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公开(公告)号：US09987478B2
公开(公告)日：2018-06-05
申请号：US14600611
申请日：2015-01-20
Applicant: Cardiac Pacemakers, Inc.
Inventor： Adegbola O. Adenusi , James P. Rohl , David R. Wulfman , Joseph T. Delaney, Jr. , Adeniyi Aremu
IPC: B29C71/02 , A61M39/08 , A61M39/00 , B32B1/08 , B32B5/02 , B32B27/08 , B32B27/12 , D01D5/00 , D01D5/098 , A61L29/04 , A61L29/06 , A61L29/08 , A61L29/14 , A61L31/04 , A61L31/06 , A61L31/10 , A61L31/14 , A61N1/05
CPC classification number: A61M39/08 , A61L29/041 , A61L29/06 , A61L29/085 , A61L29/145 , A61L29/146 , A61L31/048 , A61L31/06 , A61L31/10 , A61L31/145 , A61L31/146 , A61M39/00 , A61N1/0541 , A61N1/056 , B32B1/08 , B32B5/02 , B32B5/022 , B32B27/08 , B32B27/12 , B32B2262/0238 , B32B2535/00 , D01D5/0023 , D01D5/0076 , D01D5/0084 , D01D5/0985 , Y10T428/1372 , C08L71/02 , C08L39/06 , C08L75/04 , C08L83/04
Abstract: A method for making a tubular medical device having a hybrid polymeric structure includes forming a first layer comprising a non-woven fibrous matrix made of a first polymeric material and forming a second layer comprising a second polymeric material about the first layer such that at least a portion of the second polymeric material of the second layer embeds into at least a portion of the first polymeric material of the first layer.
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公开(公告)号：US20140107753A1
公开(公告)日：2014-04-17
申请号：US14107361
申请日：2013-12-16
Applicant: Cardiac Pacemakers, Inc.
Inventor： David R. Wulfman , Douglas D. Pagoria , Joseph C. Walker
IPC: A61N1/05
CPC classification number: A61N1/0573 , A61N1/056 , A61N1/057 , A61N1/0575 , A61N1/0587 , A61N1/375 , Y10T29/49002 , Y10T29/49826 , Y10T29/4998
Abstract: An active fixation lead may have a lead body formed at least in part from an inner member and an outer sheath. The inner member may include a pace/sense lumen and one or more cable lumens. The inner member may include one or more longitudinally extending crumple zones that are configured to reduce stress within the pace/sense lumen that could otherwise be caused by compressive forces applied to the lead.
Abstract translation: 主动固定引线可以具有至少部分地由内部构件和外部护套形成的引线体。 内部构件可以包括脚步/感测腔和一个或多个电缆腔。 内部构件可以包括一个或多个纵向延伸的折叠区域，其被配置为减少脚步/感觉腔内的应力，否则可能由施加到引线的压缩力引起。
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公开(公告)号：US20220211919A1
公开(公告)日：2022-07-07
申请号：US17701421
申请日：2022-03-22
Applicant: Cardiac Pacemakers, Inc.
Inventor： David R. Wulfman , Danielle Frankson , Adeniyi O. Aremu , Angelo Fruci , Gregory J. Sherwood , Mary M. Byron , Joseph T. Delaney, JR. , Adam McGraw
Abstract: An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.
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公开(公告)号：US11324860B2
公开(公告)日：2022-05-10
申请号：US15672674
申请日：2017-08-09
Applicant: Cardiac Pacemakers, Inc.
Inventor： David R. Wulfman , Danielle Frankson , Adeniyi O. Aremu , Angelo Fruci , Gregory J. Sherwood , Mary M. Byron , Joseph T. Delaney, Jr. , Adam McGraw
Abstract: An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.
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15.发明授权公开(公告)号：US11155933B2
公开(公告)日：2021-10-26
申请号：US16233544
申请日：2018-12-27
Applicant: Cardiac Pacemakers, Inc.
Inventor： Joseph T. Delaney, Jr. , Jeannette C. Polkinghorne , Adegbola O. Adenusi , David R. Wulfman , Kasyap Seethamraju
Abstract: A medical electrical lead includes an insulative lead body extending from a distal region to a proximal region and a conductor disposed within the insulative lead body and extending from the proximal region to the distal region. An electrode is disposed on the insulative lead body and is in electrical contact with the conductor. The medical electrical lead also includes a cross-linked hydrophilic polymer coating disposed over at least a portion of the electrode. The cross-linked hydrophilic polymer coating includes a fibrous matrix comprising a plurality of discrete fibers and pores formed between at least a portion of the fibers and a hydrophilic polyethylene glycol-containing hydrogel network disposed within the pores of the fibrous matrix.
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Patent Agency Ranking
公开(公告)号：US10335513B2
公开(公告)日：2019-07-02
申请号：US15624102
申请日：2017-06-15
Applicant: Cardiac Pacemakers, Inc.
Inventor： Danielle Frankson , Joseph T. Delaney, Jr. , Mary M. Byron , Adam McGraw , David R. Wulfman , Kylee M. Lersch
Abstract: A coating for a roughened metal surface of an implantable medical device includes a poly(ethylene glycol) disposed on at least a portion of the roughened metal surface, wherein the poly(ethylene glycol) is covalently bonded directly to the roughened metal surface.
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公开(公告)号：US09855415B2
公开(公告)日：2018-01-02
申请号：US15217178
申请日：2016-07-22
Applicant: Cardiac Pacemakers, Inc.
Inventor： Joseph T. Delaney, Jr. , David R. Wulfman , Adeniyi O. Aremu , Adegbola O. Adenusi
Abstract: A medical electrical lead includes an insulative lead body extending from a distal region to a proximal region, a conductor disposed within the insulative lead body and extending from the proximal region to the distal region, an electrode disposed on the insulative lead body and in electrical contact with the conductor, and a fibrous matrix disposed on at least part of the electrode. The fibrous matrix includes fibers. The fibers include a polyvinylidene fluoride-based (PVDF-based) polymer and a crystal-modifying additive. The PVDF-based polymer includes an amorphous PVDF phase and a crystalline PVDF phase. The crystalline PVDF phase includes a beta form crystalline structure in an amount exceeding any other crystalline structure form in the crystalline PVDF phase.
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公开(公告)号：US20170290957A1
公开(公告)日：2017-10-12
申请号：US15485491
申请日：2017-04-12
Applicant: Cardiac Pacemakers, Inc.
Inventor： Joseph T. Delaney, JR. , David R. Wulfman , Adeniyi O. Aremu , Adegbola O. Adenusi
CPC classification number: A61L31/10 , A61L27/34 , A61L2420/02 , B05D1/04 , B05D3/04 , C08G63/183 , C08L67/02 , C09D7/20 , C09D167/02 , D01D1/02 , D01D5/003 , D01D5/0084 , D01F6/62
Abstract: A method of making a solution including poly(ethylene terephthalate). The method includes dissolving poly(ethylene terephthalate) in a solvent mixture to form a solution, the solvent mixture including two solvent components. A Hansen Solubility Parameter Distance between the solvent mixture and HSP coordinates having a dispersion HSP of 18.02 MPa0.5, a polar HSP of 5.56 MPa0.5, and a hydrogen bonding HSP of 14.27 MPa0.5 is less than about 2 MPa0.5.
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公开(公告)号：US09782579B2
公开(公告)日：2017-10-10
申请号：US15043679
申请日：2016-02-15
Applicant: Cardiac Pacemakers, Inc.
Inventor： David R. Wulfman , Rahul K. Rajgarhia , David J. Smith , Tolga Tas , Daniel J. Cooke , Christopher R. Perrey
CPC classification number: A61N1/05 , B29C47/025 , B29C59/02 , B29K2995/0005 , B29K2995/0007 , B29K2995/0072 , B29L2031/3462 , B29L2031/7546 , H01R43/16 , Y10T29/49174
Abstract: Described is a medical device lead including a lead body having a conductor lumen including an inner surface. The lead also includes a conductor assembly extending through the conductor lumen; the conductor assembly comprising a conductor member and an outer insulative layer; and an electrode coupled to the conductor cable. The outer insulative layer includes a textured external surface that reduces the coefficient of friction between the outer insulative layer and the inner surface of the conductor lumen through which the conductor assembly extends. Methods of forming the conductor assembly are also described.
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公开(公告)号：US20170021160A1
公开(公告)日：2017-01-26
申请号：US15217178
申请日：2016-07-22
Applicant: Cardiac Pacemakers, Inc.
Inventor： Joseph T. Delaney, JR. , David R. Wulfman , Adeniyi O. Aremu , Adegbola O. Adenusi
Abstract: A medical electrical lead includes an insulative lead body extending from a distal region to a proximal region, a conductor disposed within the insulative lead body and extending from the proximal region to the distal region, an electrode disposed on the insulative lead body and in electrical contact with the conductor, and a fibrous matrix disposed on at least part of the electrode. The fibrous matrix includes fibers. The fibers include a polyvinylidene fluoride-based (PVDF-based) polymer and a crystal-modifying additive. The PVDF-based polymer includes an amorphous PVDF phase and a crystalline PVDF phase. The crystalline PVDF phase includes a beta form crystalline structure in an amount exceeding any other crystalline structure form in the crystalline PVDF phase.
Abstract translation: 医疗用电线包括从远端区域延伸到近端区域的绝缘引线体，设置在绝缘引线主体内并从近端区域延伸到远端区域的导体，设置在绝缘引线体上并与电接触的电极 与导体和设置在电极的至少一部分上的纤维矩阵。 纤维基质包括纤维。 纤维包括聚偏二氟乙烯（PVDF）聚合物和晶体改性添加剂。 PVDF基聚合物包括非晶PVDF相和结晶PVDF相。 结晶PVDF相包括在结晶PVDF相中超过任何其它结晶结构形式的β型晶体结构。
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