公开(公告)号：US20230168239A1

公开(公告)日：2023-06-01

申请号：US17536017

申请日：2021-11-27

Applicant: M.I.S. Electronics Inc.

Inventor： Mohammad E Khosroshahi ,  Yesha Patel

IPC: G01N33/49 ,  G01N21/65 ,  G01N21/64 ,  G01N21/31

CPC classification number: G01N33/49 ,  G01N21/658 ,  G01N21/6486 ,  G01N21/31 ,  G01N2201/08 ,  G01N2201/061

Abstract: An optical multimodal detection system for targeted detection of cancer biomarkers in blood serum. The system comprises of a nano-biosensor, a chamber for receiving the nano-biosensor, a localized surface plasmon resonance (LSPR) based detector, a plasmon enhanced fluorescence (PEF) based detector and a surface-enhanced Raman scattering (SERS) based detector. The nano-biosensor comprises of a glass substrate provided with an active site for receiving a sample of blood serum, and is dimensioned to define a flow channel for introducing the sample of blood serum into the nano-biosensor. The nano-biosensor is provided with a layer of amino-silane compound coating over the glass substrate and a plurality of gold nano-urchins (GNU) bound to the layer of silicone compound. The plurality of gold-nano-urchins are functionalized with a hydrazide linker molecule for allowing uniform-oriented conjugation of a Fc region of antibodies to a surface of gold nano-urchins thereby allowing Fab regions of antibodies for binding with cancer biomarkers.

公开(公告)号：US11656172B1

公开(公告)日：2023-05-23

申请号：US17335921

申请日：2021-06-01

Applicant: Photonics Automation Specialties LLC

Inventor： Gerard Knight-Rubino ,  Xiyao Zhang

IPC: G01N21/31

CPC classification number: G01N21/31 ,  G01N2201/0635 ,  G01N2201/0638 ,  G01N2201/08

Abstract: A multichannel angular spectrometer includes an array of fiber pickups having an arcuate arrangement and focused about a sample volume. A broadband light source is configured to illuminate a sample within the sample volume. At least one dispersion element is in optical communication with the array of fiber pickups. An imaging sensor is in optical communication with the array of fiber pickups. The imaging sensor is configured to image the broadband light received by the array of fiber pickups and dispersed by the at least one dispersion element. A processor is in electrical communication with the imaging sensor. The processor has a power supply and computer-readable memory.

公开(公告)号：US11644424B2

公开(公告)日：2023-05-09

申请号：US16859537

申请日：2020-04-27

Applicant: Animated Dynamics, Inc.

Inventor： Ran An ,  Gayatri Narayanan ,  Travis A. Morgan ,  Theodore R. Schenberg

IPC: G01N21/84 ,  G01N21/47 ,  G01N33/50 ,  G01N21/55

CPC classification number: G01N21/84 ,  G01N21/47 ,  G01N21/55 ,  G01N33/5005 ,  G01N2201/062 ,  G01N2201/08

Abstract: An interferometric method and apparatus for the non-invasive assessment of oocyte maturity and competency. The method includes placing an oocyte in a sample holder to provide a biological target; generating a near infrared light; using a beam splitter to split the near infrared light into a signal light portion and a reference light portion; projecting the signal light portion onto the biological target; collecting reflected and back scattered light from the signal light portion projected onto the biological target with a detector; collecting at least a portion of the reference light portion with the detector; generating interferometric image data based upon the collected signal and reference light; and assessing the maturity of the oocyte based upon the interferometric data while maintaining the viability of the oocyte. When the oocyte is part of a cumulus-oocyte complex, the assessment is accomplished without removing cumulus cells from the cumulus-oocyte complex while maintaining viability.

公开(公告)号：US20190150748A1

公开(公告)日：2019-05-23

申请号：US16241628

申请日：2019-01-07

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. ISLAM

IPC: A61B5/00 ,  G01J3/42 ,  G01N33/49 ,  G01J3/28 ,  G01N21/88 ,  G01J3/453 ,  G01N21/359 ,  A61B5/1455 ,  G01J3/02 ,  A61B5/145 ,  G01J3/14 ,  G01J3/10 ,  G01N33/15 ,  G16H40/67 ,  G01N33/02 ,  G01N33/44 ,  G01N21/35 ,  G01N21/39 ,  G01N21/3563

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302 ,  Y02A90/26

Abstract: A smart phone or tablet includes a first part having at least one laser diode configured to be pulsed, and a second part having at least one other laser diode, the laser diodes configured to generate near-infrared light, wherein at least some of the laser diodes comprise a distributed Bragg reflector, with some laser diode light directed to tissue including skin. An array of laser diodes generates near-infrared light and includes one or more distributed Bragg reflectors. An assembly in front of the array to forms light spots on the tissue. A first receiver includes detectors that receive light reflected from the tissue. An infrared camera generates data from light reflected from the tissue. The smart phone or tablet generates a two-dimensional or three-dimensional image or mapping using the infrared camera data, and includes a wireless receiver, a wireless transmitter, a display, a voice input module, and a speaker.

公开(公告)号：US20190120768A1

公开(公告)日：2019-04-25

申请号：US15984075

申请日：2018-05-18

Applicant: Theranos, Inc.

Inventor： Chinmay Pangarkar ,  Karan Mohan

IPC: G01N21/64 ,  G01N21/47 ,  G01N15/14

CPC classification number: G01N21/6486 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/47 ,  G01N21/4738 ,  G01N21/6428 ,  G01N2201/06113 ,  G01N2201/08

Abstract: Methods and devices for cytometric analysis are provided. A cytometry apparatus is provided which may be used with a stationary sample cuvette for analysis of a stationary sample or with a flow sample cuvette for analysis of a flowing sample. The methods and devices provided herein may be used to perform cytometric analysis of samples under a wide range of experimental and environmental conditions.

公开(公告)号：US20190104944A1

公开(公告)日：2019-04-11

申请号：US16116038

申请日：2018-08-29

Applicant: illumiSonics, Inc.

Inventor： Parsin Haji REZA ,  Roger ZEMP

IPC: A61B5/00 ,  G01N21/17

CPC classification number: A61B5/0095 ,  G01N21/1702 ,  G01N21/1717 ,  G01N2021/1706 ,  G01N2021/1725 ,  G01N2201/06113 ,  G01N2201/08 ,  G01N2201/0846

Abstract: A photoacoustic remote sensing system (PARS) for imaging a subsurface structure in a sample has an excitation beam configured to generate ultrasonic signals in the sample at an excitation location; an interrogation beam incident on the sample at the excitation location, a portion of the interrogation beam returning from the sample that is indicative of the generated ultrasonic signals; an optical system that focuses at least one of the excitation beam and the interrogation beam with a focal point that is below the surface of the sample; and a detector that detects the returning portion of the interrogation beam.

公开(公告)号：US20180317776A1

公开(公告)日：2018-11-08

申请号：US16029611

申请日：2018-07-08

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. ISLAM

IPC: A61B5/00 ,  G01J3/42 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/359 ,  G01N21/39 ,  G01N33/49 ,  G01N21/88 ,  G01J3/02 ,  G01J3/10 ,  G01J3/14 ,  G01J3/28 ,  G01N21/3563 ,  G01N21/35 ,  G01N33/44 ,  G01N33/15 ,  G01N33/02 ,  G01J3/453 ,  G01J3/18 ,  G01J3/12 ,  G01M3/38 ,  G01N21/85 ,  G01N21/95 ,  H01S3/00 ,  H01S3/30 ,  H01S3/067

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A smart phone or tablet includes pulsed laser diodes generating light with near-infrared wavelengths between 700-2500 nanometers. First lenses direct light from the laser diodes to tissue. An array of pulsed laser diodes generates light with near-infrared wavelengths between 700-2500 nanometers. Second lenses form light from the array into spots directed on the tissue. An infrared camera synchronized to the laser diodes and the array generates data based on light reflected from the tissue. The smart phone or tablet generates a two-dimensional or three-dimensional image using the data from the infrared camera. The smart phone or tablet includes a wireless receiver, a wireless transmitter, a display, a voice input module, and a speaker.

公开(公告)号：US10082462B2

公开(公告)日：2018-09-25

申请号：US15042354

申请日：2016-02-12

Applicant: Yokogawa Electric Corporation

Inventor： Yasuyuki Suzuki ,  Yukihiro Nakamura ,  Tetsushi Namatame

IPC: G01N21/00 ,  G02B17/00 ,  G01N21/59 ,  G01N21/85 ,  G01N21/03

CPC classification number: G01N21/59 ,  G01N21/8507 ,  G01N2021/0307 ,  G01N2201/0637 ,  G01N2201/08 ,  G01N2201/086 ,  G02B17/006

Abstract: An optical element includes a main body formed of a light transmissive material and including an arc-shaped optical path, and a gap formed on the arc-shaped optical path in the main body. The gap may have a notch shape. The main body may have a semicircular plate shape. The main body may have a hemispherical shape.

公开(公告)号：US10071205B2

公开(公告)日：2018-09-11

申请号：US15315621

申请日：2015-06-09

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： Gertrud Blei ,  Gunter Heumann

IPC: A61M5/31 ,  G01N21/55

CPC classification number: A61M5/31 ,  A61M5/168 ,  A61M5/1723 ,  A61M2005/3126 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/6081 ,  A61M2205/8206 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0256 ,  G01J3/0289 ,  G01J3/10 ,  G01J2003/104 ,  G01J2003/106 ,  G01N21/55 ,  G01N2201/062 ,  G01N2201/08 ,  G06K9/2018 ,  G06K9/2027 ,  G06K9/4652 ,  G06K2209/01

Abstract: Apparatus for determining information associated with reflection characteristics of a surface comprising a sensor (60) configured to generate sensor output dependent on an intensity of light incident on the sensor and having a field of view directed at an external surface (57) in use; an illumination source (58) configured to emit light onto the external surface in use; an optically transparent window (61) located such as to allow light to pass from the illumination source to the external surface and to allow light to pass to the sensor from the external surface in use; a light concentrator (66) fixed to or integral with the window, the light concentrator being configured to concentrate at least some light from the illumination source onto the external surface in use such that the concentrated light may be reflected from the external surface onto the sensor via the window; and a processor (40) configured to use the sensor output to determine information associated with reflection characteristics of the external surface.

公开(公告)号：US10036706B2

公开(公告)日：2018-07-31

申请号：US15531875

申请日：2015-11-19

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Kengo Suzuki ,  Kazuya Iguchi

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01J3/0254 ,  G01J3/28 ,  G01J3/4406 ,  G01J2003/1213 ,  G01J2003/1217 ,  G01N21/636 ,  G01N2021/6417 ,  G01N2021/6469 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/065 ,  G01N2201/08

Abstract: A spectroscopic measurement apparatus includes a light source, an integrator, a spectroscopic detector, and an analysis unit. The integrator includes an internal space in which a measurement object is disposed, a light input portion for inputting light to the internal space, a light output portion for outputting light from the internal space, a sample attachment portion for attaching the measurement object, and a filter attachment portion for attaching a filter unit. The filter unit has a transmission spectrum in which an attenuation rate for excitation light is larger than an attenuation rate for up-conversion light, and attenuates the light output from the light output portion. The analysis unit analyzes luminous efficiency of the measurement object on the basis of the transmission spectrum data and the spectroscopic spectrum data acquired by the spectroscopic detector.