公开(公告)号：US20130277548A1

公开(公告)日：2013-10-24

申请号：US13851731

申请日：2013-03-27

Applicant: Micromass UK Limited

Inventor： Emmanuelle Claude ,  Mark W. Towers ,  Kieran Neeson ,  Richard Denny ,  Jeffery M. Brown ,  Paul Murray ,  Mark McDowall

IPC: H01J49/00 ,  H01J49/26

CPC classification number: H01J49/0031 ,  G01N27/622 ,  H01J49/0027 ,  H01J49/0036 ,  H01J49/004 ,  H01J49/005 ,  H01J49/26 ,  H01J49/40 ,  H01J49/446 ,  H01J2237/05

Abstract: The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas.

公开(公告)号：US10832899B2

公开(公告)日：2020-11-10

申请号：US16272693

申请日：2019-02-11

Applicant: Micromass UK Limited

Inventor： Paul Murray ,  Mark William Towers ,  Matthew Havard

IPC: H01J49/04 ,  G01N27/62 ,  H01J49/16

Abstract: A mass and/or ion mobility spectrometer 100 comprises a sample plate 102 that supports a target sample 104. The spectrometer 100 further comprises a laser source 110 that generates a series of laser pulses 112 and a control system 118 that moves a focal point of the laser source 110 substantially continuously across the sample plate 102 such that respective packets of ions are generated by respective laser pulses 112 impinging upon respective locations on the target sample 104. The control system 118 performs plural cycles of ion analysis that each produce a set of spectral data corresponding to one or more of the packets of ions. The spectrometer 100 can provide mass and/or ion mobility spectrometry having increased speed and efficiency.

公开(公告)号：US10079136B2

公开(公告)日：2018-09-18

申请号：US15317314

申请日：2015-06-12

Applicant: Micromass UK Limited

Inventor： Jeffery Mark Brown ,  Paul Murray ,  Keith Richardson

IPC: H01J49/40 ,  H01J49/10 ,  H01J49/00

CPC classification number: H01J49/0009 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/40

Abstract: A method of calibrating a mass spectrometer is disclosed comprising mass analyzing first ions derived from an analyte molecule, wherein the first ions have a first charge state; determining a first mass or mass to charge ratio of the first ions; mass analyzing second ions derived from the analyte molecule, wherein the second ions have a second different charge state and wherein the second ions comprise protonated or adduct variants of the first ions; determining a second mass or mass to charge ratio of the second ions; a determining a calibration correction based upon the first mass or mass to charge ratio and the second mass or mass to charge ratio.

公开(公告)号：US20170082435A1

公开(公告)日：2017-03-23

申请号：US15267677

申请日：2016-09-16

Applicant: Micromass UK Limited

Inventor： Mark Towers ,  Paul Murray

IPC: G01C15/00 ,  H01J49/16 ,  H01J49/14 ,  H01J49/02 ,  H01J49/00 ,  H01J49/04

CPC classification number: G01C15/004 ,  H01J49/0031 ,  H01J49/025 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/145 ,  H01J49/165

Abstract: An ion analysis instrument is disclosed comprising an indicator device for providing an indication of a relative positioning of an ion source, a sample, and/or a sampling orifice or capillary of an ion analysis instrument such as a mass or ion mobility spectrometer in order to facilitate re-alignment of one or more of these components following a change. The indicator device comprises a source of electromagnetic radiation such as a pair of lasers or image projection devices.

公开(公告)号：US20160071716A1

公开(公告)日：2016-03-10

申请号：US14941741

申请日：2015-11-16

Applicant: Micromass UK Limited

Inventor： Jeffery Mark Brown ,  Paul Murray ,  Daniel James Kenny

IPC: H01J49/16 ,  H01J49/04 ,  H01J49/06

CPC classification number: H01J49/062 ,  H01J49/0004 ,  H01J49/0463 ,  H01J49/065 ,  H01J49/164 ,  H01J49/26

Abstract: An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length≦300 mm. The laser beam is directed onto the target substrate at an angle θ with respect to the perpendicular to the target substrate, wherein θ≦3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror.

Abstract translation: 公开了一种用于质谱仪的离子源，其包括将激光束聚焦到目标衬底的上表面上的透镜和反射镜装置。 镜头具有有效的焦距＆nlE; 300 mm。 激光束以一定角度被引导到靶基底上; 相对于与靶基板的垂直度，其中＆amp; nlE; 3°。 一个或多个离子导向器接收从目标衬底释放的离子，并沿基本上绕过透镜和反射镜的离子路径向上透射离子。

公开(公告)号：US09257268B2

公开(公告)日：2016-02-09

申请号：US14366903

申请日：2012-12-20

Applicant: Micromass UK Limited

Inventor： Paul Murray ,  Jeffrey M. Brown

IPC: H01J49/00 ,  H01J49/16 ,  H01J49/40 ,  H01J49/04

CPC classification number: H01J49/164 ,  H01J49/0004 ,  H01J49/0418 ,  H01J49/40 ,  H01J49/405

Abstract: An imaging mass spectrometer comprising an energy source adapted to substantially simultaneously provide energy to multiple spots on a sample to produce ions from the sample by a desorption process; and an analyzer adapted to detect the arrival time and spot origin of ions resulting from said desorption process.

Abstract translation: 一种成像质谱仪，其包括适于基本上同时向样品上的多个点提供能量以通过解吸过程从所述样品产生离子的能量源; 以及适于检测由所述解吸过程产生的离子的到达时间和斑点来源的分析器。

公开(公告)号：US20140361162A1

公开(公告)日：2014-12-11

申请号：US14366903

申请日：2012-12-20

Applicant: Micromass UK Limited

Inventor： Paul Murray ,  Jeffrey M. Brown

IPC: H01J49/16 ,  H01J49/04 ,  H01J49/40 ,  H01J49/00

CPC classification number: H01J49/164 ,  H01J49/0004 ,  H01J49/0418 ,  H01J49/40 ,  H01J49/405

Abstract: An imaging mass spectrometer comprising an energy source adapted to substantially simultaneously provide energy to multiple spots on a sample to produce ions from the sample by a desorption process; and an analyser adapted to detect the arrival time and spot origin of ions resulting from said desorption process.

Abstract translation: 一种成像质谱仪，其包括适于基本上同时向样品上的多个点提供能量以通过解吸过程从所述样品产生离子的能量源; 以及适于检测由所述解吸过程产生的离子的到达时间和斑点原点的分析器。

公开(公告)号：US11615950B2

公开(公告)日：2023-03-28

申请号：US17280421

申请日：2019-09-26

Applicant: Micromass UK Limited

Inventor： Paul Murray ,  Mark Towers ,  Matthew Henderson ,  Andrew Whatley

IPC: H01J49/16 ,  H01J49/04 ,  H01J49/26

Abstract: A nozzle for an ionisation source comprises: a light passage having an inlet end and an outlet end; and a gas flow passage in fluid communication with the light passage, wherein the gas flow passage is configured to convey, in use, a flow of gas into the light passage such that the flow of gas travels substantially towards the outlet end of the light passage.

公开(公告)号：US11443932B2

公开(公告)日：2022-09-13

申请号：US16956922

申请日：2018-12-21

Applicant: Micromass UK Limited

Inventor： Paul Murray ,  Mark Towers ,  Andrew Whatley ,  Matthew Henderson ,  Philippa Hart ,  Emmanuelle Claude ,  Richard Jarrold ,  Jeff Brown ,  Steve Brace ,  Edward Scott

IPC: H01J49/00 ,  H01J49/06 ,  G01N27/622 ,  H01J49/04 ,  H01J49/24 ,  H01J49/26

Abstract: A mass spectrometer is disclosed comprising a rotatable isolation valve (1) having a curved, spherical, cylindrical or concave portion. At least a portion of an ion guide (2) is positioned so as to extend within a swept volume of the isolation valve (1) enabling the ion guide (2) to be positioned close to a second downstream ion guide (3) and for ions to be transmitted from the first (2) ion guide to the second ion guide (3) with high ion transmission efficiency.

公开(公告)号：US09947523B2

公开(公告)日：2018-04-17

申请号：US15348453

申请日：2016-11-10

Applicant: MICROMASS UK LIMITED

Inventor： Jeffrey Mark Brown ,  Paul Murray

IPC: H01J49/40 ,  H01J49/24 ,  H01J49/06 ,  H01J49/00 ,  H01J49/04 ,  H01J49/16

CPC classification number: H01J49/061 ,  H01J49/0027 ,  H01J49/0495 ,  H01J49/06 ,  H01J49/164 ,  H01J49/40

Abstract: A mass spectrometer includes: an ion source; an aperture; a flight region arranged between the ion source and aperture for separating ions according to their mass to charge ratio; and ion optics arranged and configured for causing ions to be reflected or deflected while they separate according to mass to charge ratio in the flight region and such that the ions are focussed to a geometrical focal point at the aperture so that the ions are transmitted through the aperture. The multi-reflecting or multi-deflecting ion optics provides a relatively long flight path for the ions, while naturally converging the ion beam to a focus. As this focus is arranged at the aperture, it enables the aperture to be made relatively small while still maintaining high ion transmission efficiency.