公开(公告)号：US20140326884A1

公开(公告)日：2014-11-06

申请号：US14331193

申请日：2014-07-14

Applicant: Lawrence Livermore National Security, LLC

Inventor： Charles G. Stevens ,  Joseph W. Tringe ,  Christopher T. Cunningham

IPC: G01N21/35

CPC classification number: G01J3/453 ,  G01J3/10 ,  G01J3/4338 ,  G01N21/35

Abstract: In one embodiment, a heterodyne detection system for detecting light includes a first input aperture configured to receive first light from a scene input, a second input aperture configured to receive second light from a local oscillator input, a broadband local oscillator configured to provide the second light to the second input aperture, a dispersive element configured to disperse the first light and the second light, and a final condensing lens coupled to an infrared detector. The final condensing lens is configured to concentrate incident light from a primary condensing lens onto the infrared detector, and the infrared detector is a square-law detector capable of sensing the frequency difference between the first light and the second light. More systems and methods for detecting light are described according to other embodiments.

Abstract translation: 在一个实施例中，用于检测光的外差检测系统包括被配置为从场景输入接收第一光的第一输入孔，被配置为从本地振荡器输入接收第二光的第二输入孔，被配置为提供第二 被配置为分散第一光和第二光的分散元件以及耦合到红外检测器的最终聚光透镜。 最终聚光透镜被配置为将来自主聚光透镜的入射光集中到红外检测器上，并且红外检测器是能够感测第一光和第二光之间的频率差的平方律检测器。 根据其他实施例描述用于检测光的更多系统和方法。

公开(公告)号：US20140183362A1

公开(公告)日：2014-07-03

申请号：US14108986

申请日：2013-12-17

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01N21/35

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A system and method for using near-infrared or short-wave infrared (SWIR) light sources for identification of counterfeit drugs may perform spectroscopy using a super-continuum laser to provide detection in a non-contact and non-destructive manner at stand-off or remote distances with minimal sample preparation. Also, near-infrared or SWIR light may penetrate through plastic containers and packaging, permitting on-line inspection and rapid scanning. The near-infrared or SWIR spectroscopy may also be used to detect illicit drugs and their chemical composition. Moreover, the spectroscopic techniques may also be applied to quality assessment and control in pharmaceutical manufacturing, thus permitting the implementation of smart manufacturing with feedback control. Fiber super-continuum lasers may emit light in the near-infrared or SWIR between approximately 1.4-1.8 microns, 2-2.5 microns, 1.4-2.4 microns, 1-1.8 microns. In particular embodiments, the detection system may be a dispersive spectrometer, a Fourier transform infrared spectrometer, or a hyper-spectral imaging detector or camera.

Abstract translation: 使用近红外或短波红外（SWIR）光源识别假冒药物的系统和方法可以使用超连续激光器进行光谱，以在非接触和非破坏性方式提供检测 或距离最小的样品制备。 此外，近红外或SWIR光可以穿透塑料容器和包装，允许在线检查和快速扫描。 近红外或SWIR光谱也可用于检测非法药物及其化学成分。 此外，光谱技术还可以应用于药物制造中的质量评估和控制，从而允许通过反馈控制实现智能制造。 光纤超连续激光器可以在大约1.4-1.8微米，2-2.5微米，1.4-2.4微米，1-1.8微米之间的近红外或者SWIR发光。 在具体实施例中，检测系统可以是色散光谱仪，傅里叶变换红外光谱仪或超光谱成像检测器或照相机。

公开(公告)号：US20140145083A1

公开(公告)日：2014-05-29

申请号：US14072067

申请日：2013-11-05

Applicant: SHIMADZU CORPORATION

Inventor： Toru Yamaguchi ,  Naoji Moriya

IPC: G01N21/35

CPC classification number: G01N21/3563 ,  G01J3/453

Abstract: A plastic identification device includes a sample holding unit for holding, as a sample, a plastic to be identified, an infrared spectrophotometer including a light source for generating infrared light, an incident optical system for emitting the infrared light from the light source on the sample held by the sample holding unit, a light detector, and a receiver optical system for guiding the infrared light from the sample to the light detector, and a calculation device for identifying a type of the plastic which is the sample based on a detection result of the light detector. A focal length of the incident optical system is shorter than a focal length of the receiver optical system.

Abstract translation: 塑料识别装置包括用于保持要识别的塑料作为样品的样品保持单元，包括用于产生红外光的光源的红外分光光度计，用于从样品上的光源发射红外光的入射光学系统 由样本保持单元保持的光检测器和用于将来自样本的红外光引导到光检测器的接收器光学系统，以及用于基于检测结果来识别作为样本的塑料的类型的计算装置 光检测器。 入射光学系统的焦距比接收光学系统的焦距短。

公开(公告)号：US20140029004A1

公开(公告)日：2014-01-30

申请号：US13442574

申请日：2012-04-09

Applicant: Andrew Bodkin

Inventor： Andrew Bodkin

IPC: G01J3/45

CPC classification number: G01J3/45 ,  G01J3/02 ,  G01J3/021 ,  G01J3/22 ,  G01J3/2823 ,  G01J3/36 ,  G01J3/453

Abstract: A multiband spatial heterodyne spectrometer for determining spectra in first and second wavelength bands has a beamsplitter configured to split incident light and to direct the incident light upon a first and a second diffraction grating. The gratings are configured for Littrow reflection of incident light of the first wavelength band at a first order and Littrow reflection of incident light of the second wavelength band at a second order. Light reflected by the first and the second diffraction grating forms diffraction patterns imaged by an electronic camera. A dispersive device separates the imaged interference patterns onto separate groups of pixel sensors corresponding to the wavelength bands. A processing device receives information from the detector and computes spectra therefrom. The second diffraction grating is split spatially or temporally to provide two different responses, so the system can disambiguate spectra. In embodiments, the spectrometer computes hyperspectral images of a target.

Abstract translation: 用于确定第一和第二波长带中的光谱的多频带空间外差光谱仪具有被配置为分离入射光并将入射光引导到第一和第二衍射光栅上的分束器。 光栅被配置为以第一阶次的第一波长带的入射光和第二波长带的入射光的Littrow反射的二次反射。 由第一和第二衍射光栅反射的光形成由电子照相机成像的衍射图案。 分散装置将成像的干涉图案分离成对应于波长带的单独的像素传感器组。 处理装置从检测器接收信息并从其计算光谱。 第二个衍射光栅在空间上或时间上分裂以提供两种不同的响应，因此系统可以消除光谱的歧义。 在实施例中，光谱仪计算目标的高光谱图像。

公开(公告)号：US08599383B2

公开(公告)日：2013-12-03

申请号：US12436702

申请日：2009-05-06

Applicant: Michael A. Teitell ,  James K. Gimzewski ,  Jason C. Reed

Inventor： Michael A. Teitell ,  James K. Gimzewski ,  Jason C. Reed

IPC: G01N21/00 ,  G01J3/45

CPC classification number: G01N33/5008 ,  G01J3/453 ,  G02B5/126 ,  G02B21/0056 ,  G02B21/32

Abstract: The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.

Abstract translation: 本发明提供了用于确定细胞特征的光学系统和方法，例如细胞类型，对生物化学事件的细胞反应，生物学状态等。 所述方法通常涉及使用干涉测量来观察细胞中的膜特性，然后使用该信息来确定细胞的一个或多个特征。 本发明的方法对于诸如药物筛选以及诊断技术的应用是有用的。

公开(公告)号：US20130278922A1

公开(公告)日：2013-10-24

申请号：US13924065

申请日：2013-06-21

Applicant: The Arizona Board of Regents on Behalf of The University of Arizona

Inventor： Barry Gelernt ,  Thomas D. Milster ,  Thiago Jota

IPC: G02B21/16

CPC classification number: G02B21/16 ,  G01J3/0208 ,  G01J3/10 ,  G01J3/453 ,  G01N21/45 ,  G01N2021/451

Abstract: Optical systems and methods including interferometric systems and methods are disclosed herein. In some embodiments, the present invention relates to a system comprising at least one light source including a deep ultraviolet light source, a lens device, a beam splitter, and a camera device. The lens device receives first light, directs at least some of that light toward a target location, receives reflected light therefrom, and directs at least some of the reflected light toward a further location, where at least part of a light path between the deep ultraviolet light source and the target location is other than at a high vacuum. The camera device is positioned at either the further location or an additional location, whereby an image is generated by the camera device based upon at least a portion of the reflected light. Also encompassed herein are interferometric lithography and optical microscopy systems.

Abstract translation: 本文公开了包括干涉测量系统和方法的光学系统和方法。 在一些实施例中，本发明涉及包括至少一个包括深紫外光源，透镜装置，分束器和相机装置的光源的系统的系统。 透镜装置接收第一光，将至少一些光引导到目标位置，从其接收反射光，并将至少一些反射光指向另一位置，其中深紫外线之间的至少一部分光路 光源和目标位置不是在高真空下。 相机装置位于另外的位置或附加位置处，由此相机装置基于反射光的至少一部分产生图像。 本文还包括干涉光刻和光学显微镜系统。

公开(公告)号：US08451442B2

公开(公告)日：2013-05-28

申请号：US12452192

申请日：2008-06-18

Applicant: Alexander V. Benderskii ,  Igor V. Stiopkin ,  Himali Dilrukshi Jayathilake

Inventor： Alexander V. Benderskii ,  Igor V. Stiopkin ,  Himali Dilrukshi Jayathilake

IPC: G01J3/28

CPC classification number: G01N21/636 ,  G01J3/4338 ,  G01J3/453 ,  G01N21/45

Abstract: Method and apparatus for performing spectroscopy, include the combining of first and second light beams to form a reference beam, focusing the first and second light beams and the reference beam onto a sample, receiving a reflected light beam from the sample at a monochromator, and viewing a predetermined wavelength band of the reflected light beam from the monochromator. Portions of the first and second light beams, which may be visible and IR forms of electromagnetic energy, are heterodyned through a crystal. A monochromator receives a reflection of the reference beam from the sample, and Fourier transformation is performed on the output of the monochromator. The first and second beams of electromagnetic energy can be split to form first and second component beams and the reference beam, all of which are propagated to the sample.

Abstract translation: 用于执行光谱学的方法和装置包括组合第一和第二光束以形成参考光束，将第一和第二光束和参考光束聚焦到样品上，在单色仪处接收来自样品的反射光束，以及 观察来自单色仪的反射光束的预定波长带。 第一和第二光束的部分可能是可见的，IR形式的电磁能量通过晶体被外差。 单色器接收来自样本的参考光束的反射，并且对单色仪的输出进行傅里叶变换。 第一和第二电磁能束可以被分裂以形成第一和第二分量光束和参考光束，所有这些光束都被传播到样品。

公开(公告)号：US08355138B2

公开(公告)日：2013-01-15

申请号：US13191885

申请日：2011-07-27

Applicant: Seok-Hyun Yun ,  Brett Eugene Bouma ,  Guillermo J. Tearney ,  Johannes Fitzgerald De Boer

Inventor： Seok-Hyun Yun ,  Brett Eugene Bouma ,  Guillermo J. Tearney ,  Johannes Fitzgerald De Boer

IPC: G01B11/02 ,  G01B9/02

CPC classification number: H01S5/5045 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02002 ,  G01B9/02004 ,  G01B9/02043 ,  G01B9/02075 ,  G01B9/02081 ,  G01B9/02083 ,  G01B9/02084 ,  G01B9/0209 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/453 ,  G01J9/0215 ,  G01N21/4795 ,  G02B6/3604 ,  G02B26/12 ,  G02B27/48 ,  G02F1/093 ,  G02F1/11 ,  H01S3/0071 ,  H01S3/0078 ,  H01S3/08009 ,  H01S3/08063 ,  H01S3/105 ,  H01S3/1068 ,  H01S5/0071 ,  H01S5/0078 ,  H01S5/1025 ,  H01S5/14 ,  H01S5/141 ,  H01S5/146

Abstract: An apparatus and method are provided. In particular, at least one first electro-magnetic radiation may be provided to a sample and at least one second electro-magnetic radiation can be provided to a non-reflective reference. A frequency of the first and/or second radiations varies over time. An interference is detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. Alternatively, the first electro-magnetic radiation and/or second electro-magnetic radiation have a spectrum which changes over time. The spectrum may contain multiple frequencies at a particular time. In addition, it is possible to detect the interference signal between the third radiation and the fourth radiation in a first polarization state. Further, it may be preferable to detect a further interference signal between the third and fourth radiations in a second polarization state which is different from the first polarization state. The first and/or second electro-magnetic radiations may have a spectrum whose mean frequency changes substantially continuously over time at a tuning speed that is greater than 100 Tera Hertz per millisecond.

公开(公告)号：US20120190974A1

公开(公告)日：2012-07-26

申请号：US13499075

申请日：2010-09-14

Applicant: Satoru Suehara

Inventor： Satoru Suehara

IPC: A61B6/00

CPC classification number: A61B5/0066 ,  A61B1/00112 ,  A61B5/0073 ,  A61B5/6852 ,  G01J3/453 ,  G01N21/17 ,  G02B6/3604 ,  G02B6/4219

Abstract: An imaging apparatus for diagnosis is connected with a probe including a transmitting and receiving unit transmitting a light transmitted from a light source continuously to the inside of a body cavity and concurrently, receiving a reflected light continuously from the inside of the body cavity, and generates a tomographic image inside the body cavity based on the obtained reflected light by obtaining the reflected light from the transmitting and receiving unit while rotating the transmitting and receiving unit. The apparatus comprises: a mechanism for extracting intensity of the reflected light obtained by a phenomenon that the light transmitted to the transmitting and receiving unit is reflected at the transmitting and receiving unit; and a mechanism for judging whether or not the extracted intensity of each reflected light at each rotary angle of the transmitting and receiving unit lies in a range of a predetermined variation width.

Abstract translation: 一种用于诊断的成像装置与包括发射和接收单元的探针连接，所述发射和接收单元将从光源发射的光连续地传送到体腔内部，并且同时从体腔内部连续接收反射光，并且产生 通过在旋转发送和接收单元的同时获得来自发送和接收单元的反射光，基于获得的反射光在体腔内部的断层图像。 该装置包括：用于提取通过发送到发送和接收单元的光在发送和接收单元处反射的现象获得的反射光的强度的机构; 以及用于判断在发送和接收单元的每个旋转角度处提取的每个反射光的提取强度是否在预定变化宽度的范围内的机构。

公开(公告)号：US20120188538A1

公开(公告)日：2012-07-26

申请号：US13012529

申请日：2011-01-24

Applicant: Chetan A. Patil ,  Anita Mahadevan-Jansen ,  Antonius Gerardus Johannes Maria van Leeuwen ,  Jeroen Kalkman

Inventor： Chetan A. Patil ,  Anita Mahadevan-Jansen ,  Antonius Gerardus Johannes Maria van Leeuwen ,  Jeroen Kalkman

IPC: G01J3/44 ,  G01B9/02

CPC classification number: G01B9/02044 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/442 ,  A61B5/443 ,  G01B9/0203 ,  G01B9/02091 ,  G01J3/44 ,  G01J3/453 ,  G01N21/4795 ,  G01N21/65 ,  G01N2021/1787

Abstract: In one aspect of the present invention, an apparatus includes a first light source for generating a broadband light, and a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting the received broadband light into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning the received reference light into the beamsplitter, and a sample arm optically coupled to the beamsplitter and the second light source for combining the sample light and the monochromatic light, delivering the combined sample and monochromatic light to the target of interest, collecting a backscattering light and a Raman scattering light that are generated from interaction of the sample light and the monochromatic light with the target of interest, respectively, returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter, and directing the Raman scattering light in an output optical path, and a single detector optically coupled to the beamsplitter for collecting the interference signal.

Abstract translation: 在本发明的一个方面中，一种装置包括用于产生宽带光的第一光源和用于产生单色光的第二光源，光学耦合到第一光源的分束器，用于接收宽带光并分离所接收的 将宽带光转换为参考光和采样光，参考臂光耦合到分束器，用于接收参考光并将接收到的参考光返回到分光器中;以及样品臂，光学耦合到分束器和第二光源，用于组合 样品光和单色光，将组合的样品和单色光输送到感兴趣的目标，分别收集从样品光和单色光与感兴趣的目标的相互作用产生的后向散射光和拉曼散射光 ，将后向散射光返回到分束器中以产生 在分束器中返回的后向散射光和返回的参考光之间产生干涉信号，并将拉曼散射光引导到输出光路中，以及单个检测器，其光耦合到分束器以收集干扰信号。