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    Apparatus and Methods for Ion Mobility Spectrometry
    22.
    发明申请
    Apparatus and Methods for Ion Mobility Spectrometry 有权
    离子流动光谱仪的设备与方法

    公开(公告)号：US20160084799A1

    公开(公告)日：2016-03-24

    申请号：US14947119

    申请日：2015-11-20

    Applicant: Thermo Fisher Scientific (Bremen) GmbH

    Inventor： Alexander MAKAROV

    IPC: G01N27/62 ,  H01J49/24 ,  H01J49/00 ,  H01J49/06

    CPC classification number: G01N27/622 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/061 ,  H01J49/063 ,  H01J49/24

    Abstract: A method of ion mobility spectrometry wherein ions undergo multiple stages of ion mobility separation and multiple stages of inertial ion motion wherein the mean free path between ion collisions with gas is significantly longer than in the stages of ion mobility separation, wherein each stage of inertial ion motion lies between successive stages of ion mobility separation.

    Abstract translation: 一种离子迁移光谱法，其中离子经历多个离子迁移分离阶段和多个阶段的惯性离子运动，其中离子碰撞与气体之间的平均自由程度明显长于离子迁移率分离阶段，其中每个阶段的惯性离子 运动位于离子迁移分离的连续阶段之间。

    Ion gate method and apparatus
    23.
    发明授权
    Ion gate method and apparatus 有权
    离子浇口法和装置

    公开(公告)号：US09177770B2

    公开(公告)日：2015-11-03

    申请号：US12763092

    申请日：2010-04-19

    Applicant: Mark A. Osgood ,  Ching Wu

    Inventor： Mark A. Osgood ,  Ching Wu

    IPC: H01J49/06 ,  G01N27/62 ,  C07B63/00

    CPC classification number: H01J49/061 ,  C07B63/00 ,  G01N27/622 ,  Y10T29/49227

    Abstract: The present invention generally relates to systems and methods for transmitting beams of charged particles, and in particular to such systems and methods that employ defecting at least one set of grid elements into the same plane to form an ion gate. In addition, an operation method of closing a gate involving alternating voltages on the adjacent gate wires is described.

    Abstract translation: 本发明一般涉及用于传送带电粒子束的系统和方法，特别涉及这样的系统和方法，该系统和方法使用将至少一组栅格元件缺陷到同一平面中以形成离子门。 此外，描述了在相邻栅极线上闭合涉及交流电压的栅极的操作方法。

    Multireflection Time-of-flight Mass Spectrometer
    24.
    发明申请
    Multireflection Time-of-flight Mass Spectrometer 有权
    多反射飞行时间质谱仪

    公开(公告)号：US20150294849A1

    公开(公告)日：2015-10-15

    申请号：US14748582

    申请日：2015-06-24

    Applicant: Alexander A. MAKAROV ,  Dmitry E. GRINFELD ,  Mikhail A. MONASTYRSKIY

    Inventor： Alexander A. MAKAROV ,  Dmitry E. GRINFELD ,  Mikhail A. MONASTYRSKIY

    IPC: H01J49/40 ,  H01J49/06

    CPC classification number: H01J49/406 ,  H01J49/061 ,  H01J49/405

    Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.

    Abstract translation: 公开了一种在多反射飞行时间质谱仪中反射离子的方法。 该方法包括将离子导向具有多个电极的离子反射镜，并向离子镜电极施加电压以产生电场，使得离子的平均轨迹与离子反射镜的对称平面相交并离开离子 反射镜，其中离子由反射镜在空间上聚焦到第一位置并且在时间上聚焦到与第一位置不同的第二位置。 还公开了用于执行该方法的装置。

    SYSTEMS AND METHODS FOR AUTOMATED OPTIMIZATION OF A MULTI-MODE INDUCTIVELY COUPLED PLASMA MASS SPECTROMETER
    26.
    发明申请
    SYSTEMS AND METHODS FOR AUTOMATED OPTIMIZATION OF A MULTI-MODE INDUCTIVELY COUPLED PLASMA MASS SPECTROMETER 审中-公开
    用于多模感应耦合等离子体质谱仪自动优化的系统和方法

    公开(公告)号：US20150235827A1

    公开(公告)日：2015-08-20

    申请号：US14622132

    申请日：2015-02-13

    Applicant: PerkinElmer Health Sciences, Inc.

    Inventor： Samad Bazargan ,  Hamid Badiei ,  Pritesh Patel

    IPC: H01J49/00 ,  H01J49/10

    CPC classification number: H01J49/0009 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/105

    Abstract: The present disclosure provides methods and systems for automated tuning of multimode inductively coupled plasma mass spectrometers (ICP-MS). In certain embodiments, a ‘single click’ optimization method is provided for a multi-mode ICP-MS system that automates tuning of the system in one or more modes selected from among the multiple modes, e.g., a vented cell mode, a reaction cell mode (e.g., dynamic reaction cell mode), and a collision cell mode (e.g., kinetic energy discrimination mode). Workflows and computational routines, including a dynamic range optimization technique, are presented that provide faster, more efficient, and more accurate tuning.

    Abstract translation: 本公开提供了用于多模感应耦合等离子体质谱仪（ICP-MS）的自动调谐的方法和系统。 在某些实施方案中，为多模式ICP-MS系统提供了“单击”优化方法，该多模式ICP-MS系统以从多个模式中选出的一种或多种模式自动调整系统，例如通气单元模式，反应单元 模式（例如，动态反应单元模式）和碰撞单元模式（例如，动能辨别模式）。 提出了工作流程和计算程序，包括动态范围优化技术，提供更快，更高效和更精确的调整。

    Mass spectrometry apparatus
    27.
    发明授权
    Mass spectrometry apparatus 有权
    质谱仪

    公开(公告)号：US09006646B2

    公开(公告)日：2015-04-14

    申请号：US13993709

    申请日：2012-01-25

    Applicant: Iouri Kalinitchenko

    Inventor： Iouri Kalinitchenko

    IPC: B01D59/44 ,  H01J49/00 ,  H01J49/10

    CPC classification number: H01J49/0013 ,  H01J49/061 ,  H01J49/105 ,  H01J49/24

    Abstract: There is provided a mass spectrometry apparatus comprising: an ion source arranged in a substantially horizontal orientation and from which a quantity of ions may be sourced, an ion filter device arranged for receiving a stream of ions for filtering thereof; and, an ion guide arranged so as to guide ions sourced from the ion source toward the ion filter device. The ion source and the ion filter device are arranged relative to one another so that the profile of the apparatus is reduced so as to minimize the effective footprint of the apparatus.

    Abstract translation: 提供了一种质谱装置，其包括：离子源，其基本上水平的方向布置，并且可以从其中获得一定量的离子;离子过滤器装置，被布置成用于接收用于过滤的离子流; 以及离子导向器，其被布置成将源自离子源的离子引导到离子过滤器装置。 离子源和离子过滤装置相对于彼此布置，使得装置的轮廓减小，以便最小化装置的有效占地面积。

    ION DEFLECTOR FOR A MASS SPECTROMETER
    28.
    发明申请
    ION DEFLECTOR FOR A MASS SPECTROMETER 有权
    离子发射器用于质谱仪

    公开(公告)号：US20150060687A1

    公开(公告)日：2015-03-05

    申请号：US14383265

    申请日：2013-03-20

    Applicant: Bruker Chemical Analysis BV

    Inventor： Iouri Kalinitchenko

    IPC: H01J49/22 ,  H01J49/06

    CPC classification number: H01J49/22 ,  H01J49/061 ,  H01J49/067

    Abstract: There is provided an ion deflector for use with a mass spectrometer for directing a flow of ions between two distinct axes of travel. The ion deflector includes an electric field inducer arranged so as to establish at least one electrostatic field capable of deflecting ions travelling substantially along a first intended path of travel so as to travel substantially along a second intended path of travel.

    Abstract translation: 提供了一种用于质谱仪的离子偏转器，用于在两个不同的行进轴线之间引导离子流。 离子导流器包括电场诱导器，其被布置成建立至少一个静电场，该静电场能够使基本沿着第一预期行进路径行进的离子偏转，从而基本上沿着第二预期行进路径行进。

    METHOD AND APPARATUS FOR DETERMINING A MOBILITY OF IONS
    30.
    发明申请
    METHOD AND APPARATUS FOR DETERMINING A MOBILITY OF IONS 有权
    用于确定离子的移动性的方法和装置

    公开(公告)号：US20140326869A1

    公开(公告)日：2014-11-06

    申请号：US14351655

    申请日：2012-08-13

    Applicant: Richard Knochenmuss

    Inventor： Richard Knochenmuss

    IPC: G01N27/62 ,  H01J49/02

    CPC classification number: G01N27/622 ,  H01J49/02 ,  H01J49/061 ,  H01J49/40

    Abstract: A method and an apparatus for determining a mobility of ions. The method includes the steps of modulating an ion beam with an ion gate which is controlled by a modulation function for generating a modulated ion beam, of guiding the modulated ion beam through a drifting region, of measuring a signal of the modulated ion beam after the modulated ion beam has passed the drifting region and of calculating a correlation of the modulation function and the signal in order to determine the mobility of the ions. The apparatus includes the ion gate, the drifting region through which the modulated ion beam is guidable, a detector by which the signal of the modulated ion beam is measurable after the modulated ion beam has passed the drifting region and a calculation unit by which the correlation of the modulation function and the signal is calculable in order to determine the mobility of the ions. An autocorrelation of the modulation function is a two-valued function.

    Abstract translation: 用于确定离子迁移率的方法和装置。 该方法包括以下步骤：用离子门调制离子束，该离子门由用于产生调制离子束的调制功能控制，该调制离子束将经调制的离子束引导通过漂移区，测量经过调制离子束的信号 调制离子束已经通过漂移区域并且计算调制函数和信号的相关性，以便确定离子的迁移率。 该装置包括离子门，经调制的离子束可引导的漂移区域，经调制的离子束已经通过漂移区域之后可测量调制的离子束的信号的检测器，以及计算单元， 的调制函数和信号是可计算的，以便确定离子的迁移率。 调制函数的自相关是一个二值函数。

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