公开(公告)号：US09541451B2

公开(公告)日：2017-01-10

申请号：US14188276

申请日：2014-02-24

Applicant: Seiko Epson Corporation

Inventor： Tatsuaki Funamoto

IPC: G01B9/02 ,  G01J3/02 ,  G01J3/10 ,  G01J3/26 ,  G01J3/32

CPC classification number: G01J3/0229 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/26 ,  G01J3/32

Abstract: A spectrometer includes: a tungsten lamp which emits light with no peak wavelength within a wavelength range of visible light and having a light amount increasing as the wavelength becomes longer; a violet LED which emits light having a peak wavelength within the wavelength range of visible light; a light mixer which mixes light emitted from the tungsten lamp and the violet LED; an etalon which receives light mixed by the light mixer and transmits light contained in the received mixed light and having a particular wavelength; a light receiving unit which receives light transmitted by the etalon; and a measurement control unit which changes the wavelength of light that can pass through the etalon and measures spectral characteristics of the light having passed through the etalon based on the light received by the light receiving unit.

Abstract translation: 光谱仪包括：在可见光的波长范围内发射没有峰值波长的光并随着波长变长而光量增加的钨灯; 发出在可见光的波长范围内具有峰值波长的光的紫色LED; 将来自钨灯发出的光与紫色LED混合的光混合器; 接收由所述光混合器混合并发射包含在所述混合光中并具有特定波长的光的标准准则; 接收由标准具传输的光的光接收单元; 以及测量控制单元，其改变可以通过标准具的光的波长，并且基于由光接收单元接收的光来测量已经通过标准具的光的光谱特性。

公开(公告)号：US09519737B2

公开(公告)日：2016-12-13

申请号：US14611844

申请日：2015-02-02

Applicant: Ricoh Company, Ltd.

Inventor： Kathrin Berkner ,  Sapna A. Shroff

IPC: G06F17/50 ,  G01J1/04 ,  G01J3/02 ,  G01J3/36 ,  G01J3/28 ,  H04N9/04 ,  G01J4/00 ,  G02B5/20 ,  G02B5/30 ,  H04N5/225

CPC classification number: G06F17/5009 ,  G01J1/0492 ,  G01J3/0208 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/2823 ,  G01J3/36 ,  G01J4/00 ,  G02B5/201 ,  G02B5/3025 ,  G02B2207/129 ,  H04N5/2254 ,  H04N9/045

Abstract: A method for designing the spatial partition of a filter module used in an aperture-multiplexed imaging system. The filter module is spatially partitioned into filter cells, and the spatial partition is designed by considering data captured at the sensor in light of an application-specific performance metric.

公开(公告)号：US09500523B2

公开(公告)日：2016-11-22

申请号：US14702461

申请日：2015-05-01

Applicant: VERIFOOD, LTD.

Inventor： Damian Goldring ,  Dror Sharon ,  Guy Brodetzki ,  Amit Ruf ,  Menahem Kaplan ,  Sagee Rosen ,  Omer Keilaf ,  Uri Kinrot ,  Kai Engelhardt ,  Ittai Nir

IPC: G01J3/28 ,  G01J3/26 ,  G01J3/02 ,  G01J3/10 ,  G01J3/36 ,  G01J5/02 ,  G01J5/10 ,  G01J3/12

CPC classification number: G01J3/108 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0256 ,  G01J3/0259 ,  G01J3/0262 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/36 ,  G01J3/45 ,  G01J5/0265 ,  G01J5/10 ,  G01J2003/1226 ,  G01J2003/123 ,  G01J2003/1239 ,  G01N21/255 ,  G01N33/02

Abstract: A spectrometer comprises a plurality of isolated optical channels comprising a plurality of isolated optical paths. The isolated optical paths decrease cross-talk among the optical paths and allow the spectrometer to have a decreased length with increased resolution. In many embodiments, the isolated optical paths comprise isolated parallel optical paths that allow the length of the device to be decreased substantially. In many embodiments, each isolated optical path extends from a filter of a filter array, through a lens of a lens array, through a channel of a support array, to a region of a sensor array. Each region of the sensor array comprises a plurality of sensor elements in which a location of the sensor element corresponds to the wavelength of light received based on an angle of light received at the location, the focal length of the lens and the central wavelength of the filter.

Abstract translation: 光谱仪包括多个隔离光通道，其包括多个隔离光路。 孤立的光路减少光路之间的串扰，并允许光谱仪具有降低的分辨率的长度。 在许多实施例中，隔离的光路包括隔离的平行光路，其允许基本上减小器件的长度。 在许多实施例中，每个隔离的光路从滤光器阵列的滤光片延伸穿过透镜阵列的透镜，通过支撑阵列的通道延伸到传感器阵列的区域。 传感器阵列的每个区域包括多个传感器元件，其中传感器元件的位置对应于基于在该位置接收的光的角度接收的光的波长，透镜的焦距和透镜的中心波长 过滤。

公开(公告)号：US20160320305A1

公开(公告)日：2016-11-03

申请号：US14741629

申请日：2015-06-17

Applicant: National Central University

Inventor： Szu-Yu CHEN ,  Poyu SU ,  Chiao-Sheng LU ,  Yu John HSU

IPC: G01N21/64 ,  G01J3/28 ,  G01J3/12 ,  G01J3/02 ,  G01J3/10

CPC classification number: G01N21/6458 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0267 ,  G01J3/04 ,  G01J3/06 ,  G01J3/10 ,  G01J3/12 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/4406 ,  G01J2003/2813 ,  G01J2003/282 ,  G01N2021/6421 ,  G01N2021/6423 ,  G01N2021/6476 ,  G01N2021/6478

Abstract: A fluorescence hyperspectral microscopy system featuring structured illumination and parallel recording includes a light projection sub-system, a detection sub-system, and an electrical controller. The light projection sub-system includes a digital light processing (DLP) module for generating linear excitation light, a first lens set, an optical path allocation element, and an objective lens. The detection sub-system includes a second lens set, a frequency-dividing reflection element, a two-dimensional light detector, and a light collection element. With the detection sub-system performing detection in conjunction with the light projection sub-system, and the electrical controller controlling the DLP module, a two-dimensional moving platform, and the two-dimensional light detector, the fluorescence hyperspectral microscopy system provides increased resolution and can obtain accurate information in spatial and spectral dimensions and hence a four-dimensional hyperspectral image of the object under detection.

Abstract translation: 具有结构照明和并行记录的荧光高光谱显微系统包括光投影子系统，检测子系统和电控制器。 光投影子系统包括用于产生线性激发光的数字光处理（DLP）模块，第一透镜组，光路分配元件和物镜。 检测子系统包括第二透镜组，分频反射元件，二维光检测器和光收集元件。 通过检测子系统与光投影子系统进行检测，控制DLP模块的电气控制器，二维移动平台和二维光检测器，荧光高光谱显微系统提供更高的分辨率 并且可以在空间和光谱维度上获得准确的信息，并因此获得被检测物体的四维高光谱图像。

公开(公告)号：US20160296118A1

公开(公告)日：2016-10-13

申请号：US14684638

申请日：2015-04-13

Applicant: ATOPTIX, LLC

Inventor： Perry S. EDWARDS ,  Zhiwen LIU

IPC: A61B5/00 ,  G01J3/28

CPC classification number: A61B5/0075 ,  A61B5/14542 ,  A61B5/6801 ,  A61B5/6843 ,  A61B5/6898 ,  A61B5/742 ,  A61B2560/0252 ,  A61B2562/12 ,  G01J3/0229 ,  G01J3/0272 ,  G01J3/18 ,  G01J3/42 ,  G01J2003/425

Abstract: Devices for reflectance spectroscopy, processes of assembling devices for reflectance spectroscopy, and health care processes of using reflectance optical spectroscopy devices are disclosed. The devices include a light source arranged and disposed to apply broadband light to sample, and a light-receiving feature configured to receive reflected light produced by the applying of the broadband light to the sample. The light-receiving feature is arranged and disposed to direct the reflected light to an optical detection system and isolate the reflected light from the broadband light. The optical detection system is capable of differentiating individual frequencies of the reflected light. The processes of assembling include removably positioning the devices on electronic devices. The health care processes include positioning the devices.

Abstract translation: 公开了用于反射光谱的装置，用于反射光谱装配装置的工艺和使用反射光谱装置的保健工艺。 这些装置包括布置和布置以将样品宽带光应用的光源和被配置为接收通过将宽带光施加到样品产生的反射光的光接收特征。 光接收特征被布置和布置成将反射光引导到光学检测系统并将反射光与宽带光隔离。 光学检测系统能够区分反射光的各个频率。 组装过程包括将设备可拆卸地定位在电子设备上。 保健过程包括定位设备。

公开(公告)号：US20160282594A1

公开(公告)日：2016-09-29

申请号：US15180301

申请日：2016-06-13

Applicant: Verily Life Sciences LLC

Inventor： Victor Marcel Acosta ,  Adam Backer ,  John D. Perreault ,  Daniele Paolo Piponi

IPC: G02B21/00 ,  H04N5/33 ,  G06T7/40 ,  G02F1/23 ,  G02B21/06 ,  G02B21/36 ,  G01N21/27 ,  H04N5/225 ,  G06T7/00

CPC classification number: G02B21/0064 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/18 ,  G01J3/502 ,  G01J2003/1278 ,  G01J2003/468 ,  G01N21/255 ,  G01N21/27 ,  G01N2201/06113 ,  G01N2201/0675 ,  G02B5/1828 ,  G02B6/2931 ,  G02B21/06 ,  G02B21/361 ,  G02B26/0808 ,  G02F1/133553 ,  G02F1/23 ,  G02F1/292 ,  G06T7/11 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30004 ,  H04N5/2256 ,  H04N5/332

Abstract: An imaging system includes a light source configured to illuminate a target and a camera configured to image light responsively emitted from the target and reflected from a spatial light modulator (SLM). The imaging system is configured to generate high-resolution, hyperspectral images of the target. The SLM includes a refractive layer that is chromatically dispersive and that has a refractive index that is controllable. The refractive index of the refractive layer can be controlled to vary according to a gradient such that light reflected from the SLM is chromatically dispersed and spectrographic information about the target can be captured using the camera. Such a system could be operated confocally, e.g., by incorporating a micromirror device configured to control a spatial pattern of illumination of the target and to modulate the transmission of light from the target to the camera via the SLM according to a corresponding spatial pattern.

Abstract translation: 成像系统包括被配置为照射目标的光源和被配置为对从目标发射并从空间光调制器（SLM）反射的）反射的图像的照相机。 成像系统被配置为产生目标的高分辨率，高光谱图像。 SLM包括色度分散且具有可控制的折射率的折射层。 折射层的折射率可以根据梯度来变化，使得从SLM反射的光被色散，并且可以使用照相机捕获关于目标的光谱信息。 这样的系统可以协调地操作，例如通过结合配置成控制目标的照明的空间模式的微镜装置，并且根据对应的空间模式经由SLM调制从目标到照相机的光的传输。

公开(公告)号：US09433351B2

公开(公告)日：2016-09-06

申请号：US13464578

申请日：2012-05-04

Applicant: Chung-Chieh Yu ,  Condon Lau ,  Stephen Fulghum ,  Christopher Fang-yen ,  Ramachandra Dasari ,  Michael Feld ,  David Feld ,  Alison Hearn ,  Jonathan Feld

Inventor： Chung-Chieh Yu ,  Condon Lau ,  Stephen Fulghum ,  Christopher Fang-yen ,  Ramachandra Dasari ,  Michael Feld

IPC: A61B6/00 ,  A61B5/00 ,  G01J3/02 ,  G01J3/10 ,  G01J3/32 ,  G01N21/47 ,  G01N21/49

CPC classification number: A61B5/0059 ,  A61B5/0066 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/32 ,  G01N21/4738 ,  G01N21/49 ,  G01N2021/4733

Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.

Abstract translation: 本发明涉及使用自发荧光和反射图像诊断组织的光谱成像系统。 本发明的优选实施例使用多个光源照射组织区域以分别提供荧光和反射图像。

公开(公告)号：US20160245700A1

公开(公告)日：2016-08-25

申请号：US15147456

申请日：2016-05-05

Applicant: SEIKO EPSON CORPORATION

Inventor： Akira UEMATSU ,  Noriyuki NAKAMURA ,  Akira KOMATSU ,  Kunihiko YANO

IPC: G01J3/51 ,  A61B5/145 ,  G01J3/02 ,  A61B5/1455

CPC classification number: G01J3/51 ,  A61B5/14532 ,  A61B5/14552 ,  A61B2562/12 ,  G01J3/0229 ,  H01L31/02162 ,  H01L31/02325 ,  H01L31/103

Abstract: A spectroscopic sensor has plural angle limiting filters that limit incident angles of incident lights, plural light band-pass filters that transmit specific wavelengths, and plural photodiodes to which corresponding transmitted lights are input. The spectroscopic sensor is a semiconductor device in which the angle limiting filters, the light band-pass filters, and the photodiodes are integrated, and, assuming that the surface on which impurity regions for the photodiodes are formed is a front surface of a semiconductor substrate, holes for receiving lights are formed in the impurity regions from the rear surface side.

Abstract translation: 光谱传感器具有多个限制入射光的入射角的角度限制滤光器，多个发送特定波长的光带通滤波器以及输入相应透射光的多个光电二极管。 光谱传感器是将角度限制滤光器，光带通滤波器和光电二极管集成在一起的半导体器件，并且假定形成有用于光电二极管的杂质区域的表面是半导体衬底的正面 在背面侧的杂质区域形成有用于接收光的孔。

公开(公告)号：US09400432B2

公开(公告)日：2016-07-26

申请号：US13881546

申请日：2011-10-25

Applicant: Sascha Pierre Heussler ,  Herbert O. Moser

Inventor： Sascha Pierre Heussler ,  Herbert O. Moser

IPC: G03F7/20 ,  G02B5/18 ,  G03F7/00 ,  G03F7/213

CPC classification number: G02B5/18 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/4531 ,  G03F7/0002 ,  G03F7/0005 ,  G03F7/0017 ,  G03F7/0037 ,  G03F7/2014 ,  G03F7/203 ,  G03F7/213 ,  G03F7/70058 ,  G03F7/70416 ,  G03F7/70466

Abstract: A lithography method and apparatus is disclosed herein. In a described embodiment, the method comprises (i) providing a first mask having an exposure pattern for forming a three dimensional structure; (ii) exposing the first mask to radiation to form the exposure pattern on a radiation-sensitive resist; the exposure pattern defined by irradiated areas and non-irradiated areas of the resist; (ii) providing a second mask; and (iii) during exposure, changing relative positions between the first mask and the second mask to shield selected portions of the irradiated areas from radiation to enable varying depth profiles to be created in the three dimensional structure.

Abstract translation: 本文公开了一种光刻方法和装置。 在所描述的实施例中，该方法包括（i）提供具有用于形成三维结构的曝光图案的第一掩模; （ii）将第一掩模暴露于辐射以在辐射敏感抗蚀剂上形成曝光图案; 由抗蚀剂的照射区域和未照射区域限定的曝光图案; （ii）提供第二掩模; 和（iii）在曝光期间，改变第一掩模和第二掩模之间的相对位置以屏蔽被照射区域的所选部分不受辐射，以使能够在三维结构中产生变化的深度分布。

公开(公告)号：US09383258B2

公开(公告)日：2016-07-05

申请号：US14702470

申请日：2015-05-01

Applicant: VERIFOOD, LTD.

Inventor： Damian Goldring ,  Dror Sharon ,  Guy Brodetzki ,  Amit Ruf ,  Menahem Kaplan ,  Sagee Rosen ,  Omer Keilaf ,  Uri Kinrot ,  Kai Engelhardt ,  Ittai Nir

IPC: G01J3/28 ,  G01J3/10 ,  G01J3/45

CPC classification number: G01J3/108 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0256 ,  G01J3/0259 ,  G01J3/0262 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/36 ,  G01J3/45 ,  G01J5/0265 ,  G01J5/10 ,  G01J2003/1226 ,  G01J2003/123 ,  G01J2003/1239 ,  G01N21/255 ,  G01N33/02

Abstract: A spectrometer comprises a plurality of isolated optical channels comprising a plurality of isolated optical paths. The isolated optical paths decrease cross-talk among the optical paths and allow the spectrometer to have a decreased length with increased resolution. In many embodiments, the isolated optical paths comprise isolated parallel optical paths that allow the length of the device to be decreased substantially. In many embodiments, each isolated optical path extends from a filter of a filter array, through a lens of a lens array, through a channel of a support array, to a region of a sensor array. Each region of the sensor array comprises a plurality of sensor elements in which a location of the sensor element corresponds to the wavelength of light received based on an angle of light received at the location, the focal length of the lens and the central wavelength of the filter.

Abstract translation: 光谱仪包括多个隔离光通道，其包括多个隔离光路。 孤立的光路减少光路之间的串扰，并允许光谱仪具有降低的分辨率的长度。 在许多实施例中，隔离的光路包括隔离的平行光路，其允许基本上减小器件的长度。 在许多实施例中，每个隔离的光路从滤光器阵列的滤光片延伸穿过透镜阵列的透镜，通过支撑阵列的通道延伸到传感器阵列的区域。 传感器阵列的每个区域包括多个传感器元件，其中传感器元件的位置基于在该位置处接收的光的角度接收的光的波长，透镜的焦距和透镜的中心波长 过滤。