公开(公告)号：US08968658B2

公开(公告)日：2015-03-03

申请号：US13311164

申请日：2011-12-05

Applicant: Michael Katzlinger ,  Josef J. Atzler ,  Daniel M. Stock

Inventor： Michael Katzlinger ,  Josef J. Atzler ,  Daniel M. Stock

IPC: G01N21/00 ,  G01J3/02 ,  G01J3/10 ,  G01J3/427 ,  G01J3/44 ,  G01N21/76 ,  G01N21/64 ,  G01N21/17

CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/645 ,  G01N21/763 ,  G01N2021/1738 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/0618 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0692 ,  G01N2201/0696

Abstract: A cartridge and cartridge system for use in an apparatus for analyzing a sample are provided. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with a cartridge support of the apparatus in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed. The cartridge support includes a plurality of cartridge positions that receive cartridges concurrently. One of the cartridges may be a luminescence cartridge that includes an integrated detector that is movable toward and away from a sample carrier of the apparatus, and thus toward and away from a sample located at the sample carrier.

Abstract translation: 提供了用于分析样品的装置中的盒和盒系统。 该系统具有用于多模仪器的不同应用的多个盒。 墨盒以“插入”格式与装置的墨盒支架可拆卸地接合，使得一个墨盒可以从设备中取出，另一墨盒可以容易地安装。 盒支架包括同时接收盒的多个盒位置。 其中一个盒可以是发光盒，其包括集成检测器，该检测器可朝向和远离装置的样品载体移动，并且因此朝向和离开位于样品载体处的样品。

公开(公告)号：US08941828B2

公开(公告)日：2015-01-27

申请号：US13402207

申请日：2012-02-22

Applicant: Hans-Peter Loock ,  Helen Waechter

Inventor： Hans-Peter Loock ,  Helen Waechter

IPC: G01J3/42 ,  G01J3/45 ,  G01J3/427 ,  G01J3/433 ,  G01N21/77

CPC classification number: G01J3/42 ,  G01J3/427 ,  G01J3/433 ,  G01N21/7746 ,  G01N2021/7776 ,  G01N2021/7779 ,  G01N2021/7783

Abstract: Described are methods for multi-wavelength cavity ring-down spectroscopy; comprising simultaneously and continuously irradiating an optical cavity with light at two or more different wavelengths, each light being intensity-modulated at a different modulation frequency, detecting the light of two or more wavelengths after the light has traveled through the optical cavity; measuring an optical loss of each detected light; and determining a characteristic of the optical cavity from the optical loss of each detected light. Also described are apparatus and systems for multi-wavelength cavity ring-down spectroscopy.

Abstract translation: 描述了多波长腔体衰减光谱法的方法; 包括以两个或更多个不同波长的光同时且持续地照射光腔，每个光以不同的调制频率进行强度调制，在光已经穿过光腔之后检测两个或更多个波长的光; 测量每个检测到的光的光学损耗; 以及从每个检测到的光的光损失确定光腔的特性。 还描述了用于多波长腔体衰减光谱的装置和系统。

公开(公告)号：US20140043612A1

公开(公告)日：2014-02-13

申请号：US14054599

申请日：2013-10-15

Applicant: Ronald T. Logan ,  Joseph R. Demers

Inventor： Ronald T. Logan ,  Joseph R. Demers

IPC: G01J3/10

CPC classification number: G01J3/427 ,  A61B5/0507 ,  G01J3/10 ,  G01J3/42 ,  G01J3/4531 ,  G01N21/3581 ,  G01N21/3586 ,  G01N21/39

Abstract: An apparatus for analyzing, identifying or imaging an target including first and second laser beams coupled to a pair of photoconductive switches to produce CW signals in one or more bands in a range of frequencies greater than 100 GHz focused on and transmitted through or reflected from the target; and a detector for acquiring spectral information from signals received from the target and using a multi-spectral heterodyne process to generate an electrical signal representative of some characteristics of the target. The lasers are tuned to different frequencies and a frequency shifter in the path of one laser beam allows the terahertz beam to be finely adjusted in one or more selected frequency bands.

Abstract translation: 一种用于分析，识别或成像目标的装置，包括耦合到一对光电导开关的第一和第二激光束，以在大于100GHz的频率的范围内的一个或多个频带中产生CW信号，该信号集中于并经由 目标; 以及检测器，用于从从目标接收的信号中获取光谱信息，并使用多光谱外差处理产生代表目标的某些特性的电信号。 将激光器调谐到不同的频率，并且在一个激光束的路径中的频移器允许在一个或多个所选频带中微调太赫兹波束。

公开(公告)号：US08496879B2

公开(公告)日：2013-07-30

申请号：US13166595

申请日：2011-06-22

Applicant: Josef J. Atzler

Inventor： Josef J. Atzler

IPC: G01N21/64

CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/645 ,  G01N21/763 ,  G01N2021/1738 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/0618 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0692 ,  G01N2201/0696

Abstract: A cartridge and cartridge system for use in an apparatus for analyzing a sample are provided. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with a cartridge support in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed. The cartridge support includes a plurality of cartridge positions that receive cartridges concurrently. One of the cartridges is a wavelength-tunable cartridge in which different light sources, excitation filters, and/or emission filters may be selected. Tuning is further accomplished by tilting the excitation or emission filters at desired angles relative to a beam of exciting light or emitted light.

Abstract translation: 提供了用于分析样品的装置中的盒和盒系统。 该系统具有用于多模仪器的不同应用的多个盒。 盒以“插入”格式可拆卸地与盒支撑接合，使得一个盒可以从装置移除，另一个盒可以容易地安装。 盒支架包括同时接收盒的多个盒位置。 其中一个墨盒是波长可调的墨盒，其中可以选择不同的光源，激发滤光片和/或发射滤光片。 通过将激发或发射滤光片相对于激发光束或发射光以期望的角度倾斜来进一步完成调谐。

公开(公告)号：US08477304B2

公开(公告)日：2013-07-02

申请号：US13050546

申请日：2011-03-17

Applicant: Bruce A. Bushaw ,  Norman C. Anheier ,  Jon R. Phillips

Inventor： Bruce A. Bushaw ,  Norman C. Anheier ,  Jon R. Phillips

IPC: G01J3/30

CPC classification number: G01J3/427 ,  G01N21/3103 ,  G01N21/3151 ,  G01N21/631 ,  G01N2021/1761 ,  G01N2033/0093

Abstract: A system and process are disclosed that provide high accuracy and high precision destructive analysis measurements for isotope ratio determination of relative isotope abundance distributions in liquids, solids, and particulate samples. The invention utilizes a collinear probe beam to interrogate a laser ablated plume. This invention provides enhanced single-shot detection sensitivity approaching the femtogram range, and isotope ratios that can be determined at approximately 1% or better precision and accuracy (relative standard deviation).

Abstract translation: 公开了一种系统和方法，其为液体，固体和颗粒样品中相对同位素丰度分布的同位素比确定提供高精度和高精度的破坏性分析测量。 本发明利用共线探测光束询问激光烧蚀羽流。 本发明提供了接近飞镖范围的增强的单次检测灵敏度和可以以大约1％或更高的精度和精度（相对标准偏差）确定的同位素比。

公开(公告)号：US20130001407A1

公开(公告)日：2013-01-03

申请号：US13175563

申请日：2011-07-01

Applicant: Jeffrey H. Hunt ,  John H. Belk

Inventor： Jeffrey H. Hunt ,  John H. Belk

IPC: G02F1/01 ,  H01J5/16 ,  B82Y99/00

CPC classification number: G01N21/55 ,  B82Y30/00 ,  G01J1/0407 ,  G01J1/42 ,  G01J3/0208 ,  G01J3/0224 ,  G01J3/32 ,  G01J3/427 ,  G01J5/023 ,  G01J5/046 ,  G01J5/12 ,  G01J9/00

Abstract: An apparatus, system, and method are disclosed for nonlinear optical surface sensing with a single thermo-electric detector. In particular, the system includes at least two signal sources that are co-aligned to propagate photons to the same location on a surface. The system also includes at least one focusing element that focuses a sequence of photons that is reflected from the location on the surface. In addition, the system includes at least one frequency selective electromagnetic detector that detects the sequence of photons that are focused from the focusing element(s). When the frequency selective electromagnetic detector senses a photon, the frequency selective electromagnetic detector emits an electrical pulse that has a voltage that is proportional to the energy level of the photon. Additionally, the system includes a processor that processes the electrical pulses, and de-multiplexes the sequence of emitted electrical pulses based on the electrical pulse voltage of the electrical pulses.

Abstract translation: 公开了一种使用单个热电探测器进行非线性光学表面感测的装置，系统和方法。 特别地，该系统包括至少两个共同对准以将光子传播到表面上相同位置的信号源。 该系统还包括至少一个聚焦元件，其聚焦从表面上的位置反射的光子序列。 此外，该系统包括至少一个频率选择性电磁检测器，其检测聚焦元件聚焦的光子的序列。 当频率选择性电磁检测器感测到光子时，频率选择性电磁检测器发射具有与光子的能级成比例的电压的电脉冲。 此外，该系统包括处理电脉冲的处理器，并且基于电脉冲的电脉冲电压去除多路复用所发射的电脉冲序列。

公开(公告)号：US20120206727A1

公开(公告)日：2012-08-16

申请号：US13370969

申请日：2012-02-10

Applicant: Alfons Schulte ,  Silki Arora

Inventor： Alfons Schulte ,  Silki Arora

IPC: G01J3/46

CPC classification number: G01J3/42 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0289 ,  G01J3/427 ,  G01N21/03 ,  G01N21/31 ,  G01N21/314 ,  G01N21/3151 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2021/651 ,  G01N2021/656 ,  G01N2201/0627 ,  G01N2201/0846 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/26 ,  G02B21/367

Abstract: Apparatus and method to measure optical absorption spectra with spatial resolution on the micron scale. An exemplary setup combines a continuous white light excitation beam in transmission geometry with a confocal microscope. Spatial resolution better than 1.4 μm in the lateral and 3.6 μm in the axial, directions was obtained. The detection and measurement of the absorption spectrum of hemoglobin in a single red blood cell under physiological conditions on the timescale of seconds was realized. The apparatus and method enables the investigation of spatial variations in the optical density of small samples on the micron scale and the study of biological assemblies at the single cell level, leading to applications in optical diagnostics, microfluidics, and other areas.

Abstract translation: 用微米尺度测量空间分辨率的光吸收光谱的装置和方法。 示例性设置将透射几何中的连续白光激发光束与共聚焦显微镜组合。 获得横向分辨率优于1.4μm，轴向方向为3.6μm。 实现了在生理条件下单次红细胞血红蛋白吸收光谱在秒的时间刻度上的检测和测量。 该装置和方法能够调查微尺度上小样品的光密度的空间变化以及在单细胞水平上对生物组装的研究，导致在光学诊断，微流体等领域的应用。

公开(公告)号：US20110109905A1

公开(公告)日：2011-05-12

申请号：US13001885

申请日：2009-06-10

Applicant: Hans Göran Evald Martin

Inventor： Hans Göran Evald Martin

IPC: G01J3/26

CPC classification number: G01N21/3504 ,  G01J3/02 ,  G01J3/021 ,  G01J3/26 ,  G01J3/427 ,  G01J2003/1226 ,  G01J2003/1243 ,  H01L2224/48091 ,  H01L2924/00014

Abstract: An arrangement adapted for a spectral analysis, having a light transmitting means, a delimited space in the form of a cavity serving as a measuring cell and defining an optical measuring distance, a light sensing means for detecting radiation passing said optical measuring distance from said light transmitting means, and a unit, connected at least to said light sensing means and performing the spectral analysis. Beams of radiation from the light transmitting means are made to pass through an optical band-pass filter at different angles of incidence. The filter is structured so as to pass a wavelength in dependence of the angle of incidence. A first chosen wavelength component is separated from a second wavelength component, each being received in its opto-electric means. Said unit is adapted for detecting and calculating an occurring radiation intensity for each such wavelength component.

Abstract translation: 一种适用于光谱分析的装置，具有光传输装置，用作测量单元的空腔形式的限定空间并限定光学测量距离;光检测装置，用于检测通过所述光的所述光测量距离的辐射 发送装置和至少连接到所述光检测装置并执行频谱分析的单元。 来自光发射装置的光束被使得以不同的入射角通过光学带通滤光器。 滤波器被构造成使得根据入射角通过波长。 第一选择的波长分量与第二波长分量分离，每个波长分量在其光电装置中被接收。 所述单元适于检测和计算每个这样的波长分量的出现的辐射强度。

公开(公告)号：US07910876B2

公开(公告)日：2011-03-22

申请号：US12461803

申请日：2009-08-25

Applicant: Kaoru Kumagai ,  Shugo Akiyama

Inventor： Kaoru Kumagai ,  Shugo Akiyama

IPC: G01N21/27 ,  A61G7/00

CPC classification number: G01N21/3563 ,  A01C21/007 ,  G01J3/02 ,  G01J3/0286 ,  G01J3/108 ,  G01J3/427 ,  G01N21/359 ,  G01N2021/1797 ,  G01N2021/3181 ,  G01N2201/0627 ,  G01N2201/0691 ,  G01N2201/0694 ,  G01N2201/0696

Abstract: A plant sensor includes a light source section having first and second light emitters configured to irradiate first and second measuring light toward an object to be measured, respectively, and a light receiver configured to receive reflected light from the object to be measured, and output light-receiving signals. A controller is configured to control emission of the first and second light emitters at a different timing, an integrator is configured to integrate the light-receiving signals, and output an integration signal, and a calculator is configured to calculate, according to the integration signal, a reflection rate as a ratio of light intensity of the reflected light of the first measuring light from the object to be measured to light intensity of the first measuring light, a reflection rate as a ratio of light intensity of the reflected light of the second measuring light from the object to be measured to light intensity of the second measuring light, and to obtain information regarding a growing condition of the object to be measured.

Abstract translation: 植物传感器包括光源部分，其具有分别被配置为朝向被测量对象照射第一和第二测量光的第一和第二发光体和被配置为接收来自被测量物体的反射光的光接收器，以及输出光 接收信号。 控制器被配置为在不同的定时控制第一和第二光发射器的发射，积分器被配置为对光接收信号进行积分并输出积分信号，并且计算器被配置为根据积分信号 作为第一测定光的被测定光的反射光的光强度与第一测定光的光强度的比的反射率，作为第二测定光的反射光的光强度的比例的反射率 将来自待测量物体的光测量到第二测量光的光强度，并获得关于被测量物体的生长状态的信息。

公开(公告)号：US07868296B2

公开(公告)日：2011-01-11

申请号：US12413666

申请日：2009-03-30

Applicant: Frank M. Haran ,  Reena Meijer-Drees ,  Sebastien Tixier

Inventor： Frank M. Haran ,  Reena Meijer-Drees ,  Sebastien Tixier

IPC: G01J5/02

CPC classification number: G01J3/36 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/027 ,  G01J3/0297 ,  G01J3/28 ,  G01J3/427 ,  G01N21/274 ,  G01N21/3554 ,  G01N21/3563 ,  G01N21/359 ,  G01N2021/3137 ,  G01N2021/3166 ,  G01N2021/3188 ,  G01N2201/1293

Abstract: A spectroscopic method and spectroscopy system therefrom for analyzing samples. A sample includes a first chemical component that has a characteristic first absorption peak is provided. The sample is irradiated in a measurement waveband proximate to the first absorption peak, and at a first and a second reference waveband where the first chemical component lacks characteristic absorption features. Reflected or transmitted detection data is obtained including a measured power proximate to the first absorption peak and first and second reference powers at the reference wavebands. A plurality of different waveband ratios are evaluated using pairs of detection data to generate a plurality of measured waveband ratio values. A parameter of the first chemical component is then determined by evaluating a multidimensional polynomial calibration equation that relates the parameter of the first chemical component to the plurality of different waveband ratios by substituting the measured waveband ratio values into the calibration relation.

Abstract translation: 用于分析样品的光谱法和光谱系统。 样品包括具有特征性第一吸收峰的第一化学成分。 在接近第一吸收峰的测量波段和第一和第二参考波段照射样品，其中第一化学成分缺少特征吸收特征。 获得的反射或发射的检测数据包括接近第一吸收峰的测量的功率和在参考波段处的第一和第二参考功率。 使用成对的检测数据来评估多个不同的波段比，以产生多个测量的波段比值。 然后通过将测量的波段比值代入校正关系来评估将第一化学成分的参数与多个不同的波段比率相关联的多维多项式校准方程来确定第一化学成分的参数。