公开(公告)号：US09981266B2

公开(公告)日：2018-05-29

申请号：US14803594

申请日：2015-07-20

Applicant: OPKO Diagnostics, LLC

Inventor： Vincent Linder ,  David Steinmiller

IPC: G01N35/08 ,  B01L3/00 ,  G01N21/59 ,  G01N33/543 ,  G01N33/574 ,  B01L7/00

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.

公开(公告)号：US20180134973A1

公开(公告)日：2018-05-17

申请号：US15870864

申请日：2018-01-13

Applicant: Honeywell Limited

Inventor： Markku Kellomaki

IPC: C10G47/36 ,  G01N15/06 ,  C10G47/02 ,  G01N15/02

CPC classification number: C10G47/36 ,  C10G47/00 ,  C10G47/02 ,  C10G47/26 ,  G01N15/0205 ,  G01N15/0227 ,  G01N15/06 ,  G01N21/21 ,  G01N21/23 ,  G01N33/2835 ,  G01N2015/0053 ,  G01N2015/0693 ,  G01N2021/216 ,  G01N2021/479 ,  G01N2021/4792 ,  G01N2201/0612 ,  G01N2201/0697

Abstract: On-line detection of mesophase particles employs a laser diode light source to illuminate a target area with a pulsed laser linearly or circularly polarized probe beam. Analysis of images determines extent of presence the birefringent mesophase particles, which are precursors to coking in catalytic hydrocracking processes. The inherently polarized low-coherence, unfocused but sufficiently collimated, pulsed laser beam yield sharp imaging with high depth of field of very small mesophase particles that are present in a moving, dark reactor liquid environment.

公开(公告)号：US20180120344A1

公开(公告)日：2018-05-03

申请号：US15348848

申请日：2016-11-10

Applicant: Anasys Instruments

Inventor： Craig Prater ,  Kevin Kjoller

IPC: G01Q30/02 ,  G01Q60/34 ,  G01N21/35

CPC classification number: G01Q30/02 ,  G01N21/35 ,  G01N21/3563 ,  G01N2201/0612 ,  G01N2201/12 ,  G01Q60/34

Abstract: Methods and apparatus for obtaining extremely high sensitivity chemical composition maps with spatial resolution down to a few nanometers. In some embodiments these chemical composition maps are created using a combination of three techniques: (1) Illuminating the sample with IR radiation than is tuned to an absorption band in the sample; and (2) Optimizing a mechanical coupling efficiency that is tuned to a specific target material; (3) Optimizing a resonant detection that is tuned to a specific target material. With the combination of these steps it is possible to obtain (1) Chemical composition maps based on unique IR absorption; (2) spatial resolution that is enhanced by extremely short-range tip-sample interactions; and (3) resonant amplification tuned to a specific target material. In other embodiments it is possible to take advantage of any two of these steps and still achieve a substantial improvement in spatial resolution and/or sensitivity.

公开(公告)号：US09909990B1

公开(公告)日：2018-03-06

申请号：US15263063

申请日：2016-09-12

Applicant: Photon Systems, Inc.

Inventor： William F. Hug ,  Rohit Bhartia ,  Ray D. Reid ,  Arthur L. Lane

IPC: G01N21/64

CPC classification number: G01N21/64 ,  G01J3/10 ,  G01J3/36 ,  G01J3/44 ,  G01N21/6486 ,  G01N21/65 ,  G01N21/8806 ,  G01N27/44721 ,  G01N33/0047 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2201/06113 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/126

Abstract: Naphthalene, benzene, toluene, xylene, and other volatile organic compounds VOCs have been identified as serious health hazards. Embodiments of the invention are directed to methods and apparatus for near-real-time in-situ detection and accumulated dose measurement of exposure to naphthalene vapor and other hazardous gaseous VOCs. The methods and apparatus employ excitation of fluorophors native or endogenous to compounds of interest using light sources emitting in the ultraviolet below 300 nm and measurement of native fluorescence emissions in distinct wavebands above the excitation wavelength. The apparatus of some embodiments are cell-phone-sized sensor/dosimeter “badges” to be worn by personnel potentially exposed to hazardous VOCs. The badge sensor of some embodiments provides both real time detection and data logging of exposure to naphthalene or other VOCs of interest from which both instantaneous and accumulated dose can be determined.

公开(公告)号：US20180038787A1

公开(公告)日：2018-02-08

申请号：US15671040

申请日：2017-08-07

Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

Inventor： Sean E. Salazar ,  Richard A. Coffman ,  Cyrus D. Garner

IPC: G01N21/3554 ,  G01N21/359 ,  G01N33/24 ,  G01S17/88

CPC classification number: G01N21/3554 ,  G01N21/359 ,  G01N33/246 ,  G01N2021/1797 ,  G01N2201/0612 ,  G01S17/88

Abstract: A soil analysis system that provides a field deployable device that is configured to remotely measure in situ soil suction through correlation with relative humidity at the soil surface.

公开(公告)号：US09880106B2

公开(公告)日：2018-01-30

申请号：US14845918

申请日：2015-09-04

Applicant: KOITO MANUFACTURING CO., LTD.

Inventor： Tomoyuki Ichikawa

IPC: H02H3/00 ,  G01N21/95 ,  F21S8/10 ,  H02H7/20 ,  G01N21/47 ,  G01N21/64 ,  H05B37/03 ,  H01S5/00 ,  H01S5/068

CPC classification number: G01N21/95 ,  F21S41/14 ,  F21S41/16 ,  G01N21/4788 ,  G01N21/645 ,  G01N2201/0612 ,  H01S5/0092 ,  H01S5/06825 ,  H02H7/20 ,  H05B37/03

Abstract: An abnormality detector for a light source includes a laser diode which emits an excitation light and a fluorescent substance which is excited by the excitation light to generate a fluorescent light. The abnormality detector includes a first photo sensor which is sensitive to a wavelength of the excitation light, a second photo sensor which is sensitive to a wavelength of the fluorescent light, a first current-voltage conversion circuit which outputs a first detection signal based on an output of the first photo sensor, a second current-voltage conversion circuit which outputs a second detection signal based on an output of the second photo sensor, and a determination unit which determines whether an abnormality occurs based on the first detection signal and the second detection signal.

公开(公告)号：US09863880B2

公开(公告)日：2018-01-09

申请号：US14543867

申请日：2014-11-17

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid ,  Benjamin Cipriany ,  Jack Jewell ,  Lawrence West ,  Michael Ferrigno ,  Paul E. Glenn ,  Adam E. Cohen ,  Anthony Bellofiore

IPC: C12M1/00 ,  G01N21/64 ,  C12Q1/68 ,  G01N21/77

CPC classification number: G01N21/6486 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2300/0893 ,  B01L2300/168 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q2521/101 ,  C12Q2537/157 ,  C12Q2563/107 ,  C12Q2565/607 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/648 ,  G01N21/7743 ,  G01N21/7746 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6478 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/125 ,  Y10T29/49016 ,  C12Q2525/101

Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.

公开(公告)号：US09851248B2

公开(公告)日：2017-12-26

申请号：US14961872

申请日：2015-12-07

Applicant: EMX International, LLC

Inventor： Daniel Lee Graybeal ,  Alan Carey Rogers ,  Andrey Muraview ,  Charles Mark Carnifax ,  Robert E. Peale

IPC: G01J5/02 ,  G01J3/10 ,  G01J3/42 ,  G01J3/02 ,  G01N21/3504 ,  G01N21/39 ,  H01S5/34

CPC classification number: G01J3/10 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0245 ,  G01J3/108 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/39 ,  G01N2021/399 ,  G01N2201/06113 ,  G01N2201/0612 ,  G01N2201/0691 ,  G01N2201/0697 ,  G01N2201/08 ,  H01S5/3401

Abstract: An intracavity laser absorption infrared spectroscopy system for detecting trace analytes in vapor samples. The system uses a spectrometer in communications with control electronics, wherein the control electronics contain an analyte database that contains absorption profiles for each analyte the system is used to detect. The system can not only detect the presence of specific analytes, but identify them as well. The spectrometer uses a hollow cavity waveguide that creates a continuous loop inside of the device, thus creating a large path length and eliminating the need to mechanically adjust the path length to achieve a high Q-factor. In a preferred embodiment, the laser source may serve as the detector, thus eliminating the need for a separate detector.

公开(公告)号：US09841371B2

公开(公告)日：2017-12-12

申请号：US14516772

申请日：2014-10-17

Applicant: Thermo Scientific Portable Analytical Instruments Inc.

Inventor： Kevin J. Knopp ,  Robert L. Green ,  Brendon D. Tower ,  Christopher D. Brown ,  Gregory H. Vander Rhodes

IPC: G01N21/17 ,  G01J3/02 ,  G01J3/44 ,  G01N21/47 ,  G01N21/65 ,  G01J3/42 ,  G01N21/55 ,  G01N21/59 ,  G01N21/35

CPC classification number: G01N21/17 ,  G01J3/02 ,  G01J3/0232 ,  G01J3/0262 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/42 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/47 ,  G01N21/4738 ,  G01N21/55 ,  G01N21/59 ,  G01N21/65 ,  G01N2021/3595 ,  G01N2201/0221 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/105 ,  G01N2201/125

Abstract: Disclosed are apparatus, kits, methods, and systems that include a radiation source configured to direct radiation to a sample; a detector configured to measure radiation from the sample; an electronic processor configured to determine information about the sample based on the measured radiation; a housing enclosing the source, the detector, and the electronic processor, the housing having a hand-held form factor; an arm configured to maintain a separation between the sample and the housing, the arm including a first end configured to connect to the housing and a second end configured to contact the sample; and a layer positioned on the second end of the arm, the layer being configured to contact the sample and to transmit at least a portion of the radiation from the sample to the detector.

公开(公告)号：US09835550B2

公开(公告)日：2017-12-05

申请号：US15125901

申请日：2015-09-24

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Tsutomu Kakuno ,  Shigeyuki Takagi ,  Yasutomo Shiomi ,  Akira Maekawa ,  Miyuki Kusaba ,  Hiroshi Hasegawa ,  Takashi Magara ,  Isao Muraoka

IPC: G01J5/02 ,  G01N21/3504 ,  G01N33/497

CPC classification number: G01N21/3504 ,  A61B5/0059 ,  A61B5/082 ,  A61B5/0833 ,  A61B5/0836 ,  A61B5/087 ,  G01N33/497 ,  G01N2033/4975 ,  G01N2201/0612 ,  G01N2201/12 ,  H01S5/22 ,  H01S5/3402

Abstract: A breath analyzer includes a light source, a gas cell, a detection unit and a data processing unit. The light source emits infrared light of a wavelength band including an absorption line for acetone. A breath containing sample gas is introduced to the gas cell. The infrared light is incident on the gas cell. The detection unit receives transmitted light emerging from the gas cell, and outputs a sample signal value corresponding to an acetone discharge amount. The data processing unit determines an approximation formula of dependence of fat oxidation rate on acetone discharge amount in advance, and calculates a fat oxidation rate for individual sample signal values using the approximation formula. When the acetone discharge amount (microliter/min) is x, the fat oxidation rate (milligram/min) y is approximated by a following formula: y=Ax+B (where A and B are constants).