公开(公告)号：US20180372696A1

公开(公告)日：2018-12-27

申请号：US15780829

申请日：2015-12-04

Applicant: SHIMADZU CORPORATION

Inventor： Kazuma MAEDA

IPC: G01N30/72 ,  H01J49/04 ,  H01J49/10

CPC classification number: G01N30/724 ,  G01N27/62 ,  G01N30/72 ,  G01N30/7273 ,  G01N2030/027 ,  G01N2030/626 ,  H01J49/0031 ,  H01J49/0431 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/107 ,  H01J49/165

Abstract: A liquid sample analyzing system including an ion analyzer having a first ion source receiving a target sample and a second ion source receiving a reference sample; a liquid sample introduction mechanism 3 including a passage-switching section introducing reference samples into the second ion source; and a controller for repeatedly performing a series of steps in the ion analyzer, the steps including: a pre-measurement step for initiating a measurement; a measurement step for introducing a target sample into the first ion source and performing a measurement on an ion originating from the target sample along with an ion originating from a reference sample introduced into the second ion source by the liquid sample introduction mechanism; and a post-measurement step where the liquid sample introduction mechanism operates concurrently with the predetermined post-measurement step to switch the passage-switching section to a passage having a reference sample for the next analysis.

公开(公告)号：US20180330933A1

公开(公告)日：2018-11-15

申请号：US15940077

申请日：2018-03-29

Applicant: Brian Chan ,  James E Botelho ,  Peter J Morrisroe

Inventor： Brian Chan ,  James E Botelho ,  Peter J Morrisroe

IPC: H01J49/04 ,  H01J49/36 ,  F28D15/02

CPC classification number: H01J49/0468 ,  F28D15/0266 ,  G01N21/71 ,  H01J49/0445 ,  H01J49/36 ,  H05K7/20336

Abstract: Certain configurations are described herein of an instrument comprising a passive cooling device which includes, in part, a loop thermosyphon configured to thermally couple to a component of the instrument to be cooled. In some instances, the cooling device can cool a transistor, transistor pair, an interface or other components of the instrument.

公开(公告)号：US20180330932A1

公开(公告)日：2018-11-15

申请号：US16033447

申请日：2018-07-12

Applicant: Micromass UK Limited

Inventor： Zoltan TAKATS ,  Emrys JONES ,  James Ian LANGRIDGE ,  Michael Raymond MORRIS ,  Tamas KARANCSI ,  Steven Derek PRINGLE ,  Julia BALOG ,  Daniel SIMON ,  Lajos GODORHAZY ,  Daniel SZALAY ,  Keith RICHARDSON ,  Phillip Robert BENNETT ,  David Alan MACINTYRE ,  Pamela PRUSKI

IPC: H01J49/04 ,  H01J49/26 ,  H01J49/24 ,  H01J49/16 ,  H01J49/14 ,  H01J49/10 ,  H01J49/06 ,  H01J49/02 ,  H01J49/00 ,  G01N33/92 ,  G01N33/68 ,  G01N33/487 ,  G01N30/72 ,  G01N27/62 ,  G01N9/00 ,  G01N3/00 ,  G01N1/22 ,  C12Q1/24 ,  C12Q1/18 ,  C12Q1/04 ,  C12Q1/02 ,  A61F13/38 ,  A61B18/20 ,  A61B18/18 ,  A61B18/14 ,  A61B18/04 ,  A61B18/00 ,  A61B17/32 ,  A61B17/00 ,  A61B10/02 ,  A61B10/00 ,  A61B8/13 ,  A61B6/03 ,  A61B5/055 ,  A61B5/05 ,  A61B5/01 ,  A61B5/00 ,  A61B1/04 ,  A61B90/13 ,  G06F19/18 ,  A61B5/145 ,  A61B1/31 ,  A61B1/00 ,  G16H50/20 ,  G16H15/00 ,  G16H10/40

CPC classification number: G01N1/2202 ,  A61B1/00013 ,  A61B1/041 ,  A61B1/2736 ,  A61B1/31 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/055 ,  A61B5/14542 ,  A61B6/032 ,  A61B6/037 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B17/320068 ,  A61B18/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/13 ,  A61B2010/0083 ,  A61B2017/320069 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00994 ,  A61B2218/002 ,  A61B2218/008 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N3/00 ,  G01N9/00 ,  G01N27/622 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/48735 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  G01N2001/2223 ,  G01N2333/195 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/26 ,  G06F19/18 ,  G06F19/324 ,  G06F19/3481 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/049 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26

Abstract: A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

公开(公告)号：US20180286658A1

公开(公告)日：2018-10-04

申请号：US15763813

申请日：2015-10-09

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Kazushige NISHIMURA ,  Hiroyuki SATAKE ,  Masuyuki SUGIYAMA ,  Hideki HASEGAWA ,  Tomoyuki SAKAI

IPC: H01J49/16 ,  H01J49/26 ,  H01J49/06

CPC classification number: H01J49/165 ,  H01J49/0077 ,  H01J49/0445 ,  H01J49/062 ,  H01J49/167 ,  H01J49/26

Abstract: To reduce contamination of the apparatus with an additive and to quickly switch spraying and stopping of the additive, provided is an ion analyzer including: an ion source for ionizing a measurement target substance, a spray unit for atomizing and spraying toward the measurement target substance a liquid containing an additive that reacts with the measurement target substance; a separation analysis unit for separately analyzing an ion generated by a reaction between the measurement target substance and the additive; a detector for detecting the ion that has been separately analyzed by the separation analysis unit; and a control unit for lowering a flow rate of the additive supplied to the spray unit during a time when the additive is not necessary.

公开(公告)号：US20180047555A1

公开(公告)日：2018-02-15

申请号：US15556037

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Steven Derek PRINGLE ,  Michael Raymond MORRIS ,  Julia BALOG ,  Emrys JONES ,  Keith RICHARDSON ,  James Ian LANGRIDGE ,  Daniel SIMON ,  Lajos GODORHAZY ,  Daniel SZALAY ,  Zoltan TAKATS

IPC: H01J49/16 ,  A61B5/01 ,  A61B5/00 ,  A61B5/05 ,  A61B5/055 ,  H01J49/00 ,  A61B8/13 ,  A61B10/00 ,  A61B18/04 ,  A61B18/18 ,  A61B18/20 ,  G01N27/62 ,  G01N33/92 ,  A61B6/03

CPC classification number: H01J49/049 ,  A61B1/00013 ,  A61B1/041 ,  A61B1/2736 ,  A61B1/31 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/055 ,  A61B5/14542 ,  A61B6/032 ,  A61B6/037 ,  A61B8/0841 ,  A61B8/085 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B17/320068 ,  A61B18/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B34/20 ,  A61B90/13 ,  A61B90/37 ,  A61B2010/0083 ,  A61B2017/320069 ,  A61B2018/00315 ,  A61B2018/00327 ,  A61B2018/00339 ,  A61B2018/00351 ,  A61B2018/0044 ,  A61B2018/00446 ,  A61B2018/00517 ,  A61B2018/00547 ,  A61B2018/00577 ,  A61B2018/00583 ,  A61B2018/00589 ,  A61B2018/00791 ,  A61B2018/00994 ,  A61B2018/126 ,  A61B2034/2051 ,  A61B2034/2063 ,  A61B2034/301 ,  A61B2090/373 ,  A61B2090/3735 ,  A61B2090/374 ,  A61B2090/376 ,  A61B2090/3762 ,  A61B2090/378 ,  A61B2218/002 ,  A61B2218/005 ,  A61B2218/006 ,  A61B2218/007 ,  A61B2218/008 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/2202 ,  G01N3/00 ,  G01N9/00 ,  G01N27/622 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/48735 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  G01N2001/2223 ,  G01N2333/195 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/26 ,  G06F19/324 ,  G06F19/3481 ,  G16B20/00 ,  G16C20/20 ,  G16H10/40 ,  G16H15/00 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26

Abstract: A method is disclosed comprising obtaining or acquiring image or other data from one or more regions of a target using an imaging sensor. The image or other data may then be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then be used to generate aerosol, smoke or vapour from one or more regions of the target.

公开(公告)号：US20180042582A1

公开(公告)日：2018-02-15

申请号：US15556052

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Steven Derek PRINGLE ,  Emrys JONES ,  Michael Raymond MORRIS ,  Julia BALOG ,  James Ian LANGRIDGE ,  Keith RICHARDSON ,  Daniel SIMON ,  Lajos GODORHAZY ,  Daniel SZALAY ,  Zoltan TAKATS

IPC: A61B10/00 ,  A61B18/04 ,  G01N27/62 ,  A61B18/20 ,  H01J49/04 ,  G01N33/92 ,  A61B18/18

CPC classification number: H01J49/049 ,  A61B1/00013 ,  A61B1/041 ,  A61B1/2736 ,  A61B1/31 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/055 ,  A61B5/14542 ,  A61B6/032 ,  A61B6/037 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B17/320068 ,  A61B18/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/13 ,  A61B2010/0083 ,  A61B2017/320069 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00994 ,  A61B2218/002 ,  A61B2218/008 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/2202 ,  G01N3/00 ,  G01N9/00 ,  G01N27/622 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/48735 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  G01N2001/2223 ,  G01N2333/195 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/26 ,  G06F19/324 ,  G06F19/3481 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26

Abstract: A method is disclosed comprising obtaining physical or other non-mass spectrometric data from one or more regions of a target using a probe. The physical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then used to generate an aerosol, smoke or vapour from one or more regions of the target.

公开(公告)号：US09892898B2

公开(公告)日：2018-02-13

申请号：US14756980

申请日：2015-11-03

Applicant: Joseph J. Bango ,  Michael E. Dziekan

Inventor： Joseph J. Bango ,  Michael E. Dziekan

IPC: H01J49/00 ,  H01J49/04

CPC classification number: H01J49/0445 ,  H01J49/167

Abstract: The disclosed invention relates to electrospray and more specifically to wick based electrospray of analytes. The disclosed invention provides a means for improved electrospray extraction of analytes using a capillarity based fluid delivery system. The disclosed invention employs a wire screen mesh sandwiching the substrate media, without impeding capillarity of a wetting solvent spray fluid applied to the substrate. A further benefit is that electrical contact can be made to the substrate. Yet another benefit is that the substrate and wire mesh can be further enclosed in a polymer or other insulating sleeve that is flat and very thin, the preferred form factor is very similar to that of a credit card.

公开(公告)号：US20170273605A1

公开(公告)日：2017-09-28

申请号：US15617013

申请日：2017-06-08

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-Hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: A61B5/1477 ,  H01J49/16 ,  A61M11/00 ,  A61M25/00 ,  G01N33/483 ,  H01J49/04 ,  H01J49/00 ,  H01J49/34

CPC classification number: A61B5/1477 ,  A61B5/1405 ,  A61B5/145 ,  A61B5/150015 ,  A61B5/150992 ,  A61B5/157 ,  A61B10/0045 ,  A61M11/00 ,  A61M25/00 ,  A61M2202/0468 ,  G01N33/4833 ,  G01N2001/028 ,  H01J49/0022 ,  H01J49/0404 ,  H01J49/0445 ,  H01J49/167 ,  H01J49/34

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US09761426B2

公开(公告)日：2017-09-12

申请号：US14936197

申请日：2015-11-09

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Jason Duncan ,  Guangming Huang ,  Guangtao Li ,  Xin Yan ,  Ewa Sokol ,  Xin Li

IPC: G01N24/00 ,  H01J49/04 ,  G01N27/62 ,  H01J49/00 ,  H01J49/42

CPC classification number: H01J49/04 ,  G01N27/62 ,  H01J49/0031 ,  H01J49/0445 ,  H01J49/4205 ,  Y10T436/24

Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

公开(公告)号：US20170250063A1

公开(公告)日：2017-08-31

申请号：US15454558

申请日：2017-03-09

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. CHIU ,  Dingsheng LIU

IPC: H01J49/16 ,  B05B5/03

CPC classification number: H01J49/165 ,  B05B5/025 ,  B05B5/03 ,  H01J49/0445

Abstract: The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer. The present disclosure further describes methods, systems, and apparatuses for using the devices and interfaces described to perform analysis, including mass spectrometry. The present disclosure also describes methods, systems, and apparatuses for generating and using multi-phase emulsions to perform analysis.