公开(公告)号：US20180045651A1

公开(公告)日：2018-02-15

申请号：US15298561

申请日：2016-10-20

Applicant: China Jiliang University

Inventor： Huaizhou Jin ,  Kaiyuan Liu ,  Shangzhong Jin ,  Lingling Chen ,  Wenhuai Li ,  Kun Yuan

IPC: G01N21/87 ,  G01J3/26 ,  G01N21/65 ,  G01J3/44

CPC classification number: G01N21/87 ,  G01J3/0208 ,  G01J3/26 ,  G01J3/44 ,  G01N21/65 ,  G01N2201/06113

Abstract: A Raman spectrometer includes a laser, a lens, a dichroscope, a confocal microscope, an optical system, a Fabri-Perot tunable filter and a silicon detector. The light emitted by the laser impinges on the dichroscope after passing through the lens. The dichroscope reflects the light, and the reflected light impinges on a sample through the confocal microscope. The light generates a Rayleigh scattering and a Raman scattering upon reaching the sample, scattered light generating the Rayleigh scattering and the scattered light generating the Raman scattering impinge on the dichroscope again after passing through the confocal microscope. The Raman scattered light transmitted by the dichroscope passes through the optical system and the Fabri-Perot tunable filter successively, and the light passing through the Fabri-Perot tunable filter is detected by the silicon detector to obtain a light signal. The Raman spectrometer has the advantages of small volume and low cost.

公开(公告)号：US20180045644A1

公开(公告)日：2018-02-15

申请号：US15557507

申请日：2016-03-07

Applicant: Plasmonix, Inc.

Inventor： Jesse Baumgold

IPC: G01N21/64 ,  G01N33/553 ,  G02B21/34 ,  G01N33/543

CPC classification number: G01N21/648 ,  B82Y20/00 ,  G01N21/553 ,  G01N21/554 ,  G01N21/6428 ,  G01N21/7703 ,  G01N33/54373 ,  G01N33/553 ,  G01N2021/6439 ,  G01N2201/06113 ,  G02B21/34

Abstract: The invention describes generating and use of a multi-layer plasmonic slide, wherein the plasmonic slide comprises at least 6 layers of metallic nanoparticles that can enhance the detection of fluorescent signals and wherein the plasmonic slide can be printed as a microarray of any size. The microarray containing the plasmonic slide can further be printed with a protein, a glycan, or an antibody. The multi-layer plasmonic slide is capable of detecting proteins, polynucleotides, and/or glycans at orders of magnitude lower concentration than non-plasmonic substrates.

公开(公告)号：US20180045561A1

公开(公告)日：2018-02-15

申请号：US15235401

申请日：2016-08-12

Applicant: ABB, Inc.

Inventor： John Brian Leen ,  Nathan E. Bramall

IPC: G01J3/02 ,  G01N21/3504 ,  G01J3/42

CPC classification number: G01J3/021 ,  G01J3/0208 ,  G01J3/0243 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/39 ,  G01N2021/391 ,  G01N2021/399 ,  G01N2201/06113

Abstract: A cavity-enhanced absorption spectroscopy instrument has an optical cavity with two or more cavity mirrors, one mirror of which having a hole or other aperture for injecting a light beam, and the same or another mirror of which being partially transmissive to allow exit of light to a detector. A spherical-spherical configuration with at least one astigmatic mirror or a spherical-cylindrical configuration where the spherical mirror could also be astigmatic prevents a reentrant condition wherein the injected beam would prematurely exit the cavity through the aperture. This combination substantially increases the number of passes of the injected beam through a sample volume for sensitive detection of chemical species even in less than ideal conditions including low power laser or LED sources, poor mirror reflectivity or detector noise at the wavelengths of interest, or cavity alignment issues such as vibration or temperature and pressure changes.

公开(公告)号：US09885698B2

公开(公告)日：2018-02-06

申请号：US15212549

申请日：2016-07-18

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  G01N33/15 ,  A61B5/1455 ,  A61B5/00 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/359 ,  G01J3/14 ,  A61B5/145 ,  G01N33/49 ,  G01N21/3563 ,  G01N21/39 ,  G01N33/02 ,  G01N33/44 ,  G01N21/88 ,  G01J3/42 ,  G01J3/02 ,  H01S3/30 ,  G01J3/18 ,  G01M3/38 ,  G01J3/12 ,  G01N21/35 ,  G01N21/85 ,  G01N21/95 ,  H01S3/067 ,  H01S3/00

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A wearable device for use with a smart phone or tablet includes a measurement device having a light source with a plurality of light emitting diodes (LEDs) for measuring physiological parameters and configured to generate an optical beam with wavelengths including a near-infrared wavelength between 700 and 2500 nanometers. The measurement device includes lenses configured to deliver the optical beam to a sample of skin or tissue, which reflects the optical beam to a receiver located a first distance from one of the LEDs and a different distance from another of the LEDs, and is also configured to generate an output signal representing a non-invasive measurement on blood contained within the sample. The wearable device is configured to communicate with the smart phone or tablet, which receives, processes, stores and displays the output signal with the processed output signal configured to be transmitted over a wireless transmission link.

公开(公告)号：US20180031472A1

公开(公告)日：2018-02-01

申请号：US15549507

申请日：2016-02-10

Applicant: University Court of the University of St Andrews

Inventor： Robert J H HAMMOND ,  Mario E GIARDINI ,  Stephen H GILLESPIE

IPC: G01N21/47 ,  G01N21/53 ,  C12Q1/02 ,  C12Q1/18 ,  C12Q1/06 ,  G01N21/51 ,  G01N15/06

CPC classification number: G01N21/474 ,  C12Q1/00 ,  C12Q1/02 ,  C12Q1/06 ,  C12Q1/18 ,  G01J3/0254 ,  G01J3/433 ,  G01J2003/4334 ,  G01N15/06 ,  G01N21/031 ,  G01N21/11 ,  G01N21/51 ,  G01N21/53 ,  G01N2015/0065 ,  G01N2015/0693 ,  G01N2021/6469 ,  G01N2021/6482 ,  G01N2201/06113 ,  G01N2201/0642 ,  G01N2201/065

Abstract: A system for measuring a sample comprising: an integrating sphere light collector (12) for collecting light and containing the sample; a light source (24) for introducing light in the integrating sphere light collector (12), wherein the light source (24) is operable to output light with a known modulation, preferably by using a signal generator (26); a detector (22) for detecting scattered light in the integrating sphere light collector (12) and generating a signal indicative of the scattered light, and a lock-in amplifier (28) operable use the known light modulation and the signal generated by the detector (22) to provide an output for analysis.

公开(公告)号：US09874522B2

公开(公告)日：2018-01-23

申请号：US15128111

申请日：2015-03-23

Applicant: OPTIQGAIN LTD.

Inventor： Ram Alon ,  Dan Leigh ,  Nitzan Eliyahu ,  Yaron Lapidot

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/10

CPC classification number: G01N21/65 ,  G01J3/10 ,  G01J3/44 ,  G01J3/4412 ,  G01J2003/102 ,  G01N21/274 ,  G01N2021/655 ,  G01N2201/06113

Abstract: A small size, robust stimulated Raman scattering (SRS) spectrophotometer system for industrial, medical and field use, exhibiting high SNR, high resolution and very short acquisition times. The architecture of the system allowing for such features comprises three main elements: (1). Use of a narrow range tunable pump laser and an array of fixed wavelength lasers to produce the wavelength differences as required to generate the SRS (Raman) spectrum; (2). Application of analog signal processing, prior to the digital conversion, in order to obtain higher resolution and SNR; (3). Use of relatively inaccurate or unstable laser sources coupled to calibration samples, followed by various calibration methods to compensate for system instabilities, such as wavelength drift, laser inaccuracies, and variations in the optical components/elements of the system.

公开(公告)号：US09869637B2

公开(公告)日：2018-01-16

申请号：US14733433

申请日：2015-06-08

Applicant: Raytheon Company

Inventor： Eric J. Griffin ,  Kalin Spariosu ,  Erik D. Johnson

IPC: G01N21/63 ,  G01N33/00 ,  G01N21/25 ,  G01J3/02 ,  B66C1/10 ,  B66C13/18 ,  B66C19/00 ,  G01J3/443 ,  G01N1/22 ,  G01V5/00 ,  G01N21/64 ,  G01N21/71 ,  G06Q10/08 ,  G01N15/14 ,  B64F1/32 ,  B64F1/36 ,  G01N1/24 ,  G01N15/00

CPC classification number: G01N21/63 ,  B64F1/32 ,  B64F1/368 ,  B66C1/101 ,  B66C13/18 ,  B66C19/002 ,  G01J3/0291 ,  G01J3/443 ,  G01N1/2226 ,  G01N1/24 ,  G01N15/1459 ,  G01N21/25 ,  G01N21/6404 ,  G01N21/718 ,  G01N33/004 ,  G01N33/0057 ,  G01N2015/0046 ,  G01N2021/6406 ,  G01N2201/06113 ,  G01V5/0091 ,  G06Q10/083

Abstract: A detector apparatus is provided and includes a collector having access to a sample of a gaseous fluid and a tester coupled to and disposed remotely from the collector. The tester includes a test chamber into which a sample is directed from the collector, an excitation element to excite the sample in the test chamber and a spectrum analyzing device coupled to the test chamber to analyze the excited sample for evidence of a concentration of particles of interest in the gaseous fluid exceeding a threshold concentration. The threshold concentration is defined in accordance with a type of the particles of interest and a residence time of the sample.

公开(公告)号：US09869634B2

公开(公告)日：2018-01-16

申请号：US14837052

申请日：2015-08-27

Applicant: General Electric Company

Inventor： Samhitha Palanganda Poonacha ,  Sandip Maity ,  Nagapriya Kavoori Sethumadhavan

IPC: G01N21/25 ,  G01N21/39 ,  G01J3/433 ,  G01N21/3504 ,  G01N21/03 ,  G01N21/31

CPC classification number: G01N21/39 ,  G01J3/4338 ,  G01N21/031 ,  G01N21/314 ,  G01N21/3504 ,  G01N2021/399 ,  G01N2201/06113

Abstract: A method implemented on a processor includes emitting a light beam from a light source to a component in an absorption cell, wherein the light beam comprises a plurality of wavelength beams. The method further includes generating a plurality of response signals due to the presence of the component, corresponding to the plurality of wavelength beams of the light beam. The method also includes detecting the plurality of response signals by a photo detector coupled to the absorption cell. The method includes determining a concentration of the component based on the plurality of response signals.

公开(公告)号：US09869625B2

公开(公告)日：2018-01-16

申请号：US14345073

申请日：2012-09-11

Applicant: David Michael Spriggs ,  Duncan Stephenson

Inventor： David Michael Spriggs ,  Duncan Stephenson

IPC: G01N15/02 ,  G01N21/47 ,  G01N21/49

CPC classification number: G01N15/0205 ,  G01N15/0211 ,  G01N21/47 ,  G01N21/49 ,  G01N2201/06113 ,  G01N2201/062

Abstract: Apparatus (100) for measuring particle size distribution by light scattering comprises a blue LED (102) and a 633 nm helium neon laser (104). Light output from the LED and laser is separately passed or reflected by a dichroic element (116) onto a common path through a sample cell (122) containing a sample, the particle size distribution of which is to be measured. Light scattered from the sample cell is detected by one or more detectors (112B-H). Light transmitted by the sample cell is detected by detectors 112A, 112J. Output signals from one or more of the detectors are passed to a computation unit (114) which calculates particle size distribution. A small percentage of light from the blue LED is reflected by the dichroic element to a detector (110). Similarly, a small percentage of light from the laser is passed by the dichroic element to the detector. Output signals from the detector are fed back to control units (106, 108) to stabilize the output power of the LED and laser.

公开(公告)号：US09857345B2

公开(公告)日：2018-01-02

申请号：US14554902

申请日：2014-11-26

Applicant: VALMET POWER OY

Inventor： Juha Toivonen ,  Antti Aalto ,  Matti Sarén ,  Juha Roppo

IPC: G01N25/00 ,  G01K11/00 ,  G01N33/00 ,  G01L11/02 ,  G01S17/88 ,  G01N21/51 ,  F28F27/00 ,  G01N21/39 ,  G01N21/49 ,  F23N5/02 ,  F23N5/08 ,  G01N21/17

CPC classification number: G01N33/0036 ,  F23N5/022 ,  F23N5/082 ,  F23N2025/04 ,  F23N2025/08 ,  F28F27/00 ,  G01K11/00 ,  G01L11/02 ,  G01N21/39 ,  G01N21/49 ,  G01N21/51 ,  G01N2021/1734 ,  G01N2201/06113 ,  G01N2201/0697 ,  G01S17/88

Abstract: A method for measuring, from a thermal device, temperature, molecular number density, and/or pressure of a gaseous compound as function of distance, the gaseous compound absorbing at least some light. The method comprises generating, for a first wavelength band and a second wavelength band, a pulse sequence comprising a light pulse or light pulses, guiding the pulse sequence into the thermal device, and measuring, as function of time, the intensity of the scattered light at the first wavelength band and at the second wavelength band. The method further comprises determining information indicative of the differential absorption between the two wavelengths bands using measured intensities and determining the temperature, the molecular number density, and/or the pressure of the gaseous compound using the information indicative of the differential absorption between the two wavelengths bands. A thermal system arranged to carry out the method.