公开(公告)号：US20150330898A1

公开(公告)日：2015-11-19

申请号：US14404788

申请日：2013-06-04

Applicant: Veritide Limited

Inventor： Joon Koo Choi ,  Robert Ian Johnston

IPC: G01N21/64 ,  C12Q1/04

CPC classification number: G01N21/64 ,  C12Q1/04 ,  G01J3/0218 ,  G01J3/36 ,  G01J3/42 ,  G01N21/645 ,  G01N21/6486 ,  G01N33/12 ,  G01N2021/635 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2201/0612

Abstract: A system and method for the detection of bacteria on a sample, utilises spectroscopic analysis of the sample and the fluorescent properties of bacteria or other substance(s) or matter associated with the bacteria to identify the presence of bacteria on the sample. A detector analyses light emitted from the sample in response to illumination. The detector 5 is arranged to analyse the emission spectra across two wavebands, a first waveband containing the wavelengths associated with the fluorescent properties of the bacterial species or other substance or matter to be detected, and a second waveband excluding these wavelengths but also having an overlapping region with the first waveband.

Abstract translation: 用于检测样品上的细菌的系统和方法，利用样品的光谱分析和细菌或其它物质或与细菌相关的物质的荧光性质来鉴定样品中细菌的存在。 检测器响应于照明而分析从样品发射的光。 检测器5被布置成分析两个波段上的发射光谱，第一波段包含与细菌物质或其他物质或待检测物质的荧光特性相关联的波长，以及除了这些波长之外还具有重叠的第二波段 具有第一波段的区域。

公开(公告)号：US20150327755A1

公开(公告)日：2015-11-19

申请号：US14812084

申请日：2015-07-29

Applicant: OLYMPUS CORPORATION

Inventor： Bakusui DAIDOJI ,  Kazuaki TAMURA ,  Takeshi ITO ,  Hiroyuki KAMEE

IPC: A61B1/06 ,  G02B23/24 ,  G01J3/10

CPC classification number: A61B1/0638 ,  A61B1/0653 ,  A61B1/0661 ,  G01J3/0218 ,  G01J3/10 ,  G02B23/2469

Abstract: A light source device includes: excitation light sources configured to emit a plurality of excitation light including mutually different spectra; wavelength converting members configured to wavelength-convert the excitation light emitted from the excitation light sources into light having mutually different spectra and configured to be disposed in a common application region of the excitation light; and a light source control unit configured to switch a combination of the excitation light sources that are lighted among the excitation light sources based on the observation mode including a normal light observation mode and a special light observation mode to highlight a particular observation target input to an input unit, wherein light emitted from the wavelength converting members is used as illumination light, and the illumination light corresponding to the observation modes is emitted from a same emitting portion.

Abstract translation: 光源装置包括：被配置为发射包括相互不同的光谱的多个激发光的激发光源; 被配置为将从激发光源发射的激发光波长转换成具有相互不同光谱的光的波长转换部件，并被配置为设置在激发光的共同的应用区域中; 以及光源控制单元，被配置为基于包括正常光观察模式和特殊光观察模式的观察模式来切换在激励光源之间点亮的激发光源的组合，以突出输入到特定观察目标的特定观察目标 输入单元，其中从波长转换构件发射的光用作照明光，并且与观察模式相对应的照明光从相同的发射部分发射。

公开(公告)号：US20150305658A1

公开(公告)日：2015-10-29

申请号：US14650897

申请日：2013-12-17

Applicant: OMNI MEDSCI. INC.

Inventor： Mohammed N. ISLAM

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: Non-invasive monitoring of blood constituents such as glucose, ketones, or hemoglobin A1c may be accomplished using near-infrared or short-wave infrared (SWIR) light sources through absorbance, diffuse reflection, or transmission spectroscopy. As an example, hydro-carbon related substances such as glucose or ketones have distinct spectral features in the SWIR between approximately 1500 and 2500 nm. An SWIR super-continuum laser based on laser diodes and fiber optics may be used as the light source for the non-invasive monitoring. Light may be transmitted or reflected through a tooth, since an intact tooth and its enamel and dentine may be nearly transparent in the SWIR. Blood constituents or analytes within the capillaries in the dental pulp may be detected. The non-invasive monitoring device may communicate with a device such as a smart phone or tablet, which may transmit a signal related to the measurement to the cloud with cloud-based value-added services.

Abstract translation: 通过吸收，漫反射或透射光谱可以使用近红外或短波红外（SWIR）光源实现对血液成分如葡萄糖，酮或血红蛋白A1c的非侵入性监测。 作为示例，水 - 碳相关物质如葡萄糖或酮在SWIR中在约1500和2500nm之间具有不同的光谱特征。 可以使用基于激光二极管和光纤的SWIR超连续激光器作为非侵入性监测的光源。 光可以通过牙齿传播或反射，因为完整的牙齿及其牙釉质和牙质在SWIR中可能几乎是透明的。 可以检测牙髓中毛细血管内的血液成分或分析物。 非侵入式监测设备可以与诸如智能电话或平板电脑的设备进行通信，智能电话或平板电脑可以使用基于云的增值业务将与测量相关的信号传输到云。

公开(公告)号：US20150297329A1

公开(公告)日：2015-10-22

申请号：US14755171

申请日：2015-06-30

Applicant: Align Technology, Inc.

Inventor： Noam Babayoff

IPC: A61C19/04 ,  A61B5/107 ,  A61B1/247 ,  A61B5/00 ,  A61B1/00 ,  A61B1/06

CPC classification number: H04N13/15 ,  A61B1/00009 ,  A61B1/00096 ,  A61B1/0615 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0676 ,  A61B1/0684 ,  A61B1/24 ,  A61B1/247 ,  A61B5/0068 ,  A61B5/0088 ,  A61B5/1077 ,  A61B5/1079 ,  A61C9/0053 ,  A61C9/0066 ,  A61C19/04 ,  G01B11/24 ,  G01B11/25 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/0243 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/462 ,  G01J3/50 ,  G01J3/501 ,  G01J3/508 ,  G01J3/51 ,  G01N21/255 ,  G06F19/00 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10028 ,  G06T2207/30036 ,  H01L27/14868 ,  H04N13/207 ,  H04N13/257 ,  H04N13/271 ,  H04N13/296

Abstract: A device for determining the surface topology and associated color of a structure, such as a teeth segment, includes a scanner for providing depth data for points along a two-dimensional array substantially orthogonal to the depth direction, and an image acquisition means for providing color data for each of the points of the array, while the spatial disposition of the device with respect to the structure is maintained substantially unchanged. A processor combines the color data and depth data for each point in the array, thereby providing a three-dimensional color virtual model of the surface of the structure. A corresponding method for determining the surface topology and associate color of a structure is also provided.

Abstract translation: 用于确定诸如齿段的结构的表面拓扑和相关联颜色的装置包括用于为基本上与深度方向正交的二维阵列的点提供深度数据的扫描器，以及用于提供颜色的图像获取装置 数据，而阵列相对于结构的空间布置基本上保持不变。 处理器组合阵列中每个点的颜色数据和深度数据，从而提供结构表面的三维颜色虚拟模型。 还提供了用于确定结构的表面拓扑和关联颜色的相应方法。

公开(公告)号：US09164032B2

公开(公告)日：2015-10-20

申请号：US14108986

申请日：2013-12-17

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01N21/35 ,  G01N21/359 ,  A61B5/1455 ,  G01J3/453 ,  A61B5/00 ,  H01S3/30 ,  G01J3/14 ,  G01J3/18 ,  G01J3/28

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A system and method for using near-infrared or short-wave infrared (SWIR) light sources for identification of counterfeit drugs may perform spectroscopy using a super-continuum laser to provide detection in a non-contact and non-destructive manner at stand-off or remote distances with minimal sample preparation. Also, near-infrared or SWIR light may penetrate through plastic containers and packaging, permitting on-line inspection and rapid scanning. The near-infrared or SWIR spectroscopy may also be used to detect illicit drugs and their chemical composition. Moreover, the spectroscopic techniques may also be applied to quality assessment and control in pharmaceutical manufacturing, thus permitting the implementation of smart manufacturing with feedback control. Fiber super-continuum lasers may emit light in the near-infrared or SWIR between approximately 1.4-1.8 microns, 2-2.5 microns, 1.4-2.4 microns, 1-1.8 microns. In particular embodiments, the detection system may be a dispersive spectrometer, a Fourier transform infrared spectrometer, or a hyper-spectral imaging detector or camera.

Abstract translation: 使用近红外或短波红外（SWIR）光源识别假冒药物的系统和方法可以使用超连续激光器进行光谱，以在非接触和非破坏性方式提供检测 或距离最小的样品制备。 此外，近红外或SWIR光可以穿透塑料容器和包装，允许在线检查和快速扫描。 近红外或SWIR光谱也可用于检测非法药物及其化学成分。 此外，光谱技术还可以应用于药物制造中的质量评估和控制，从而允许通过反馈控制实现智能制造。 光纤超连续激光器可以在大约1.4-1.8微米，2-2.5微米，1.4-2.4微米，1-1.8微米之间的近红外或者SWIR发光。 在具体实施例中，检测系统可以是色散光谱仪，傅里叶变换红外光谱仪或超光谱成像检测器或照相机。

公开(公告)号：US09105217B2

公开(公告)日：2015-08-11

申请号：US14072722

申请日：2013-11-05

Applicant: Gary Demos

Inventor： Gary Demos

IPC: G09G5/02 ,  G01J3/02 ,  G01J3/28 ,  G01J3/46 ,  G01J3/50 ,  H04N9/67

CPC classification number: G09G5/02 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/2823 ,  G01J3/46 ,  G01J3/462 ,  G01J3/465 ,  G01J3/50 ,  G06F3/013 ,  G06T5/007 ,  G06T7/90 ,  G09G2340/0407 ,  G09G2340/06 ,  H04N9/67

Abstract: A method and system for accurate and precise representation of color for still and moving images, particularly sequences of digitized color images. Spectral and/or extended dynamic range information is retained as images are captured, processed, and presented during color adjustment. Using this extra spectral information, various methodologies for further presenting or processing the color within these images can be optimized. Presentation-device independence is achieved not by attempting to discover a device-independent intermediate representation, but rather by deferring the binding and mapping of color representation onto a presentation device until its actual use.

公开(公告)号：US09104030B2

公开(公告)日：2015-08-11

申请号：US14297082

申请日：2014-06-05

Applicant: President and Fellows of Harvard College ,  The Arizona Board of Regents on Behalf of the University of Arizona

Inventor： Khanh Kieu ,  Nasser Peyghambarian ,  Xiaoling Sunney Xie ,  Christian W. Freudiger ,  Dan Fu

IPC: G02B21/16 ,  G01J3/44 ,  G02F1/37 ,  H01S3/10 ,  H01S3/23 ,  G02F1/35 ,  H01S3/067 ,  H01S3/11 ,  H01S3/16 ,  H01S3/00

CPC classification number: G02B21/16 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/44 ,  G01N2021/653 ,  G01N2021/655 ,  G02B21/002 ,  G02B21/008 ,  G02B2207/114 ,  G02F1/353 ,  G02F1/37 ,  G02F2001/354 ,  H01S3/0057 ,  H01S3/0092 ,  H01S3/06754 ,  H01S3/06791 ,  H01S3/10023 ,  H01S3/1118 ,  H01S3/1608 ,  H01S3/1618 ,  H01S3/2391

Abstract: An illumination system is disclosed for providing dual-excitation wavelength illumination for non-linear optical microscopy and micro-spectroscopy. The illumination system includes a laser system, an optical splitting means, a frequency shifting system, and a picosecond amplifier system. The laser system includes a laser for providing a first train of pulses at a center optical frequency ω1. The optical splitting means divides the first train of pulses at the center optical frequency ω1 into two trains of pulses. The frequency shifting system shifts the optical frequency of one of the two trains of pulses to provide a frequency shifted train of pulses. The picosecond amplifier system amplifies the frequency shifted train of pulses to provide an amplified frequency-shifted train of pulses having a pulse duration of at least 0.5 picoseconds.

Abstract translation: 公开了用于为非线性光学显微镜和微光谱提供双激发波长照明的照明系统。 照明系统包括激光系统，光分离装置，变频系统和皮秒放大器系统。 激光系统包括用于以中心光频率ω1提供第一脉冲串的激光器。 光分路装置将中心光频率ω1处的第一脉冲串划分成两列脉冲。 频移系统移动两列脉冲之一的光频，以提供频移的脉冲串。 皮秒放大器系统放大脉冲串的频移列，以提供具有至少0.5皮秒的脉冲持续时间的经脉冲放大的频移列。

公开(公告)号：US20150212004A1

公开(公告)日：2015-07-30

申请号：US14605400

申请日：2015-01-26

Applicant: Seiko Epson Corporation

Inventor： Tetsuo MANO

IPC: G01N21/65 ,  G01N21/03 ,  G01J3/44

CPC classification number: G01N21/658 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/26 ,  G01J3/32 ,  G01J3/4412 ,  G01N21/05

Abstract: An electric field enhancement element includes a metal fine structure layer configured including a metal fine structure smaller in size than a wavelength of incident light, a mirror layer adapted to reflect light having passed through the metal fine structure layer, a magnetooptic material layer disposed between the metal fine structure layer and the mirror layer, and adapted to cause at least one of a Faraday effect and a Cotton-Mouton effect, and a magnetic field generation device adapted to apply a magnetic field to the magnetooptic material layer.

Abstract translation: 电场增强元件包括金属精细结构层，其被配置为包括尺寸小于入射光的波长的金属微细结构，适于反射穿过金属精细结构层的光的镜面层，设置在该金属细结构层之间的磁光材料层 金属精细结构层和镜层，并且适于引起法拉第效应和棉花 - 木质素效应中的至少一种效应，以及适于向磁光材料层施加磁场的磁场产生装置。

公开(公告)号：US20150208983A9

公开(公告)日：2015-07-30

申请号：US13145927

申请日：2010-01-23

Applicant: Trent Ridder ,  Ben Ver Steeg ,  Mike Mills ,  Bentley Laaksonen

Inventor： Trent Ridder ,  Ben Ver Steeg ,  Mike Mills ,  Bentley Laaksonen

IPC: A61B5/1455 ,  A61B5/145

CPC classification number: A61B5/4845 ,  A61B5/0075 ,  A61B5/0088 ,  A61B5/117 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6826 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0291 ,  G01J3/14 ,  G01J2003/1286 ,  G01N21/274 ,  G01N21/359 ,  G01N21/474 ,  G01N2201/129

Abstract: An apparatus and method for non-invasive determination of attributes of human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal- to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems include an illumination/modulation subsystem, a tissue sampling subsystem, a calibration maintenance subsystem, an FTIR spectrometer subsystem, a data acquisition subsystem, and a computing subsystem.

Abstract translation: 一种用于通过定量红外光谱法非侵入性地确定人体组织属性的装置和方法，其临床相关的精度和准确性水平。 该系统包括针对组织谱的复杂性，高信噪比和光度精度要求进行优化的子系统，组织抽样误差，校准维护问题和校准传递问题。 子系统包括照明/调制子系统，组织采样子系统，校准维护子系统，FTIR光谱仪子系统，数据采集子系统和计算子系统。

公开(公告)号：US20150192469A1

公开(公告)日：2015-07-09

申请号：US14660543

申请日：2015-03-17

Applicant: Yoshitaka TERAOKA ,  Katsutoshi TSURUTANI ,  Yuta YAMANOI

Inventor： Yoshitaka TERAOKA ,  Katsutoshi TSURUTANI ,  Yuta YAMANOI

IPC: G01J3/50 ,  G01N21/25

CPC classification number: G01J3/50 ,  G01J3/0218 ,  G01J3/0272 ,  G01J3/08 ,  G01J3/504 ,  G01N21/251 ,  G01N21/255 ,  G01N2021/4711 ,  G01N2021/4735 ,  G01N2021/575 ,  G01N2201/0221 ,  G01N2201/061 ,  G01N2201/08

Abstract: A multi-angle colorimeter employs a multi-angle mode and a symmetrical arrangement mode in an optical arrangement. Light detection on both sides of the symmetrical arrangement is performed by a single photodetector unit. The photodetector unit is used on both sides, and thus, the device becomes simpler, without any impact on individual difference in characteristics of multiple photodetector units. Conversely, elements for illumination can be used on both sides. Also in a case where multiple photodetector units are used, the size and cost of the device can be reduced with the use of a photodetector unit having a relatively low wavelength resolution as a photodetector unit to be used on one side. This enables to reduce an attitude error due to relative tilting of a measurement surface while reducing the size and cost of the device.

Abstract translation: 多角度比色计在光学装置中采用多角度模式和对称排列模式。 对称布置的两侧的光检测由单个光电检测器单元执行。 光检测器单元用于两侧，因此，器件变得更简单，而不会对多个光电检测器单元的特性的个体差异产生任何影响。 相反，用于照明的元件可以在两侧使用。 此外，在使用多个光检测器单元的情况下，可以通过使用具有相对低的波长分辨率的光电检测器单元作为一侧使用的光电检测器单元来减小器件的尺寸和成本。 这能够减少由于测量表面的相对倾斜导致的姿态误差，同时减小了装置的尺寸和成本。