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公开(公告)号：US20240353259A1
公开(公告)日：2024-10-24
申请号：US18303814
申请日：2023-04-20
Inventor： Dwane F. Sample , Nathan J. Gengler , Peter Magee
CPC classification number: G01J3/2803 , G01J3/0227 , G01J2003/2859
Abstract: A spectrographic analyzer of pulses within a signal includes a data interface, an edge detection filter, a delay buffer, an integrator, and a histogram buffer. The data interface duplicates a stream of digital amplitude samples for the signal into a first and second stream. The edge detection filter determines the beginning and end of each pulse within the first stream of the digital amplitude samples. The delay buffer delays the second stream by a duration sufficient for the edge detection filter to determine both the beginning and end of each pulse. The integrator sums a respective amplitude total for each pulse. The respective amplitude total sums the digital amplitude samples between the beginning and end of each pulse in the second stream as delayed by the delay buffer. The histogram buffer maintains bins and increments a respective one of the bins encompassing the respective amplitude total for each pulse.
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公开(公告)号：US12050130B2
公开(公告)日：2024-07-30
申请号：US18542717
申请日：2023-12-17
Applicant: MIFTEK CORPORATION
CPC classification number: G01J3/4406 , G01J3/0218 , G01J3/0227
Abstract: A measurement system is disclosed which includes a vessel configured to suspend molecules of interest therein, optical sources configured to excite the molecules of interest by an excitation light activated and deactivated in a stepwise fashion, during the activation, the sources activated according to a pulse train, the molecules of interest emitting emission light in response to being excited by the excitation light, one or more sensor packages each comprising a plurality of photodetectors configured to receive emission light from the molecules of interest and, in response, provide an output voltage signal and an output current signal corresponding to photoelectron response of an incident photon on the one or more sensor packages, and a detector configured to determine successive single molecular decay of the molecules of interest, generate an emission pulse associated with each incident photon on the one or more sensor packages, and count the number of emission pulses.
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公开(公告)号：US20240133740A1
公开(公告)日：2024-04-25
申请号：US18542717
申请日：2023-12-17
Applicant: MIFTEK CORPORATION
CPC classification number: G01J3/4406 , G01J3/0218 , G01J3/0227
Abstract: A measurement system is disclosed which includes a vessel configured to suspend molecules of interest therein, optical sources configured to excite the molecules of interest by an excitation light activated and deactivated in a stepwise fashion, during the activation, the sources activated according to a pulse train, the molecules of interest emitting emission light in response to being excited by the excitation light, one or more sensor packages each comprising a plurality of photodetectors configured to receive emission light from the molecules of interest and, in response, provide an output voltage signal and an output current signal corresponding to photoelectron response of an incident photon on the one or more sensor packages, and a detector configured to determine successive single molecular decay of the molecules of interest, generate an emission pulse associated with each incident photon on the one or more sensor packages, and count the number of emission pulses.
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公开(公告)号：US11852537B2
公开(公告)日：2023-12-26
申请号：US18130867
申请日：2023-04-04
Applicant: MIFTEK CORPORATION
CPC classification number: G01J3/4406 , G01J3/0218 , G01J3/0227
Abstract: A flow cytometry measurement system is disclosed which includes a flow chamber configured to flow particles of interest in a flow stream, one or more optical sources configured to excite the particles of interest by an excitation light activated and deactivated according to a pulse train thus causing particles of interest emitting emission light, one or more sensor packages each comprising a plurality of photodetectors configured to receive emission light from the particles of interest and, in response, provide an output voltage signal and an output current signal corresponding to photoelectron response of an incident photon on the one or more sensor packages, and a detector configured to determine successive single molecular decay of the particles of interest, generate an emission pulse associated with each incident photon on the one or more sensor packages, and count the number of emission pulses.
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公开(公告)号：US20230296439A1
公开(公告)日：2023-09-21
申请号：US18123488
申请日：2023-03-20
Inventor： Kin Chiu Ng , Subrata Sanyal
CPC classification number: G01J3/4412 , G06V40/1318 , G01J3/0286 , G01J3/0272 , G01J3/0229 , G01J3/0202 , G01J3/0227 , G01J3/0275
Abstract: Provided is a portable biosensor that includes a sample filter cartridge, a filter collector, an optical sphere, an electromagnetic radiation emitter, a photo-detector, a processor, a signal display, a vacuum pump, and a power supply. The sample filter cartridge selectively removes small molecules to minimize spectral interference in the detection signal. The sample is concentrated onto the filter collector and subjected to illumination by the electromagnetic radiation emitter, producing Raman-scattering. The optical sphere collects and distributes the Raman-scattering shifts, which then pass through a spectral filter to produce spectral filtered scattering, which is then reflected by the concave holographic flat-field grating onto the photo-detector. The data is displayed graphically to provide the Raman-scattering shift data. The data is compared with a database for sample identification. The device is contained within a housing that is small enough to be easily transported for field use.
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Patent Agency Ranking
66.发明申请公开(公告)号：US20190195803A1
公开(公告)日：2019-06-27
申请号：US16232339
申请日：2018-12-26
Applicant: NUCTECH COMPANY LIMITED
Inventor： Haihui Liu , Hongqiu Wang , Jianhong Zhang
CPC classification number: G01N21/65 , G01J3/0205 , G01J3/021 , G01J3/0227 , G01J3/0248 , G01J3/10 , G01J3/36 , G01J3/44 , G01J3/4412 , G01N2021/1765 , G01N2021/1793 , G01N2201/06113
Abstract: A detection apparatus, including: a laser configured to emit laser light towards an object to be detected; a Raman spectrometer configured to receive Raman light from the object; an imaging device configured to obtain an image of the object; a light sensor configured to receive light reflected and scattered by the object under irradiation of the laser light, and to determine the power of the received light; and a controller configured to control an operation of the detection apparatus based on the image obtained by the imaging device and the power determined by the light sensor. A detection method using the detection apparatus.
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公开(公告)号：US20190033128A1
公开(公告)日：2019-01-31
申请号：US16043900
申请日：2018-07-24
Applicant: NUCTECH COMPANY LIMITED
Inventor： Jianhong ZHANG , Hongqiu WANG , Li ZHANG
CPC classification number: G01J3/0208 , G01J3/0202 , G01J3/021 , G01J3/0227 , G01J3/0229 , G01J3/10 , G01J3/44 , G01J2003/4424 , G01N21/65
Abstract: A Raman spectrum inspection apparatus is provided, including: a exciting light source configured to emit an exciting light to a sample to be inspected; an optical device configured to collect an optical signal from a position, which is irradiated by the exciting light, of the sample to be inspected; and a spectrometer configured to generate a Raman spectrum of the sample to be inspected from the received optical signal, wherein an excitation optical path in which the exciting light passes from the exciting light device to the sample to be inspected and a detection optical path in which the optical signal received by the spectrometer passes from the sample to be inspected to the spectrometer are separated from each other.
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公开(公告)号：US09970876B2
公开(公告)日：2018-05-15
申请号：US13591907
申请日：2012-08-22
Applicant: Donald W. Sackett
Inventor： Donald W. Sackett
IPC: G01J3/42 , G01N21/65 , G01J3/44 , G01J3/02 , G01J3/18 , G01J3/28 , G01J3/443 , G01N21/359 , G01N21/71 , G01N21/27
CPC classification number: G01N21/65 , G01J3/0208 , G01J3/0227 , G01J3/18 , G01J3/2803 , G01J3/44 , G01J3/443 , G01N21/274 , G01N21/359 , G01N21/718
Abstract: A dual source system and method includes a high power laser used to determine elements in a sample and a lower power device used to determine compounds present in the sample. An optical subsystem directs photons from a sample to a detector subsystem after laser energy from the laser strikes the sample along an optical path. After energy from the device strikes the sample protons are directed to the detector subsystem along the same optical path. The detector subsystem receives photons after laser energy from the laser strikes the sample and provides a first signal, and receives photons after energy from the device strikes the sample and provides a second signal. A controller subsystem pulses the high power laser and processes the first signal to determine elements present in the sample, energizes the lower power device and processes the second signal to determine compounds present in the sample.
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公开(公告)号：US20180067295A1
公开(公告)日：2018-03-08
申请号：US15695464
申请日：2017-09-05
Applicant: USHIO DENKI KABUSHIKI KAISHA
Inventor： Ryohei TAKAKI , Kiyoyuki KABUKI
CPC classification number: G02B21/06 , F21K9/64 , G01J1/58 , G01J3/0208 , G01J3/0227 , G01J3/024 , G01J3/0243 , G01J3/10 , G01J3/12 , G01J3/4406 , G01J2003/1213 , G02B5/22 , G02B6/00 , G02B19/00 , G02B19/0052 , G02B21/0032 , G02B21/0076 , G02B21/082
Abstract: Disclosed are a fluorescence microscope light source apparatus and a fluorescence microscope capable of obtaining high-luminance light in a wavelength of 500 to 550 nm and having reduced background noise when a sample is observed. The fluorescence microscope light source apparatus to be installed in a fluorescence microscope including an illumination light bandpass filter includes: a laser diode that emits blue light as excitation light; a phosphor that converts the excitation light from the laser diode into illumination fluorescence with a wavelength region of 500 to 550 nm; an optical system that extracts the illumination fluorescence from the phosphor; a first condenser lens that condenses the excitation light onto the phosphor; a light guide body having one end face on which the illumination fluorescence is incident and the other end face from which the illumination fluorescence exits; and a second condenser lens that condenses the illumination fluorescence onto the one end face of the light guide body. A band-elimination filter that blocks or attenuates light, out of the illumination fluorescence, in a wavelength region including a transmission maximum wavelength and including no transmission minimum wavelength in the illumination light bandpass filter is provided on a light path of the illumination fluorescence.
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公开(公告)号：US09909992B2
公开(公告)日：2018-03-06
申请号：US15119055
申请日：2015-02-28
Applicant: IMEC VZW
Inventor： Pol Van Dorpe , Peter Peumans
IPC: G01J3/30 , G01N21/65 , A61B5/00 , A61B5/145 , A61B5/1455 , G01J3/02 , G01J3/36 , G01J3/44 , G01J3/26 , G01N33/49 , G01J3/12
CPC classification number: G01N21/65 , A61B5/0066 , A61B5/14532 , A61B5/1455 , A61B5/443 , A61B2562/0233 , A61B2562/0238 , G01J1/0204 , G01J1/0425 , G01J1/0477 , G01J3/0205 , G01J3/0208 , G01J3/021 , G01J3/0227 , G01J3/0256 , G01J3/0264 , G01J3/0291 , G01J3/1895 , G01J3/26 , G01J3/36 , G01J3/44 , G01J2003/1213 , G01N33/49 , G01N2201/06113 , G01N2201/0633 , G01N2201/0636 , G02B6/0026 , G02B6/0031 , G02B6/0038 , G02B6/0048
Abstract: The present disclosure relates to systems, methods, and sensors configured to characterize a radiation beam. At least one embodiment relates to an optical system. The optical system includes an optical radiation guiding system. The optical radiation guiding system includes a collimator configured to collimate the radiation beam into a collimated radiation beam. The optical radiation guiding system also includes a beam shaper configured to distribute power of the collimated radiation beam over a discrete number of line shaped fields. A spectrum of the collimated radiation beam entering the beam shaper is delivered to each of the discrete number of line shaped fields. The optical system further includes a spectrometer chip. The spectrometer chip is configured to process the spectrum of the collimated radiation beam in each of the discrete number of line shaped fields coming from the beam shaper.
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