公开(公告)号：US20120232404A1

公开(公告)日：2012-09-13

申请号：US13228717

申请日：2011-09-09

Applicant: Shabbir Bakir Bambot ,  Mark Faupel ,  Jonathan David Mongin

Inventor： Shabbir Bakir Bambot ,  Mark Faupel ,  Jonathan David Mongin

IPC: A61B6/00

CPC classification number: A61B5/4331 ,  A61B5/0059 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0077 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/0262 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/28 ,  G01J3/4406 ,  G01J2003/1213 ,  G01J2003/2866 ,  G01N21/274 ,  G01N21/31 ,  G01N21/474 ,  G01N21/645 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/6484 ,  G01N2201/0221

Abstract: A method and apparatus are provided that interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics and correlate same to photographic images. Further, the system and method accomplish this measurement rapidly by increasing the light throughput by integrating optics into a hand held unit and avoiding the need for a coherent fiber optic bundle being used. The method includes illuminating a first portion of a target tissue with optical energy, forming a first image of the target tissue, illuminating a second portion of the target tissue with optical energy, performing spectroscopic measurements on optical energy reflected and/or emitted by the target tissue upon illumination of the second portion of the target tissue with optical energy, and determining tissue characteristics of the target tissue based on the results of the spectroscopic measurements.

Abstract translation: 提供了一种方法和装置，用于询问，接收和分析至少一种荧光激发波长的全发射光谱，以及至少一种反射测量以确定组织特征并将其与摄影图像相关联。 此外，该系统和方法通过将光学器件集成到手持式单元中并且避免对使用的相干光纤束的需要而增加光通量而快速地完成该测量。 该方法包括用光能照射目标组织的第一部分，形成目标组织的第一图像，用光能照射目标组织的第二部分，对目标反射和/或发射的光能进行光谱测量 基于光谱测量的结果确定目标组织的第二部分的光能量的组织，以及确定靶组织的组织特征。

公开(公告)号：US08264687B2

公开(公告)日：2012-09-11

申请号：US13102551

申请日：2011-05-06

Applicant: Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

Inventor： Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

IPC: G01N21/25

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/10 ,  G01J3/14 ,  G01J3/2803 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/6417 ,  G01N2201/126

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

Abstract translation: 用于实时监测来自信号源阵列的光信号的方法和系统，特别是具有频谱不同信号分量的光信号源。 系统包括与光学列车光学通信的信号源阵列，其将激发辐射引导到来自这种阵列的信号和从这些阵列发出的信号，并将信号映射到检测器阵列上，从而可以对这些信号进行额外的处理。

公开(公告)号：US08259297B1

公开(公告)日：2012-09-04

申请号：US13074774

申请日：2011-03-29

Applicant: Richard A. Yarussi

Inventor： Richard A. Yarussi

IPC: G01J3/28

CPC classification number: G01J3/02 ,  G01J3/0278 ,  G01N21/55 ,  G01N21/8422

Abstract: An optical metrology system collects data while scanning over the focal range. The data is evaluated to determine a peak intensity value from the data. In one embodiment, only data from one side of the peak value is used. The characteristic of the sample is determined based on the peak value. In one embodiment, monochromatic light is used. In another embodiment, polychromatic light is used and peak intensity values for a plurality of wavelengths are determine and combined to form a measured spectrum for the sample, which can then be used to determine the sample properties of interest. In one embodiment, the peak intensity is determined using curve fitting.

Abstract translation: 光学测量系统在扫描焦距范围时收集数据。 评估数据以确定数据中的峰值强度值。 在一个实施例中，仅使用来自峰值一侧的数据。 根据峰值确定样品的特性。 在一个实施例中，使用单色光。 在另一个实施例中，使用多色光，并确定并组合多个波长的峰值强度值，以形成样品的测量光谱，然后可以将其用于确定感兴趣的样品特性。 在一个实施例中，使用曲线拟合来确定峰强度。

公开(公告)号：US08259296B1

公开(公告)日：2012-09-04

申请号：US12750577

申请日：2010-03-30

Applicant: Richard A. Yarussi ,  Martin Ebert

Inventor： Richard A. Yarussi ,  Martin Ebert

IPC: G01J3/28

CPC classification number: G01J3/02 ,  G01J3/0278

Abstract: An optical metrology system collects spectral data while scanning over the focal range. The spectral data is evaluated to determine a plurality of peak intensity values for wavelengths in the spectra. The peak intensities are then combined to form the measured spectrum for the sample, which can then be used to determine the sample properties of interest. In one embodiment, the peak intensity is determined based on the measured maximum intensity and a number n of intensity values around the measured maximum intensity, e.g., using curve fitting. If desired, the number n may be varied as a function of wavelength to vary the effective spot size of the metrology system while optimizing noise performance. The peak intensity may also be derived as the measured maximum intensity or through a statistical analysis.

Abstract translation: 光学测量系统在扫描焦距范围时收集光谱数据。 评估光谱数据以确定光谱中波长的多个峰强度值。 然后将峰强度组合以形成样品的测量光谱，然后可以将其用于确定感兴趣的样品性质。 在一个实施例中，基于所测量的最大强度和围绕测量的最大强度的强度值的数量n，例如使用曲线拟合来确定峰值强度。 如果需要，数量n可以随着波长的变化而变化，以改变测量系统的有效光斑尺寸，同时优化噪声性能。 峰值强度也可以作为测量的最大强度或统计分析得出。

公开(公告)号：US20120218548A1

公开(公告)日：2012-08-30

申请号：US13465911

申请日：2012-05-07

Applicant: Andrew Bodkin

Inventor： Andrew Bodkin

IPC: G01J3/28

CPC classification number: G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0235 ,  G01J3/0294 ,  G01J3/14 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/36

Abstract: Hyperspectral imaging system and methods that may be used for imaging objects in three-dimensions are disclosed. A cylindrical lens array and/or a slit array may be used to re-image and divide a field of view into multiple channels. The multiple channels are dispersed into multiple spectral signatures and observed on a two-dimensional focal plane array in real time. The entire hyperspectral data cube is collected simultaneously.

Abstract translation: 公开了可以用于三维成像对象的高光谱成像系统和方法。 可以使用柱面透镜阵列和/或狭缝阵列来将视场重新图像分割成多个通道。 将多个通道分散到多个光谱特征中，并在二维焦平面阵列上实时观察。 整个高光谱数据立方体被同时收集。

公开(公告)号：US08253936B2

公开(公告)日：2012-08-28

申请号：US12537513

申请日：2009-08-07

Applicant: Jeffrey Cohen ,  John S Maier ,  Shona Stewart

Inventor： Jeffrey Cohen ,  John S Maier ,  Shona Stewart

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/44 ,  G01N2021/656

Abstract: A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.

Abstract translation: 用于确定样品的疾病状态和临床结果的系统和方法。 照射样品以产生拉曼散射光子，评估拉曼散射光子以产生代表样品的拉曼光谱数据集，其中所述拉曼光谱数据集包括以下至少一个：样品的拉曼光谱和空间准确的 样品的波长分辨拉曼图像; 使用化学计量技术评估拉曼光谱数据集，以将样品的疾病状态分类为急性，慢性，初期或无。 在一个实施方案中，化学方法是主要成分分析。 在另一个实施方案中，在移植之前获得样品，并且分析可以确定宿主排斥的可能性。

公开(公告)号：US08247240B2

公开(公告)日：2012-08-21

申请号：US12782630

申请日：2010-05-18

Applicant: Homer Paul Pien ,  William C. Karl ,  Derek Puff ,  Peter Li ,  Brian Cunningham

Inventor： Homer Paul Pien ,  William C. Karl ,  Derek Puff ,  Peter Li ,  Brian Cunningham

IPC: G01N33/543

CPC classification number: G01N21/7743 ,  B01L3/5085 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/1804 ,  G01J3/42 ,  G01N21/253 ,  G01N21/31 ,  G01N33/54373 ,  G01N2021/3196 ,  G01N2021/7773 ,  G02B5/1809 ,  Y10S436/805

Abstract: Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs.

Abstract translation: 对生物传感器的光谱特性进行相对偏移的高分辨率测定。 生物传感器的共振峰的偏移指示与生物传感器的表面结合的材料的量。 优选的生物传感器是引导模式谐振滤波器生物传感器（GMRFB）。 在本发明的一个方面，使用曲线拟合来确定未暴露的生物传感器的光谱相对于通过存在与生物传感器的表面结合的材料而被改变（例如，偏移）的那些光谱的相对位置。 在替代实施例中，互相关函数用于检测参考光谱和从暴露的生物传感器测量的光谱之间的光谱峰值偏移。 在另一替代方案中，使用最大似然估计技术来确定频谱偏移或偏移。

公开(公告)号：US08242427B2

公开(公告)日：2012-08-14

申请号：US12190447

申请日：2008-08-12

Applicant: Dane J. Phillips ,  Michael W. Jones

Inventor： Dane J. Phillips ,  Michael W. Jones

IPC: G02B27/10 ,  G02B13/16

CPC classification number: G01J3/36 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0224 ,  G01J3/2823 ,  G01J4/04 ,  G01J2003/1213 ,  H04N5/2254 ,  H04N5/33

Abstract: A system of the present disclosure has an optical element having a plurality of contiguous lenses, a detecting device having a plurality of light-sensitive pixels, the optical element having a lens in the plurality of lenses associated with each of the plurality of light-sensitive pixels, and intermediate imaging optics for receiving light indicative of an image and focusing the light onto the plurality of contiguous lenses such that the image is divided on each of the associated light-sensitive pixels.

Abstract translation: 本公开的系统具有具有多个相邻透镜的光学元件，具有多个感光像素的检测装置，所述光学元件具有与所述多个光敏感中的每一个相关联的所述多个透镜中的透镜 像素和中间成像光学器件，用于接收指示图像的光并将光聚焦到多个相邻透镜上，使得图像在每个相关联的感光像素上被划分。

公开(公告)号：US08237929B2

公开(公告)日：2012-08-07

申请号：US13196802

申请日：2011-08-02

Applicant: Michael L. Myrick ,  Robert P. Freese ,  William Soltmann ,  David L. Perkins

Inventor： Michael L. Myrick ,  Robert P. Freese ,  William Soltmann ,  David L. Perkins

IPC: G01N21/00

CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0286 ,  G01J3/08 ,  G01J3/28 ,  G01J3/42 ,  G01J2003/1213 ,  G01N2201/1293

Abstract: The present subject matter relates to methods of high-speed analysis of product samples during production of the product. Light is directed to a portion of a product under analysis and reflected from or transmitted through the product toward optical detectors. Signals from the optical detectors are compared to determine characteristics of the product under analysis. Temperature within the monitoring system may be monitored in order to provide compensation for the signals produced by the optical detectors. The products under analysis may be stationary, moved by an inspection point by conveyor or other means, or may be contained within a container, the container including a window portion through which the product illuminating light may pass.

Abstract translation: 本主题涉及产品生产过程中产品样品的高速分析方法。 光被引导到被分析产品的一部分，从产品反射或透射到光学检测器。 将来自光学检测器的信号进行比较，以确定正在分析的产品的特性。 可以监视监视系统内的温度，以便为由光学检测器产生的信号提供补偿。 被分析的产品可以是固定的，由检查点通过输送机或其他方式移动，或者可以容纳在容器内，该容器包括产品照明光通过的窗口部分。

公开(公告)号：US08233189B2

公开(公告)日：2012-07-31

申请号：US12042088

申请日：2008-03-04

Applicant: Danny C. Rich

Inventor： Danny C. Rich

IPC: H04N1/46 ,  H04N1/50 ,  G06K9/00

CPC classification number: G01J3/46 ,  G01J3/02 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/462 ,  G01J3/463 ,  G01J3/465 ,  G05B19/042 ,  H04N1/603 ,  Y02P90/265

Abstract: The present invention provides a plurality of representations of color that are stored in an electronic color library and that can be selected by a user. After a color selection is made, a plurality of color ink formulas and/or colorant formulas capable of producing the selected color are provided. Further, other selections can be made to define a substrate or other criteria that can impact the color ink formulas. The user can make a selection among the plurality of color ink formulas and/or colorant formulas. The selected color ink formula(s) (or colorant formula(s)) can be transmitted over a communication network, such as the Internet or a local Intranet to another party, such as an ink manufacturer.

Abstract translation: 本发明提供存储在电子色谱库中并可由用户选择的多种颜色表示。 在进行颜色选择之后，提供能够产生所选颜色的多种彩色墨水配方和/或着色剂配方。 此外，可以进行其他选择以限定可影响彩色墨水配方的基底或其它标准。 用户可以在多种颜色墨水配方和/或着色剂配方中进行选择。 所选择的彩色墨水配方（或着色剂配方）可以通过诸如因特网或本地内联网的通信网络传送到诸如墨水制造商的另一方。