
Inventor： Don Relyea , Michelle Felt
CPC classification number: G06T11/60 , G01J3/02 , G01J3/0264 , G01J3/0294 , G01J3/2823 , G06K9/4604 , G06T5/00 , H04N5/2226 , H04N5/225 , H04N9/75
Abstract: A video image capture component includes a light source operable in a first spectrum, a first image detector operable in the first spectrum, a second light source operable in a second spectrum, and a second image detector operable in the second spectrum. A filtering component generates a combination image by filtering a first image obtained by the first image detector with a high-contrast filter, resulting in a high-contrast image, and masking a second image obtained by the second image detector using the high-contrast image. A compositing component creates a composite image from the combination image and a selected image. A display component displays the composite image.Alternative systems and methods for creating a combination image include techniques involving thermal imaging, laser detection, and narrow band frequency detection.
Abstract translation: 视频图像捕捉组件包括可在第一频谱中操作的光源，可在第一频谱中操作的第一图像检测器，可在第二频谱中操作的第二光源和可在第二频谱中操作的第二图像检测器。 滤波组件通过用高对比度滤波器对由第一图像检测器获得的第一图像进行滤波来产生组合图像，导致高对比度图像，并且使用高对比度图像掩蔽由第二图像检测器获得的第二图像 。 合成组件从组合图像和所选图像创建合成图像。 显示组件显示合成图像。 用于创建组合图像的替代系统和方法包括涉及热成像，激光检测和窄带频率检测的技术。
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104.发明申请SPECTROMETRIC MEASUREMENT APPARATUS, IMAGE EVALUATION APPARATUS, AND IMAGE FORMING APPARATUS 有权光谱测量装置，图像评估装置和图像形成装置公开(公告)号：US20110106472A1
公开(公告)日：2011-05-05
申请号：US12901280
申请日：2010-10-08
Applicant: Manabu Seo , Naohiro Kamijo , Kohei Shimbo
Inventor： Manabu Seo , Naohiro Kamijo , Kohei Shimbo
CPC classification number: G01J3/18 , G01J3/02 , G01J3/0205 , G01J3/0229 , G01J3/0294 , G01J3/14 , G01J3/2803
Abstract: A spectrometric measurement apparatus includes a light radiation unit for radiating light onto a medium; a hole array including openings arranged one-dimensionally for transmitting diffusion light from the medium; an imaging optical system configured to focus an image from the hole array; a diffraction element configured to diffract the light for focusing the image; and a light receiving unit including pixels arranged one-dimensionally configured to receive the light that has been dispersed by the diffraction element and spectrometric sensors each corresponding to a predetermined number of the pixels. The light transmitted through each of the openings of the hole array is dispersed by the diffraction element, and then the light enters the pixels so that spectral properties of the diffusion light are acquired. The structure of the diffraction element includes variations that are formed in accordance with the height of the image that is focused by the imaging optical system.
Abstract translation: 光谱测量装置包括用于将光照射到介质上的光辐射单元; 孔阵列，包括一维排列的用于从介质传播漫射光的开口; 成像光学系统，被配置为聚焦来自孔阵列的图像; 被配置为衍射用于聚焦图像的光的衍射元件; 以及光接收单元，其包括被一维地配置为接收由衍射元件分散的光和各自对应于预定数量的像素的光谱传感器的像素。 穿过孔阵列的每个开口的光被衍射元件分散，然后光进入像素，从而获得漫射光的光谱特性。 衍射元件的结构包括根据由成像光学系统聚焦的图像的高度形成的变化。
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公开(公告)号：US20110019261A1
公开(公告)日：2011-01-27
申请号：US12509154
申请日：2009-07-24
Applicant: Aaron Boyd Cole
Inventor： Aaron Boyd Cole
IPC: G02B26/00
CPC classification number: G01J3/18 , G01J3/02 , G01J3/0264 , G01J3/0294 , G01J3/36
Abstract: A tunable bandwidth selector is disclosed. The tunable bandwidth selector may include a plurality of spaced apart electron sheets which selectively separate a first bandwidth from an input spectrum.
Abstract translation: 公开了一种可调谐带宽选择器。 可调谐带宽选择器可以包括多个间隔开的电子薄片，其选择性地将第一带宽与输入光谱分离。
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Patent Agency Ranking
公开(公告)号：US20100328659A1
公开(公告)日：2010-12-30
申请号：US11933253
申请日：2007-10-31
Applicant: Andrew Bodkin
Inventor： Andrew Bodkin
IPC: G01J3/28
CPC classification number: G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/021 , G01J3/0229 , G01J3/0235 , G01J3/0294 , G01J3/14 , G01J3/2803 , G01J3/2823 , G01J3/36
Abstract: Hyperspectral imaging system and methods that may be used for imaging objects in three-dimensions are disclosed. A cylindrical lens array and/or a slit array may be used to re-image and divide a field of view into multiple channels. The multiple channels are dispersed into multiple spectral signatures and observed on a two-dimensional focal plane array in real time. The entire hyperspectral data cube is collected simultaneously.
Abstract translation: 公开了可以用于三维成像对象的高光谱成像系统和方法。 可以使用柱面透镜阵列和/或狭缝阵列来将视场重新图像分割成多个通道。 将多个通道分散到多个光谱特征中，并在二维焦平面阵列上实时观察。 整个高光谱数据立方体被同时收集。
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107.发明申请System and Method for Analyzing Biological Samples Using Raman Molecular Imaging 有权使用拉曼分子成像分析生物样品的系统和方法公开(公告)号：US20100280762A1
公开(公告)日：2010-11-04
申请号：US12834370
申请日：2010-07-12
Applicant: John Maier , Shona Stewart , Jeffrey Cohen
Inventor： John Maier , Shona Stewart , Jeffrey Cohen
CPC classification number: G01J3/10 , A61B5/0071 , A61B5/0075 , A61B5/417 , A61B5/7264 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G02B21/365 , G06F19/00 , G16H50/70
Abstract: A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression.
Abstract translation: 用于确定测试的肾或前列腺样品的疾病状态，代谢状态，临床结果和疾病进展中的至少一个的系统和方法。 从样品获得测试拉曼数据集，其中所述测试拉曼数据集可以包括多个拉曼光谱和多个空间上准确的波长分辨拉曼图像中的至少一个。 使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。 对于肾样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知肾样品和相关联的已知代谢状态，临床结果和/或疾病进展。 对于前列腺样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知前列腺样品和相关的已知疾病状态，代谢状态，临床结果和/或疾病进展。
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公开(公告)号：US07808635B2
公开(公告)日：2010-10-05
申请号：US12199575
申请日：2008-08-27
Applicant: Michael P. Chrisp
Inventor： Michael P. Chrisp
IPC: G01J3/28
CPC classification number: G01J3/2823 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0291 , G01J3/0294 , G01J3/04 , G01J3/2803 , G01J3/36 , G02B17/0642
Abstract: A wide swath imaging spectrometer utilizing an array of individual spectrometer modules in the telescope focal plane to provide an extended field of view. The spectrometer modules with their individual detectors are arranged so that their slits overlap with motion on the scene providing contiguous spatial coverage. The number of modules can be varied to take full advantage of the field of view available from the telescope.
Abstract translation: 利用在望远镜焦平面中的各个光谱仪模块的阵列的宽幅成像光谱仪来提供扩展的视野。 具有各自检测器的光谱仪模块被布置成使得它们的狭缝与场景上的运动重叠，提供连续的空间覆盖。 模块的数量可以变化，以充分利用望远镜可用的视野。
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109.发明申请Compact Objective Lens Assembly for Simultaneously Imaging Multiple Spectral Bands 有权用于同时成像多个光谱带的紧凑型物镜组件公开(公告)号：US20100208372A1
公开(公告)日：2010-08-19
申请号：US12388783
申请日：2009-02-19
Applicant: Richard J. Heimer
Inventor： Richard J. Heimer
CPC classification number: H04N5/332 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0294 , G01J3/2823 , G01J3/36 , G01J2005/0077 , G02B23/125 , G02B27/1013 , G02B27/14 , H04N5/2254 , H04N5/33
Abstract: An objective lens assembly suitable for use in helmet-mounted applications. The objective lens assembly comprises two prisms that collectively are configured, oriented and bonded relative to each other to separate and allow simultaneous imaging of two separate spectral bands (such as VNIR and LWIR bands) received from the same object scene via a common window such that the object scene may be viewed from the same perspective without the effects of parallax.
Abstract translation: 适用于头盔安装应用的物镜组件。 物镜组件包括两个共同配置，定向并相对于彼此结合的棱镜，以分离并允许通过公共窗口从相同对象场景接收的两个分开的光谱带（例如VNIR和LWIR带）同时成像，使得 可以从相同的视角观看对象场景而不产生视差的影响。
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公开(公告)号：US20100182594A1
公开(公告)日：2010-07-22
申请号：US12690205
申请日：2010-01-20
Applicant: Keith Carron
Inventor： Keith Carron
CPC classification number: G01J3/42 , G01J3/02 , G01J3/021 , G01J3/0229 , G01J3/0264 , G01J3/0294 , G01J3/1809 , G01J3/44 , G01J2001/4242
Abstract: An apparatus is described for the real-time identification of one or more selected components of a target material. In one embodiment, an infrared spectrometer and a separate Raman spectrometer are coupled to exchange respective spectral information of the target material preferably normalized and presented in a single graph. In an alternative embodiment, both an infrared spectrometer and a Raman spectrometer are included in a single instrument and a common infrared light source is used by both spectrometers. In another embodiment, a vibrational spectrometer and a stoichiometric spectrometer are combined in a single instrument and are coupled to exchange respective spectral information of the target material and to compare the spectral information against a library of spectra to generate a real-time signal if a selected component is present in the target material.
Abstract translation: 描述了用于实时识别目标材料的一个或多个选定部件的装置。 在一个实施例中，红外光谱仪和单独的拉曼光谱仪被耦合以交换目标材料的各个光谱信息，优选地被归一化并呈现在单个图中。 在替代实施例中，红外光谱仪和拉曼光谱仪均包括在单个仪器中，并且两个光谱仪都使用通用的红外光源。 在另一个实施例中，将振动光谱仪和化学计量光谱仪组合在单个仪器中，并耦合以交换目标材料的相应光谱信息，并将光谱信息与光谱库进行比较以产生实时信号，如果选定 组分存在于目标材料中。
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