公开(公告)号：US07456957B2

公开(公告)日：2008-11-25

申请号：US11196043

申请日：2005-08-03

Applicant: Matthew J. Everett ,  Yan Zhou ,  Jochen M. M. Horn ,  Keith O'Hara ,  James P. Foley

Inventor： Matthew J. Everett ,  Yan Zhou ,  Jochen M. M. Horn ,  Keith O'Hara ,  James P. Foley

IPC: G01J3/28

CPC classification number: G01N21/4795 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0224 ,  G01J3/0256 ,  G01J3/0286 ,  G01J3/18 ,  G01J3/22 ,  G02B5/1814 ,  G02B27/4244

Abstract: A compact conical diffraction Littrow spectrometer is disclosed. The distortion of the conically diffracted spectral component beams is compensated and as a result, the diffracted spectral beams can still be focused into a substantially straight line to shine onto a detector array. A spectral domain optical coherence tomography (SD-OCT) system incorporating a Littrow spectrometer or a spectrometer having one or more shared focusing element(s) and an SD-OCT system incorporating a spectrometer that is substantially polarization independent are also disclosed.

Abstract translation: 公开了一种紧凑的圆锥衍射Littrow光谱仪。 对锥形衍射光谱分量光束的失真进行补偿，结果衍射的光束束仍可被聚焦成基本上直线以照射到检测器阵列上。 还公开了包含Littrow光谱仪或具有一个或多个共享聚焦元件的光谱仪的光谱相干光学相干断层扫描（SD-OCT）系统和包含基本上偏振无关的光谱仪的SD-OCT系统。

公开(公告)号：US07456956B2

公开(公告)日：2008-11-25

申请号：US11601344

申请日：2006-11-17

Applicant: Eric Jiang ,  Francis J. Deck

Inventor： Eric Jiang ,  Francis J. Deck

IPC: G01J3/28 ,  G01J3/447

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/447 ,  G01N21/19

Abstract: A spectrometer generates Vibrational Circular Dichroism (VCD) measurements having an exceedingly high signal-to-noise ratio, as well as a greater wavelength range over which measurements may be accurately provided. This is achieved by utilizing reflective optics (preferably solely reflective optics, i.e., no refractive elements) to supply a concentrated and collimated input light beam to a sample within a sample cell, and similarly collecting the light output from the sample cell via reflective optics for supply to a detector.

Abstract translation: 光谱仪产生具有非常高的信噪比的振动圆二色性（VCD）测量，以及可以准确地提供测量的更大的波长范围。 这通过利用反射光学器件（优选地仅反射光学器件，即没有折射元件）来实现，以将集中和准直的输入光束提供给样品池内的样品，并且类似地通过反射光学器件收集来自样品池的光输出，用于 供应到检测器。

公开(公告)号：US07456950B2

公开(公告)日：2008-11-25

申请号：US11846508

申请日：2007-08-28

Applicant: Francis J. Deck ,  John Magie Coffin

Inventor： Francis J. Deck ,  John Magie Coffin

IPC: G01J3/02 ,  G02B17/00

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/024 ,  G01J3/0262

Abstract: In a spectrometer, preferably in a spectrometric microscope, light from a specimen is collected at a collector objective element and delivered to a camera element, which in turn provides the light to a photosensitive detector. A focal plane is provided between the collector objective element and the camera element, and one or more aperture arrays may be situated in the focal plane to restrict the detector's field of view of the specimen to the areas within the apertures. By utilizing aperture arrays with apertures of different sizes and shapes, the spatial resolution of the spectrometer readings may be varied without the need to vary the optics of the spectrometer. As a result, if the optics are optimized to minimize vignetting, spatial resolution may be varied without adverse increases in vignetting.

Abstract translation: 在光谱仪中，优选在光谱显微镜中，将来自样本的光收集在收集器目标元件处并传送到相机元件，照相机元件又将光提供给光敏检测器。 焦平面设置在收集器目标元件和相机元件之间，并且一个或多个孔阵列可以位于焦平面中，以将检测器的视场的视野限制在孔内的区域内。 通过利用具有不同尺寸和形状的孔的孔径阵列，可以改变光谱仪读数的空间分辨率，而不需要改变光谱仪的光学器件。 结果，如果光学器件被优化以最小化渐晕，则可以改变空间分辨率而不增加渐晕。

公开(公告)号：US07446876B2

公开(公告)日：2008-11-04

申请号：US11517894

申请日：2006-09-08

Applicant: Dale A. Harrison

Inventor： Dale A. Harrison

IPC: G01N21/55

CPC classification number: G01J3/2803 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/027 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/08 ,  G01J3/10 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/36 ,  G01J3/42 ,  G01J3/4531 ,  G01N21/211 ,  G01N21/274 ,  G01N21/33 ,  G01N21/47 ,  G01N21/55 ,  G01N21/9501 ,  G01N2021/335

Abstract: A spectroscopy system is provided which is optimized for operation in the VUV region and capable of performing well in the DUV-NIR region. Additionally, the system incorporates an optical module which presents selectable sources and detectors optimized for use in the VUV and DUV-NIR. As well, the optical module provides common delivery and collection optics to enable measurements in both spectral regions to be collected using similar spot properties. The module also provides a means of quickly referencing measured data so as to ensure that highly repeatable results are achieved. The module further provides a controlled environment between the VUV source, sample chamber and VUV detector which acts to limit in a repeatable manner the absorption of VUV photons. The use of broad band data sets which encompass VUV wavelengths, in addition to the DUV-NIR wavelengths enables a greater variety of materials to be meaningfully characterized. Array based detection instrumentation may be exploited to permit the simultaneous collection of larger wavelength regions.

Abstract translation: 提供了一种光谱系统，其被优化用于在VUV区域中的操作并且能够在DUV-NIR区域中表现良好。 此外，该系统还包含一个光学模块，该模块提供可用于VUV和DUV-NIR中优化的可选择的源和检测器。 同样，光学模块提供通用的传送和收集光学器件，以使得能够使用类似的光点特性来收集两个光谱区域中的测量。 该模块还提供了快速参考测量数据的方法，以确保实现高度可重复的结果。 该模块还在VUV源，样品室和VUV检测器之间提供受控的环境，其作用是以可重复的方式限制VUV光子的吸收。 除了DUV-NIR波长之外，使用包含VUV波长的宽带数据集使得可以有意义地表征更多种类的材料。 可以利用基于阵列的检测仪器来允许同时收集更大的波长区域。

公开(公告)号：US20080241843A1

公开(公告)日：2008-10-02

申请号：US12004874

申请日：2007-12-21

Applicant: Richard N. Zare ,  Bo Huang

Inventor： Richard N. Zare ,  Bo Huang

IPC: C12Q1/68 ,  C12M1/00 ,  G01J1/58 ,  C12Q1/02

CPC classification number: G01N33/5005 ,  B01L3/502761 ,  G01J3/02 ,  G01J3/0208 ,  G01N21/6428

Abstract: Embodiments of the present disclosure provide for single-cell analysis systems, methods of detecting target components in a single cell, cylindrical fluorescence detection systems, and the like.

Abstract translation: 本公开的实施例提供单细胞分析系统，检测单个细胞中的靶组分的方法，圆柱形荧光检测系统等。

公开(公告)号：US20080239307A1

公开(公告)日：2008-10-02

申请号：US11731418

申请日：2007-03-30

Applicant: Chad E. Talley ,  Thomas R. Huser ,  Christopher W. Hollars ,  Stephen M. Lane

Inventor： Chad E. Talley ,  Thomas R. Huser ,  Christopher W. Hollars ,  Stephen M. Lane

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0262 ,  G01N21/658

Abstract: A surface-enhanced Raman scattering method and apparatus to sequence polymeric biomolecules such as DNA, RNA, or proteins is introduced. The method uses metallic nanostructures such as, for example, spherical or cylindrical Au or Ag nanoparticles having characteristic lengths of 10-100 nm which when illuminated with light of the appropriate wavelength produce resonant oscillations of the conduction electrons (plasmon resonance). Electric field enhancements of 30-1000 near the particle surface resulting from such oscillations increase Raman scattering cross-sections by about 106-1015 due to the E4 dependence of the Raman scattering, wherein the largest enhancements occur in the gap/junction between novel closely spaced structures as disclosed herein.

Abstract translation: 引入表面增强拉曼散射方法和用于对聚合物生物分子如DNA，RNA或蛋白质进行排序的装置。 该方法使用金属纳米结构，例如具有特征长度为10-100nm的球形或圆柱形Au或Ag纳米颗粒，当用适当波长的光照射时，会导致传导电子（等离子体共振）的共振振荡。 由于这种振荡导致的颗粒表面附近的30-1000的电场增强使由于E 4引起的拉曼散射横截面增加约10 -6 -10 15 拉曼散射的依赖性，其中最大的增强发生在本文公开的新颖的紧密间隔的结构之间的间隙/接合处。

公开(公告)号：US20080218752A1

公开(公告)日：2008-09-11

申请号：US11925076

申请日：2007-10-26

Applicant: Thomas W. Hagler

Inventor： Thomas W. Hagler

IPC: G01J3/30

CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/06 ,  G01J3/1804 ,  G01J3/2846 ,  G01J3/42 ,  G01J2001/4242 ,  G01J2003/1217

Abstract: A chemometric analyzer for analyzing a plurality of analytes. The analyzer disperses radiation by wavelength along an encoding axis. The analyzer includes a spatial radiation modulator having a plurality of radiation filters. Each radiation filter modulates the intensity of a corresponding spectral component in the radiation.

Abstract translation: 用于分析多种分析物的化学计量分析仪。 分析仪沿着编码轴沿波长分散辐射。 分析仪包括具有多个辐射过滤器的空间辐射调制器。 每个辐射滤波器调制辐射中对应的光谱分量的强度。

公开(公告)号：US07423749B2

公开(公告)日：2008-09-09

申请号：US11833897

申请日：2007-08-03

Applicant: Thomas W. Hagler

Inventor： Thomas W. Hagler

IPC: G01J3/06 ,  G01J3/18 ,  G01J3/28

CPC classification number: G01N21/552 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/18 ,  G01J3/28 ,  G01J3/42 ,  G01N21/274 ,  G01N21/31 ,  G01N2021/317 ,  G01N2201/129

Abstract: An encoder spectrograph is used to analyze radiation from one or more samples in various configurations. The radiation is analyzed by spatially modulating the radiation after it has been dispersed by wavelength or imaged along a line. Dual encoder spectrographs may be used to encode radiation using a single modulator. An encoded photometric infrared spectroscopy (“EPIR”) analyzer employs orthogonal encoded components having substantially identical modulation frequencies, which may allow for the multiplexing of up to twice as many encoded components.

Abstract translation: 编码器光谱仪用于分析来自一种或多种不同配置样品的辐射。 通过在辐射被波长分散或沿着一条线成像后，通过空间调制辐射来分析辐射。 双编码器光谱仪可用于使用单个调制器对辐射进行编码。 编码的光度红外光谱（“EPIR”）分析仪使用具有基本上相同的调制频率的正交编码分量，这可以允许多达两倍的编码分量的多路复用。

公开(公告)号：US20080204711A1

公开(公告)日：2008-08-28

申请号：US11711908

申请日：2007-02-27

Applicant: Dale A. Harrison ,  Anthony T. Hayes

Inventor： Dale A. Harrison ,  Anthony T. Hayes

IPC: G01J3/28 ,  G01J3/00

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0294 ,  G01J3/14 ,  G01J3/2803

Abstract: An optical spectroscopy tool is provided. In one embodiment a highly efficient means by which moderate resolution spectroscopy may be performed in the vacuum ultraviolet (VUV) is described. In one embodiment the techniques can be used as a high throughput spectrometer to spatially disperse wavelengths in and around the VUV in such a manner as to generate a substantially flat field focal plane, suitable for use in combination with an array detector. Some embodiments utilize prism based spectrometers. Some embodiments utilize detector elements that may be movable and/or located within the spectrometer. In some embodiments, collimated light may be provided as an input to the spectrometer.

Abstract translation: 提供光谱仪。 在一个实施例中，描述了可以在真空紫外线（VUV）中进行中分辨光谱的高效手段。 在一个实施例中，该技术可以用作高通量光谱仪，以便以这样的方式空间分散VUV中和周围的波长，以便产生适合与阵列检测器组合使用的基本平坦的场焦平面。 一些实施例使用基于棱镜的光谱仪。 一些实施例利用可移动和/或位于分光计内的检测器元件。 在一些实施例中，准直光可以作为光谱仪的输入提供。

公开(公告)号：US20080203314A1

公开(公告)日：2008-08-28

申请号：US11711482

申请日：2007-02-27

Applicant: Dale A. Harrison ,  Anthony T. Hayes

Inventor： Dale A. Harrison ,  Anthony T. Hayes

IPC: G01J1/42

CPC classification number: G01J3/14 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/0237 ,  G01J3/0256 ,  G01J3/0262 ,  G01J3/027 ,  G01J3/0286 ,  G01J3/2803 ,  G01J3/36

Abstract: An optical spectroscopy tool is provided. In one embodiment a highly efficient means by which moderate resolution spectroscopy may be performed in the vacuum ultraviolet (VUV) is described. In one embodiment the techniques can be used as a high throughput spectrometer to spatially disperse wavelengths in and around the VUV in such a manner as to generate a substantially flat field focal plane, suitable for use in combination with an array detector. Some embodiments utilize prism based spectrometers. Some embodiments utilize detector elements that may be movable and/or located within the spectrometer. In some embodiments, collimated light may be provided as an input to the spectrometer.

Abstract translation: 提供光谱仪。 在一个实施例中，描述了可以在真空紫外线（VUV）中进行中分辨光谱的高效手段。 在一个实施例中，该技术可以用作高通量光谱仪，以便以这样的方式空间分散VUV中和周围的波长，以便产生适合与阵列检测器组合使用的基本平坦的场焦平面。 一些实施例使用基于棱镜的光谱仪。 一些实施例利用可移动和/或位于分光计内的检测器元件。 在一些实施例中，准直光可以作为光谱仪的输入提供。