SYSTEM AND METHOD FOR DETERMINING SUCCESSIVE SINGLE MOLECULAR DECAY

    公开(公告)号:US20240133740A1

    公开(公告)日:2024-04-25

    申请号:US18542717

    申请日:2023-12-17

    CPC classification number: G01J3/4406 G01J3/0218 G01J3/0227

    Abstract: A measurement system is disclosed which includes a vessel configured to suspend molecules of interest therein, optical sources configured to excite the molecules of interest by an excitation light activated and deactivated in a stepwise fashion, during the activation, the sources activated according to a pulse train, the molecules of interest emitting emission light in response to being excited by the excitation light, one or more sensor packages each comprising a plurality of photodetectors configured to receive emission light from the molecules of interest and, in response, provide an output voltage signal and an output current signal corresponding to photoelectron response of an incident photon on the one or more sensor packages, and a detector configured to determine successive single molecular decay of the molecules of interest, generate an emission pulse associated with each incident photon on the one or more sensor packages, and count the number of emission pulses.

    Sensor configuration
    14.
    发明授权

    公开(公告)号:US11931146B2

    公开(公告)日:2024-03-19

    申请号:US16810387

    申请日:2020-03-05

    Abstract: The present invention relates to a sensor configuration (1) for non-invasive measurement of parameters of a body tissue with a sensor unit (10) and a sensor mat (12) for detachable placement of the sensor configuration (1) on a body surface (20). Furthermore the sensor unit (10) of the sensor configuration (1) is connectible to a contact head (16), which is designed for electrical contacting of the sensor unit (10) and for supply of light from a light source to the sensor unit (10), the sensor unit (10) being designed as a flexible printed circuit board with optical components, at least comprising a light detector device (2), in order to detect light that is emitted into the body tissue and has passed through the latter, a first contact means (30) and conducting tracks (5) for operative connection of the sensor unit (10) to the contact head (16). The sensor mat (12) of the sensor configuration (1) has a multi-layered structure, with a lower layer (13), which has a lower contact surface for contact on the body surface (20) and an upper contact surface for contact of the sensor unit (10), whereby openings (15, 17) are provided which are aligned with the optical components of the sensor unit (10), and form an optical passage, and with an upper layer (14), which is connected to the upper contact surface of the lower layer (13) in a way detachable from one another.

    RAMAN SPECTROSCOPY PROBE AND RAMAN SPECTROSCOPY DETECTION DEVICE

    公开(公告)号:US20240044708A1

    公开(公告)日:2024-02-08

    申请号:US18548032

    申请日:2023-02-22

    CPC classification number: A61B5/0075 G01N21/65 G01J3/44 G01J3/0208 G01J3/0218

    Abstract: A Raman spectroscopy probe and a Raman spectroscopy detection device are provided, including an optical fiber module, and a magnifying lens group and a detection window sequentially arranged on an optical path thereof. The module includes an excitation fiber and parallel collection fibers surrounding a periphery thereof. The magnifying lens group includes sequentially-arranged convex lenses. The detection window is located near an object-distance position of a lens close to a detection end. A distance between two adjacent convex lenses is equal to a sum of former's image distance and latter's object distance. Focal lengths of the convex lenses in the magnifying lens group are f, and satisfy a ratio of the object distance to the image distance of n:1, and a length L of the magnifying lens group satisfies:





    L
    =




    n
    +
    2
    +

    1
    n




    log
    10


    n


    ·
    f
    ·

    log
    10



    N


    ,




    wherein





    n
    =

    N
    m


    ,




    N is a magnification, and m is a number of the convex lenses.

    OPTICAL SPECTROMETER SYSTEM
    18.
    发明公开

    公开(公告)号:US20240044705A1

    公开(公告)日:2024-02-08

    申请号:US18258962

    申请日:2021-12-21

    CPC classification number: G01J3/28 G01J3/0218 G01J3/1895

    Abstract: A spectrometer system is described. The system comprises a signal input port and a pump input port, respective signal and pump dispersion fibers, a nonlinear optical fiber section, and an output dispersion fiber. The dispersion fibers are configured to apply predetermined spectral dispersion on light input associated with signal and pump inputs. The nonlinear optical fiber section is configured to receive dispersed signal and pump waves and enable nonlinear interaction between the signal and pump waves. The output dispersion fiber is configured to receive light resulting from said nonlinear interaction and apply predetermined dispersion to the received light, thereby providing output light having mapping between time and spectral components of the input signal. Wherein at least one of the signal input port and pump input port comprises temporal speckle generating unit configured to affect optical pulses passing through to induce temporal speckles within said optical pulses.

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