公开(公告)号：US08064053B2

公开(公告)日：2011-11-22

申请号：US12318373

申请日：2008-12-29

Applicant: Jae Yong Lee ,  Eun Seong Lee ,  Dae Won Moon

Inventor： Jae Yong Lee ,  Eun Seong Lee ,  Dae Won Moon

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/0227 ,  G01J3/0237 ,  G01J3/4412

Abstract: The present invention relates to a 3-color multiplex CARS spectrometer. In the 3-color multiplex CARS spectrometer, Raman resonance is achieved for multiple molecular vibrations of a sample by the combination of a short-wavelength pump beam generated by a broadband laser light source and a long-wavelength Stokes beam generated by a stable laser light source, and another short-wavelength laser beam having a narrow linewidth is then introduced separately to serve as a probe beam that interacts with the laser-driven sample, thereby generating CARS spectral signals whose wavelength components can be resolved. Accordingly, the 3-color multiplex CARS spectrometer solves problem of the conventional 2-color multiplex CARS spectroscopy in which the wavelength decomposition of CARS signals, necessary for high spectral resolution, is not possible with broadband pump light causing the CARS spectrum distortion.

Abstract translation: 本发明涉及一种三色多重CARS光谱仪。 在三色多重CARS光谱仪中，通过将由宽带激光光源产生的短波长泵浦光束与由稳定的激光产生的长波长斯托克斯光束组合，实现了样品的多分子振动的拉曼共振 源和另一个具有窄线宽的短波长激光束然后被单独引入以用作与激光驱动样本相互作用的探测光束，从而产生其波长分量可以被解析的CARS光谱信号。 因此，三色多路CARS光谱仪解决了传统的双色多重CARS光谱的问题，其中对于高分辨率分辨率需要的CARS信号的波长分解在宽带泵浦光引起CARS频谱失真是不可能的。

公开(公告)号：US08022370B2

公开(公告)日：2011-09-20

申请号：US12798298

申请日：2010-03-31

Applicant: Roderick A. Hyde ,  Muriel Y Ishikawa ,  Edward K. Y. Jung ,  Nathan P. Myhrvold ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr.

Inventor： Roderick A. Hyde ,  Muriel Y Ishikawa ,  Edward K. Y. Jung ,  Nathan P. Myhrvold ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr.

IPC: G01T1/00

CPC classification number: G01J1/4228 ,  G01J1/0448 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0256 ,  G01J3/2803 ,  G01J3/36 ,  G01J9/00

Abstract: A waveform detector may include multiple stages.

Abstract translation: 波形检测器可以包括多个级。

公开(公告)号：US07864379B2

公开(公告)日：2011-01-04

申请号：US11644564

申请日：2006-12-23

Applicant: Artur G. Olszak ,  Chen Liang

Inventor： Artur G. Olszak ,  Chen Liang

IPC: G02B6/04 ,  H04N1/04

CPC classification number: G01J3/2803 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0235 ,  G01J3/0237 ,  G01J3/10 ,  G01J3/2823 ,  G01N21/253 ,  G01N21/31 ,  G02B21/367

Abstract: An array microscope scans a slide in rapid sequence at different wavelengths to record multiple spectral images of the sample. Full spatial resolution of the image sensor is realized at each color because pixels are not shared between spectral bands. The object and detector are placed at conjugate distances selected to produce substantially equal magnification with minimum chromatic aberration at all wavelengths to ensure registration of all images. Spectral analysis is carried out by combining the images captured at each wavelength. The greater-than-RGB spectral resolution provided by the combination of images enables the isolation and display of the effects produced by the contemporaneous use of more than two stains on a tissue for improved pathological analysis.

Abstract translation: 阵列显微镜以不同波长的快速序列扫描载玻片以记录样品的多个光谱图像。 由于像素不在光谱带之间共享，因此在每种颜色下实现图像传感器的全空间分辨率。 物体和检测器被放置在所选择的共轭距离处以在所有波长处产生具有最小色差的基本相等的倍率，以确保所有图像的配准。 通过组合在每个波长处拍摄的图像进行光谱分析。 由图像组合提供的大于RGB的光谱分辨率使得能够隔离和显示由组织上同时使用两种以上污渍产生的效果，以改善病理分析。

公开(公告)号：US20100278543A1

公开(公告)日：2010-11-04

申请号：US12769247

申请日：2010-04-28

Applicant: Tokuji Takizawa ,  Kazumi Kimura ,  Nobuyuki Tochigi ,  Masayasu Teramura

Inventor： Tokuji Takizawa ,  Kazumi Kimura ,  Nobuyuki Tochigi ,  Masayasu Teramura

IPC: G03G15/00 ,  G01J3/28

CPC classification number: G01N21/251 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0216 ,  G01J3/0237 ,  G01J3/024 ,  G01J3/0291 ,  G01J3/20 ,  G01J3/2803 ,  G01J3/50 ,  G03G15/0131 ,  G03G15/0194 ,  G03G15/50 ,  G03G2215/0132 ,  G03G2215/0164

Abstract: A spectral colorimetric apparatus for detecting a color of an image of a subject, including: an illumination optical system illuminating the subject on a detection surface; a spectral optical system including a spectral element spectrally separating the beam diffused by the subject and a light receiving element array detecting a spectral intensity distribution; and a guiding optical system for guiding a beam diffused by the subject, wherein: the detection surface is parallel to a spectral plane including a principal ray of a beam entering the spectral optical system and a principal ray of a beam spectrally separated; the principal ray of the beam enters the spectral optical system within the spectral plane obliquely to a line joining a center of the light receiving element array with a surface vertex of the spectral element; and a light receiving surface of the light receiving element array is orthogonal to the spectral plane.

Abstract translation: 一种用于检测被摄体的图像的颜色的光谱比色装置，包括：照射光学系统，在检测面上照射被摄体; 光谱光学系统，包括频谱分离由对象漫射的光束的光谱元件和检测光谱强度分布的光接收元件阵列; 以及引导光学系统，用于引导被对象漫射的光束，其中：所述检测表面平行于包括进入所述光谱系统的光束的主光线和光谱分离的光束的主光束的光谱平面; 光束的主射线进入光谱平面内的光谱系统，倾斜于连接光接收元件阵列的中心与光谱元件的表面顶点的线; 并且光接收元件阵列的光接收表面与光谱平面正交。

公开(公告)号：US07804593B2

公开(公告)日：2010-09-28

申请号：US11629143

申请日：2005-06-02

Applicant: Helmut Becker-Roβ ,  Stefan Florek ,  Günter Wesemann ,  Michael Okruss

Inventor： Helmut Becker-Roβ ,  Stefan Florek ,  Günter Wesemann ,  Michael Okruss

IPC: G01J3/28

CPC classification number: G01J3/1809 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/0237 ,  G01J3/0286 ,  G01J3/0294 ,  G01J3/08 ,  G01J3/12 ,  G01J3/2803

Abstract: The invention relates to a spectrometer arrangement (10) comprising a spectrometer (14) for producing a spectrum of a first wavelength range of radiation from a radiation source on a detector (42). Said arrangement also comprises: an Echelle grating (36) for the spectral decomposition of the radiation penetrating the spectrometer arrangement (10) in a main dispersion direction (46); a dispersing element (34) for separating the degrees by means of spectral decomposition of the radiation in a transversal dispersion direction (48) which forms an angle with the main dispersion direction of the Echelle grating (36), in such a way that a two-dimensional spectrum (50) can be produced with a plurality of separated degrees (52); an imaging optical element (24, 38) for imaging the radiation penetrating through an inlet gap (20) into the spectrometer arrangement (10), in an image plane (40); and a surface detector (42) comprising a two dimensional arrangement of a plurality of detector elements in the image plane (40). The inventive arrangement is characterized in that another spectrometer (12) comprising at least one other dispersing element (64) and another imaging optical element (60,66) is provided in order to produce a spectrum (68) of a second wavelength range of radiation, which is different from the first wavelength range, from a radiation source on the same detector (42). The spectra can be spatially or temporally separated on the detector.

Abstract translation: 本发明涉及一种分光计装置（10），其包括用于产生来自检测器（42）上的辐射源的第一波长范围的光谱仪（14）。 所述布置还包括：用于在主色散方向（46）上穿透光谱仪装置（10）的辐射的光谱分解的梯形光栅（36）; 分散元件（34），用于通过在与梯形光栅（36）的主色散方向形成角度的横向色散方向（48）上的辐射的光谱分解来分离度数，使得两个 可以用多个分离的度数（52）产生维度谱（50）; 用于在图像平面（40）中将穿过入口间隙（20）的辐射成像到成像光学装置（10）中的成像光学元件（24,38）; 以及包括所述图像平面（40）中的多个检测器元件的二维排列的表面检测器（42）。 本发明的装置的特征在于，提供包括至少一个其它分散元件（64）和另一成像光学元件（60,66）的另一个光谱仪（12），以产生第二波长范围的辐射（68） ，其与第一波长范围不同，来自相同检测器（42）上的辐射源。 光谱可以在检测器上进行空间或时间分离。

公开(公告)号：US07731090B2

公开(公告)日：2010-06-08

申请号：US10591849

申请日：2005-03-04

Applicant: Wilfrid Meffre

Inventor： Wilfrid Meffre

IPC: G06K7/14

CPC classification number: G01J3/50 ,  G01J3/0237

Abstract: A novel control device and a method for using the device for the calorimetric quality assurance of photographic documents or any color and monochrome products printed on any type of supports. The inventive control device is embodied in the form of an improved reflective spectrophotometer which also makes it possible to read bar codes. The use of the novel control device requires the use of a novel method which enables any user of a production machine to be assigned with an unique alpha digital identifier for any arbitrary product configuration leading to an arbitrary chromatic response (reflectance spectrum or colour spectrum obtained according to a printed file values) which are considered by the competent user as desirable and retainable for certain products.

Abstract translation: 一种新颖的控制装置和用于使用该装置进行照相文件或印刷在任何类型的支持体上的任何彩色和单色产品的量热质量保证的方法。 本发明的控制装置以改进的反射分光光度计的形式实现，这也使得读取条形码成为可能。 使用新颖的控制装置需要使用一种新颖的方法，其使生产机器的任何用户能够被分配有任何任意产品配置的唯一的α数字标识符，导致任意的色彩响应（反射光谱或根据 对于打印的文件值），由主管用户认为对于某些产品是可取的和可保留的。

公开(公告)号：US07688445B2

公开(公告)日：2010-03-30

申请号：US11760337

申请日：2007-06-08

Applicant: Yoichiro Handa ,  Norihiko Utsunomiya

Inventor： Yoichiro Handa ,  Norihiko Utsunomiya

IPC: G01J3/30

CPC classification number: G01J3/20 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/04 ,  G01J3/18

Abstract: A spectroscope of the present invention includes a concave diffraction grating which disperses incident light, an incident light introduction unit which introduces incident light into the concave diffraction grating, and an outgoing light receiving unit which receives outgoing light dispersed for different wavelengths by the concave diffraction grating. The spectroscope further includes an incident aperture which limits an incident angle of light emitted by the incident light introduction unit to the concave diffraction grating, and an outgoing aperture which limits an outgoing angle of outgoing light dispersed for different wavelengths by the concave diffraction grating to the light receiving unit. The spectroscope is constructed so that relatively rotational transfer of at least two out of the concave diffraction grating, the incident aperture and the outgoing apertures can be performed along a Rowland circle which the concave diffraction grating forms.

Abstract translation: 本发明的分光镜包括散射入射光的凹面衍射光栅，将入射光引入到凹面衍射光栅中的入射光导入单元和通过凹面衍射光栅接收不同波长散射的出射光的出射光接收单元 。 分光器还包括将入射光引入单元发射的光的入射角限制到凹面衍射光栅的入射孔径，以及通过凹面衍射光栅将散射的不同波长的出射光的出射角限制在外部的出射孔， 光接收单元。 分光镜被构造成使得可以沿凹面衍射光栅形成的Rowland圆进行至少两个凹入衍射光栅，入射孔和出射孔的相对旋转传递。

公开(公告)号：US20100068740A1

公开(公告)日：2010-03-18

申请号：US12513416

申请日：2007-11-05

Applicant: David L. Kaplan ,  Fiorenzo Omenetto ,  Brian Lawrence ,  Mark Cronin-Golomb ,  Irene Georgakoudi ,  Hannah Perry

Inventor： David L. Kaplan ,  Fiorenzo Omenetto ,  Brian Lawrence ,  Mark Cronin-Golomb ,  Irene Georgakoudi ,  Hannah Perry

IPC: C12M1/34 ,  B29C39/02 ,  C12Q1/02 ,  C12Q1/28 ,  C12Q1/54 ,  C12Q1/34

CPC classification number: B29D11/0074 ,  B01L3/502707 ,  B01L2300/0816 ,  B01L2300/12 ,  B01L2300/163 ,  B29C39/02 ,  B81B2201/058 ,  B81B2201/06 ,  B81C1/00071 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0256 ,  G01J3/06 ,  G01J3/10 ,  G01J3/1804 ,  G01J3/42 ,  G01N33/54386 ,  G01N2021/0346

Abstract: A method of manufacturing a microfluidic device having at least one cylindrical microchannel includes providing a substrate, casting an uncured polymer matrix solution onto the substrate, embedding an elongated rod in the uncured polymer matrix solution, curing the polymer matrix solution to form a solidified body, and extracting the elongated rod to form the cylindrical microchannel in the solidified body. In another embodiment, the method includes forming an optical feature on a surface of the microfluidic device. A microfluidic device is also provided, the device including a polymer body, and at least one cylindrical microchannel in the polymer body, the cylindrical microchannel having a diameter between approximately 40 ?m and 250 ?m, inclusive. An additional microfluidic device is provided that functions as an optofluidic spectrometer. The optofluidic spectrometer includes a polymer body, a diffraction grating integrated within the polymer body, and a cylindrical microchannel behind the diffraction grating on the polymer body.

Abstract translation: 制造具有至少一个圆柱形微通道的微流体装置的方法包括提供基底，将未固化的聚合物基质溶液浇铸到基底上，将细长棒嵌入未固化的聚合物基质溶液中，固化聚合物基质溶液以形成凝固体， 并提取细长杆以在凝固体中形成圆柱形微通道。 在另一个实施例中，该方法包括在微流体装置的表面上形成光学特征。 还提供了一种微流体装置，该装置包括聚合物主体和聚合物主体中的至少一个圆柱形微通道，所述圆柱形微通道的直径在约40μm至250μm之间，包括端点在内。 提供额外的微流体装置，其用作光流体光谱仪。 光流体光谱仪包括聚合物体，集成在聚合物主体内的衍射光栅，以及聚合物主体上的衍射光栅后面的圆柱形微通道。

公开(公告)号：US07679066B2

公开(公告)日：2010-03-16

申请号：US12215064

申请日：2008-06-24

Applicant: Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Nathan P. Myhrvold ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr.

Inventor： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Nathan P. Myhrvold ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr.

IPC: G01J1/42

CPC classification number: G01J1/4228 ,  G01J1/0448 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0256 ,  G01J3/2803 ,  G01J3/36 ,  G01J9/00

Abstract: A waveform detector may include multiple stages.

公开(公告)号：US20100004511A1

公开(公告)日：2010-01-07

申请号：US12524796

申请日：2008-01-29

Applicant: Yasuhiro Kamihara

Inventor： Yasuhiro Kamihara

IPC: A61B1/06 ,  G01J3/28

CPC classification number: G01J3/26 ,  A61B1/04 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0237 ,  G01J3/027 ,  G01J3/0291 ,  G02B23/2469

Abstract: Desired spectral characteristics are achieved while achieving reduced size and decreased noise, and detecting the distance between optical substrates with superior precision. Provided is a variable spectroscopy element (1) including optical coating layers (3) provided on opposing surfaces, which face each other, of first and second optical substrates (4a, 4b) that face each other with a gap therebetween; an actuator (4c) that changes the gap between the first and second optical substrates (4a, 4b); a first sensor portion (6a) provided on the first optical substrate (4a), for detecting the gap between the first and second optical substrates (4a, 4b); and a second sensor portion (6b) provided on the second optical substrate (4b) so as to oppose the first sensor portion (6a), for detecting the gap between the first and second optical substrates (4a, 4b), wherein the numbers of the first and second sensor electrodes (6a, 6b) differ.

Abstract translation: 实现所需的光谱特性，同时实现尺寸减小和噪声降低，并且以优异的精度检测光学基片之间的距离。 提供一种可变光谱元件（1），包括设置在彼此面对的第一和第二光学基板（4a，4b）的彼此面对的相对表面上的光学涂层（3），所述第一和第二光学基板彼此面对; 改变第一和第二光学基板（4a，4b）之间的间隙的致动器（4c）; 设置在第一光学基板（4a）上的第一传感器部分（6a），用于检测第一和第二光学基板（4a，4b）之间的间隙; 以及设置在所述第二光学基板（4b）上以与所述第一传感器部分（6a）相对的用于检测所述第一和第二光学基板（4a，4b）之间的间隙的第二传感器部分（6b），其中， 第一和第二传感器电极（6a，6b）不同。