公开(公告)号：US20240096613A1

公开(公告)日：2024-03-21

申请号：US18467553

申请日：2023-09-14

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Hamish STEWART

IPC: H01J49/06 ,  H01J49/16

CPC classification number: H01J49/065 ,  H01J49/164

Abstract: An ion guide is provided for a spectrometer. The ion guide comprises a first electrode assembly, comprising a plurality of guide electrodes aligned along a central axis. Each guide electrode comprises an aperture. The apertures define an ion channel from a first end of the first electrode assembly to a second end of the first electrode assembly. The ion channel is configured to receive an ion beam at the first end. The guide electrodes are configured to receive RF voltages to define a confinement volume for the ion beam, wherein the confinement volume is centred about the central axis. The ion guide comprises a second electrode assembly adjacent to the first electrode assembly, wherein the second electrode assembly is configured to receive a DC voltage, such that a centre of the ion beam is deflected to be off the central axis.

公开(公告)号：US11670495B2

公开(公告)日：2023-06-06

申请号：US16880206

申请日：2020-05-21

Applicant: MOBILion Systems, Inc.

Inventor： John Daniel DeBord ,  Gordon A. Anderson

IPC: H01J49/06 ,  H01J49/30 ,  H01J49/02

CPC classification number: H01J49/063 ,  H01J49/022 ,  H01J49/065 ,  H01J49/30

Abstract: A device includes a first surface, a second surface and a controller. The second surface is adjacent to the first surface. The first and the second surfaces define a first ion channel therebetween. The first ion channel extends along a first direction. The second surface includes a first plurality of electrodes including a first electrode and a second electrode spaced apart from the first electrode along a second direction lateral to the first direction. The first plurality of electrodes extends along the first direction. The first electrode is configured to receive a first voltage signal and generate at least a portion of a pseudopotential that inhibits ions in the first ion channel from approaching the second surface. The second plurality of electrodes is located between the first electrode and the second electrode and arranged along the first direction. The second plurality of electrodes are configured to receive a second voltage signal to generate a first traveling drive potential that travels along the first direction. The first traveling drive potential is configured to guide ions along the first ion channel. The device further includes a controller electrically coupled to the first and the second surface. The controller is configured to generate the first voltage signal and the second voltage signal.

公开(公告)号：US20230162964A1

公开(公告)日：2023-05-25

申请号：US17906548

申请日：2021-03-19

Applicant: Micromass UK Limited

Inventor： Jason Wildgoose ,  Darren Hewitt ,  Matthew Collier ,  Oliver Malpas

IPC: H01J49/06 ,  G01N27/622

CPC classification number: H01J49/065 ,  G01N27/622 ,  H01J49/067 ,  H01J49/068

Abstract: An ion guide assembly (2) is disclosed comprising: two planar mounting components (4); and first and second ion guides (6,8) mounted on the two planar mounting components such that the ion guides are spaced apart from each other, wherein at least one of the planar mounting components has an aperture (14) therethrough that is located between the positions on said at least one mounting component at which the first and second ion guides are mounted; and an ion optical device sized and configured to be inserted through the aperture in the planar mounting component and into the space between the first and second ion guides.

公开(公告)号：US09978572B2

公开(公告)日：2018-05-22

申请号：US15307576

申请日：2015-04-30

Applicant: MICROMASS UK LIMITED

Inventor： Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

IPC: H01J49/26 ,  H01J49/28 ,  H01J49/40 ,  H01J49/06 ,  H01J49/00

CPC classification number: H01J49/0031 ,  H01J49/004 ,  H01J49/005 ,  H01J49/062 ,  H01J49/063 ,  H01J49/065 ,  H01J49/401

Abstract: A method of mass spectrometry is disclosed comprising providing a first device and a second device disposed downstream of the first device. The method further comprises introducing a potential difference between the exit of the first device and the entrance of the second device and reducing the total potential drop across the first and second devices by applying a reverse axial electric field to the first device and/or the second device. Ions are driven through the first device and/or the second device against the reverse axial electric field.

公开(公告)号：US20180068839A1

公开(公告)日：2018-03-08

申请号：US15260046

申请日：2016-09-08

Applicant: Battelle Memorial Institute

Inventor： Yehia M. Ibrahim ,  Richard D. Smith

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/42

CPC classification number: H01J49/0095 ,  H01J49/062 ,  H01J49/063 ,  H01J49/065 ,  H01J49/4235

Abstract: An apparatus includes a first pair of opposing electrode arrangements that confine ions between them in a portion of a confinement volume inwardly laterally in a first confinement direction with respect to a longitudinal ion propagation direction, each opposing electrode arrangement including an arrangement of RF electrodes situated to receive an unbiased RF voltage having an alternate phase between adjacent RF electrodes of the arrangement of RF electrodes so as to provide the confining of ions between the first pair of opposing electrode arrangements, and a second pair of opposing electrode arrangements that confine the ions between the second pair in the confinement volume inwardly laterally in a second confinement direction that complements the first confinement direction, each opposing electrode arrangement of the second pair including an arrangement of RF electrodes that receive an unbiased RF voltage having an alternate phase between adjacent RF electrodes.

公开(公告)号：US09899200B2

公开(公告)日：2018-02-20

申请号：US15310694

申请日：2015-05-13

Applicant: MICROMASS UK LIMITED

Inventor： Kevin Giles ,  Jason Lee Wildgoose

IPC: H01J49/06 ,  H01J49/26 ,  H01J49/00 ,  B01D59/44 ,  G01N27/62 ,  H01J49/40

CPC classification number: H01J49/065 ,  H01J49/0027 ,  H01J49/004 ,  H01J49/40

Abstract: A sub-ambient gas pressure ion separation device is disclosed comprising: an ion entrance aperture having an axis therethrough that extends in a first direction, and an ion exit aperture; wherein the entrance aperture and exit aperture are spatially separated from each other in the first direction and in a second, orthogonal direction; and means for urging ions in said second direction as the ions travel in the first direction, said means for causing ions to separate in said second direction according to a physicochemical property such that ions having a first value, or first range of values, of the physicochemical property exit the device through the exit aperture and other ions having a different value, or different range of values, of said physicochemical property do not exit the device through the exit aperture.

公开(公告)号：US09887075B2

公开(公告)日：2018-02-06

申请号：US14895520

申请日：2014-05-28

Applicant: Micromass UK Limited

Inventor： John Brian Hoyes

IPC: H01J49/00 ,  H01J49/40 ,  H01J49/06 ,  H01J49/42

CPC classification number: H01J49/405 ,  H01J49/062 ,  H01J49/063 ,  H01J49/065 ,  H01J49/40 ,  H01J49/4215 ,  H01J49/4225 ,  H01J49/4235

Abstract: A device for manipulating charged particles using an axial electric field as they travel along a longitudinal axis of the device is disclosed. The method comprises providing an outer electrode for generating an electric field and providing a plurality of inner electrodes that are separated by gaps of different lengths. The electric field generated by the outer electrode penetrates the gaps between the inner electrodes and the gaps are selected such that the desired potential profile is arranged along the longitudinal axis in order to manipulate the charged particles in the desired manner.

公开(公告)号：US09786485B2

公开(公告)日：2017-10-10

申请号：US15310990

申请日：2015-04-29

Applicant: SHIMADZU CORPORATION

Inventor： Li Ding ,  Aleksandr Rusinov

IPC: H01J49/28 ,  H01J49/40 ,  H01J49/06

CPC classification number: H01J49/401 ,  H01J49/065 ,  H01J49/067 ,  H01J49/068 ,  H01J49/282 ,  H01J49/406

Abstract: A mass analyser comprises a pair of electrode arrays. Each array has a set of focusing electrodes which are supplied, in use, with voltage to create an electrostatic field in a space between the electrode arrays causing ions to undergo periodic, oscillatory motion in the space, ions passing between electrodes of the sets of focusing electrodes and being repeatedly focused at a center plane, mid-way between the electrode arrays. At least one electrode of each set of focusing electrodes has an electrode surface closer to the center plane than the electrode surfaces of other electrodes of the same set. The analyzer may be an ion trap mass analyser or a multi-turn ToF mass analyzer.

公开(公告)号：US20170200595A1

公开(公告)日：2017-07-13

申请号：US15412595

申请日：2017-01-23

Applicant: Micromass UK Limited

Inventor： Kevin GILES ,  Jason Lee WILDGOOSE

IPC: H01J49/00 ,  H01J49/36 ,  H01J49/06

CPC classification number: H01J49/0031 ,  G01N27/622 ,  H01J49/062 ,  H01J49/065 ,  H01J49/36 ,  H01J49/4235

Abstract: An ion mobility separator and a method of separating ions according to their ion mobility are disclosed. An RF ion guide is provided having a plurality of electrodes that are arranged to form an ion guiding path that extends in a closed loop. RF voltages are supplied to at least some of the electrodes in order to confine ions within said ion guiding path. A DC voltage gradient is maintained along at least a portion of a longitudinal axis of the ion guide, wherein the voltage gradient urges ions to undergo one or more cycles around the ion guide and thus causes the ions to separate according to their ion mobility as the ions pass along the ion guide. The closed loop ion guide enables the resolution of the ion mobility separator to be increased without necessitating a large device, since the drift length through the device can be increased by causing the ions to undergo multiple cycles around the device.

公开(公告)号：US09570281B2

公开(公告)日：2017-02-14

申请号：US14835526

申请日：2015-08-25

Applicant: SHIMADZU CORPORATION

Inventor： Xiaoqiang Zhang ,  Wenjian Sun

IPC: H01J49/06 ,  H01J49/16 ,  H01J49/00

CPC classification number: H01J49/065 ,  H01J49/0072 ,  H01J49/165

Abstract: The invention relates to an ion generation device and an ion generation method, and more particularly to a device and a method which generates ions at the low pressure and then said ions can be transferred into the next stage in an off-axis manner. In the invention, ions from electrospray or other types of ion source are generated in the pressure which is lower than atmosphere pressure. A followed ion guide device can then transfer most of said generated ions into next stage in an off-axis manner, while most of neutral noise can be eliminated in this process.

Abstract translation: 本发明涉及离子产生装置和离子产生方法，更具体地说，涉及一种在低压下产生离子的装置和方法，然后所述离子可以以离轴方式转移到下一阶段。 在本发明中，来自电喷雾或其它类型的离子源的离子产生的压力低于大气压。 随后的离子引导装置然后可以以离轴方式将大部分所产生的离子转移到下一级，而在该过程中可以消除大部分中性噪声。