CYLINDRICAL ILLUMINATION CONFOCAL SPECTROSCOPY SYSTEM

    公开(公告)号:US20100118300A1

    公开(公告)日:2010-05-13

    申请号:US12612300

    申请日:2009-11-04

    Abstract: A cylindrical illumination confocal spectroscopy system has a fluidic device having a fluid channel defined therein, an objective lens unit arranged proximate the fluidic device, an illumination system in optical communication with the objective lens unit to provide light to illuminate a sample through the objective lens unit, and a detection system in optical communication with the objective lens unit to receive at least a portion of light that passes through the objective lens unit from the sample. The illumination system includes a beam-shaping lens unit constructed and arranged to provide a substantially planar illumination beam that subtends across, and is longer than, a lateral dimension of the fluid channel, the substantially planar illumination beam having a diffraction limited thickness in a direction substantially orthogonal to the lateral dimension of the fluid channel. The substantially planar illumination beam incident upon the fluidic device has a width that is substantially longer than the lateral dimension of the fluid channel such that the substantially planar illumination beam has an illumination intensity that is uniform across the lateral dimension of the fluid channel to within ±10%. The detection system comprises an aperture stop defining a substantially rectangular aperture having a longitudinal dimension and a transverse dimension. The aperture stop is arranged so that the substantially rectangular aperture is confocal with an illuminated portion of the fluid channel such that the transverse dimension of the substantially rectangular aperture substantially subtends the lateral dimension of the fluid channel without extending substantially beyond the fluid channel and allows light to pass from only a uniform excitation region while occluding light from outside the uniform excitation region, and the lateral dimension of the substantially rectangular aperture substantially matches the diffraction limited thickness of the planar illumination beam.

    Raman spectrometry assembly
    62.
    发明授权
    Raman spectrometry assembly 有权
    拉曼光谱装配

    公开(公告)号:US07701571B2

    公开(公告)日:2010-04-20

    申请号:US11894887

    申请日:2007-08-22

    Abstract: A Raman spectrometry assembly includes a Raman spectrometer having a laser light source and a Raman signal analyzer, an interface module comprising a housing which is connectable to and disconnectable from the spectrometer, and a fiber optic assembly which is connectable to and disconnectable from the interface module, the fiber optic assembly including optical fibers and a probe head at a distal end thereof for disposition adjacent a specimen to be tested, the optical fibers extending from the probe head and adapted to extend to the interface module.

    Abstract translation: 拉曼光谱仪组件包括具有激光光源和拉曼信号分析器的拉曼光谱仪,包括可与光谱仪连接并可与光谱仪分离的外壳的接口模块,以及可与接口模块连接并与其分离的光纤组件 ,所述光纤组件包括光纤和在其远端处的探针头,用于邻近待测试的样品布置,所述光纤从探头延伸并适于延伸到接口模块。

    Assembly and method for identifying coatings lying on the surface of components and for determining their characteristics
    64.
    发明授权
    Assembly and method for identifying coatings lying on the surface of components and for determining their characteristics 失效
    用于识别位于组件表面上的涂层并确定其特性的装配和方法

    公开(公告)号:US07502108B2

    公开(公告)日:2009-03-10

    申请号:US10559175

    申请日:2004-05-21

    Abstract: The invention is directed to an arrangement for detecting coatings which are arranged on surfaces of structural component parts or objects and for determining the chemical characteristics and surface properties of these coatings. It comprises a light source for illuminating the coating to be analyzed on the surface of the structural component part and means for imaging the light source on an entrance slit over the surface of the coating to be analyzed. The entrance slit is imaged in a wavelength-dependent manner on a two-dimensional detector unit by a grating. An evaluating unit which is electrically connected to the detector unit serves to evaluate and process the signals supplied by the exposed detector elements of the detector unit.

    Abstract translation: 本发明涉及一种用于检测涂层的布置,其布置在结构部件或物体的表面上并用于确定这些涂层的化学特性和表面性质。 它包括用于照亮在结构部件表面上待分析的涂层的光源,以及用于将光源成像在待分析涂层的表面上的入口狭缝上的装置。 入射狭缝通过光栅以波长依赖的方式成像在二维检测器单元上。 电连接到检测器单元的评估单元用于评估和处理由检测器单元的暴露的检测器元件提供的信号。

    System and method for spectral unmixing in a fiber array spectral translator based polymorph screening system
    65.
    发明授权
    System and method for spectral unmixing in a fiber array spectral translator based polymorph screening system 有权
    基于光纤阵列光谱变换器的多态性筛选系统中光谱解混合的系统和方法

    公开(公告)号:US07471386B2

    公开(公告)日:2008-12-30

    申请号:US11679112

    申请日:2007-02-26

    Abstract: The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based (“FAST”) spectroscopic system for performing spectral unmixing of a mixture containing multiple polymorphs. In an embodiment, a first spectrum of a mixture containing polymorphs of a compound is obtained using a photon detector and a fiber array spectral translator having plural fibers. A set of second spectra is provided where each spectrum of the set of second spectra may be representative of a different polymorph of the compound. The first spectrum and the set of second spectra may be compared, and based on the comparison, the presence of one or more polymorphs in the mixture may be determined.

    Abstract translation: 本公开总体上涉及使用用于执行含有多个多晶型物的混合物的光谱解混合的光纤阵列光谱转换器(“FAST”)光谱系统的方法和装置。 在一个实施方案中,使用具有多个纤维的光子检测器和光纤阵列光谱转换器获得含有化合物多晶型物的混合物的第一光谱。 提供了一组第二光谱,其中该组第二光谱的每个光谱可以代表该化合物的不同多晶型物。 可以比较第一光谱和第二光谱集,并且基于比较,可以确定混合物中一个或多个多晶型物的存在。

    Transmitting light with photon energy information
    67.
    发明申请
    Transmitting light with photon energy information 有权
    用光子能量信息传输光

    公开(公告)号:US20070147726A1

    公开(公告)日:2007-06-28

    申请号:US11316241

    申请日:2005-12-22

    Abstract: In detection and sensing, light is transmitted through layers or structures that vary laterally, such as with a constant gradient or a step-like gradient. After transmission, a position of a transmitted portion of the light or of output photons can be used to determine wavelength change or to obtain other photon energy information. The light can be received, for example, from a stimulus-wavelength converter such as an optical fiber sensor or another optical sensor. A component that propagates the light from the converter to a transmission structure can spread the light across the transmission structure's entry surface. At the exit surface of the transmission structure, photosensor components can sense or detect transmitted light or output photons, such as with a photosensor array or a position sensor. A photosensed quantity can be compared, such as with another photosensed quantity or with a calibration quantity. A differential quantity can be obtained using photosensed quantities.

    Abstract translation: 在检测和感测中,光通过横向变化的层或结构透射,例如以恒定的梯度或阶梯状梯度。 在传输之后,可以使用光或输出光子的透射部分的位置来确定波长变化或获得其它光子能量信息。 光可以例如从诸如光纤传感器或另一光学传感器的刺激 - 波长转换器接收。 将来自转换器的光传播到透射结构的部件可以将光传播穿过透射结构的入射表面。 在透射结构的出射表面处,光电传感器部件可以感测或检测透射光或输出光子,例如用光电传感器阵列或位置传感器。 可以比较光照数量,例如与另一张照片数量或校准数量。 使用光照量可以获得差分量。

    High-resolution, all-reflective imaging spectrometer
    69.
    发明授权
    High-resolution, all-reflective imaging spectrometer 有权
    高分辨率,全反射成像光谱仪

    公开(公告)号:US07080912B2

    公开(公告)日:2006-07-25

    申请号:US11034412

    申请日:2005-01-12

    Applicant: Lacy G. Cook

    Inventor: Lacy G. Cook

    CPC classification number: G01J3/024 G01J3/02 G01J3/0208 G01J3/2823 G02B17/0663

    Abstract: An imaging spectrometer includes an all-reflective objective module that receives an image input and produces an objective module output at an exit slit, and an all-reflective collimating-and-imaging module that receives the objective module output as an objective-end input and produces a collimating-end output, wherein the collimating-and-imaging module comprises a reflective triplet. A dispersive element receives the collimating-end output and produces a dispersive-end input into the collimating-and-imaging module that is reflected through the collimating-and-imaging module to produce a spectral-image-end output. An imaging detector receives the spectral-image-end output of the collimating-and-imaging module. The objective module may be a three-mirror anastigmat having an integral corrector mirror therein, or an all-reflective, relayed optical system comprising a set of five powered mirrors whose powers sum to substantially zero. The collimating-and-imaging module may be optimized to minimize spectral smile.

    Abstract translation: 成像光谱仪包括全反射目标模块,其接收图像输入并在出射狭缝处产生目标模块输出,以及全反射准直和成像模块,其将目标模块输出接收为目标端输入, 产生准直结束输出,其中准直和成像模块包括反射三联体。 色散元件接收准直端输出,并产生通过准直和成像模块反射的准直和成像模块中的色散端输入,以产生光谱图像端输出。 成像检测器接收准直和成像模块的光谱图像端输出。 目标模块可以是其中具有整体校正器镜的三镜式反射镜,或全反射中继光学系统,其包括一组五个电源镜,其功率基本为零。 可以优化准直和成像模块以最小化光谱微笑。

    Achromatic and absorption reducing light collecting system, particularly adapted to optical spectrometric analysis
    70.
    发明申请
    Achromatic and absorption reducing light collecting system, particularly adapted to optical spectrometric analysis 失效
    消色差和吸收减少光采集系统,特别适用于光谱分析

    公开(公告)号:US20060109571A1

    公开(公告)日:2006-05-25

    申请号:US10530608

    申请日:2003-10-07

    CPC classification number: G01J3/28 G01J3/0208 G01J3/024

    Abstract: This system collects light emitted by at least one light source (52) and focuses it onto at least one light detection device (54). Preferably, it comprises a first mirror (58) that collects light emitted by the source and focuses it on a second mirror (60) that focuses it in turn onto the device. The system is provided with a chamber that is opaque to all light, particularly ultraviolet radiation, and in which the light source, the light detection device and the mirrors are placed, and means of creating a vacuum in this chamber and filling it with a gas that is transparent to ultraviolet radiation.

    Abstract translation: 该系统收集由至少一个光源(52)发射的光并将其聚焦到至少一个光检测装置(54)上。 优选地,其包括第一反射镜(58),其收集由源发射的光并将其聚焦在第二反射镜(60)上,所述第二反射镜将其依次聚焦到所述装置上。 该系统设置有对所有光,特别是紫外线辐射是不透明的室,其中放置有光源,光检测装置和反射镜,以及在该室中产生真空并用气体填充的装置 对紫外线辐射是透明的。

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