公开(公告)号：US20160086785A1

公开(公告)日：2016-03-24

申请号：US14891620

申请日：2014-05-30

Applicant: UNIVERSITY OF WASHINGTON through its CENTER FOR COMMERCIALIZATION

Inventor： Daniel T. CHIU ,  Bejan HAKIMI ,  Dingsheng LIU ,  Frantisek TURECEK ,  Michael VOLNY ,  Joelle ROLFS

IPC: H01J49/16 ,  B05B5/025

CPC classification number: H01J49/165 ,  B05B5/025 ,  B05B5/03 ,  H01J49/0445

Abstract: The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer. The present disclosure further describes methods, systems, and apparatuses for using the devices and interfaces described to perform analysis, including mass spectrometry. The present disclosure also describes methods, systems, and apparatuses for generating and using multi-phase emulsions to perform analysis.

Abstract translation: 本公开描述了能够产生多相乳液的装置和方法，包括气相中的双乳液液滴。 本公开还描述了用于将多相乳液液滴源耦合到诸如质谱仪的分析仪器的界面。 本公开进一步描述了使用所描述的装置和接口进行分析的方法，系统和装置，包括质谱法。 本公开还描述了用于产生和使用多相乳液进行分析的方法，系统和装置。

公开(公告)号：US20150371837A1

公开(公告)日：2015-12-24

申请号：US14762916

申请日：2014-01-27

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Hiroyuki YASUDA ,  Shinya ITO ,  Akira FUJII ,  Yasushi TERUI

IPC: H01J49/04 ,  G01N30/72

CPC classification number: H01J49/0445 ,  G01N30/724 ,  H01J49/165

Abstract: A mass spectrometry is equipped with a liquid specimen supply part which supplies a liquid specimen sandwiched between bubbles, an ion source part ionizes the specimen, and a mass spectrometry part which detects ions separated in accordance with mass. In particular the ion source part is configured so as to include a liquid supply tube for transporting a specimen from the liquid specimen supply part, a degassing/liquid retention part in which bubbles are removed, a spraying part which ionizes the specimen, and a high-voltage power supply part which applies a high voltage to the spraying part. The device is further characterized in that after removing the bubbles, a Taylor cone is formed from the resultant pre-solution, and the specimen is ionized thereafter. Thus, the ionization of an intended specimen is stabilized, and the measurement reproducibility is improved.

Abstract translation: 质谱仪配备有液体试样供给部件，其供给夹在气泡之间的液体试样，离子源部件将样品离子化，以及检测根据质量分离的离子的质谱部分。 特别地，离子源部构成为包括用于从液体试样供给部输送试样的液体供给管，除去气泡的脱气/液体滞留部，使样本电离的喷射部， - 对喷涂部施加高电压的电压电源部。 该装置的特征还在于，在除去气泡之后，由所得预溶液形成泰勒锥体，然后将样品电离。 因此，期望的样品的电离稳定，并且测量再现性提高。

公开(公告)号：US09209003B2

公开(公告)日：2015-12-08

申请号：US14354313

申请日：2012-10-26

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD. ,  PHYTRONIX TECHNOLOGIES INC.

Inventor： Serge Auger ,  Gregory Blachon ,  Hesham Ghobarah ,  Michael Jarvis ,  Pierre Picard

IPC: H01J49/04 ,  G01N33/82 ,  H01J49/36 ,  H01J49/00 ,  H01J49/16 ,  G01N27/62

CPC classification number: H01J49/0031 ,  G01N27/624 ,  G01N33/82 ,  H01J49/0431 ,  H01J49/0445 ,  H01J49/0463 ,  H01J49/168

Abstract: Methods and systems for quantifying analytes in a biological sample are provided comprising preparing a biological sample for mass spectrometric analysis, utilizing an ionization source to ionize at least a portion of the prepared biological sample to generate an ionized analyte flow, introducing the ionized analyte flow into a differential mobility spectrometer set at a compensation voltage selected to extract ionized analyte molecules from the ionized analyte flow, introducing an output analyte flow of the differential mobility spectrometer into a mass spectrometer to detect and quantify analyte ions in the output analyte flow.

Abstract translation: 提供了用于量化生物样品中分析物的方法和系统，包括制备用于质谱分析的生物样品，利用电离源将至少一部分制备的生物样品电离以产生电离的分析物流，将电离的分析物流引入 差示迁移率光谱仪设置在选择的电压分析物流中的离子化分析物分子的选择补偿电压，将差分迁移率光谱仪的输出分析物流引入质谱仪中，以检测和量化输出分析物流中的分析物离子。

公开(公告)号：US20150340219A1

公开(公告)日：2015-11-26

申请号：US14402278

申请日：2013-06-05

Applicant: The University of North Carolina at Chapel Hill

Inventor： John Scott Mellors ,  John Michael Ramsey ,  Nicholas George Batz

IPC: H01J49/04 ,  H01J49/16 ,  H01J49/26 ,  G01N27/447

CPC classification number: H01J49/165 ,  G01N27/4473 ,  G01N27/44743 ,  G01N27/44791 ,  G01N30/7266 ,  H01J49/0431 ,  H01J49/0445 ,  H01J49/26

Abstract: Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one ESI emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one ESI emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one ESI emitter thereby preferentially directing analyte molecules out of the at least one ESI emitter. The methods, systems and devices are particularly suitable for use with a mass spectrometer.

Abstract translation: 在具有至少一个流体样品分离流动通道的流体装置中产生差分轴向输送的方法，系统和装置以及与所述至少一个样品分离流动通道连通的至少一个ESI发射器。 响应于产生的差分轴向传输，包含在与样品分离通道连通的样品储存器中的至少一个目标分析物被选择性地输送到至少一个ESI发射体，同时抑制样品储存器中包含的污染物质向着 至少一个ESI发射体从而优先地将分析物分子导出至少一个ESI发射体。 方法，系统和装置特别适用于质谱仪。

公开(公告)号：US09184036B2

公开(公告)日：2015-11-10

申请号：US13887911

申请日：2013-05-06

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Jason Duncan ,  Guangming Huang ,  Guangtao Li ,  Xin Yan ,  Ewa Sokol ,  Xin Li

IPC: G01N24/00 ,  H01J49/04 ,  G01N27/62 ,  H01J49/00

CPC classification number: H01J49/04 ,  G01N27/62 ,  H01J49/0031 ,  H01J49/0445 ,  H01J49/4205 ,  Y10T436/24

Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

Abstract translation: 本发明一般涉及用于使离子产生与不连续大气界面的循环同步的方法和装置。 在某些实施方案中，本发明提供了一种用于分析样品的系统，该样品包括产生样品离子的质谱探针，不连续大气界面和质量分析仪，其中该系统配置成使得离子形成与 不连续大气界面。

公开(公告)号：US09111739B2

公开(公告)日：2015-08-18

申请号：US13491331

申请日：2012-06-07

Applicant: Kenzo Hiraoka

Inventor： Kenzo Hiraoka

IPC: H01J49/26 ,  H01J49/16 ,  G01N30/72 ,  G01N1/38

CPC classification number: H01J49/165 ,  G01N1/38 ,  G01N30/7266 ,  H01J49/0404 ,  H01J49/0445 ,  H01J49/167

Abstract: It is arranged so that living tissue that has not been pretreated can be adopted as a sample of interest. A sample is introduced into at least a tip portion of a hollow insulated sample holder 11 having a small hole 11a in the tip portion. A slender metal wire 12, which has been inserted into the sample holder 11 from the rear, is projected outwardly from the sample holder 11 through the hole 11a while being brought into contact with the sample. A high voltage is applied to the slender metal wire 12 at least in a portion of a time period in which the tip of the slender metal wire 12 is being projected outwardly from the hole 11a, thereby ionizing, by electrospray, the sample adhering to the tip of the slender metal wire 12. The ions are introduced into an analyzing apparatus and are analyzed.

Abstract translation: 可以采用未经预处理的活体组织作为感兴趣的样本。 至少在尖端部分具有小孔11a的中空绝缘样品保持器11的尖端部分中引入样品。 已经从后方插入到样品保持器11中的细长金属线12在与样品接触的同时通过孔11a从样品保持器11向外突出。 至少在细长金属线12的前端从孔11a向外突出的时间段的至少一部分时间内对细长的金属线12施加高电压，从而通过电喷雾使附着在 细长金属线12的尖端。将离子引入分析装置并进行分析。

公开(公告)号：US20150144781A1

公开(公告)日：2015-05-28

申请号：US14409735

申请日：2013-06-17

Applicant: Micromass UK Limited

Inventor： Kevin R. Howes ,  Simon Meffan-Main ,  Richard B. Moulds

IPC: H01J49/10 ,  H01J49/00 ,  H01J49/04

CPC classification number: H01J49/10 ,  H01J49/0031 ,  H01J49/0431 ,  H01J49/0445 ,  H01J49/045 ,  H01J49/16

Abstract: A method for controlling the supply of ions from a liquid chromatograph through an ion source into a mass spectrometer. The ion source is foreseen to be either an electrospray ionization sources or an impaction spraying ion sources. The ion source can be operated in two modes: a mode in which ions are supplied into the mass spectrometer and a mode in which ions are prevented to be supplied into the mass spectrometer. In this latter mode, the supply of ions into the mass spectrometer is prevented by reducing the potential applied to the ionization source, reducing the nebulizer gas flow and/or increasing the cone gas flow.

Abstract translation: 用于控制从液相色谱仪通过离子源将离子供给到质谱仪中的方法。 离子源可预见为电喷雾离子源或冲击喷射离子源。 离子源可以以两种模式操作：将离子供给到质谱仪中的模式以及防止将离子供给到质谱仪中的模式。 在后一种模式中，通过降低施加到电离源的电位，减少雾化器气体流量和/或增加锥形气体流量来防止向质谱仪中提供离子。

公开(公告)号：US20140374589A1

公开(公告)日：2014-12-25

申请号：US14375497

申请日：2013-02-01

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Hassan Javaheri ,  Bruce A. Thomson

IPC: H01J49/06 ,  H01J49/24 ,  H01J49/00 ,  H01J49/26

CPC classification number: H01J49/063 ,  H01J49/0031 ,  H01J49/0445 ,  H01J49/062 ,  H01J49/24 ,  H01J49/26

Abstract: Ions are generated in a high pressure region and are passed into a vacuum chamber having an inlet and an exit aperture. The configuration of the inlet aperture and the pressure difference between the high pressure region and the vacuum chamber provides a supersonic free jet expansion that has a barrel shock of predetermined diameter. At least one ion guide is provided between the inlet and exit apertures having a predetermined cross-section defining an internal volume wherein the cross-section of the at least one ion guide is sized to be at least 50% of the predetermined diameter of the barrel shock of the supersonic free jet expansion. An RF voltage is provided to the at least one ion guide. Radial gas conductance is reduced in a first section of the at least one ion guide for damping shock waves resulting from the supersonic free jet expansion.

Abstract translation: 离子在高压区域产生，并且进入具有入口和出口的真空室。 入口孔的构型和高压区域与真空室之间的压力差提供超音速自由射流膨胀，其具有预定直径的桶形冲击。 至少一个离子导向件设置在入口孔和出口孔之间，其具有限定内部体积的预定横截面，其中至少一个离子导向件的横截面的尺寸被设定为桶的预定直径的至少50％ 超音速自由射流膨胀的冲击。 向至少一个离子导向器提供RF电压。 径向气体导电在至少一个离子导向器的第一部分中减小，用于阻尼由超音速自由射流膨胀产生的冲击波。

公开(公告)号：US08809775B2

公开(公告)日：2014-08-19

申请号：US13816136

申请日：2010-08-10

Applicant: Hermann Wollnik

Inventor： Hermann Wollnik

IPC: H01J49/00

CPC classification number: H01J49/0422 ,  G01N27/624 ,  H01J49/0445

Abstract: A curtain-gas filter for a mass- or mobility-spectrometer that bars gases or vapors of a high-flux atmospheric pressure ion source, as we ions of high mobility and charged droplets, from entering an evacuated mass spectrometer or a mobility spectrometer that is at a lower pressure than the main filter volume of the curtain-gas filter. A portion of the ion-source buffer gas in the ion-source plume is sucked through an ion-source buffer gas inlet into the main filter volume of the curtain-gas filter, from where this ion-source gas is exhausted after a properly shaped electric field has pushed a large portion of the embedded ions into an externally provided stream of a clean buffer gas, which is sucked through a passage into a mass- or mobility-spectrometer that is at a lower pressure.

Abstract translation: 用于大规模或迁移率光谱仪的帘式气体过滤器，其将高通量大气压离子源的气体或蒸气截留，因为高迁移率和带电液滴的离子进入抽真空的质谱仪或迁移谱仪 在低于帘式气体过滤器的主过滤器体积的压力下。 离子源羽流中的一部分离子源缓冲气体通过离子源缓冲气体入口被吸入到幕式气体过滤器的主过滤器体积中，从该离子源缓冲气体中排出适当的形状 电场将大部分嵌入式离子推入干净的缓冲气体的外部提供的流中，该干净的缓冲气体通过通道被吸入到处于较低压力的质谱仪或移动光谱仪中。

公开(公告)号：US20140147921A1

公开(公告)日：2014-05-29

申请号：US13697621

申请日：2011-05-17

Applicant: Hao Chen ,  Zhixin Miao

Inventor： Hao Chen ,  Zhixin Miao

IPC: G01N27/68 ,  G01N33/487

CPC classification number: G01N27/68 ,  G01N1/00 ,  G01N33/48707 ,  G01N33/6848 ,  H01J49/0445 ,  H01J49/045 ,  H01J49/145 ,  H01J49/165

Abstract: A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization (10) was described for the kinetic study of fast reactions. The device includes a liquid jet generator (64) that is configured to emit a continuous liquid jet (50) having a length. An ambient ionization source (10) is directed toward a selected variable location along the continuous liquid jet (50) to desorb at least a portion of the continuous liquid jet (50). A mass analyzer (30) analyzes a mass-to-charge ratio of an ionized sample that is within the desorbed portion of the continuous liquid jet (50). The acquired mass spectra reflect the reaction progress in different reaction times and, therefore, may be used to derive the reaction rate.

Abstract translation: 描述了用于快速反应的动力学研究的微秒时间分辨质谱装置和使用解吸电喷雾电离的方法（10）。 该装置包括液体喷射发生器（64），其构造成发射具有长度的连续液体射流（50）。 环境电离源（10）沿着连续液体射流（50）指向选定的可变位置以解吸至少一部分连续液体射流（50）。 质量分析器（30）分析在连续液体射流（50）的解吸附部分内的电离样品的质荷比。 所获得的质谱反映了不同反应时间的反应进程，因此可用于得到反应速率。