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    Atmospheric pressure charged particle discriminator for mass spectrometry
    11.
    发明申请
    Atmospheric pressure charged particle discriminator for mass spectrometry 审中-公开
    用于质谱的大气压电荷粒子鉴别器

    公开(公告)号：US20060118715A1

    公开(公告)日：2006-06-08

    申请号：US11330605

    申请日：2006-01-12

    Applicant: Bradley Schneider ,  Thomas Covey

    Inventor： Bradley Schneider ,  Thomas Covey

    IPC: B01D59/44

    CPC classification number: H01J49/06 ,  H01J49/044

    Abstract: An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.

    Abstract translation: 用于执行质谱的装置和方法使用离子界面来提供在离子流进入真空室之前从大气压离子源（例如电喷雾源或MALDI源）从离子流中除去不期望的微粒的功能， 质谱仪。 离子界面包括具有孔的入口单元，其可以在离子源是电喷雾源时被加热用于对带电液滴进行脱溶剂;以及颗粒鉴别单元，孔设置在入口单元的孔的下游，并且在通向孔 真空室。 颗粒鉴别池产生气体动态和电场条件，其使得能够从离子流中分离不期望的带电粒子。

    Ionization by droplet impact
    12.
    发明申请
    Ionization by droplet impact 有权
    电离液滴影响

    公开(公告)号：US20060108539A1

    公开(公告)日：2006-05-25

    申请号：US11264657

    申请日：2005-11-01

    Applicant: Jochen Franzen

    Inventor： Jochen Franzen

    IPC: H01J49/00

    CPC classification number: H01J49/165 ,  G01N27/68 ,  H01J49/0404 ,  H01J49/044

    Abstract: The invention relates to methods and instruments for ionizing analyte molecules, preferably biomolecules, which are dissolved in liquids or firmly adsorbed on surfaces. Liquids are nebulized at atmospheric pressure by electrospraying. Highly charged microdroplets, which enter the vacuum of the mass spectrometer through the inlet capillary, strike an impact plate when energy is fed in. The repulsive Coulomb force of the charges, the absorption of additional thermal energy and/or the conversion of their kinetic energy into thermal energy cause the microdroplets to burst and evaporate. Analyte molecules which are located in the nebulized liquid or on the impact plate are released in charged form and can be fed to the mass spectrometer for analysis by the extraction and collection effect of an ion funnel operated with RF and DC voltages.

    Abstract translation: 本发明涉及用于电离被分析物分子（优选生物分子）的方法和仪器，它们溶于液体或牢固地吸附在表面上。 液体通过电喷雾在大气压下雾化。 通过入口毛细管进入质谱仪的真空的高电荷微滴在进入能量时撞击冲击板。电荷的排斥库仑力，附加热能的吸收和/或其动能转化 进入热能导致微滴爆裂和蒸发。 位于雾化液体或冲击板上的分析物分子以带电的形式释放，并且可以通过用RF和DC电压操作的离子漏斗的提取和收集效应进料到质谱仪进行分析。

    Mass spectrometer
    13.
    发明申请
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US20040262512A1

    公开(公告)日：2004-12-30

    申请号：US10494335

    申请日：2004-04-30

    Inventor： Tomoyuki Tobita ,  Toshihiro Ishizuka ,  Masaru Tomioka ,  Kiyomi Yoshinari ,  Masami Sakamoto

    IPC: H01J049/00

    CPC classification number: H01J49/067 ,  H01J49/044

    Abstract: In a mass spectrometer utilizing an atmospheric pressure ion source, the amount of un-vaporized droplets that reach a mass spectrometric section is reduced. A mass spectrometer comprises: an ionization section for ionizing a sample at substantially atmospheric pressure; a first and a second intermediate pressure section in which the pressure is maintained lower than the pressure in said ionization section; a high vacuum section in which the pressure is maintained lower than the pressure in said intermediate pressure section and in which a mass spectrometric means for subjecting ions to mass spectrometry is disposed; a first pore electrode disposed between said ionization section and said first intermediate pressure section; an intermediate pore electrode disposed between said first intermediate pressure section and said second intermediate pressure section; and a second pore electrode disposed between said second intermediate pressure section and said high vacuum section. A first converging electrode is provided in the first intermediate pressure section, the first converging electrode having an opening towards the first pore electrode and another opening towards the intermediate pore electrode. The opening towards the first pore electrode has a larger diameter than the opening towards the intermediate pore electrode, such that the first converging electrode has a tapered shape.

    Abstract translation: 在使用大气压离子源的质谱仪中，达到质谱分析的未汽化液滴的量减少。 质谱仪包括：用于在基本上大气压下电离样品的电离部分; 第一和第二中间压力段，其中所述压力保持低于所述电离部分中的压力; 其中压力保持低于所述中压部分中的压力并且其中设置用于使离子进行质谱分析的质谱装置的高真空部分; 设置在所述电离部和所述第一中间压部之间的第一孔电极; 设置在所述第一中间压力部分和所述第二中间压力部分之间的中间孔电极; 以及设置在所述第二中间压力部分和所述高真空部分之间的第二孔电极。 第一会聚电极设置在第一中间压力部分中，第一会聚电极具有朝向第一孔电极的开口和朝向中间孔电极的另一开口。 朝向第一孔电极的开口具有比朝向中间孔电极的开口更大的直径，使得第一会聚电极具有锥形形状。

    Atmospheric pressure ionization ion mobility spectrometry
    14.
    发明申请
    Atmospheric pressure ionization ion mobility spectrometry 失效
    大气压电离离子迁移谱

    公开(公告)号：US20020113207A1

    公开(公告)日：2002-08-22

    申请号：US09788837

    申请日：2001-02-20

    Inventor： Milton L. Lee ,  David C. Collins

    IPC: H01J049/00 ,  B01D059/44

    CPC classification number: H01J49/044 ,  G01N27/622 ,  H01J49/165

    Abstract: A high voltage ion propulsion field is applied across the length of an ion mobility spectrometer that is divided by a barrier wall into a desolvation region and a drift tube. A plume of ions and solvent is electrosprayed into the desolvation region, and ions are propelled from the desolvation region through the drift tube to an ion target. Drift gas flows through the drift tube in the opposite direction to oppose the ion flow. A portal in the barrier wall permits ions to move from the desolvation region into the drift tube, and restricts flow of drift gas from the drift tube into the desolvation region. The resulting drift gas velocity increase effects desolvation without requiring elevated temperature or decreased pressure. An ion gate is located near the portal and an aperture grid is located near the ion target. The drift gas flow rate is varied to change the ionization spectra to alter selectivity.

    Abstract translation: 将高压离子推进场施加在离子迁移谱仪的长度上，隔离壁被隔离区域和漂移管分隔开。 离子和溶剂的羽流电喷雾到去溶剂化区域，离子从去溶剂化区域通过漂移管推进到离子靶。 漂移气体在相反方向流过漂移管，以反对离子流。 阻挡壁中的入口允许离子从去溶剂化区域移动到漂移管中，并且将漂移气体从漂移管的流动限制到去溶剂化区域中。 所产生的漂移气体速度增加了脱溶剂的作用，而不需要升高的温度或降低的压力。 离子门位于门口附近，孔格栅位于离子靶附近。 改变漂移气体流速以改变电离光谱以改变选择性。

    Ion trap mass spectrometer and ion trap mass spectrometry
    16.
    发明授权
    Ion trap mass spectrometer and ion trap mass spectrometry 失效
    离子阱质谱仪和离子阱质谱法

    公开(公告)号：US5994697A

    公开(公告)日：1999-11-30

    申请号：US61699

    申请日：1998-04-16

    Applicant: Yoshiaki Kato

    Inventor： Yoshiaki Kato

    IPC: G01N27/62 ,  H01J49/04 ,  H01J49/42 ,  B01D59/44 ,  H01J49/00

    CPC classification number: H01J49/424 ,  H01J49/044 ,  H01J49/0481

    Abstract: In the operation of a ion trap mass spectrometer, a high temperature gas at about 300.degree. C. is introduced as a buffer gas. As a result, water molecules absorbed on the inner wall of the quadrupole electrodes of the ion trap mass spectrometer are desorbed and evacuated. Further, the quadrupole electrodes themselves and vacuum chamber are also heated. As the high temperature gas is introduced into the ion trap space, the time necessary for evacuating the ion trap space is shortened and the noise during the measurement time is effectively reduced. During the measurement time, the temperature is controlled to be low, and the thermal degradation of the sample is prevented.

    Abstract translation: 在离子阱质谱仪的操作中，引入约300℃的高温气体作为缓冲气体。 结果，吸附在离子阱质谱仪的四极电极的内壁上的水分子解吸和抽真空。 此外，四极电极本身和真空室也被加热。 当高温气体被引入到离子阱空间中时，疏散离子阱空间所需的时间被缩短，并且有效地降低了测量时间期间的噪声。 在测量时间期间，将温度控制得较低，并且可以防止样品的热降解。

    Atmospheric pressure ion interface for a mass analyzer
    17.
    发明授权
    Atmospheric pressure ion interface for a mass analyzer 失效
    用于质量分析仪的大气压离子界面

    公开(公告)号：US5352892A

    公开(公告)日：1994-10-04

    申请号：US9063

    申请日：1993-01-26

    Applicant: Alex Mordehai ,  Gerard Hopfgartner ,  John D. Henion

    Inventor： Alex Mordehai ,  Gerard Hopfgartner ,  John D. Henion

    IPC: G01N27/62 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10 ,  B01D59/44 ,  H01J49/00

    CPC classification number: H01J49/067 ,  G01N30/7266 ,  H01J49/044 ,  G01N30/7246 ,  G01N30/7273

    Abstract: A novel atmospheric pressure ionization device for the transport of charged particle produced by at atmospheric pressure to a mass analyzer includes a liquid shield between the particle source and the sample inlet into the mass analyzer. The liquid shield may be in the form of a disk with a central aperture and acts as a spray splitter and aerofocusing device which increases the flow rate of a liquid sample into the analyzer. The mass analyzer is located in a high vacuum region and an intermediate low vacuum region is provided between the sample inlet and the analyzer. An ion optical system includes electrostatic lens assemblies in said vacuum regions for transporting charged particles from the inlet to the analyzer.

    Abstract translation: 用于将通过大气压产生的带电粒子输送到质量分析器的新型大气压电离装置包括在粒子源和质量分析器的样品入口之间的液体屏蔽。 液体屏蔽可以是具有中心孔的盘的形式，并且用作喷雾分离器和空气聚焦装置，其将液体样品的流速增加到分析器中。 质量分析仪位于高真空区域，并且在样品入口和分析仪之间提供中间低真空区域。 离子光学系统包括在所述真空区域中的静电透镜组件，用于将带电粒子从入口传送到分析器。

    IONIZATION DEVICE AND IONIZATION METHOD
    18.
    发明公开
    IONIZATION DEVICE AND IONIZATION METHOD 审中-公开

    公开(公告)号：US20230420239A1

    公开(公告)日：2023-12-28

    申请号：US17960447

    申请日：2022-10-05

    Applicant: Shimadzu Corporation

    Inventor： Keisuke ISO

    IPC: H01J49/16 ,  H01J49/04 ,  G01N30/72

    CPC classification number: H01J49/165 ,  H01J49/044 ,  H01J49/0477 ,  G01N30/7246

    Abstract: In an ionization device for an ionization chamber (11) separated from an analysis chamber (12-14) by a partition wall having an ion introduction port (113), an ionization probe (111) sprays a liquid sample. A heated-gas supply mechanism (112), which includes a gas supply source and a heating section (1122) for heating a gas supplied from the gas supply source, expels the gas in a direction intersecting with the direction in which the liquid sample is sprayed from the ionization probe. A controller (32) controls an operation of the heated-gas supply mechanism so that the gas is continuously expelled from the heated-gas supply mechanism regardless of the presence or absence of an operation by a user while the liquid sample is sprayed from the ionization probe. The continuous expulsion of the gas from the heated-gas supply mechanism prevents this mechanism from being contaminated by the sprayed liquid.

    LIQUID SAMPLE ANALYSIS SYSTEM
    19.
    发明申请
    LIQUID SAMPLE ANALYSIS SYSTEM 审中-公开

    公开(公告)号：US20180372696A1

    公开(公告)日：2018-12-27

    申请号：US15780829

    申请日：2015-12-04

    Applicant: SHIMADZU CORPORATION

    Inventor： Kazuma MAEDA

    IPC: G01N30/72 ,  H01J49/04 ,  H01J49/10

    CPC classification number: G01N30/724 ,  G01N27/62 ,  G01N30/72 ,  G01N30/7273 ,  G01N2030/027 ,  G01N2030/626 ,  H01J49/0031 ,  H01J49/0431 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/107 ,  H01J49/165

    Abstract: A liquid sample analyzing system including an ion analyzer having a first ion source receiving a target sample and a second ion source receiving a reference sample; a liquid sample introduction mechanism 3 including a passage-switching section introducing reference samples into the second ion source; and a controller for repeatedly performing a series of steps in the ion analyzer, the steps including: a pre-measurement step for initiating a measurement; a measurement step for introducing a target sample into the first ion source and performing a measurement on an ion originating from the target sample along with an ion originating from a reference sample introduced into the second ion source by the liquid sample introduction mechanism; and a post-measurement step where the liquid sample introduction mechanism operates concurrently with the predetermined post-measurement step to switch the passage-switching section to a passage having a reference sample for the next analysis.

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