-
公开(公告)号：US20230324384A1
公开(公告)日：2023-10-12
申请号：US18022591
申请日：2021-09-09
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen
IPC: G01N33/569 , G01N33/58 , G01N33/50 , G01N21/64
CPC classification number: G01N33/56972 , G01N33/582 , G01N33/5047 , G01N21/6428 , G01N2333/70596 , G01N2800/24 , G01N2800/52 , G01N2021/6439
Abstract: The present disclosure relates to aptamer mediated BAT for diagnosing and/or prognosing an individual's allergic reaction to an allergen.
-
公开(公告)号：US11591557B2
公开(公告)日：2023-02-28
申请号：US16487450
申请日：2018-02-21
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Gregory J. Kintz , Adam J. Young , Patrick Murphy , Joshua Glenn Anthony , Paul Fleming , Brett Gorham , Ryan Griswold , Bruce Richardson
IPC: C12M3/06 , C12M1/32 , G01J3/42 , G01J3/44 , G01N21/51 , G01N21/53 , G01N21/64 , G01N33/02 , G01N21/17
Abstract: The present invention is drawn to devices and systems for allergen detection in a sample. The allergen detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system. In some embodiments, the allergen detection utilizes aptamer nucleic acid molecules as detection agents. In some embodiments, the nucleic acids are conjugated to magnetic beads or solid surfaces such as glasses, microwells and microchips.
-
公开(公告)号：US20220073911A1
公开(公告)日：2022-03-10
申请号：US17265550
申请日：2019-08-02
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Sarah Elizabeth Stidham , Olivia Jean Alley
IPC: C12N15/11 , C12N15/10 , C12Q1/6806 , C12Q1/686 , G01N33/02
Abstract: The present disclosure relates to methods for identifying aptamers against allergen proteins and signaling polynucleotides (SPNs) for allergen detection. The screening method of the present disclosure combines several positive SELEX selections, and on-chip positive and counter selections to identify aptamer sequences that are preferentially bind to target proteins when competing with short complementary sequences.
-
公开(公告)号：US10908139B2
公开(公告)日：2021-02-02
申请号：US16084996
申请日：2017-03-10
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Renuka Babu Brown , Sarah Stidham , Valerie Villareal , Adam J. Young , Joshua Glenn Anthony , Patrick Murphy , John H. Kepler , Adam Jacobs
IPC: B01L3/00 , B01L1/00 , G01N33/02 , C12M1/34 , G01N1/08 , C12N15/115 , G01N1/14 , G01N1/28 , G01N33/53 , G01N33/58
Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.
-
公开(公告)号：US20210016269A1
公开(公告)日：2021-01-21
申请号：US17063067
申请日：2020-10-05
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Renuka Babu Brown , John H. Kepler , Gaurav Rohatgi , Philip Charles Walker , Mark Bates , Christopher James Page
Abstract: The present invention provides systems, devices and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sample pickup, one or more disposables for receiving and processing a test sample and a detection device that can execute an allergen detection testing in minutes. The present detection system and device is compact and portable.
-
Patent Agency Ranking
公开(公告)号：US20190292544A1
公开(公告)日：2019-09-26
申请号：US16347935
申请日：2017-11-08
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Valerie Villareal , Sarah Stidham , Morris Nehama
IPC: C12N15/115 , G01N33/02 , C12N15/10 , G01N33/533
Abstract: The present application discloses nucleic acid aptamer based signaling polynucleotides (SPNs) that specifically bind an allergen protein. Provided in the present invention include aptamers, SPNs, SPN-complement complexes, magnetic particle conjugates, DNA printed glass slides and detection agents, and detection methods using the same for detecting the presence, or absence of an allergen protein in a food sample.
-
公开(公告)号：US10344319B2
公开(公告)日：2019-07-09
申请号：US15030564
申请日：2014-10-28
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Renuka Babu Brown
IPC: C12Q1/68 , C12Q1/6818 , C12Q1/6811 , G01N33/53 , C12N15/10 , G01N33/02
Abstract: The present invention provides allergen detection molecules and devices useful in on-site and rapid detection of allergens, including food allergens.
-
公开(公告)号：US20190079063A1
公开(公告)日：2019-03-14
申请号：US16084996
申请日：2017-03-10
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Renuka Babu Brown , Sarah Stidham , Valerie Villareal , Adam J. Young , Joshua Glenn Anthony , Patrick Murphy , John H. Kepler , Adam Jacobs
Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.
-
公开(公告)号：US20180154350A1
公开(公告)日：2018-06-07
申请号：US15705328
申请日：2016-03-15
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Renuka Babu Brown , John H. Kepler , Gaurav Rohatgi , Philip Charles Walker , Mark Bates , Christopher James Page
CPC classification number: B01L3/502 , B01L2200/025 , B01L2200/026 , B01L2200/0605 , B01L2200/0689 , B01L2300/042 , B01L2300/047 , B01L2300/0609 , B01L2300/0654 , B01L2300/0681 , B01L2300/0867 , B01L2300/1822 , B01L2300/1827 , B01L2400/0487 , B01L2400/049 , B01L2400/0694 , C12Q1/6804 , G01N1/08 , G01N1/286 , G01N33/02 , G01N33/5308 , G01N2001/2866 , C12Q2525/205 , C12Q2563/107 , C12Q2565/1015 , C12Q2565/107
Abstract: The present invention provides systems, devices and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sample pickup, one or more disposables for receiving and processing a test sample and a detection device that can execute an allergen detection testing in minutes. The present detection system and device is compact and portable.
-
公开(公告)号：US20240299940A1
公开(公告)日：2024-09-12
申请号：US18260600
申请日：2022-01-06
Applicant: DOTS Technology Corp.
Inventor： Adi Gilboa-Geffen , Renuka Babu Brown
IPC: B01L3/00 , G01N33/543
CPC classification number: B01L3/502738 , G01N33/54366 , B01L2200/04 , B01L2200/0689 , B01L2200/10 , B01L2300/042 , B01L2300/044 , B01L2300/0672 , B01L2300/0681 , B01L2300/12 , B01L2400/0644
Abstract: The present disclosure is drawn to devices and systems for target detection in samples, including food samples, clinical samples, environmental samples and veterinary samples. The target detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system.
-
-
-
-
-
-
-
-
-
Search Results
25
records
(took 0.032 seconds)
